Drosophila melanogaster

89 known processes

Nup214 (Dmel_CG3820)

Nucleoporin 214

(Aliases: l(2)10444,DNup214,DCAN,dCAN,CAN/Nup214,CAN,CG3820,nup214,Dmel\CG3820,Nup 214)

Nup214 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
smad protein import into nucleus GO:0007184 11 0.782
negative regulation of gene expression GO:0010629 387 0.494
positive regulation of nucleic acid templated transcription GO:1903508 266 0.410
Fly
positive regulation of gene expression GO:0010628 290 0.398
Fly
positive regulation of transcription dna templated GO:0045893 266 0.376
Fly
nuclear transport GO:0051169 72 0.375
intracellular protein transport GO:0006886 104 0.368
cell proliferation GO:0008283 299 0.354
single organism nuclear import GO:1902593 51 0.310
nucleus organization GO:0006997 45 0.304
positive regulation of rna biosynthetic process GO:1902680 266 0.284
Fly
nucleocytoplasmic transport GO:0006913 72 0.278
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.276
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.267
transcription from rna polymerase ii promoter GO:0006366 368 0.240
Fly
protein import GO:0017038 55 0.238
protein import into nucleus GO:0006606 51 0.218
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.200
Fly
negative regulation of cell cycle phase transition GO:1901988 103 0.191
protein localization to nucleus GO:0034504 55 0.187
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.170
cellular macromolecule localization GO:0070727 220 0.163
catabolic process GO:0009056 409 0.139
cell cycle checkpoint GO:0000075 95 0.138
vesicle mediated transport GO:0016192 381 0.132
positive regulation of macromolecule metabolic process GO:0010604 405 0.131
Fly
macromolecular complex assembly GO:0065003 256 0.123
single organism cellular localization GO:1902580 180 0.122
protein targeting to nucleus GO:0044744 51 0.121
rna localization GO:0006403 115 0.118
mitotic cell cycle checkpoint GO:0007093 88 0.118
mrna metabolic process GO:0016071 124 0.104
chromatin organization GO:0006325 207 0.102
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.100
Fly
protein complex biogenesis GO:0070271 201 0.096
positive regulation of biosynthetic process GO:0009891 316 0.095
Fly
positive regulation of response to stimulus GO:0048584 323 0.086
positive regulation of rna metabolic process GO:0051254 271 0.085
Fly
gene silencing GO:0016458 138 0.083
protein targeting GO:0006605 64 0.080
regulation of mitotic cell cycle phase transition GO:1901990 130 0.080
translation GO:0006412 69 0.076
macromolecule catabolic process GO:0009057 161 0.076
protein transport GO:0015031 155 0.074
negative regulation of cell cycle GO:0045786 116 0.074
multi organism reproductive behavior GO:0044705 121 0.071
phagocytosis GO:0006909 215 0.071
lateral inhibition GO:0046331 206 0.071
negative regulation of cell cycle process GO:0010948 109 0.070
mitotic g2 dna damage checkpoint GO:0007095 69 0.070
protein localization GO:0008104 284 0.070
g2 dna damage checkpoint GO:0031572 69 0.069
reproductive structure development GO:0048608 74 0.068
cytoplasmic transport GO:0016482 130 0.067
chromatin modification GO:0016568 147 0.066
Fly
establishment of localization in cell GO:0051649 402 0.065
cellular protein modification process GO:0006464 438 0.061
organic substance transport GO:0071702 257 0.061
response to light stimulus GO:0009416 124 0.061
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.060
Fly
protein localization to organelle GO:0033365 82 0.059
cellular protein localization GO:0034613 160 0.058
protein complex assembly GO:0006461 200 0.058
establishment of protein localization GO:0045184 163 0.058
negative regulation of biosynthetic process GO:0009890 277 0.057
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.057
Fly
developmental growth GO:0048589 280 0.056
positive regulation of signaling GO:0023056 243 0.055
multi multicellular organism process GO:0044706 123 0.054
regulation of mitotic cell cycle GO:0007346 190 0.054
rna processing GO:0006396 147 0.053
chromatin assembly or disassembly GO:0006333 52 0.052
nls bearing protein import into nucleus GO:0006607 5 0.052
Fly
embryo development ending in birth or egg hatching GO:0009792 152 0.051
protein modification process GO:0036211 438 0.051
ubiquitin dependent protein catabolic process GO:0006511 78 0.051
regulation of cellular protein metabolic process GO:0032268 243 0.051
mrna processing GO:0006397 104 0.050
body morphogenesis GO:0010171 2 0.050
negative regulation of signal transduction GO:0009968 206 0.049
aging GO:0007568 143 0.048
nuclear import GO:0051170 51 0.047
regulation of cell differentiation GO:0045595 302 0.047
cellular macromolecule catabolic process GO:0044265 136 0.046
endocytosis GO:0006897 310 0.045
growth GO:0040007 359 0.045
organic substance catabolic process GO:1901575 308 0.043
imaginal disc derived appendage development GO:0048737 399 0.043
positive regulation of cellular biosynthetic process GO:0031328 316 0.041
Fly
gonad development GO:0008406 50 0.040
reproductive behavior GO:0019098 122 0.040
regulation of protein metabolic process GO:0051246 256 0.040
cellular catabolic process GO:0044248 372 0.039
organonitrogen compound metabolic process GO:1901564 318 0.039
response to organic substance GO:0010033 284 0.039
intracellular transport GO:0046907 228 0.039
cell motility GO:0048870 251 0.039
head development GO:0060322 135 0.038
positive regulation of signal transduction GO:0009967 223 0.037
regulation of cell cycle GO:0051726 291 0.036
negative regulation of cellular biosynthetic process GO:0031327 277 0.036
connective tissue development GO:0061448 3 0.035
regulation of intracellular signal transduction GO:1902531 236 0.035
reproductive system development GO:0061458 74 0.034
mitotic dna damage checkpoint GO:0044773 74 0.034
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.034
regulation of chromatin modification GO:1903308 28 0.034
appendage morphogenesis GO:0035107 397 0.033
apoptotic process GO:0006915 159 0.033
determination of adult lifespan GO:0008340 137 0.033
multicellular organismal aging GO:0010259 140 0.032
heterocycle catabolic process GO:0046700 166 0.032
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.032
cell migration GO:0016477 238 0.031
histone modification GO:0016570 106 0.031
cell death GO:0008219 279 0.031
positive regulation of intracellular signal transduction GO:1902533 116 0.031
posttranscriptional regulation of gene expression GO:0010608 145 0.031
rna transport GO:0050658 46 0.031
appendage development GO:0048736 401 0.030
negative regulation of rna biosynthetic process GO:1902679 240 0.030
sex differentiation GO:0007548 81 0.029
multi organism behavior GO:0051705 175 0.029
imaginal disc derived appendage morphogenesis GO:0035114 395 0.029
multicellular organismal reproductive behavior GO:0033057 110 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.028
Fly
response to other organism GO:0051707 293 0.028
establishment of protein localization to organelle GO:0072594 62 0.028
single organism intracellular transport GO:1902582 207 0.028
enzyme linked receptor protein signaling pathway GO:0007167 179 0.027
regulation of cellular component biogenesis GO:0044087 201 0.027
regulation of cell development GO:0060284 215 0.027
regulation of cytoplasmic transport GO:1903649 47 0.027
regulation of growth GO:0040008 233 0.026
mitotic spindle organization GO:0007052 220 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.025
negative regulation of translation GO:0017148 28 0.025
spindle organization GO:0007051 253 0.025
protein alkylation GO:0008213 43 0.024
negative regulation of transcription dna templated GO:0045892 237 0.024
negative regulation of mitotic cell cycle GO:0045930 109 0.024
regulation of gene expression epigenetic GO:0040029 128 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
mitotic cell cycle phase transition GO:0044772 138 0.024
imaginal disc derived wing morphogenesis GO:0007476 337 0.024
dna integrity checkpoint GO:0031570 81 0.024
mitotic sister chromatid segregation GO:0000070 87 0.023
negative regulation of protein metabolic process GO:0051248 85 0.022
sister chromatid segregation GO:0000819 92 0.022
macromolecular complex disassembly GO:0032984 37 0.021
central nervous system development GO:0007417 201 0.021
mitotic nuclear division GO:0007067 213 0.021
mitotic dna integrity checkpoint GO:0044774 75 0.021
single organism biosynthetic process GO:0044711 206 0.020
regulation of proteolysis GO:0030162 87 0.020
nuclear pore organization GO:0006999 1 0.020
Fly
mitotic g2 m transition checkpoint GO:0044818 70 0.020
response to biotic stimulus GO:0009607 294 0.019
mrna catabolic process GO:0006402 33 0.019
rna splicing GO:0008380 83 0.019
larval development GO:0002164 104 0.019
negative regulation of cellular component organization GO:0051129 108 0.019
brain development GO:0007420 120 0.019
cellular amino acid metabolic process GO:0006520 61 0.018
aromatic compound catabolic process GO:0019439 166 0.018
cellular ketone metabolic process GO:0042180 24 0.018
post embryonic appendage morphogenesis GO:0035120 385 0.018
modification dependent macromolecule catabolic process GO:0043632 79 0.018
wing disc morphogenesis GO:0007472 344 0.018
nitrogen compound transport GO:0071705 85 0.017
establishment of rna localization GO:0051236 47 0.017
ribonucleoprotein complex subunit organization GO:0071826 28 0.017
negative regulation of cell proliferation GO:0008285 69 0.017
homeostatic process GO:0042592 199 0.017
histone acetylation GO:0016573 38 0.017
regulation of transport GO:0051049 181 0.017
rna polyadenylation GO:0043631 12 0.017
cellular response to dna damage stimulus GO:0006974 223 0.017
negative regulation of nucleic acid templated transcription GO:1903507 240 0.017
cell cycle phase transition GO:0044770 140 0.016
protein maturation GO:0051604 71 0.016
regulation of chromatin organization GO:1902275 32 0.016
response to nitrogen compound GO:1901698 90 0.016
nuclear division GO:0000280 332 0.016
covalent chromatin modification GO:0016569 106 0.016
regulation of mrna processing GO:0050684 71 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
regulation of chromosome organization GO:0033044 64 0.015
regulation of neuron differentiation GO:0045664 103 0.015
dna replication GO:0006260 48 0.015
regulation of protein transport GO:0051223 57 0.015
establishment of nucleus localization GO:0040023 26 0.015
positive regulation of cell communication GO:0010647 250 0.014
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.014
chromosome segregation GO:0007059 157 0.014
dendrite development GO:0016358 204 0.014
anterior posterior pattern specification GO:0009952 136 0.014
protein phosphorylation GO:0006468 169 0.014
cellular response to chemical stimulus GO:0070887 199 0.014
protein methylation GO:0006479 43 0.014
negative regulation of signaling GO:0023057 219 0.014
cellular response to organic substance GO:0071310 132 0.014
response to oxygen containing compound GO:1901700 200 0.014
regulation of programmed cell death GO:0043067 152 0.014
regulation of cellular localization GO:0060341 136 0.014
rna catabolic process GO:0006401 37 0.014
regulation of cell proliferation GO:0042127 163 0.013
ribonucleoprotein complex assembly GO:0022618 23 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
peptidyl lysine modification GO:0018205 57 0.013
regulation of nervous system development GO:0051960 248 0.013
organelle localization GO:0051640 148 0.013
regulation of cell cycle phase transition GO:1901987 130 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
proteolysis GO:0006508 192 0.013
wound healing GO:0042060 75 0.013
regulation of organelle organization GO:0033043 196 0.013
negative regulation of cell communication GO:0010648 223 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
negative regulation of apoptotic process GO:0043066 63 0.013
chromosome organization GO:0051276 360 0.012
Fly
regulation of translation GO:0006417 56 0.012
positive regulation of programmed cell death GO:0043068 62 0.012
positive regulation of protein modification process GO:0031401 58 0.012
dna metabolic process GO:0006259 227 0.012
chromosome condensation GO:0030261 41 0.012
regulation of neurogenesis GO:0050767 158 0.012
regulation of protein catabolic process GO:0042176 55 0.012
nucleobase containing compound transport GO:0015931 56 0.012
phosphorylation GO:0016310 294 0.012
dendrite morphogenesis GO:0048813 199 0.012
response to endogenous stimulus GO:0009719 119 0.011
axonogenesis GO:0007409 290 0.011
cellular protein complex assembly GO:0043623 71 0.011
organic acid metabolic process GO:0006082 103 0.011
chromatin remodeling GO:0006338 72 0.011
Fly
imaginal disc derived leg morphogenesis GO:0007480 80 0.011
response to lipopolysaccharide GO:0032496 4 0.011
regulation of transcription by chromatin organization GO:0034401 3 0.011
Fly
negative regulation of cellular catabolic process GO:0031330 34 0.011
regulation of multi organism process GO:0043900 131 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
regulation of protein modification process GO:0031399 112 0.011
intracellular signal transduction GO:0035556 300 0.011
regulation of nucleocytoplasmic transport GO:0046822 35 0.011
establishment of organelle localization GO:0051656 122 0.010
death GO:0016265 284 0.010
histone lysine demethylation GO:0070076 6 0.010
regulation of mrna splicing via spliceosome GO:0048024 64 0.010
nucleic acid transport GO:0050657 46 0.010
blastoderm segmentation GO:0007350 159 0.010
negative regulation of response to stimulus GO:0048585 258 0.010
regulation of protein import into nucleus GO:0042306 28 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.010

Nup214 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.032
disease of cellular proliferation DOID:14566 0 0.014
nervous system disease DOID:863 0 0.013
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.010
central nervous system disease DOID:331 0 0.010
neurodegenerative disease DOID:1289 0 0.010