Drosophila melanogaster

18 known processes

phol (Dmel_CG3445)

pleiohomeotic like

(Aliases: CG3445,Dmel\CG3445,PHOL,Phol)

phol biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular biosynthetic process GO:0031327 277 0.248
Human Mouse Rat Fly
negative regulation of transcription dna templated GO:0045892 237 0.219
Human Mouse Rat Fly
negative regulation of biosynthetic process GO:0009890 277 0.214
Human Mouse Rat Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.194
Human Mouse Rat
negative regulation of rna biosynthetic process GO:1902679 240 0.192
Human Mouse Rat Fly
dorsal closure GO:0007391 79 0.184
imaginal disc derived appendage morphogenesis GO:0035114 395 0.183
appendage morphogenesis GO:0035107 397 0.165
negative regulation of cellular metabolic process GO:0031324 382 0.165
Human Mouse Rat Fly
multicellular organism growth GO:0035264 46 0.161
gland development GO:0048732 191 0.155
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.149
Human Mouse Rat Fly
embryonic morphogenesis GO:0048598 206 0.134
protein modification process GO:0036211 438 0.128
negative regulation of nucleic acid templated transcription GO:1903507 240 0.126
Human Mouse Rat Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.119
Human Mouse Rat
positive regulation of biosynthetic process GO:0009891 316 0.112
Rat Fly
taxis GO:0042330 304 0.104
regulation of developmental growth GO:0048638 174 0.102
cellular protein modification process GO:0006464 438 0.101
female meiotic division GO:0007143 70 0.100
meiotic chromosome segregation GO:0045132 59 0.100
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.098
Human Mouse Rat Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.095
Human Mouse Rat Fly
actin cytoskeleton organization GO:0030036 206 0.090
growth GO:0040007 359 0.085
positive regulation of cellular catabolic process GO:0031331 95 0.085
mitotic cell cycle phase transition GO:0044772 138 0.074
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.072
Human Mouse Rat Fly
tissue death GO:0016271 102 0.071
regulation of intracellular signal transduction GO:1902531 236 0.070
meiotic nuclear division GO:0007126 151 0.069
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.068
Rat
negative regulation of gene expression GO:0010629 387 0.067
response to abiotic stimulus GO:0009628 341 0.063
Human Mouse
positive regulation of response to stimulus GO:0048584 323 0.062
meiotic cell cycle GO:0051321 171 0.062
positive regulation of cell communication GO:0010647 250 0.062
regulation of phosphorus metabolic process GO:0051174 210 0.060
cellular macromolecule catabolic process GO:0044265 136 0.060
neurological system process GO:0050877 358 0.059
phosphorylation GO:0016310 294 0.059
developmental growth GO:0048589 280 0.058
imaginal disc derived appendage development GO:0048737 399 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.057
Rat Fly
negative regulation of rna metabolic process GO:0051253 251 0.057
Human Mouse Rat Fly
positive regulation of signal transduction GO:0009967 223 0.054
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.054
Rat Fly
positive regulation of transcription dna templated GO:0045893 266 0.054
Rat Fly
digestive tract development GO:0048565 149 0.053
positive regulation of signaling GO:0023056 243 0.053
regulation of dna metabolic process GO:0051052 34 0.053
post embryonic appendage morphogenesis GO:0035120 385 0.051
embryo development ending in birth or egg hatching GO:0009792 152 0.051
Mouse
synapse organization GO:0050808 196 0.048
single organism behavior GO:0044708 391 0.048
intracellular signal transduction GO:0035556 300 0.047
regulation of cellular protein metabolic process GO:0032268 243 0.047
regulation of mitotic cell cycle phase transition GO:1901990 130 0.046
regulation of cell proliferation GO:0042127 163 0.045
meiotic cell cycle process GO:1903046 132 0.044
chemosensory behavior GO:0007635 106 0.042
regulation of multicellular organismal development GO:2000026 414 0.041
regulation of phosphate metabolic process GO:0019220 210 0.041
digestive system development GO:0055123 149 0.041
cognition GO:0050890 141 0.040
purine nucleotide metabolic process GO:0006163 146 0.038
cell death GO:0008219 279 0.038
regulation of cellular catabolic process GO:0031329 157 0.038
death GO:0016265 284 0.037
wing disc morphogenesis GO:0007472 344 0.037
small gtpase mediated signal transduction GO:0007264 88 0.037
purine ribonucleoside metabolic process GO:0046128 127 0.037
digestive tract morphogenesis GO:0048546 127 0.037
regulation of cellular amino acid metabolic process GO:0006521 0 0.035
programmed cell death GO:0012501 257 0.035
actin filament based process GO:0030029 220 0.035
cell proliferation GO:0008283 299 0.034
axon development GO:0061564 297 0.034
segmentation GO:0035282 207 0.034
nucleotide metabolic process GO:0009117 161 0.033
axon guidance GO:0007411 233 0.033
nuclear division GO:0000280 332 0.033
eye development GO:0001654 323 0.033
Mouse
salivary gland morphogenesis GO:0007435 145 0.032
macromolecule catabolic process GO:0009057 161 0.032
central nervous system development GO:0007417 201 0.032
mrna metabolic process GO:0016071 124 0.032
positive regulation of cellular component organization GO:0051130 156 0.032
regulation of anatomical structure size GO:0090066 163 0.031
salivary gland development GO:0007431 162 0.031
histolysis GO:0007559 102 0.031
regulation of protein metabolic process GO:0051246 256 0.031
embryonic pattern specification GO:0009880 174 0.030
immune system process GO:0002376 347 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
endocytosis GO:0006897 310 0.029
positive regulation of rna biosynthetic process GO:1902680 266 0.029
Rat Fly
negative regulation of developmental process GO:0051093 201 0.029
heterocycle catabolic process GO:0046700 166 0.029
purine nucleoside triphosphate metabolic process GO:0009144 119 0.029
gland morphogenesis GO:0022612 145 0.028
response to starvation GO:0042594 97 0.028
protein k48 linked ubiquitination GO:0070936 3 0.028
developmental programmed cell death GO:0010623 138 0.028
immune system development GO:0002520 57 0.028
gravitaxis GO:0042332 26 0.028
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.028
protein phosphorylation GO:0006468 169 0.027
response to nitrogen compound GO:1901698 90 0.027
regulation of cell cycle phase transition GO:1901987 130 0.027
tube development GO:0035295 244 0.027
small molecule metabolic process GO:0044281 305 0.026
gastrulation with mouth forming first GO:0001703 36 0.026
chromatin modification GO:0016568 147 0.026
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.026
Rat Fly
positive regulation of nucleic acid templated transcription GO:1903508 266 0.026
Rat Fly
regulation of molecular function GO:0065009 217 0.026
organic cyclic compound catabolic process GO:1901361 168 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.025
salivary gland histolysis GO:0035070 88 0.025
cellular amine metabolic process GO:0044106 12 0.025
catabolic process GO:0009056 409 0.025
spermatogenesis GO:0007283 200 0.025
Mouse
localization of cell GO:0051674 257 0.025
regulation of organelle organization GO:0033043 196 0.024
axonogenesis GO:0007409 290 0.024
nucleoside catabolic process GO:0009164 112 0.024
chromosome segregation GO:0007059 157 0.024
guanosine containing compound metabolic process GO:1901068 74 0.024
aging GO:0007568 143 0.024
actomyosin structure organization GO:0031032 56 0.023
aromatic compound catabolic process GO:0019439 166 0.023
regulation of cell cycle GO:0051726 291 0.023
ras protein signal transduction GO:0007265 88 0.023
sex differentiation GO:0007548 81 0.023
Human
purine ribonucleotide metabolic process GO:0009150 145 0.023
guanosine containing compound catabolic process GO:1901069 74 0.023
glycosyl compound metabolic process GO:1901657 127 0.023
response to reactive oxygen species GO:0000302 24 0.022
gtp metabolic process GO:0046039 72 0.022
ribose phosphate metabolic process GO:0019693 145 0.022
multi organism behavior GO:0051705 175 0.022
nucleotide catabolic process GO:0009166 109 0.022
ribonucleotide catabolic process GO:0009261 109 0.022
hemopoiesis GO:0030097 46 0.022
ribonucleoside metabolic process GO:0009119 127 0.022
cellular protein catabolic process GO:0044257 83 0.022
positive regulation of catabolic process GO:0009896 105 0.022
regulation of catabolic process GO:0009894 170 0.022
exocrine system development GO:0035272 162 0.022
oocyte microtubule cytoskeleton organization GO:0016325 35 0.022
connective tissue development GO:0061448 3 0.022
purine ribonucleotide catabolic process GO:0009154 109 0.021
wnt signaling pathway GO:0016055 98 0.021
cellular catabolic process GO:0044248 372 0.021
proteolysis GO:0006508 192 0.021
imaginal disc derived wing morphogenesis GO:0007476 337 0.020
organic substance catabolic process GO:1901575 308 0.020
hematopoietic or lymphoid organ development GO:0048534 57 0.020
autophagic cell death GO:0048102 83 0.020
nucleobase containing small molecule metabolic process GO:0055086 174 0.020
negative regulation of protein metabolic process GO:0051248 85 0.020
response to gravity GO:0009629 26 0.020
cellular response to nitrogen compound GO:1901699 51 0.020
regulation of catalytic activity GO:0050790 185 0.020
cellular nitrogen compound catabolic process GO:0044270 165 0.020
covalent chromatin modification GO:0016569 106 0.020
regulation of cell cycle process GO:0010564 181 0.019
mrna processing GO:0006397 104 0.019
cellular macromolecular complex assembly GO:0034622 153 0.019
protein modification by small protein conjugation GO:0032446 79 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.019
response to nutrient levels GO:0031667 114 0.019
response to organic cyclic compound GO:0014070 89 0.019
regulation of mapk cascade GO:0043408 92 0.018
cell aging GO:0007569 2 0.018
phagocytosis GO:0006909 215 0.018
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.018
regulation of cellular component biogenesis GO:0044087 201 0.018
nucleoside phosphate catabolic process GO:1901292 110 0.018
response to other organism GO:0051707 293 0.018
eye morphogenesis GO:0048592 260 0.018
Mouse
positive regulation of cellular component biogenesis GO:0044089 80 0.018
camera type eye development GO:0043010 4 0.018
Mouse
appendage development GO:0048736 401 0.018
positive regulation of cell motility GO:2000147 3 0.018
single organism biosynthetic process GO:0044711 206 0.018
Zebrafish
regulation of cell shape GO:0008360 113 0.018
establishment or maintenance of cell polarity GO:0007163 167 0.018
regulation of lamellipodium assembly GO:0010591 15 0.018
positive regulation of intracellular signal transduction GO:1902533 116 0.018
tube morphogenesis GO:0035239 191 0.017
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.017
mitotic nuclear division GO:0007067 213 0.017
regulation of purine nucleotide metabolic process GO:1900542 62 0.017
positive regulation of cell proliferation GO:0008284 47 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
signal transduction by phosphorylation GO:0023014 107 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
Rat Fly
male gamete generation GO:0048232 201 0.017
Mouse
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
nucleobase containing compound catabolic process GO:0034655 165 0.017
regulation of mrna metabolic process GO:1903311 72 0.017
chaeta development GO:0022416 97 0.017
epithelial cell differentiation GO:0030855 322 0.017
heart process GO:0003015 37 0.017
protein ubiquitination GO:0016567 70 0.016
positive regulation of phosphate metabolic process GO:0045937 139 0.016
purine nucleoside metabolic process GO:0042278 127 0.016
columnar cuboidal epithelial cell development GO:0002066 249 0.016
defense response GO:0006952 300 0.016
chemotaxis GO:0006935 249 0.016
gtp catabolic process GO:0006184 72 0.016
protein modification by small protein conjugation or removal GO:0070647 106 0.016
regulation of mrna processing GO:0050684 71 0.016
salivary gland cell autophagic cell death GO:0035071 83 0.016
protein catabolic process GO:0030163 101 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.016
regulation of gene expression epigenetic GO:0040029 128 0.016
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.016
Human Mouse Rat
sensory organ morphogenesis GO:0090596 260 0.016
Mouse
cellular response to chemical stimulus GO:0070887 199 0.016
Rat
locomotory behavior GO:0007626 176 0.015
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
negative regulation of signaling GO:0023057 219 0.015
imaginal disc derived leg morphogenesis GO:0007480 80 0.015
chaeta morphogenesis GO:0008407 42 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
protein localization GO:0008104 284 0.015
embryonic development via the syncytial blastoderm GO:0001700 148 0.015
muscle structure development GO:0061061 224 0.015
cellular lipid metabolic process GO:0044255 83 0.015
regulation of multicellular organism growth GO:0040014 40 0.015
organonitrogen compound biosynthetic process GO:1901566 117 0.014
regulation of blood circulation GO:1903522 21 0.014
regulation of ras protein signal transduction GO:0046578 93 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
single organism intracellular transport GO:1902582 207 0.014
cell cycle phase transition GO:0044770 140 0.014
heart contraction GO:0060047 26 0.014
nucleoside triphosphate metabolic process GO:0009141 120 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
secondary metabolic process GO:0019748 75 0.014
regionalization GO:0003002 416 0.014
Mouse
eye photoreceptor cell fate commitment GO:0042706 37 0.014
neural precursor cell proliferation GO:0061351 75 0.013
morphogenesis of embryonic epithelium GO:0016331 94 0.013
regulation of cell differentiation GO:0045595 302 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
cellular response to organic substance GO:0071310 132 0.013
Rat
apoptotic process GO:0006915 159 0.013
olfactory behavior GO:0042048 97 0.013
body morphogenesis GO:0010171 2 0.013
alternative mrna splicing via spliceosome GO:0000380 60 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
regulation of compound eye cone cell fate specification GO:0042682 4 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
macromolecular complex assembly GO:0065003 256 0.013
protein processing GO:0016485 68 0.013
gastrulation involving germ band extension GO:0010004 36 0.013
axis specification GO:0009798 167 0.013
regulation of nucleotide metabolic process GO:0006140 62 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
negative regulation of cell communication GO:0010648 223 0.013
regulation of growth GO:0040008 233 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
response to organonitrogen compound GO:0010243 75 0.013
gastrulation GO:0007369 70 0.013
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.013
photoreceptor cell fate commitment GO:0046552 41 0.013
oxoacid metabolic process GO:0043436 103 0.013
blood circulation GO:0008015 26 0.013
cellular response to endogenous stimulus GO:0071495 80 0.013
epidermal growth factor receptor signaling pathway GO:0007173 58 0.012
actin filament organization GO:0007015 126 0.012
defense response to other organism GO:0098542 225 0.012
organelle fission GO:0048285 340 0.012
regulation of wnt signaling pathway GO:0030111 68 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.012
protein maturation GO:0051604 71 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
vesicle mediated transport GO:0016192 381 0.012
circulatory system process GO:0003013 37 0.012
regulation of programmed cell death GO:0043067 152 0.012
cell fate specification GO:0001708 71 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
epithelial cell migration open tracheal system GO:0007427 32 0.012
larval development GO:0002164 104 0.012
organophosphate catabolic process GO:0046434 112 0.012
response to biotic stimulus GO:0009607 294 0.012
protein complex assembly GO:0006461 200 0.012
single organism catabolic process GO:0044712 228 0.012
determination of adult lifespan GO:0008340 137 0.011
peptidyl amino acid modification GO:0018193 105 0.011
regulation of gtpase activity GO:0043087 44 0.011
tor signaling GO:0031929 32 0.011
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.011
synaptic transmission GO:0007268 288 0.011
inositol lipid mediated signaling GO:0048017 4 0.011
positive regulation of gene expression GO:0010628 290 0.011
Mouse Rat Fly
organic substance transport GO:0071702 257 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
positive regulation of organelle organization GO:0010638 65 0.011
mapk cascade GO:0000165 107 0.011
establishment of localization in cell GO:0051649 402 0.011
regulation of response to stress GO:0080134 200 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
regulation of protein modification process GO:0031399 112 0.011
reproductive behavior GO:0019098 122 0.011
regulation of rna splicing GO:0043484 69 0.011
purine ribonucleoside catabolic process GO:0046130 112 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
purine containing compound metabolic process GO:0072521 155 0.010
organelle assembly GO:0070925 198 0.010
negative regulation of cell cycle phase transition GO:1901988 103 0.010
negative regulation of cell cycle process GO:0010948 109 0.010
regulation of translation GO:0006417 56 0.010
embryonic axis specification GO:0000578 107 0.010
dendrite morphogenesis GO:0048813 199 0.010
Fly
response to temperature stimulus GO:0009266 106 0.010
metaphase anaphase transition of cell cycle GO:0044784 28 0.010
regulation of actin cytoskeleton organization GO:0032956 42 0.010
positive regulation of cell differentiation GO:0045597 64 0.010
erbb signaling pathway GO:0038127 58 0.010
epithelial cell development GO:0002064 274 0.010
regulation of gene silencing GO:0060968 63 0.010

phol disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
nervous system disease DOID:863 0 0.014
central nervous system disease DOID:331 0 0.012
organ system cancer DOID:0050686 0 0.012