Drosophila melanogaster

32 known processes

lace (Dmel_CG4162)

CG4162 gene product from transcript CG4162-RA

(Aliases: Lace,BG:DS01845.3,l(2)35Dc,anon-EST:Posey289,CG4162,SPT-II,l(2)br36,l35Dc,Dmel\CG4162,br36)

lace biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism behavior GO:0044708 391 0.785
sensory organ morphogenesis GO:0090596 260 0.714
lateral inhibition GO:0046331 206 0.478
negative regulation of multicellular organismal process GO:0051241 142 0.468
endocytosis GO:0006897 310 0.407
vesicle mediated transport GO:0016192 381 0.326
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.322
chaeta development GO:0022416 97 0.289
compound eye development GO:0048749 307 0.269
reproductive behavior GO:0019098 122 0.269
programmed cell death GO:0012501 257 0.257
negative regulation of signaling GO:0023057 219 0.253
cell cell signaling involved in cell fate commitment GO:0045168 210 0.233
synaptic growth at neuromuscular junction GO:0051124 119 0.231
positive regulation of response to stimulus GO:0048584 323 0.224
intracellular signal transduction GO:0035556 300 0.217
phosphorylation GO:0016310 294 0.216
regulation of notch signaling pathway GO:0008593 100 0.214
cytokinesis GO:0000910 90 0.211
post embryonic appendage morphogenesis GO:0035120 385 0.204
locomotory behavior GO:0007626 176 0.203
eye development GO:0001654 323 0.196
regulation of multicellular organismal development GO:2000026 414 0.192
cell proliferation GO:0008283 299 0.185
organelle assembly GO:0070925 198 0.184
regulation of protein metabolic process GO:0051246 256 0.184
regulation of cytoskeleton organization GO:0051493 89 0.182
negative regulation of apoptotic process GO:0043066 63 0.180
appendage morphogenesis GO:0035107 397 0.178
response to lipopolysaccharide GO:0032496 4 0.177
regulation of cellular component biogenesis GO:0044087 201 0.166
cell division GO:0051301 248 0.165
synapse organization GO:0050808 196 0.153
embryo development ending in birth or egg hatching GO:0009792 152 0.151
regulation of immune effector process GO:0002697 52 0.147
organonitrogen compound biosynthetic process GO:1901566 117 0.146
epithelial cell differentiation GO:0030855 322 0.143
regulation of anatomical structure morphogenesis GO:0022603 242 0.142
cellular catabolic process GO:0044248 372 0.139
compound eye morphogenesis GO:0001745 249 0.139
organonitrogen compound metabolic process GO:1901564 318 0.138
larval development GO:0002164 104 0.136
immune effector process GO:0002252 98 0.135
wing disc morphogenesis GO:0007472 344 0.134
regulation of r7 cell differentiation GO:0045676 15 0.121
negative regulation of response to stimulus GO:0048585 258 0.121
catabolic process GO:0009056 409 0.121
wound healing GO:0042060 75 0.119
regulation of apoptotic process GO:0042981 130 0.118
negative regulation of cellular metabolic process GO:0031324 382 0.116
eye morphogenesis GO:0048592 260 0.115
adult behavior GO:0030534 137 0.112
striated muscle tissue development GO:0014706 27 0.111
notch signaling pathway GO:0007219 120 0.110
cellular macromolecule localization GO:0070727 220 0.107
ion transport GO:0006811 145 0.107
protein complex biogenesis GO:0070271 201 0.106
regulation of actin polymerization or depolymerization GO:0008064 27 0.105
amino acid transport GO:0006865 12 0.103
organelle localization GO:0051640 148 0.100
ion transmembrane transport GO:0034220 122 0.098
protein modification process GO:0036211 438 0.097
cellular macromolecular complex assembly GO:0034622 153 0.096
organic acid transport GO:0015849 18 0.095
protein localization GO:0008104 284 0.095
cellular protein modification process GO:0006464 438 0.094
cortical cytoskeleton organization GO:0030865 29 0.092
negative regulation of signal transduction GO:0009968 206 0.091
negative regulation of cell communication GO:0010648 223 0.091
small molecule metabolic process GO:0044281 305 0.088
Mouse
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.088
protein complex assembly GO:0006461 200 0.084
spermatid development GO:0007286 98 0.083
columnar cuboidal epithelial cell development GO:0002066 249 0.082
regulation of nervous system development GO:0051960 248 0.082
erbb signaling pathway GO:0038127 58 0.082
skin development GO:0043588 65 0.081
ovarian follicle cell migration GO:0007297 121 0.081
humoral immune response GO:0006959 117 0.080
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.080
regulation of organelle organization GO:0033043 196 0.079
lipid metabolic process GO:0006629 121 0.078
cellular protein localization GO:0034613 160 0.077
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.076
regulation of developmental growth GO:0048638 174 0.076
organic substance catabolic process GO:1901575 308 0.075
circulatory system development GO:0072359 82 0.073
cortical actin cytoskeleton organization GO:0030866 24 0.072
establishment of organelle localization GO:0051656 122 0.071
peripheral nervous system development GO:0007422 52 0.071
cell projection assembly GO:0030031 94 0.071
cell death GO:0008219 279 0.069
regulation of actin filament polymerization GO:0030833 25 0.068
epidermal growth factor receptor signaling pathway GO:0007173 58 0.067
neuromuscular junction development GO:0007528 149 0.066
epithelium migration GO:0090132 148 0.066
positive regulation of macromolecule metabolic process GO:0010604 405 0.064
death GO:0016265 284 0.063
receptor mediated endocytosis GO:0006898 21 0.063
regulation of actin filament length GO:0030832 27 0.062
response to wounding GO:0009611 94 0.061
positive regulation of transcription dna templated GO:0045893 266 0.061
multicellular organismal reproductive behavior GO:0033057 110 0.060
single organism cellular localization GO:1902580 180 0.060
vesicle localization GO:0051648 55 0.059
actin filament organization GO:0007015 126 0.059
cardiovascular system development GO:0072358 82 0.058
immune response GO:0006955 246 0.058
regulation of cellular localization GO:0060341 136 0.057
appendage development GO:0048736 401 0.056
synapse assembly GO:0007416 143 0.056
multi organism behavior GO:0051705 175 0.056
regulation of immune response GO:0050776 118 0.054
negative regulation of cell death GO:0060548 81 0.054
regulation of growth GO:0040008 233 0.053
cytoskeleton dependent cytokinesis GO:0061640 81 0.053
imaginal disc derived wing morphogenesis GO:0007476 337 0.052
regulation of cell differentiation GO:0045595 302 0.052
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.052
macromolecule catabolic process GO:0009057 161 0.051
tube development GO:0035295 244 0.050
peptidyl amino acid modification GO:0018193 105 0.049
anion transport GO:0006820 41 0.049
actin filament polymerization GO:0030041 27 0.049
positive regulation of rna biosynthetic process GO:1902680 266 0.048
carbohydrate derivative biosynthetic process GO:1901137 85 0.047
regulation of anatomical structure size GO:0090066 163 0.047
immune response activating signal transduction GO:0002757 2 0.047
meiotic nuclear division GO:0007126 151 0.045
establishment of localization in cell GO:0051649 402 0.045
negative regulation of synapse assembly GO:0051964 39 0.045
cellular lipid metabolic process GO:0044255 83 0.045
regulation of cellular protein metabolic process GO:0032268 243 0.044
regulation of localization GO:0032879 275 0.044
cellular macromolecule catabolic process GO:0044265 136 0.044
negative regulation of protein modification process GO:0031400 29 0.044
multi organism reproductive behavior GO:0044705 121 0.042
epidermis development GO:0008544 65 0.039
embryonic pattern specification GO:0009880 174 0.039
growth GO:0040007 359 0.039
negative regulation of cellular protein metabolic process GO:0032269 85 0.039
positive regulation of cell migration GO:0030335 2 0.038
regulation of catalytic activity GO:0050790 185 0.038
regulation of molecular function GO:0065009 217 0.037
protein localization to nucleus GO:0034504 55 0.037
lipid biosynthetic process GO:0008610 46 0.037
cognition GO:0050890 141 0.036
actin cytoskeleton organization GO:0030036 206 0.036
immune system process GO:0002376 347 0.036
protein catabolic process GO:0030163 101 0.036
i kappab phosphorylation GO:0007252 3 0.036
innate immune response activating signal transduction GO:0002758 2 0.036
arp2 3 complex mediated actin nucleation GO:0034314 3 0.035
imaginal disc derived appendage development GO:0048737 399 0.035
tube morphogenesis GO:0035239 191 0.035
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.035
regulation of synapse assembly GO:0051963 94 0.035
ovarian follicle cell development GO:0030707 248 0.034
positive regulation of cellular component organization GO:0051130 156 0.034
regulation of cell death GO:0010941 173 0.034
oocyte differentiation GO:0009994 145 0.033
cell activation GO:0001775 9 0.033
transcription from rna polymerase ii promoter GO:0006366 368 0.032
regulation of multi organism process GO:0043900 131 0.032
regulation of catabolic process GO:0009894 170 0.032
carbohydrate derivative metabolic process GO:1901135 217 0.031
actin filament based movement GO:0030048 26 0.031
oocyte development GO:0048599 124 0.031
regulation of protein modification process GO:0031399 112 0.030
regulation of phosphate metabolic process GO:0019220 210 0.030
positive regulation of nucleic acid templated transcription GO:1903508 266 0.030
regulation of photoreceptor cell differentiation GO:0046532 34 0.029
regulation of response to biotic stimulus GO:0002831 63 0.029
regulation of protein kinase activity GO:0045859 51 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.029
heart process GO:0003015 37 0.028
single organism biosynthetic process GO:0044711 206 0.028
response to virus GO:0009615 28 0.028
negative regulation of programmed cell death GO:0043069 72 0.028
positive regulation of immune system process GO:0002684 68 0.028
macromolecular complex assembly GO:0065003 256 0.028
negative regulation of phosphatase activity GO:0010923 3 0.027
positive regulation of notch signaling pathway GO:0045747 34 0.027
regulation of cell development GO:0060284 215 0.027
regulation of cell cycle process GO:0010564 181 0.027
activation of innate immune response GO:0002218 4 0.027
proteolysis GO:0006508 192 0.027
actin filament capping GO:0051693 2 0.027
regulation of intracellular signal transduction GO:1902531 236 0.027
negative regulation of cytoskeleton organization GO:0051494 30 0.027
homeostatic process GO:0042592 199 0.026
transmembrane transport GO:0055085 139 0.026
single organism catabolic process GO:0044712 228 0.026
positive regulation of cellular biosynthetic process GO:0031328 316 0.026
mitotic cytokinesis GO:0000281 50 0.026
positive regulation of cellular component biogenesis GO:0044089 80 0.026
organophosphate metabolic process GO:0019637 195 0.026
Mouse
regulation of tube size GO:0035150 46 0.025
regulation of lamellipodium organization GO:1902743 15 0.025
regulation of vesicle mediated transport GO:0060627 59 0.025
regulation of programmed cell death GO:0043067 152 0.025
female germ line cyst formation GO:0048135 42 0.025
regulation of phosphatase activity GO:0010921 3 0.025
actin filament depolymerization GO:0030042 5 0.025
skeletal muscle fiber development GO:0048741 3 0.025
nucleoside phosphate metabolic process GO:0006753 162 0.025
epidermal cell differentiation GO:0009913 51 0.024
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.024
response to other organism GO:0051707 293 0.024
defense response to virus GO:0051607 23 0.024
carboxylic acid transport GO:0046942 18 0.024
negative regulation of protein metabolic process GO:0051248 85 0.024
positive regulation of signaling GO:0023056 243 0.024
regulation of phosphorus metabolic process GO:0051174 210 0.024
positive regulation of multicellular organismal process GO:0051240 143 0.023
asymmetric cell division GO:0008356 37 0.023
negative regulation of organelle organization GO:0010639 56 0.023
lamellipodium assembly GO:0030032 21 0.023
regulation of canonical wnt signaling pathway GO:0060828 15 0.023
nuclear division GO:0000280 332 0.023
regulation of actin filament based process GO:0032970 42 0.023
positive regulation of cell communication GO:0010647 250 0.023
nucleocytoplasmic transport GO:0006913 72 0.023
germarium derived egg chamber formation GO:0007293 101 0.022
exocytosis GO:0006887 28 0.022
negative regulation of epithelial cell proliferation GO:0050680 4 0.022
cellular component disassembly GO:0022411 46 0.022
response to organophosphorus GO:0046683 2 0.022
positive regulation of immune response GO:0050778 63 0.022
apoptotic process GO:0006915 159 0.022
single organism membrane organization GO:0044802 93 0.021
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.021
protein phosphorylation GO:0006468 169 0.021
positive regulation of axon extension GO:0045773 2 0.021
endodermal cell fate commitment GO:0001711 3 0.021
negative regulation of nervous system development GO:0051961 92 0.021
cell cycle arrest GO:0007050 4 0.021
muscle organ development GO:0007517 127 0.021
negative regulation of erbb signaling pathway GO:1901185 29 0.021
regulation of humoral immune response GO:0002920 51 0.021
mitotic nuclear division GO:0007067 213 0.021
regulation of cell projection organization GO:0031344 92 0.020
regulation of actin filament depolymerization GO:0030834 3 0.020
regulation of cell proliferation GO:0042127 163 0.020
positive regulation of transport GO:0051050 92 0.020
actin filament based process GO:0030029 220 0.020
regulation of hemocyte proliferation GO:0035206 37 0.020
glycoprotein biosynthetic process GO:0009101 41 0.020
regionalization GO:0003002 416 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.019
oxoacid metabolic process GO:0043436 103 0.019
regulation of cell shape GO:0008360 113 0.019
positive regulation of cell motility GO:2000147 3 0.019
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.019
cytoplasmic transport GO:0016482 130 0.019
establishment of protein localization GO:0045184 163 0.019
regulation of actin cytoskeleton organization GO:0032956 42 0.019
regulation of cell morphogenesis GO:0022604 163 0.019
regulation of immune system process GO:0002682 176 0.019
leucine transport GO:0015820 3 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.019
positive regulation of gene expression GO:0010628 290 0.019
multi multicellular organism process GO:0044706 123 0.018
cellular response to endogenous stimulus GO:0071495 80 0.018
positive regulation of protein transport GO:0051222 37 0.018
negative regulation of cellular component organization GO:0051129 108 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
chemotaxis GO:0006935 249 0.018
regulation of neuron differentiation GO:0045664 103 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
developmental growth GO:0048589 280 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
myotube cell development GO:0014904 3 0.018
cellular amine metabolic process GO:0044106 12 0.018
Mouse
eye photoreceptor cell differentiation GO:0001754 145 0.017
response to biotic stimulus GO:0009607 294 0.017
protein acylation GO:0043543 42 0.017
organic acid metabolic process GO:0006082 103 0.017
pole plasm mrna localization GO:0019094 49 0.017
epithelial tube morphogenesis GO:0060562 88 0.017
regulation of phosphorylation GO:0042325 147 0.017
regulation of transferase activity GO:0051338 58 0.017
epithelial cell migration GO:0010631 148 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
cell motility GO:0048870 251 0.016
purine ribonucleoside metabolic process GO:0046128 127 0.016
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
neuromuscular synaptic transmission GO:0007274 67 0.016
secretion by cell GO:0032940 101 0.016
protein complex localization GO:0031503 4 0.016
regulation of endocytosis GO:0030100 37 0.016
regulation of lamellipodium assembly GO:0010591 15 0.016
protein complex disassembly GO:0043241 36 0.016
heart development GO:0007507 82 0.016
positive regulation of hydrolase activity GO:0051345 78 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
regulation of defense response GO:0031347 102 0.016
embryonic morphogenesis GO:0048598 206 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.016
cilium assembly GO:0042384 38 0.015
nucleotide metabolic process GO:0009117 161 0.015
regulation of transport GO:0051049 181 0.015
organic substance transport GO:0071702 257 0.015
negative regulation of phosphorus metabolic process GO:0010563 45 0.015
regulation of protein localization GO:0032880 76 0.015
response to external biotic stimulus GO:0043207 293 0.015
renal system development GO:0072001 72 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
protein transport GO:0015031 155 0.014
body morphogenesis GO:0010171 2 0.014
cellular protein complex assembly GO:0043623 71 0.014
negative regulation of transcription dna templated GO:0045892 237 0.014
actin filament bundle organization GO:0061572 28 0.014
response to organic substance GO:0010033 284 0.014
intracellular mrna localization GO:0008298 66 0.014
hematopoietic progenitor cell differentiation GO:0002244 1 0.014
rna localization GO:0006403 115 0.014
organelle fission GO:0048285 340 0.014
blood circulation GO:0008015 26 0.014
intracellular transport GO:0046907 228 0.014
regulation of phagocytosis engulfment GO:0060099 1 0.014
negative regulation of developmental growth GO:0048640 64 0.014
positive regulation of protein localization to nucleus GO:1900182 21 0.014
cellular amide metabolic process GO:0043603 80 0.014
Mouse
jnk cascade GO:0007254 50 0.014
ovarian nurse cell to oocyte transport GO:0007300 27 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
muscle tissue development GO:0060537 30 0.013
regulation of protein complex assembly GO:0043254 42 0.013
regulation of organ morphogenesis GO:2000027 78 0.013
muscle cell differentiation GO:0042692 103 0.013
nitrogen compound transport GO:0071705 85 0.013
regulation of synapse organization GO:0050807 110 0.013
regulation of neurogenesis GO:0050767 158 0.013
regulation of stress activated mapk cascade GO:0032872 41 0.013
axonogenesis GO:0007409 290 0.013
morphogenesis of embryonic epithelium GO:0016331 94 0.013
protein acetylation GO:0006473 39 0.013
synaptic transmission GO:0007268 288 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
cation transmembrane transport GO:0098655 88 0.012
immune response regulating signaling pathway GO:0002764 2 0.012
digestive tract morphogenesis GO:0048546 127 0.012
positive regulation of innate immune response GO:0045089 38 0.012
ubiquitin dependent protein catabolic process GO:0006511 78 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
vesicle organization GO:0016050 44 0.012
sensory organ precursor cell division GO:0045035 10 0.012
positive regulation of protein catabolic process GO:0045732 34 0.012
cell growth GO:0016049 108 0.012
lamellipodium organization GO:0097581 21 0.012
muscle attachment GO:0016203 36 0.012
somatic muscle development GO:0007525 66 0.012
actin polymerization or depolymerization GO:0008154 31 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
regulation of filopodium assembly GO:0051489 24 0.011
epithelial cell development GO:0002064 274 0.011
pseudocleavage involved in syncytial blastoderm formation GO:0030589 9 0.011
cellular protein catabolic process GO:0044257 83 0.011
blastoderm segmentation GO:0007350 159 0.011
positive regulation of binding GO:0051099 4 0.011
regulation of cellular amide metabolic process GO:0034248 39 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
positive regulation of wnt signaling pathway GO:0030177 25 0.011
hemopoiesis GO:0030097 46 0.011
eggshell chorion assembly GO:0007306 66 0.011
response to hexose GO:0009746 3 0.011
lipid catabolic process GO:0016042 21 0.011
transmission of nerve impulse GO:0019226 12 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
axis specification GO:0009798 167 0.011
adult locomotory behavior GO:0008344 76 0.011
regulation of hydrolase activity GO:0051336 97 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.011
monocarboxylic acid transport GO:0015718 3 0.011
maintenance of location GO:0051235 73 0.011
organic anion transport GO:0015711 28 0.011
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.010
camera type eye morphogenesis GO:0048593 2 0.010
regulation of pole plasm oskar mrna localization GO:0007317 27 0.010
cellular response to hexose stimulus GO:0071331 1 0.010
negative regulation of developmental process GO:0051093 201 0.010
nuclear transport GO:0051169 72 0.010
oocyte anterior posterior axis specification GO:0007314 72 0.010
notum morphogenesis GO:0048802 4 0.010
taxis GO:0042330 304 0.010

lace disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
cardiovascular system disease DOID:1287 0 0.046
musculoskeletal system disease DOID:17 0 0.024