Drosophila melanogaster

69 known processes

tlk (Dmel_CG34412)

Tousled-like kinase

(Aliases: BcDNA:GH07910,EP1413,anon-WO03040301.114,anon-WO03040301.116,CG34412,Tlk,Dmel_CG32782,Dmel_CG32781,CG32782,CG32781,CG33219,l(1)G0054,CG12462,TLK,CG2829,Dmel\CG34412,dtlk,EP(X)1413)

tlk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
death GO:0016265 284 0.654
imaginal disc derived wing morphogenesis GO:0007476 337 0.570
positive regulation of gene expression GO:0010628 290 0.435
negative regulation of cellular metabolic process GO:0031324 382 0.381
Human
imaginal disc derived appendage morphogenesis GO:0035114 395 0.373
glial cell differentiation GO:0010001 35 0.346
cell death GO:0008219 279 0.313
centrosome cycle GO:0007098 137 0.301
imaginal disc derived appendage development GO:0048737 399 0.300
immune system process GO:0002376 347 0.259
gliogenesis GO:0042063 80 0.254
developmental maturation GO:0021700 172 0.239
tissue death GO:0016271 102 0.225
centrosome duplication GO:0051298 121 0.216
regulation of cell development GO:0060284 215 0.213
wing disc morphogenesis GO:0007472 344 0.180
programmed cell death GO:0012501 257 0.169
positive regulation of macromolecule metabolic process GO:0010604 405 0.169
Worm
head development GO:0060322 135 0.155
intracellular transport GO:0046907 228 0.154
Human
salivary gland development GO:0007431 162 0.153
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.150
appendage development GO:0048736 401 0.141
regionalization GO:0003002 416 0.128
regulation of programmed cell death GO:0043067 152 0.126
dendrite development GO:0016358 204 0.117
regulation of cell cycle GO:0051726 291 0.117
post embryonic appendage morphogenesis GO:0035120 385 0.114
regulation of multi organism process GO:0043900 131 0.114
cell fate determination GO:0001709 91 0.114
meiotic cell cycle process GO:1903046 132 0.112
eye development GO:0001654 323 0.111
anterior posterior axis specification GO:0009948 109 0.109
cellular protein modification process GO:0006464 438 0.105
chemosensory behavior GO:0007635 106 0.101
cellular response to dna damage stimulus GO:0006974 223 0.100
Human
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.098
developmental programmed cell death GO:0010623 138 0.098
establishment of localization in cell GO:0051649 402 0.097
Human
positive regulation of cell development GO:0010720 61 0.095
negative regulation of transcription dna templated GO:0045892 237 0.094
organelle fission GO:0048285 340 0.093
protein localization GO:0008104 284 0.093
Human
gland development GO:0048732 191 0.093
regulation of cell death GO:0010941 173 0.092
secretion GO:0046903 109 0.092
negative regulation of gene expression epigenetic GO:0045814 77 0.092
gland morphogenesis GO:0022612 145 0.091
stem cell differentiation GO:0048863 117 0.090
positive regulation of rna metabolic process GO:0051254 271 0.088
macromolecule catabolic process GO:0009057 161 0.088
Human
salivary gland cell autophagic cell death GO:0035071 83 0.086
positive regulation of nucleic acid templated transcription GO:1903508 266 0.083
single organism intracellular transport GO:1902582 207 0.082
dendrite morphogenesis GO:0048813 199 0.081
dna metabolic process GO:0006259 227 0.081
negative regulation of nervous system development GO:0051961 92 0.081
microtubule organizing center organization GO:0031023 168 0.080
cell proliferation GO:0008283 299 0.077
defense response GO:0006952 300 0.077
cell cycle checkpoint GO:0000075 95 0.077
cell motility GO:0048870 251 0.074
organic substance transport GO:0071702 257 0.071
Human
glial cell development GO:0021782 27 0.070
negative regulation of neurogenesis GO:0050768 53 0.070
negative regulation of developmental process GO:0051093 201 0.067
regulation of proteolysis GO:0030162 87 0.067
Human
chromatin organization GO:0006325 207 0.066
mitotic spindle organization GO:0007052 220 0.066
central nervous system development GO:0007417 201 0.066
phosphorylation GO:0016310 294 0.065
digestive tract morphogenesis GO:0048546 127 0.065
apoptotic process GO:0006915 159 0.064
regulation of developmental growth GO:0048638 174 0.063
Worm
segmentation GO:0035282 207 0.063
protein modification process GO:0036211 438 0.060
centrosome organization GO:0051297 163 0.059
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.058
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.058
positive regulation of proteolysis GO:0045862 52 0.057
transcription from rna polymerase ii promoter GO:0006366 368 0.057
Worm
tube development GO:0035295 244 0.056
regulation of cell differentiation GO:0045595 302 0.055
regulation of chromosome organization GO:0033044 64 0.055
Human
negative regulation of gene expression GO:0010629 387 0.054
Human
regulation of cell cycle phase transition GO:1901987 130 0.054
regulation of protein metabolic process GO:0051246 256 0.053
Human Worm
regulation of multicellular organismal development GO:2000026 414 0.053
negative regulation of multicellular organismal process GO:0051241 142 0.052
spindle elongation GO:0051231 83 0.052
ecdysone mediated induction of salivary gland cell autophagic cell death GO:0035072 12 0.051
developmental growth GO:0048589 280 0.050
Worm
embryonic morphogenesis GO:0048598 206 0.050
protein transport GO:0015031 155 0.050
Human
salivary gland morphogenesis GO:0007435 145 0.050
regulation of molecular function GO:0065009 217 0.049
Worm
regulation of anatomical structure morphogenesis GO:0022603 242 0.049
cell division GO:0051301 248 0.049
negative regulation of nucleic acid templated transcription GO:1903507 240 0.049
regulation of mitotic cell cycle GO:0007346 190 0.048
vesicle mediated transport GO:0016192 381 0.048
negative regulation of biosynthetic process GO:0009890 277 0.047
positive regulation of rna biosynthetic process GO:1902680 266 0.047
positive regulation of biosynthetic process GO:0009891 316 0.047
blastoderm segmentation GO:0007350 159 0.047
regulation of neuron differentiation GO:0045664 103 0.047
nuclear division GO:0000280 332 0.047
meiotic cell cycle GO:0051321 171 0.047
gene silencing GO:0016458 138 0.047
spindle organization GO:0007051 253 0.047
histolysis GO:0007559 102 0.046
salivary gland histolysis GO:0035070 88 0.046
cellular component disassembly GO:0022411 46 0.046
compound eye photoreceptor fate commitment GO:0001752 36 0.044
mitotic nuclear division GO:0007067 213 0.043
posttranscriptional gene silencing by rna GO:0035194 45 0.043
brain development GO:0007420 120 0.043
exocrine system development GO:0035272 162 0.042
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.042
regulation of gene expression epigenetic GO:0040029 128 0.041
cellular macromolecular complex assembly GO:0034622 153 0.041
embryonic development via the syncytial blastoderm GO:0001700 148 0.041
camera type eye development GO:0043010 4 0.040
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.040
cellular response to chemical stimulus GO:0070887 199 0.039
dna conformation change GO:0071103 105 0.039
negative regulation of cell proliferation GO:0008285 69 0.038
stem cell fate commitment GO:0048865 25 0.038
morphogenesis of an epithelium GO:0002009 276 0.038
negative regulation of rna metabolic process GO:0051253 251 0.038
digestive tract development GO:0048565 149 0.038
establishment of protein localization to organelle GO:0072594 62 0.038
regulation of cell proliferation GO:0042127 163 0.037
embryonic pattern specification GO:0009880 174 0.037
regulation of immune system process GO:0002682 176 0.036
translation GO:0006412 69 0.036
dna replication GO:0006260 48 0.036
negative regulation of protein metabolic process GO:0051248 85 0.036
Human
organelle localization GO:0051640 148 0.036
phagocytosis GO:0006909 215 0.036
eye morphogenesis GO:0048592 260 0.036
homeostatic process GO:0042592 199 0.035
forebrain development GO:0030900 2 0.035
biological adhesion GO:0022610 138 0.035
negative regulation of cellular biosynthetic process GO:0031327 277 0.035
response to oxygen containing compound GO:1901700 200 0.034
proteolysis GO:0006508 192 0.034
Human
secretion by cell GO:0032940 101 0.034
chromosome organization GO:0051276 360 0.033
localization of cell GO:0051674 257 0.033
regulation of mrna processing GO:0050684 71 0.033
tube morphogenesis GO:0035239 191 0.033
dna packaging GO:0006323 91 0.032
anterior posterior pattern specification GO:0009952 136 0.032
autophagic cell death GO:0048102 83 0.032
regulation of cellular protein metabolic process GO:0032268 243 0.032
Human Worm
locomotory behavior GO:0007626 176 0.032
peptidyl amino acid modification GO:0018193 105 0.032
Human
regulation of cellular localization GO:0060341 136 0.031
sensory organ morphogenesis GO:0090596 260 0.031
negative regulation of cell differentiation GO:0045596 143 0.031
single organism behavior GO:0044708 391 0.030
compound eye morphogenesis GO:0001745 249 0.030
regulation of cell cycle process GO:0010564 181 0.029
positive regulation of transcription dna templated GO:0045893 266 0.029
cellular macromolecule localization GO:0070727 220 0.029
Human
smoothened signaling pathway GO:0007224 49 0.029
taxis GO:0042330 304 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.029
catabolic process GO:0009056 409 0.029
Human
chromatin modification GO:0016568 147 0.028
respiratory system development GO:0060541 213 0.028
muscle structure development GO:0061061 224 0.028
posttranscriptional regulation of gene expression GO:0010608 145 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.027
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.027
protein acylation GO:0043543 42 0.026
circulatory system development GO:0072359 82 0.026
protein complex biogenesis GO:0070271 201 0.026
neuroblast fate commitment GO:0014017 19 0.026
response to biotic stimulus GO:0009607 294 0.026
tissue morphogenesis GO:0048729 297 0.025
negative regulation of cell cycle phase transition GO:1901988 103 0.025
positive regulation of cell proliferation GO:0008284 47 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
cell maturation GO:0048469 144 0.025
positive regulation of mitotic cell cycle GO:0045931 34 0.025
protein import GO:0017038 55 0.025
positive regulation of developmental process GO:0051094 143 0.024
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.024
Worm
induction of programmed cell death GO:0012502 12 0.024
positive regulation of cell differentiation GO:0045597 64 0.024
regulation of localization GO:0032879 275 0.023
sister chromatid segregation GO:0000819 92 0.023
olfactory behavior GO:0042048 97 0.023
regulation of anatomical structure size GO:0090066 163 0.023
cell adhesion GO:0007155 136 0.023
regulation of response to external stimulus GO:0032101 115 0.023
compound eye development GO:0048749 307 0.023
protein targeting GO:0006605 64 0.023
nuclear transport GO:0051169 72 0.023
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
Human
photoreceptor cell development GO:0042461 96 0.023
mitotic cell cycle phase transition GO:0044772 138 0.023
growth GO:0040007 359 0.023
Worm
endocytosis GO:0006897 310 0.022
response to ecdysone GO:0035075 34 0.022
telencephalon development GO:0021537 2 0.022
response to ketone GO:1901654 34 0.022
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.022
stem cell maintenance GO:0019827 67 0.021
regulation of nervous system development GO:0051960 248 0.021
cognition GO:0050890 141 0.021
mrna metabolic process GO:0016071 124 0.021
regulation of mitotic cell cycle phase transition GO:1901990 130 0.021
axonogenesis GO:0007409 290 0.021
modification dependent protein catabolic process GO:0019941 78 0.021
Human
regulation of growth GO:0040008 233 0.021
Worm
regulation of endopeptidase activity GO:0052548 36 0.021
eye photoreceptor cell development GO:0042462 81 0.021
induction of programmed cell death by ecdysone GO:0035078 12 0.021
negative regulation of cell death GO:0060548 81 0.020
regulation of apoptotic process GO:0042981 130 0.020
protein import into nucleus GO:0006606 51 0.020
protein localization to nucleus GO:0034504 55 0.020
embryo development ending in birth or egg hatching GO:0009792 152 0.020
Worm
meiotic nuclear division GO:0007126 151 0.020
neuroblast proliferation GO:0007405 74 0.020
regulation of gliogenesis GO:0014013 11 0.020
negative regulation of developmental growth GO:0048640 64 0.020
tripartite regional subdivision GO:0007351 103 0.020
regulation of translation GO:0006417 56 0.020
microtubule based movement GO:0007018 51 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.020
Human
response to abiotic stimulus GO:0009628 341 0.019
Human
positive regulation of cellular biosynthetic process GO:0031328 316 0.019
chemotaxis GO:0006935 249 0.019
cellular catabolic process GO:0044248 372 0.019
Human
cellular protein localization GO:0034613 160 0.019
Human
retina development in camera type eye GO:0060041 4 0.019
negative regulation of phosphate metabolic process GO:0045936 45 0.019
positive regulation of protein metabolic process GO:0051247 128 0.019
Worm
response to other organism GO:0051707 293 0.019
photoreceptor cell fate commitment GO:0046552 41 0.019
positive regulation of cell death GO:0010942 69 0.018
circadian behavior GO:0048512 76 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
compound eye photoreceptor cell differentiation GO:0001751 140 0.018
positive regulation of cell cycle GO:0045787 43 0.017
regulation of response to stress GO:0080134 200 0.017
defense response to other organism GO:0098542 225 0.017
establishment of organelle localization GO:0051656 122 0.017
positive regulation of molecular function GO:0044093 136 0.017
Worm
negative regulation of cell communication GO:0010648 223 0.017
intracellular protein transport GO:0006886 104 0.017
Human
negative regulation of mitotic cell cycle GO:0045930 109 0.017
chromatin silencing GO:0006342 76 0.017
response to radiation GO:0009314 155 0.017
Human
cellular amine metabolic process GO:0044106 12 0.017
hindgut morphogenesis GO:0007442 58 0.017
chromatin assembly GO:0031497 48 0.017
negative regulation of programmed cell death GO:0043069 72 0.016
reproductive behavior GO:0019098 122 0.016
nucleocytoplasmic transport GO:0006913 72 0.016
protein targeting to nucleus GO:0044744 51 0.016
nuclear import GO:0051170 51 0.016
histone ubiquitination GO:0016574 4 0.016
regulation of mrna metabolic process GO:1903311 72 0.016
mitotic sister chromatid segregation GO:0000070 87 0.016
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.015
wnt signaling pathway GO:0016055 98 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
amine metabolic process GO:0009308 12 0.015
mesenchymal cell differentiation GO:0048762 1 0.015
epithelial cell differentiation GO:0030855 322 0.015
spinal cord development GO:0021510 1 0.015
adult behavior GO:0030534 137 0.015
protein phosphorylation GO:0006468 169 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
dna endoreduplication GO:0042023 22 0.015
response to bacterium GO:0009617 198 0.014
cell cycle phase transition GO:0044770 140 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
compound eye photoreceptor development GO:0042051 78 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
axis specification GO:0009798 167 0.014
negative regulation of transcription regulatory region dna binding GO:2000678 3 0.014
chromosome segregation GO:0007059 157 0.014
appendage morphogenesis GO:0035107 397 0.014
regulation of neuroblast proliferation GO:1902692 34 0.014
cell cycle g1 s phase transition GO:0044843 31 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
protein localization to organelle GO:0033365 82 0.014
actin filament based process GO:0030029 220 0.014
metaphase plate congression GO:0051310 19 0.014
neuron projection guidance GO:0097485 241 0.014
cell migration GO:0016477 238 0.013
cranial nerve development GO:0021545 1 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
regulation of cell division GO:0051302 72 0.013
regulation of neurogenesis GO:0050767 158 0.013
gastrulation with mouth forming first GO:0001703 36 0.013
regulation of embryonic development GO:0045995 68 0.013
asymmetric cell division GO:0008356 37 0.013
response to nutrient levels GO:0031667 114 0.013
regulation of glial cell differentiation GO:0045685 1 0.013
muscle organ development GO:0007517 127 0.013
positive regulation of catabolic process GO:0009896 105 0.013
organic substance catabolic process GO:1901575 308 0.013
Human
macromolecular complex assembly GO:0065003 256 0.013
negative regulation of cell development GO:0010721 62 0.013
establishment of chromosome localization GO:0051303 20 0.013
spermatogenesis GO:0007283 200 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
Worm
positive regulation of response to stimulus GO:0048584 323 0.012
peripheral nervous system development GO:0007422 52 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.012
aging GO:0007568 143 0.012
neuroblast division GO:0055057 35 0.012
organonitrogen compound metabolic process GO:1901564 318 0.012
positive regulation of cell migration GO:0030335 2 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.012
regulation of gene silencing GO:0060968 63 0.012
rna processing GO:0006396 147 0.012
ras protein signal transduction GO:0007265 88 0.012
single organism nuclear import GO:1902593 51 0.012
response to organic substance GO:0010033 284 0.012
response to sterol GO:0036314 34 0.012
neuron maturation GO:0042551 31 0.012
regulation of transport GO:0051049 181 0.012
meiosis i GO:0007127 59 0.011
actomyosin structure organization GO:0031032 56 0.011
positive regulation of binding GO:0051099 4 0.011
digestive system development GO:0055123 149 0.011
signal release GO:0023061 49 0.011
cytoplasmic transport GO:0016482 130 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
Human
eye photoreceptor cell differentiation GO:0001754 145 0.011
regulation of synapse assembly GO:0051963 94 0.011
cardiovascular system development GO:0072358 82 0.011
negative regulation of signal transduction GO:0009968 206 0.011
regulation of protein localization GO:0032880 76 0.010
neural retina development GO:0003407 4 0.010
regulation of glial cell proliferation GO:0060251 11 0.010
positive regulation of transport GO:0051050 92 0.010
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.010
chromatin assembly or disassembly GO:0006333 52 0.010
Human
stem cell development GO:0048864 79 0.010
mesenchymal cell development GO:0014031 1 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.010
establishment of nucleus localization GO:0040023 26 0.010
larval development GO:0002164 104 0.010
ovarian follicle cell development GO:0030707 248 0.010
dna integrity checkpoint GO:0031570 81 0.010
proteasomal protein catabolic process GO:0010498 59 0.010
Human
regulation of hydrolase activity GO:0051336 97 0.010

tlk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013