Drosophila melanogaster

60 known processes

ppk (Dmel_CG3478)

pickpocket

(Aliases: CG3478,BG:DS06238.1,pkt,Dmel\CG3478,PPK,mdNaC1,dmdNaC1,dmdNaCl,PPK1,ppk1)

ppk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval behavior GO:0030537 42 0.951
single organism behavior GO:0044708 391 0.786
circadian behavior GO:0048512 76 0.697
regulation of behavior GO:0050795 75 0.608
multi organism reproductive behavior GO:0044705 121 0.598
Fly
aggressive behavior GO:0002118 63 0.521
Fly
circadian rhythm GO:0007623 105 0.501
mating GO:0007618 120 0.481
Fly
rhythmic process GO:0048511 106 0.475
response to temperature stimulus GO:0009266 106 0.451
response to abiotic stimulus GO:0009628 341 0.438
locomotory behavior GO:0007626 176 0.401
sensory perception of mechanical stimulus GO:0050954 72 0.369
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 2 0.359
feeding behavior GO:0007631 50 0.349
response to radiation GO:0009314 155 0.329
response to light stimulus GO:0009416 124 0.311
larval locomotory behavior GO:0008345 27 0.308
synaptic transmission GO:0007268 288 0.296
Fly
mating behavior GO:0007617 106 0.251
Fly
multi organism behavior GO:0051705 175 0.237
Fly
multicellular organismal reproductive behavior GO:0033057 110 0.219
Fly
negative regulation of response to stimulus GO:0048585 258 0.197
inter male aggressive behavior GO:0002121 60 0.167
Fly
response to organic substance GO:0010033 284 0.166
Fly
cellular response to abiotic stimulus GO:0071214 58 0.161
Fly
larval feeding behavior GO:0030536 15 0.155
courtship behavior GO:0007619 68 0.147
Fly
male courtship behavior GO:0008049 63 0.139
Fly
rhythmic behavior GO:0007622 76 0.133
cell migration GO:0016477 238 0.131
Rat
cellular response to organonitrogen compound GO:0071417 36 0.130
regulation of anatomical structure size GO:0090066 163 0.114
glycerolipid catabolic process GO:0046503 3 0.112
positive regulation of cell communication GO:0010647 250 0.111
cellular response to insulin stimulus GO:0032869 28 0.110
multi multicellular organism process GO:0044706 123 0.108
Fly
cell motility GO:0048870 251 0.101
Rat
localization of cell GO:0051674 257 0.100
Rat
aging GO:0007568 143 0.100
positive regulation of response to stimulus GO:0048584 323 0.098
male mating behavior GO:0060179 70 0.097
Fly
reproductive behavior GO:0019098 122 0.095
Fly
negative regulation of developmental process GO:0051093 201 0.093
sensory perception of salty taste GO:0050914 3 0.090
Fly
response to insulin GO:0032868 29 0.089
taxis GO:0042330 304 0.089
determination of adult lifespan GO:0008340 137 0.089
mechanosensory behavior GO:0007638 12 0.087
detection of stimulus involved in sensory perception GO:0050906 92 0.085
positive regulation of multicellular organismal process GO:0051240 143 0.080
growth GO:0040007 359 0.079
chemical homeostasis GO:0048878 92 0.076
Human
developmental growth GO:0048589 280 0.076
cellular response to organic substance GO:0071310 132 0.075
embryonic morphogenesis GO:0048598 206 0.074
intracellular signal transduction GO:0035556 300 0.074
negative regulation of behavior GO:0048521 8 0.070
cellular response to nitrogen compound GO:1901699 51 0.070
response to mechanical stimulus GO:0009612 28 0.069
response to oxygen containing compound GO:1901700 200 0.069
Fly
multicellular organismal aging GO:0010259 140 0.066
sensory perception of pain GO:0019233 4 0.066
response to food GO:0032094 3 0.062
locomotor rhythm GO:0045475 56 0.061
positive regulation of signaling GO:0023056 243 0.060
intraspecies interaction between organisms GO:0051703 4 0.059
negative regulation of signaling GO:0023057 219 0.058
regulation of growth GO:0040008 233 0.056
homeostatic process GO:0042592 199 0.055
Human
response to pain GO:0048265 3 0.055
cellular response to peptide hormone stimulus GO:0071375 28 0.054
positive regulation of growth GO:0045927 75 0.053
single organism catabolic process GO:0044712 228 0.053
organic substance catabolic process GO:1901575 308 0.052
regulation of developmental growth GO:0048638 174 0.052
response to wounding GO:0009611 94 0.051
Rat
response to peptide hormone GO:0043434 29 0.051
small molecule metabolic process GO:0044281 305 0.051
cellular response to oxygen containing compound GO:1901701 79 0.050
Fly
cellular response to endogenous stimulus GO:0071495 80 0.049
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.048
social behavior GO:0035176 4 0.048
regulation of synapse structure and activity GO:0050803 128 0.048
Fly
response to nitrogen compound GO:1901698 90 0.047
organonitrogen compound metabolic process GO:1901564 318 0.046
detection of stimulus GO:0051606 156 0.045
regulation of localization GO:0032879 275 0.045
Rat
kidney development GO:0001822 3 0.044
regulation of circadian rhythm GO:0042752 49 0.044
enzyme linked receptor protein signaling pathway GO:0007167 179 0.044
wound healing GO:0042060 75 0.043
Rat
regulation of cell development GO:0060284 215 0.042
cellular response to peptide GO:1901653 28 0.041
cilium morphogenesis GO:0060271 39 0.041
cell proliferation GO:0008283 299 0.041
neurological system process GO:0050877 358 0.040
cellular protein modification process GO:0006464 438 0.039
positive regulation of developmental growth GO:0048639 62 0.039
telencephalon development GO:0021537 2 0.039
regulation of cell morphogenesis GO:0022604 163 0.038
g protein coupled receptor signaling pathway GO:0007186 136 0.038
response to nutrient levels GO:0031667 114 0.038
cation homeostasis GO:0055080 51 0.038
Human
female mating behavior GO:0060180 30 0.037
regulation of tube size GO:0035150 46 0.037
regulation of dendrite development GO:0050773 37 0.037
negative regulation of cellular component organization GO:0051129 108 0.036
response to endogenous stimulus GO:0009719 119 0.036
tissue morphogenesis GO:0048729 297 0.036
Rat
digestive tract development GO:0048565 149 0.036
organic acid metabolic process GO:0006082 103 0.036
response to inorganic substance GO:0010035 44 0.035
Fly
morphogenesis of an epithelium GO:0002009 276 0.035
Rat
protein modification process GO:0036211 438 0.035
detection of abiotic stimulus GO:0009582 66 0.034
regulation of camp biosynthetic process GO:0030817 12 0.034
protein phosphorylation GO:0006468 169 0.034
epiboly GO:0090504 2 0.033
Rat
response to acid chemical GO:0001101 25 0.033
Fly
negative regulation of nervous system development GO:0051961 92 0.033
negative regulation of developmental growth GO:0048640 64 0.033
regionalization GO:0003002 416 0.032
olfactory learning GO:0008355 56 0.032
forebrain development GO:0030900 2 0.032
spermatogenesis GO:0007283 200 0.032
oxoacid metabolic process GO:0043436 103 0.031
water homeostasis GO:0030104 3 0.031
Human
epiboly involved in wound healing GO:0090505 2 0.031
Rat
negative regulation of cell communication GO:0010648 223 0.030
response to extracellular stimulus GO:0009991 116 0.030
chemosensory behavior GO:0007635 106 0.030
cognition GO:0050890 141 0.029
regulation of multicellular organismal development GO:2000026 414 0.029
regulation of synaptic transmission GO:0050804 69 0.029
Fly
positive regulation of phosphate metabolic process GO:0045937 139 0.029
olfactory behavior GO:0042048 97 0.028
regulation of cell size GO:0008361 63 0.028
regulation of nervous system development GO:0051960 248 0.028
thermotaxis GO:0043052 16 0.028
cuticle development GO:0042335 86 0.028
convergent extension GO:0060026 2 0.027
circulatory system process GO:0003013 37 0.027
sensory perception GO:0007600 196 0.027
anatomical structure homeostasis GO:0060249 97 0.027
cellular response to chemical stimulus GO:0070887 199 0.027
Fly
camera type eye development GO:0043010 4 0.026
developmental maturation GO:0021700 172 0.026
salt aversion GO:0035199 3 0.025
Fly
actin filament based process GO:0030029 220 0.025
epithelial cell differentiation GO:0030855 322 0.025
columnar cuboidal epithelial cell development GO:0002066 249 0.025
regulation of dendrite morphogenesis GO:0048814 28 0.025
negative regulation of multicellular organismal process GO:0051241 142 0.024
regulation of cellular protein metabolic process GO:0032268 243 0.024
ovarian follicle cell development GO:0030707 248 0.024
mitotic nuclear division GO:0007067 213 0.024
sleep GO:0030431 49 0.024
positive regulation of biosynthetic process GO:0009891 316 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.023
spinal cord development GO:0021510 1 0.023
regulation of locomotion GO:0040012 42 0.023
stem cell differentiation GO:0048863 117 0.023
cellular amino acid metabolic process GO:0006520 61 0.023
sensory organ morphogenesis GO:0090596 260 0.022
monovalent inorganic cation transport GO:0015672 40 0.022
regulation of feeding behavior GO:0060259 16 0.022
regulation of anatomical structure morphogenesis GO:0022603 242 0.021
negative regulation of growth GO:0045926 84 0.021
regulation of membrane potential GO:0042391 35 0.021
cellular response to hormone stimulus GO:0032870 44 0.021
appendage development GO:0048736 401 0.021
positive regulation of developmental process GO:0051094 143 0.021
post embryonic appendage morphogenesis GO:0035120 385 0.020
negative regulation of signal transduction GO:0009968 206 0.020
catabolic process GO:0009056 409 0.020
cell projection assembly GO:0030031 94 0.020
carboxylic acid metabolic process GO:0019752 92 0.020
digestive tract morphogenesis GO:0048546 127 0.020
phototaxis GO:0042331 21 0.020
sodium ion transport GO:0006814 22 0.019
regulation of system process GO:0044057 36 0.019
respiratory system development GO:0060541 213 0.019
Fly
central nervous system development GO:0007417 201 0.019
gastrulation GO:0007369 70 0.019
actin cytoskeleton organization GO:0030036 206 0.019
epithelial cell development GO:0002064 274 0.019
cell recognition GO:0008037 102 0.019
cellular lipid catabolic process GO:0044242 16 0.019
learning GO:0007612 75 0.019
phosphorylation GO:0016310 294 0.019
cellular amine metabolic process GO:0044106 12 0.019
biological adhesion GO:0022610 138 0.018
positive regulation of signal transduction GO:0009967 223 0.018
eye development GO:0001654 323 0.018
chaeta development GO:0022416 97 0.018
negative regulation of cellular metabolic process GO:0031324 382 0.018
regulation of phosphorylation GO:0042325 147 0.018
regulation of protein metabolic process GO:0051246 256 0.018
sensory perception of sound GO:0007605 56 0.018
positive regulation of intracellular signal transduction GO:1902533 116 0.017
detection of mechanical stimulus GO:0050982 6 0.017
dendrite development GO:0016358 204 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
epithelial tube morphogenesis GO:0060562 88 0.017
regulation of protein modification process GO:0031399 112 0.017
vesicle mediated transport GO:0016192 381 0.017
regulation of programmed cell death GO:0043067 152 0.017
appendage morphogenesis GO:0035107 397 0.017
camera type eye morphogenesis GO:0048593 2 0.017
photoreceptor cell axon guidance GO:0072499 23 0.017
regulation of cell cycle GO:0051726 291 0.017
regulation of cellular component size GO:0032535 98 0.016
neuropeptide signaling pathway GO:0007218 45 0.016
response to ethanol GO:0045471 59 0.016
regulation of intracellular signal transduction GO:1902531 236 0.016
response to oxygen levels GO:0070482 59 0.016
Rat
regulation of blood circulation GO:1903522 21 0.016
response to organophosphorus GO:0046683 2 0.016
notch signaling pathway GO:0007219 120 0.016
memory GO:0007613 94 0.016
cyclic purine nucleotide metabolic process GO:0052652 25 0.016
ion transmembrane transport GO:0034220 122 0.016
response to alcohol GO:0097305 95 0.015
ras protein signal transduction GO:0007265 88 0.015
nuclear division GO:0000280 332 0.015
metal ion transport GO:0030001 74 0.015
urogenital system development GO:0001655 72 0.015
negative regulation of phosphorylation GO:0042326 35 0.015
digestive system development GO:0055123 149 0.015
steroid catabolic process GO:0006706 1 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
insulin receptor signaling pathway GO:0008286 25 0.015
negative regulation of cellular protein metabolic process GO:0032269 85 0.015
cellular response to carbohydrate stimulus GO:0071322 4 0.015
behavioral response to pain GO:0048266 3 0.014
antennal morphogenesis GO:0048800 14 0.014
sensory perception of touch GO:0050975 11 0.014
Fly
response to alkaloid GO:0043279 26 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
apoptotic process GO:0006915 159 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
dendrite morphogenesis GO:0048813 199 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
adult locomotory behavior GO:0008344 76 0.014
stem cell proliferation GO:0072089 88 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
organelle fission GO:0048285 340 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
purine containing compound metabolic process GO:0072521 155 0.014
protein localization GO:0008104 284 0.014
regulation of camp metabolic process GO:0030814 12 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
protein processing GO:0016485 68 0.013
organelle assembly GO:0070925 198 0.013
tube morphogenesis GO:0035239 191 0.013
associative learning GO:0008306 65 0.013
chitin based cuticle development GO:0040003 49 0.013
regulation of response to extracellular stimulus GO:0032104 18 0.013
neuromuscular junction development GO:0007528 149 0.013
cellular protein localization GO:0034613 160 0.013
eggshell formation GO:0030703 105 0.013
cellular ketone metabolic process GO:0042180 24 0.013
response to organonitrogen compound GO:0010243 75 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
response to heat GO:0009408 63 0.013
programmed cell death GO:0012501 257 0.013
organophosphate catabolic process GO:0046434 112 0.013
actin filament based movement GO:0030048 26 0.012
phagocytosis GO:0006909 215 0.012
response to hypoxia GO:0001666 53 0.012
Rat
purine nucleotide metabolic process GO:0006163 146 0.012
single organism biosynthetic process GO:0044711 206 0.012
cilium assembly GO:0042384 38 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
response to decreased oxygen levels GO:0036293 58 0.012
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.012
regulation of transport GO:0051049 181 0.012
Rat
organic substance transport GO:0071702 257 0.012
visual learning GO:0008542 4 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
transmembrane transport GO:0055085 139 0.012
response to other organism GO:0051707 293 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
lipid catabolic process GO:0016042 21 0.012
regulation of cell differentiation GO:0045595 302 0.012
dorsal ventral pattern formation GO:0009953 133 0.012
compound eye morphogenesis GO:0001745 249 0.012
hindbrain development GO:0030902 2 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
blood circulation GO:0008015 26 0.012
protein maturation GO:0051604 71 0.012
regulation of cellular component movement GO:0051270 42 0.012
regulation of neuron projection development GO:0010975 69 0.012
mesenchymal cell development GO:0014031 1 0.012
axon development GO:0061564 297 0.012
regulation of cell substrate adhesion GO:0010810 2 0.011
salivary gland morphogenesis GO:0007435 145 0.011
lipid homeostasis GO:0055088 33 0.011
regulation of protein phosphorylation GO:0001932 64 0.011
positive regulation of behavior GO:0048520 19 0.011
adult behavior GO:0030534 137 0.011
macromolecular complex assembly GO:0065003 256 0.011
metal ion homeostasis GO:0055065 44 0.011
Human
purine nucleotide biosynthetic process GO:0006164 29 0.011
imaginal disc derived appendage morphogenesis GO:0035114 395 0.011
regulation of response to nutrient levels GO:0032107 18 0.011
tube development GO:0035295 244 0.011
dendrite self avoidance GO:0070593 8 0.011
carbohydrate metabolic process GO:0005975 82 0.011
response to peptide GO:1901652 29 0.011
response to salt stress GO:0009651 11 0.011
Fly
renal system development GO:0072001 72 0.011
nucleotide metabolic process GO:0009117 161 0.011
endocytosis GO:0006897 310 0.011
cell maturation GO:0048469 144 0.011
regulation of cell shape GO:0008360 113 0.011
chemotaxis GO:0006935 249 0.011
chaeta morphogenesis GO:0008407 42 0.010
retina development in camera type eye GO:0060041 4 0.010
formation of anatomical boundary GO:0048859 37 0.010
compound eye development GO:0048749 307 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010
synapse organization GO:0050808 196 0.010
regulation of apoptotic process GO:0042981 130 0.010
mapk cascade GO:0000165 107 0.010
circadian sleep wake cycle sleep GO:0050802 23 0.010
carbohydrate derivative metabolic process GO:1901135 217 0.010
response to drug GO:0042493 17 0.010
male courtship behavior veined wing generated song production GO:0045433 20 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.010

ppk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
liddle syndrome DOID:0050477 0 0.358
Human
renal tubular transport disease DOID:447 0 0.358
Human
kidney disease DOID:557 0 0.358
Human
disease of anatomical entity DOID:7 0 0.358
Human
urinary system disease DOID:18 0 0.358
Human
respiratory system disease DOID:1579 0 0.307
Human
lower respiratory tract disease DOID:0050161 0 0.307
Human
bronchial disease DOID:1176 0 0.275
Human
nervous system disease DOID:863 0 0.038
central nervous system disease DOID:331 0 0.019
bronchiectasis DOID:9563 0 0.013
Human
sensory system disease DOID:0050155 0 0.010