Drosophila melanogaster

110 known processes

eIF-4E (Dmel_CG4035)

Eukaryotic initiation factor 4E

(Aliases: l(3)S058711,l(3)07238,eif-4e,0919/12,eIF-4EII,CT13384,D-eIF4E,eIF4e,CG4035,eIF-4e,Eif4E,deIF4E,eIF-4E2,eIF-4E1,IF4E,dEif4e,2,Eif4e,l(3)S091912,eIF4E-2,eIF4E1,eIF 4E,CT39426,0260/09,CT39424,deIF-4E,eIF4E-1/2,0587/11,eIF4E,0589/11,l(3)S026009,l(3)S025007,7238,Dmel\CG4035,1004/13,l(3)67Af,CBP,eIF4E-1,eif-4E)

eIF-4E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of growth GO:0040008 233 0.992
regulation of developmental growth GO:0048638 174 0.986
axon development GO:0061564 297 0.985
axonogenesis GO:0007409 290 0.981
axon guidance GO:0007411 233 0.955
meiotic cell cycle GO:0051321 171 0.925
chemotaxis GO:0006935 249 0.914
organelle assembly GO:0070925 198 0.910
cellular protein modification process GO:0006464 438 0.910
neuron projection guidance GO:0097485 241 0.909
microtubule organizing center organization GO:0031023 168 0.902
taxis GO:0042330 304 0.900
protein complex biogenesis GO:0070271 201 0.886
positive regulation of macromolecule metabolic process GO:0010604 405 0.858
Worm
cell proliferation GO:0008283 299 0.856
protein modification process GO:0036211 438 0.849
small molecule metabolic process GO:0044281 305 0.847
regulation of cellular protein metabolic process GO:0032268 243 0.844
Human Worm
macromolecular complex assembly GO:0065003 256 0.817
cellular protein localization GO:0034613 160 0.810
female meiotic division GO:0007143 70 0.790
cell migration GO:0016477 238 0.789
ribonucleoside triphosphate catabolic process GO:0009203 108 0.780
synaptic growth at neuromuscular junction GO:0051124 119 0.748
protein complex assembly GO:0006461 200 0.745
positive regulation of multicellular organismal process GO:0051240 143 0.745
cell motility GO:0048870 251 0.730
positive regulation of phosphate metabolic process GO:0045937 139 0.689
intracellular signal transduction GO:0035556 300 0.654
positive regulation of signaling GO:0023056 243 0.646
death GO:0016265 284 0.642
cellular catabolic process GO:0044248 372 0.611
regulation of multicellular organismal development GO:2000026 414 0.604
positive regulation of developmental growth GO:0048639 62 0.604
establishment or maintenance of cell polarity GO:0007163 167 0.603
dendrite development GO:0016358 204 0.597
cell death GO:0008219 279 0.591
regulation of intracellular signal transduction GO:1902531 236 0.578
mitotic spindle organization GO:0007052 220 0.560
positive regulation of developmental process GO:0051094 143 0.558
phosphorylation GO:0016310 294 0.553
regulation of molecular function GO:0065009 217 0.534
localization of cell GO:0051674 257 0.514
regulation of anatomical structure morphogenesis GO:0022603 242 0.510
aromatic compound catabolic process GO:0019439 166 0.501
mapk cascade GO:0000165 107 0.491
meiotic nuclear division GO:0007126 151 0.485
nuclear division GO:0000280 332 0.482
regulation of phosphate metabolic process GO:0019220 210 0.467
organelle fission GO:0048285 340 0.459
mitotic nuclear division GO:0007067 213 0.457
nucleotide metabolic process GO:0009117 161 0.452
positive regulation of response to stimulus GO:0048584 323 0.452
regulation of cell death GO:0010941 173 0.451
regulation of phosphorylation GO:0042325 147 0.437
oocyte development GO:0048599 124 0.419
Worm
lateral inhibition GO:0046331 206 0.415
muscle structure development GO:0061061 224 0.413
developmental growth GO:0048589 280 0.404
multicellular organismal reproductive behavior GO:0033057 110 0.402
circulatory system development GO:0072359 82 0.398
cellular macromolecule localization GO:0070727 220 0.396
organic substance catabolic process GO:1901575 308 0.386
positive regulation of catalytic activity GO:0043085 118 0.383
protein localization GO:0008104 284 0.377
positive regulation of phosphorus metabolic process GO:0010562 139 0.369
chromosome organization GO:0051276 360 0.364
apoptotic process GO:0006915 159 0.359
positive regulation of cellular component organization GO:0051130 156 0.354
regulation of cellular component biogenesis GO:0044087 201 0.336
synapse organization GO:0050808 196 0.334
positive regulation of molecular function GO:0044093 136 0.331
response to inorganic substance GO:0010035 44 0.328
spermatogenesis GO:0007283 200 0.301
Worm
positive regulation of growth GO:0045927 75 0.301
organic cyclic compound catabolic process GO:1901361 168 0.301
biological adhesion GO:0022610 138 0.290
cellular macromolecular complex assembly GO:0034622 153 0.282
dendrite morphogenesis GO:0048813 199 0.282
regulation of cell morphogenesis GO:0022604 163 0.280
meiotic chromosome segregation GO:0045132 59 0.273
organic acid metabolic process GO:0006082 103 0.271
positive regulation of multicellular organism growth GO:0040018 21 0.270
cellular response to dna damage stimulus GO:0006974 223 0.267
tube development GO:0035295 244 0.259
organonitrogen compound metabolic process GO:1901564 318 0.258
regulation of transferase activity GO:0051338 58 0.256
growth GO:0040007 359 0.251
regulation of cellular catabolic process GO:0031329 157 0.243
regulation of purine nucleotide metabolic process GO:1900542 62 0.241
neurological system process GO:0050877 358 0.240
regulation of neurogenesis GO:0050767 158 0.233
dna integrity checkpoint GO:0031570 81 0.232
regulation of protein metabolic process GO:0051246 256 0.224
Human Worm
cellular component assembly involved in morphogenesis GO:0010927 151 0.223
regulation of catalytic activity GO:0050790 185 0.219
dna damage checkpoint GO:0000077 78 0.217
protein phosphorylation GO:0006468 169 0.209
peptidyl amino acid modification GO:0018193 105 0.209
positive regulation of protein metabolic process GO:0051247 128 0.206
Worm
body morphogenesis GO:0010171 2 0.199
purine nucleoside triphosphate catabolic process GO:0009146 108 0.198
positive regulation of cell communication GO:0010647 250 0.197
nucleobase containing compound catabolic process GO:0034655 165 0.197
posttranscriptional regulation of gene expression GO:0010608 145 0.196
Human Worm
regulation of kinase activity GO:0043549 53 0.194
male gamete generation GO:0048232 201 0.190
Worm
actomyosin structure organization GO:0031032 56 0.183
stem cell development GO:0048864 79 0.181
actin filament based process GO:0030029 220 0.178
meiotic cytokinesis GO:0033206 33 0.178
endocytosis GO:0006897 310 0.177
cellular protein complex assembly GO:0043623 71 0.175
regulation of cellular response to stress GO:0080135 89 0.167
regulation of neuron differentiation GO:0045664 103 0.166
myofibril assembly GO:0030239 36 0.165
establishment of localization in cell GO:0051649 402 0.163
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.163
cell cycle phase transition GO:0044770 140 0.159
Human
chromosome segregation GO:0007059 157 0.157
signal transduction by phosphorylation GO:0023014 107 0.155
purine ribonucleotide metabolic process GO:0009150 145 0.150
homeostatic process GO:0042592 199 0.149
organophosphate catabolic process GO:0046434 112 0.148
regulation of response to stress GO:0080134 200 0.147
cardiovascular system development GO:0072358 82 0.146
programmed cell death GO:0012501 257 0.145
single organism cellular localization GO:1902580 180 0.145
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.143
ras protein signal transduction GO:0007265 88 0.143
regulation of phosphorus metabolic process GO:0051174 210 0.141
protein maturation GO:0051604 71 0.141
purine nucleoside triphosphate metabolic process GO:0009144 119 0.138
translation GO:0006412 69 0.136
head development GO:0060322 135 0.136
nucleotide catabolic process GO:0009166 109 0.135
positive regulation of cellular catabolic process GO:0031331 95 0.130
heterocycle catabolic process GO:0046700 166 0.127
regulation of protein modification process GO:0031399 112 0.124
cell adhesion GO:0007155 136 0.123
regulation of localization GO:0032879 275 0.121
tissue morphogenesis GO:0048729 297 0.121
regulation of catabolic process GO:0009894 170 0.119
multicellular organismal aging GO:0010259 140 0.116
Worm
oocyte axis specification GO:0007309 108 0.114
imaginal disc derived appendage development GO:0048737 399 0.108
regulation of apoptotic process GO:0042981 130 0.107
centrosome organization GO:0051297 163 0.106
regulation of translation GO:0006417 56 0.106
Human Worm
positive regulation of intracellular signal transduction GO:1902533 116 0.102
centrosome cycle GO:0007098 137 0.102
regulation of mapk cascade GO:0043408 92 0.099
positive regulation of signal transduction GO:0009967 223 0.098
ectodermal digestive tract morphogenesis GO:0048567 7 0.095
sarcomere organization GO:0045214 26 0.094
developmental maturation GO:0021700 172 0.093
Worm
mitotic g2 m transition checkpoint GO:0044818 70 0.091
reproductive behavior GO:0019098 122 0.090
larval development GO:0002164 104 0.089
regulation of small gtpase mediated signal transduction GO:0051056 93 0.089
response to light stimulus GO:0009416 124 0.087
nucleoside catabolic process GO:0009164 112 0.087
nucleoside phosphate catabolic process GO:1901292 110 0.084
morphogenesis of an epithelium GO:0002009 276 0.083
regulation of cell differentiation GO:0045595 302 0.083
striated muscle cell development GO:0055002 50 0.083
hematopoietic or lymphoid organ development GO:0048534 57 0.083
purine ribonucleoside catabolic process GO:0046130 112 0.082
organophosphate metabolic process GO:0019637 195 0.081
cellular response to chemical stimulus GO:0070887 199 0.081
regulation of cell cycle GO:0051726 291 0.079
Human
catabolic process GO:0009056 409 0.079
gland development GO:0048732 191 0.078
single organismal cell cell adhesion GO:0016337 45 0.078
regulation of cell projection organization GO:0031344 92 0.078
striated muscle myosin thick filament assembly GO:0071688 3 0.078
mitotic cell cycle phase transition GO:0044772 138 0.077
Human
ribose phosphate metabolic process GO:0019693 145 0.076
ribonucleoside metabolic process GO:0009119 127 0.075
glycosyl compound metabolic process GO:1901657 127 0.074
regulation of cell migration GO:0030334 22 0.074
eggshell formation GO:0030703 105 0.072
regulation of protein kinase activity GO:0045859 51 0.070
negative regulation of protein metabolic process GO:0051248 85 0.069
organic substance transport GO:0071702 257 0.069
genitalia development GO:0048806 26 0.068
stem cell maintenance GO:0019827 67 0.068
mitotic g2 dna damage checkpoint GO:0007095 69 0.067
purine nucleoside metabolic process GO:0042278 127 0.064
apoptotic signaling pathway GO:0097190 27 0.064
g2 dna damage checkpoint GO:0031572 69 0.064
dephosphorylation GO:0016311 51 0.064
carbohydrate derivative metabolic process GO:1901135 217 0.063
cell maturation GO:0048469 144 0.063
Worm
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.062
mitotic dna damage checkpoint GO:0044773 74 0.061
neuron death GO:0070997 27 0.061
positive regulation of hydrolase activity GO:0051345 78 0.061
regulation of cell shape GO:0008360 113 0.061
negative regulation of apoptotic process GO:0043066 63 0.060
central nervous system development GO:0007417 201 0.059
purine nucleotide metabolic process GO:0006163 146 0.059
negative regulation of cellular metabolic process GO:0031324 382 0.059
glycosyl compound catabolic process GO:1901658 112 0.058
positive regulation of phosphorylation GO:0042327 87 0.057
negative regulation of response to stimulus GO:0048585 258 0.056
multi organism behavior GO:0051705 175 0.056
response to radiation GO:0009314 155 0.056
purine ribonucleoside metabolic process GO:0046128 127 0.055
ribonucleotide catabolic process GO:0009261 109 0.054
regulation of mitotic cell cycle GO:0007346 190 0.054
Human
guanosine containing compound metabolic process GO:1901068 74 0.053
development of primary sexual characteristics GO:0045137 50 0.050
hematopoietic stem cell differentiation GO:0060218 1 0.049
vesicle mediated transport GO:0016192 381 0.049
ribonucleoside catabolic process GO:0042454 112 0.049
establishment of nucleus localization GO:0040023 26 0.048
reproductive system development GO:0061458 74 0.048
regulation of cytoskeleton organization GO:0051493 89 0.048
peptidyl tyrosine phosphorylation GO:0018108 24 0.048
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.048
developmental cell growth GO:0048588 52 0.047
regulation of neuron projection development GO:0010975 69 0.045
positive regulation of catabolic process GO:0009896 105 0.045
regulation of proteasomal protein catabolic process GO:0061136 39 0.045
protein catabolic process GO:0030163 101 0.045
regulation of neuron death GO:1901214 26 0.044
regulation of trichome morphogenesis GO:2000039 3 0.044
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.044
purine ribonucleotide catabolic process GO:0009154 109 0.043
regulation of cell cycle process GO:0010564 181 0.043
proteasomal protein catabolic process GO:0010498 59 0.043
skin development GO:0043588 65 0.042
gonad development GO:0008406 50 0.042
cell cycle checkpoint GO:0000075 95 0.041
positive regulation of nucleic acid templated transcription GO:1903508 266 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.041
negative regulation of molecular function GO:0044092 51 0.040
actin cytoskeleton organization GO:0030036 206 0.040
positive regulation of kinase activity GO:0033674 25 0.040
regulation of organelle organization GO:0033043 196 0.040
oocyte morphogenesis GO:0048601 3 0.040
spindle assembly GO:0051225 80 0.040
regulation of locomotion GO:0040012 42 0.038
striated muscle cell differentiation GO:0051146 90 0.038
gliogenesis GO:0042063 80 0.037
positive regulation of protein phosphorylation GO:0001934 34 0.037
anterior posterior pattern specification GO:0009952 136 0.037
ribonucleotide metabolic process GO:0009259 145 0.037
oviposition GO:0018991 19 0.037
regulation of protein phosphorylation GO:0001932 64 0.036
nucleoside triphosphate metabolic process GO:0009141 120 0.036
carboxylic acid metabolic process GO:0019752 92 0.036
multi multicellular organism process GO:0044706 123 0.035
single organism nuclear import GO:1902593 51 0.035
sex differentiation GO:0007548 81 0.035
purine nucleotide catabolic process GO:0006195 109 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.034
Worm
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.034
dna replication GO:0006260 48 0.033
negative regulation of nervous system development GO:0051961 92 0.033
nucleoside triphosphate catabolic process GO:0009143 108 0.033
embryo development ending in birth or egg hatching GO:0009792 152 0.033
Worm
single organism catabolic process GO:0044712 228 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.032
regulation of programmed cell death GO:0043067 152 0.032
developmental programmed cell death GO:0010623 138 0.031
dendrite regeneration GO:0031104 2 0.031
cellular amino acid metabolic process GO:0006520 61 0.031
cellular nitrogen compound catabolic process GO:0044270 165 0.030
negative regulation of cellular protein metabolic process GO:0032269 85 0.030
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.030
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.030
purine nucleoside catabolic process GO:0006152 112 0.030
muscle attachment GO:0016203 36 0.030
negative regulation of developmental growth GO:0048640 64 0.030
oocyte construction GO:0007308 112 0.030
regulation of centriole centriole cohesion GO:0030997 1 0.029
regulation of multicellular organism growth GO:0040014 40 0.029
protein targeting GO:0006605 64 0.029
negative regulation of multicellular organismal process GO:0051241 142 0.029
negative regulation of cell cycle GO:0045786 116 0.028
epithelial cell fate determination open tracheal system GO:0007425 2 0.028
tube morphogenesis GO:0035239 191 0.028
multicellular organism growth GO:0035264 46 0.027
positive regulation of cell maturation GO:1903431 2 0.027
response to red or far red light GO:0009639 2 0.027
small gtpase mediated signal transduction GO:0007264 88 0.026
ameboidal type cell migration GO:0001667 151 0.026
chromatin modification GO:0016568 147 0.026
activation of anaphase promoting complex activity GO:0051488 1 0.026
cell recognition GO:0008037 102 0.025
enzyme linked receptor protein signaling pathway GO:0007167 179 0.025
negative regulation of translation GO:0017148 28 0.025
imaginal disc derived wing morphogenesis GO:0007476 337 0.025
regulation of cell cycle phase transition GO:1901987 130 0.025
negative regulation of signaling GO:0023057 219 0.024
female germ line cyst formation GO:0048135 42 0.024
negative regulation of cell communication GO:0010648 223 0.024
regulation of cell development GO:0060284 215 0.024
regulation of nucleotide metabolic process GO:0006140 62 0.024
respiratory system development GO:0060541 213 0.024
synaptic transmission GO:0007268 288 0.023
oocyte fate commitment GO:0048600 2 0.023
axis specification GO:0009798 167 0.023
detection of external stimulus GO:0009581 66 0.023
camera type eye development GO:0043010 4 0.023
ubiquitin dependent protein catabolic process GO:0006511 78 0.023
regulation of cell substrate adhesion GO:0010810 2 0.023
regulation of synapse assembly GO:0051963 94 0.022
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.022
meiotic nuclear envelope disassembly GO:0051078 2 0.022
phagocytosis GO:0006909 215 0.022
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.022
cellularization GO:0007349 90 0.022
cellular protein catabolic process GO:0044257 83 0.022
modification dependent macromolecule catabolic process GO:0043632 79 0.022
meiotic cell cycle process GO:1903046 132 0.022
mitotic spindle elongation GO:0000022 81 0.022
establishment of cell polarity GO:0030010 40 0.021
photoreceptor cell differentiation GO:0046530 170 0.021
aging GO:0007568 143 0.021
Worm
maintenance of location GO:0051235 73 0.021
Worm
peptidyl tyrosine modification GO:0018212 24 0.021
response to biotic stimulus GO:0009607 294 0.021
regulation of calcium ion transmembrane transport GO:1903169 2 0.021
meiotic spindle checkpoint GO:0044779 1 0.021
purine containing compound catabolic process GO:0072523 112 0.020
regulation of synapse structure and activity GO:0050803 128 0.020
embryonic development via the syncytial blastoderm GO:0001700 148 0.020
regulation of intracellular transport GO:0032386 64 0.020
negative regulation of terminal cell fate specification open tracheal system GO:0035155 2 0.020
muscle organ development GO:0007517 127 0.020
protein targeting to nucleus GO:0044744 51 0.019
negative regulation of nucleotide metabolic process GO:0045980 4 0.019
negative regulation of mitotic cell cycle GO:0045930 109 0.019
germarium derived female germ line cyst formation GO:0030727 42 0.019
regulation of cell proliferation GO:0042127 163 0.019
nucleoside phosphate metabolic process GO:0006753 162 0.018
immune system process GO:0002376 347 0.018
centrosome duplication GO:0051298 121 0.018
positive regulation of protein modification process GO:0031401 58 0.018
negative regulation of phosphatase activity GO:0010923 3 0.018
intracellular transport GO:0046907 228 0.018
single organism behavior GO:0044708 391 0.018
positive regulation of transferase activity GO:0051347 26 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.017
positive regulation of biosynthetic process GO:0009891 316 0.017
Worm
post embryonic appendage morphogenesis GO:0035120 385 0.017
positive regulation of synaptic transmission cholinergic GO:0032224 2 0.016
protein localization to organelle GO:0033365 82 0.016
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 2 0.016
cell aging GO:0007569 2 0.016
specification of segmental identity antennal segment GO:0007383 2 0.016
dna metabolic process GO:0006259 227 0.016
immune system development GO:0002520 57 0.016
chorion containing eggshell formation GO:0007304 105 0.016
positive regulation of intracellular protein transport GO:0090316 30 0.016
spindle localization GO:0051653 22 0.016
membrane organization GO:0061024 112 0.015
regulation of nucleocytoplasmic transport GO:0046822 35 0.015
myosin filament organization GO:0031033 5 0.015
negative regulation of signal transduction GO:0009968 206 0.015
regulation of cell size GO:0008361 63 0.015
negative regulation of filopodium assembly GO:0051490 3 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.015
regulation of immune system process GO:0002682 176 0.015
histone h3 k9 modification GO:0061647 12 0.015
negative regulation of cellular catabolic process GO:0031330 34 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
regulation of behavior GO:0050795 75 0.015
negative regulation of dna templated transcription initiation GO:2000143 1 0.015
brain development GO:0007420 120 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
establishment of organelle localization GO:0051656 122 0.014
nucleoside metabolic process GO:0009116 127 0.014
regulation of cellular localization GO:0060341 136 0.014
epidermis development GO:0008544 65 0.014
dorsal vessel heart proper cell fate commitment GO:0035053 2 0.014
embryonic morphogenesis GO:0048598 206 0.014
anterior posterior axis specification GO:0009948 109 0.014
cellular response to nutrient GO:0031670 1 0.014
neuronal action potential GO:0019228 10 0.014
positive regulation of apoptotic process GO:0043065 47 0.014
dna integration GO:0015074 1 0.014
regulation of protein catabolic process GO:0042176 55 0.014
neuromuscular junction development GO:0007528 149 0.013
negative regulation of cell death GO:0060548 81 0.013
negative regulation of growth GO:0045926 84 0.013
lipid localization GO:0010876 54 0.013
Worm
dna catabolic process endonucleolytic GO:0000737 6 0.013
positive regulation of cell substrate adhesion GO:0010811 1 0.013
open tracheal system development GO:0007424 204 0.013
spindle assembly involved in mitosis GO:0090307 50 0.013
lipid storage GO:0019915 38 0.013
Worm
regulation of mitotic spindle checkpoint GO:1903504 1 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.013
positive regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0090282 1 0.013
protein processing GO:0016485 68 0.012
regulation of cell division GO:0051302 72 0.012
regulation of histone methylation GO:0031060 10 0.012
muscle cell development GO:0055001 50 0.012
dna templated transcriptional start site selection GO:0001173 1 0.012
cell division GO:0051301 248 0.012
anterior posterior axis specification follicular epithelium GO:0030714 2 0.012
meiotic dna repair synthesis GO:0000711 3 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.012
multicellular organismal homeostasis GO:0048871 41 0.012
anterior head segmentation GO:0035288 3 0.012
epidermal cell differentiation GO:0009913 51 0.012
hormone metabolic process GO:0042445 33 0.012
telencephalon development GO:0021537 2 0.012
response to oxygen containing compound GO:1901700 200 0.011
negative regulation of mrna 3 end processing GO:0031441 3 0.011
negative regulation of developmental process GO:0051093 201 0.011
negative regulation of gene expression GO:0010629 387 0.011
purine containing compound metabolic process GO:0072521 155 0.011
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 1 0.011
positive regulation of store operated calcium channel activity GO:1901341 1 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
axonal fasciculation GO:0007413 12 0.011
notum development GO:0007477 8 0.011
embryonic axis specification GO:0000578 107 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
determination of adult lifespan GO:0008340 137 0.011
Worm
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.011
eggshell chorion assembly GO:0007306 66 0.011
p granule organization GO:0030719 4 0.011
regulation of mitotic sister chromatid segregation GO:0033047 28 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
asymmetric neuroblast division resulting in ganglion mother cell formation GO:0055060 2 0.011
microtubule cytoskeleton organization involved in establishment of planar polarity GO:0090176 3 0.011
reproductive structure development GO:0048608 74 0.011
positive regulation of posttranscriptional gene silencing GO:0060148 5 0.011
multi organism reproductive behavior GO:0044705 121 0.010
positive regulation of transcription dna templated GO:0045893 266 0.010
regulation of substrate adhesion dependent cell spreading GO:1900024 1 0.010
regulation of sphingolipid biosynthetic process GO:0090153 2 0.010
release of cytoplasmic sequestered nf kappab GO:0008588 1 0.010
morphogenesis of a branching structure GO:0001763 45 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
positive regulation of proteolysis GO:0045862 52 0.010

eIF-4E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.115
brachydactyly DOID:0050581 0 0.067
bone development disease DOID:0080006 0 0.067
bone disease DOID:0080001 0 0.067
disease of anatomical entity DOID:7 0 0.067
dysostosis DOID:1934 0 0.067
musculoskeletal system disease DOID:17 0 0.067
connective tissue disease DOID:65 0 0.067
cancer DOID:162 0 0.052
organ system cancer DOID:0050686 0 0.052
reproductive organ cancer DOID:193 0 0.034
ovarian cancer DOID:2394 0 0.034
female reproductive organ cancer DOID:120 0 0.034
artery disease DOID:0050828 0 0.030
aortic aneurysm DOID:3627 0 0.030
vascular disease DOID:178 0 0.030
cardiovascular system disease DOID:1287 0 0.030
aortic disease DOID:520 0 0.030
pancreatic carcinoma DOID:4905 0 0.016
endocrine gland cancer DOID:170 0 0.016
pancreatic cancer DOID:1793 0 0.016
pervasive developmental disorder DOID:0060040 0 0.015
Human
disease of mental health DOID:150 0 0.015
Human
developmental disorder of mental health DOID:0060037 0 0.015
Human
hepatobiliary disease DOID:3118 0 0.013
gastrointestinal system disease DOID:77 0 0.013
liver disease DOID:409 0 0.013
alagille syndrome DOID:9245 0 0.013