Drosophila melanogaster

115 known processes

ird5 (Dmel_CG4201)

immune response deficient 5

(Aliases: Ikkbeta,DIK,ird5/DmIkk[beta],Dmel\CG4201,Dmikkbeta,IKKb,DmIKKb,Ird-5,dIKK,IKKbeta,Lak,dIKK-beta,Ird5,DmIKKbeta,DmIkkbeta,IKKB,IKK,ird,IKK-beta,DLAK,DmIKK,IK,DmIKKBeta,ikk,anon-89Bd,IRD-5,LRK,dLak,CG4201,Ik,dmIKKbeta)

ird5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.997
humoral immune response GO:0006959 117 0.993
antibacterial humoral response GO:0019731 44 0.991
positive regulation of defense response to virus by host GO:0002230 10 0.970
immune response GO:0006955 246 0.966
positive regulation of antibacterial peptide production GO:0002803 20 0.962
regulation of defense response to virus by host GO:0050691 10 0.958
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.952
positive regulation of antimicrobial humoral response GO:0002760 28 0.950
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.930
antibacterial peptide production GO:0002778 22 0.925
regulation of defense response to virus GO:0050688 14 0.924
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.923
antimicrobial peptide production GO:0002775 46 0.923
immune system process GO:0002376 347 0.918
positive regulation of antimicrobial peptide production GO:0002225 28 0.917
regulation of defense response to bacterium GO:1900424 30 0.908
antimicrobial humoral response GO:0019730 99 0.906
defense response to virus GO:0051607 23 0.904
antibacterial peptide biosynthetic process GO:0002780 22 0.903
regulation of antibacterial peptide production GO:0002786 22 0.900
antifungal peptide production GO:0002781 7 0.894
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.876
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.851
defense response to bacterium GO:0042742 178 0.851
regulation of response to external stimulus GO:0032101 115 0.840
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.838
immune effector process GO:0002252 98 0.834
defense response to other organism GO:0098542 225 0.825
peptide metabolic process GO:0006518 80 0.819
regulation of antimicrobial peptide production GO:0002784 44 0.815
positive regulation of humoral immune response GO:0002922 28 0.792
antifungal humoral response GO:0019732 12 0.761
response to peptidoglycan GO:0032494 2 0.749
regulation of response to biotic stimulus GO:0002831 63 0.738
positive regulation of response to biotic stimulus GO:0002833 31 0.737
regulation of immune effector process GO:0002697 52 0.722
regulation of humoral immune response GO:0002920 51 0.716
regulation of multi organism process GO:0043900 131 0.716
response to external biotic stimulus GO:0043207 293 0.715
cellular amide metabolic process GO:0043603 80 0.685
positive regulation of immune effector process GO:0002699 28 0.677
regulation of antimicrobial humoral response GO:0002759 50 0.661
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.658
regulation of cellular amide metabolic process GO:0034248 39 0.649
positive regulation of antifungal peptide biosynthetic process GO:0006967 5 0.641
response to biotic stimulus GO:0009607 294 0.632
regulation of production of molecular mediator of immune response GO:0002700 44 0.631
response to bacterium GO:0009617 198 0.628
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.625
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.623
defense response GO:0006952 300 0.607
positive regulation of response to external stimulus GO:0032103 44 0.605
regulation of immune response GO:0050776 118 0.600
antimicrobial peptide biosynthetic process GO:0002777 38 0.594
defense response to gram negative bacterium GO:0050829 94 0.585
response to other organism GO:0051707 293 0.574
response to virus GO:0009615 28 0.566
production of molecular mediator of immune response GO:0002440 46 0.526
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.427
regulation of defense response GO:0031347 102 0.401
positive regulation of cellular amide metabolic process GO:0034250 26 0.320
cellular protein modification process GO:0006464 438 0.313
positive regulation of defense response to bacterium GO:1900426 23 0.302
amide biosynthetic process GO:0043604 42 0.282
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0006965 3 0.280
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.280
positive regulation of defense response GO:0031349 59 0.274
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.266
Zebrafish Mouse
positive regulation of immune response GO:0050778 63 0.228
activation of innate immune response GO:0002218 4 0.210
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.207
regulation of antifungal peptide production GO:0002788 6 0.199
regulation of endopeptidase activity GO:0052548 36 0.191
Fly
regulation of innate immune response GO:0045088 71 0.190
positive regulation of endopeptidase activity GO:0010950 26 0.189
Fly
regulation of antifungal peptide biosynthetic process GO:0002810 5 0.189
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.189
Fly
cellular response to external stimulus GO:0071496 66 0.185
cellular response to extracellular stimulus GO:0031668 64 0.183
regulation of immune system process GO:0002682 176 0.183
innate immune response GO:0045087 144 0.181
positive regulation of multi organism process GO:0043902 40 0.181
negative regulation of gene expression GO:0010629 387 0.175
peptide biosynthetic process GO:0043043 42 0.173
organonitrogen compound metabolic process GO:1901564 318 0.166
gene silencing by rna GO:0031047 57 0.161
positive regulation of biosynthetic process GO:0009891 316 0.159
cognition GO:0050890 141 0.155
organonitrogen compound biosynthetic process GO:1901566 117 0.151
antifungal peptide biosynthetic process GO:0002783 5 0.149
establishment of localization in cell GO:0051649 402 0.147
Fly
protein localization GO:0008104 284 0.145
response to extracellular stimulus GO:0009991 116 0.143
cell cycle checkpoint GO:0000075 95 0.136
regulation of response to stress GO:0080134 200 0.136
chromosome organization GO:0051276 360 0.132
immune response regulating signaling pathway GO:0002764 2 0.132
establishment of protein localization GO:0045184 163 0.129
intracellular signal transduction GO:0035556 300 0.129
Zebrafish Mouse
cellular response to mechanical stimulus GO:0071260 2 0.128
regulation of defense response to fungus GO:1900150 6 0.127
pigmentation GO:0043473 75 0.126
positive regulation of antifungal peptide production GO:0002804 6 0.125
response to nutrient levels GO:0031667 114 0.122
regulation of cell cycle GO:0051726 291 0.121
dendrite morphogenesis GO:0048813 199 0.121
single organism intracellular transport GO:1902582 207 0.120
Fly
mitotic dna integrity checkpoint GO:0044774 75 0.120
defense response to gram positive bacterium GO:0050830 41 0.119
negative regulation of defense response to bacterium GO:1900425 7 0.113
cellularization GO:0007349 90 0.110
negative regulation of cellular metabolic process GO:0031324 382 0.109
death GO:0016265 284 0.108
Zebrafish Rat Fly
negative regulation of cell cycle phase transition GO:1901988 103 0.107
small rna loading onto risc GO:0070922 6 0.106
imaginal disc derived appendage morphogenesis GO:0035114 395 0.106
regulation of cellular protein metabolic process GO:0032268 243 0.105
Fly
posttranscriptional regulation of gene expression GO:0010608 145 0.104
response to lipopolysaccharide GO:0032496 4 0.104
immune response activating signal transduction GO:0002757 2 0.104
response to starvation GO:0042594 97 0.104
positive regulation of immune system process GO:0002684 68 0.101
organelle assembly GO:0070925 198 0.098
programmed cell death GO:0012501 257 0.097
Zebrafish Fly
catabolic process GO:0009056 409 0.093
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.093
reactive oxygen species metabolic process GO:0072593 22 0.092
internal peptidyl lysine acetylation GO:0018393 38 0.090
heterochromatin organization GO:0070828 25 0.088
innate immune response activating signal transduction GO:0002758 2 0.088
positive regulation of response to stimulus GO:0048584 323 0.086
rna interference GO:0016246 27 0.085
gene silencing GO:0016458 138 0.085
regulation of intracellular signal transduction GO:1902531 236 0.085
Human Zebrafish Mouse
cell death GO:0008219 279 0.081
Zebrafish Rat Fly
negative regulation of stem cell proliferation GO:2000647 30 0.081
cytoplasmic transport GO:0016482 130 0.079
dna metabolic process GO:0006259 227 0.078
signal transduction in response to dna damage GO:0042770 3 0.077
regulation of cell differentiation GO:0045595 302 0.077
negative regulation of cell communication GO:0010648 223 0.076
Zebrafish
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.075
Fly
chromatin organization GO:0006325 207 0.074
activation of cysteine type endopeptidase activity GO:0097202 17 0.074
melanization defense response GO:0035006 45 0.072
cellular macromolecule localization GO:0070727 220 0.072
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.071
response to organophosphorus GO:0046683 2 0.071
regulation of cell death GO:0010941 173 0.071
Zebrafish Rat Fly
regulation of macroautophagy GO:0016241 15 0.070
dna integrity checkpoint GO:0031570 81 0.070
developmental maturation GO:0021700 172 0.070
Fly
nuclear transport GO:0051169 72 0.069
regulation of programmed cell death GO:0043067 152 0.068
Zebrafish Fly
regulation of protein metabolic process GO:0051246 256 0.068
Fly
cellular catabolic process GO:0044248 372 0.067
maintenance of protein location in cell GO:0032507 26 0.066
response to abiotic stimulus GO:0009628 341 0.065
positive regulation of cellular biosynthetic process GO:0031328 316 0.064
positive regulation of cell death GO:0010942 69 0.064
Rat Fly
protein transport GO:0015031 155 0.064
secondary metabolic process GO:0019748 75 0.063
single organism catabolic process GO:0044712 228 0.062
fat soluble vitamin metabolic process GO:0006775 1 0.062
zymogen activation GO:0031638 20 0.061
negative regulation of signaling GO:0023057 219 0.060
Zebrafish
cellular protein localization GO:0034613 160 0.059
pigment metabolic process GO:0042440 84 0.059
negative regulation of mitotic cell cycle GO:0045930 109 0.059
i kappab kinase nf kappab signaling GO:0007249 6 0.058
Zebrafish Mouse
mitotic spindle organization GO:0007052 220 0.057
pattern recognition receptor signaling pathway GO:0002221 2 0.057
benzene containing compound metabolic process GO:0042537 3 0.056
positive regulation of multicellular organismal process GO:0051240 143 0.055
regulation of peptidase activity GO:0052547 39 0.054
Fly
cardiovascular system development GO:0072358 82 0.053
internal protein amino acid acetylation GO:0006475 38 0.053
dendrite development GO:0016358 204 0.053
protein localization to nucleus GO:0034504 55 0.053
regulation of gene expression epigenetic GO:0040029 128 0.053
regulation of cell cycle process GO:0010564 181 0.053
positive regulation of cell communication GO:0010647 250 0.052
Mouse
intracellular transport GO:0046907 228 0.052
Fly
cellular response to dna damage stimulus GO:0006974 223 0.052
protein complex assembly GO:0006461 200 0.052
regulation of nucleocytoplasmic transport GO:0046822 35 0.052
mucosal immune response GO:0002385 10 0.052
nucleocytoplasmic transport GO:0006913 72 0.051
macromolecular complex assembly GO:0065003 256 0.051
positive regulation of protein transport GO:0051222 37 0.050
negative regulation of response to stimulus GO:0048585 258 0.050
Zebrafish
regulation of cellular response to stress GO:0080135 89 0.050
organic substance transport GO:0071702 257 0.049
salivary gland morphogenesis GO:0007435 145 0.049
regulation of mitotic cell cycle GO:0007346 190 0.049
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.049
cellular response to lipopolysaccharide GO:0071222 3 0.049
posttranscriptional gene silencing by rna GO:0035194 45 0.049
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.048
cellular response to starvation GO:0009267 61 0.048
microtubule organizing center organization GO:0031023 168 0.048
response to wounding GO:0009611 94 0.048
dna damage checkpoint GO:0000077 78 0.047
positive regulation of proteolysis GO:0045862 52 0.047
Fly
cellular response to abiotic stimulus GO:0071214 58 0.047
positive regulation of macromolecule metabolic process GO:0010604 405 0.047
Human Fly
g2 dna damage checkpoint GO:0031572 69 0.047
gastrulation involving germ band extension GO:0010004 36 0.047
melanin metabolic process GO:0006582 47 0.046
developmental programmed cell death GO:0010623 138 0.046
regulation of autophagy GO:0010506 62 0.045
head involution GO:0008258 35 0.045
response to organonitrogen compound GO:0010243 75 0.045
regulation of establishment of protein localization GO:0070201 61 0.045
positive regulation of signaling GO:0023056 243 0.043
Mouse
organic substance catabolic process GO:1901575 308 0.043
histolysis GO:0007559 102 0.043
response to organic cyclic compound GO:0014070 89 0.042
regulation of mitotic cell cycle phase transition GO:1901990 130 0.042
apoptotic signaling pathway GO:0097190 27 0.042
tissue death GO:0016271 102 0.042
chitin based cuticle sclerotization GO:0007593 19 0.041
response to organic substance GO:0010033 284 0.041
Human Rat
regulation of intracellular transport GO:0032386 64 0.041
regulation of multicellular organismal development GO:2000026 414 0.040
jnk cascade GO:0007254 50 0.040
positive regulation of cellular component organization GO:0051130 156 0.040
positive regulation of molecular function GO:0044093 136 0.040
Human Mouse Rat Fly
nf kappab import into nucleus GO:0042348 1 0.040
extrinsic apoptotic signaling pathway GO:0097191 1 0.040
organelle fission GO:0048285 340 0.040
positive regulation of gene expression GO:0010628 290 0.039
Human
regulation of catalytic activity GO:0050790 185 0.039
Fly
cellular response to molecule of bacterial origin GO:0071219 3 0.038
protein modification process GO:0036211 438 0.038
single organism cellular localization GO:1902580 180 0.038
salivary gland cell autophagic cell death GO:0035071 83 0.038
posttranscriptional gene silencing GO:0016441 46 0.037
regulation of cytoplasmic transport GO:1903649 47 0.037
negative regulation of rna biosynthetic process GO:1902679 240 0.037
phagocytosis GO:0006909 215 0.037
salivary gland histolysis GO:0035070 88 0.037
defense response to fungus GO:0050832 48 0.037
regulation of intracellular protein transport GO:0033157 46 0.037
apoptotic process GO:0006915 159 0.036
Zebrafish Fly
regulation of cell cycle phase transition GO:1901987 130 0.036
positive regulation of cellular catabolic process GO:0031331 95 0.036
cellular response to biotic stimulus GO:0071216 4 0.036
response to temperature stimulus GO:0009266 106 0.036
cell proliferation GO:0008283 299 0.036
Mouse Rat
negative regulation of cell cycle process GO:0010948 109 0.036
gland morphogenesis GO:0022612 145 0.036
cellular response to organic substance GO:0071310 132 0.036
Human
regulation of gene silencing GO:0060968 63 0.036
post embryonic appendage morphogenesis GO:0035120 385 0.035
courtship behavior GO:0007619 68 0.035
cellular response to oxygen containing compound GO:1901701 79 0.034
macromolecule catabolic process GO:0009057 161 0.034
response to fungus GO:0009620 50 0.034
cellular response to dsrna GO:0071359 15 0.034
regulation of cellular localization GO:0060341 136 0.034
heterocycle catabolic process GO:0046700 166 0.034
mitotic cell cycle phase transition GO:0044772 138 0.034
compound eye morphogenesis GO:0001745 249 0.034
regulation of protein import into nucleus GO:0042306 28 0.033
neuron remodeling GO:0016322 29 0.033
Fly
protein complex biogenesis GO:0070271 201 0.033
production of small rna involved in gene silencing by rna GO:0070918 15 0.033
single organism behavior GO:0044708 391 0.033
imaginal disc derived wing morphogenesis GO:0007476 337 0.033
protein targeting to nucleus GO:0044744 51 0.033
regulation of nf kappab import into nucleus GO:0042345 1 0.033
response to radiation GO:0009314 155 0.033
negative regulation of rna metabolic process GO:0051253 251 0.033
regulation of molecular function GO:0065009 217 0.033
Human Mouse Rat Fly
regulation of catabolic process GO:0009894 170 0.032
proteolysis GO:0006508 192 0.032
Fly
membrane organization GO:0061024 112 0.032
regulation of transport GO:0051049 181 0.032
Mouse
neurological system process GO:0050877 358 0.032
regulation of cellular component biogenesis GO:0044087 201 0.032
memory GO:0007613 94 0.032
negative regulation of response to external stimulus GO:0032102 22 0.031
protein localization to organelle GO:0033365 82 0.031
regulation of cellular catabolic process GO:0031329 157 0.031
negative regulation of cellular biosynthetic process GO:0031327 277 0.031
male mating behavior GO:0060179 70 0.030
salivary gland development GO:0007431 162 0.030
regulation of response to wounding GO:1903034 19 0.030
nuclear division GO:0000280 332 0.030
negative regulation of signal transduction GO:0009968 206 0.030
Zebrafish
positive regulation of cell cycle process GO:0090068 28 0.030
retinal cell programmed cell death GO:0046666 25 0.029
wing disc morphogenesis GO:0007472 344 0.029
response to nitrogen compound GO:1901698 90 0.029
organ or tissue specific immune response GO:0002251 10 0.029
autophagy GO:0006914 108 0.029
single organism nuclear import GO:1902593 51 0.029
protein targeting GO:0006605 64 0.029
cell cycle phase transition GO:0044770 140 0.029
negative regulation of cell cycle GO:0045786 116 0.029
positive regulation of transport GO:0051050 92 0.028
Mouse
regulation of jnk cascade GO:0046328 40 0.028
central nervous system development GO:0007417 201 0.028
Zebrafish
developmental pigmentation GO:0048066 68 0.028
regulation of localization GO:0032879 275 0.028
Mouse
endocytosis GO:0006897 310 0.028
lysosomal transport GO:0007041 13 0.028
response to alkaloid GO:0043279 26 0.028
positive regulation of protein import into nucleus GO:0042307 21 0.028
response to unfolded protein GO:0006986 9 0.028
mitotic dna damage checkpoint GO:0044773 74 0.028
chromosome segregation GO:0007059 157 0.027
stem cell proliferation GO:0072089 88 0.027
protein maturation GO:0051604 71 0.027
dsrna fragmentation GO:0031050 15 0.027
dorsal closure GO:0007391 79 0.027
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.027
positive regulation of peptidase activity GO:0010952 29 0.027
Fly
response to dsrna GO:0043331 15 0.026
cellular response to organic cyclic compound GO:0071407 32 0.026
nitrogen compound transport GO:0071705 85 0.026
digestive tract development GO:0048565 149 0.026
Zebrafish
autophagic cell death GO:0048102 83 0.026
apoptotic process involved in development GO:1902742 20 0.026
regulation of cysteine type endopeptidase activity GO:2000116 27 0.026
Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.026
Human
neuromuscular synaptic transmission GO:0007274 67 0.026
peptidyl amino acid modification GO:0018193 105 0.026
nuclear import GO:0051170 51 0.026
histone acetylation GO:0016573 38 0.026
embryonic development via the syncytial blastoderm GO:0001700 148 0.025
cuticle development GO:0042335 86 0.025
intracellular protein transport GO:0006886 104 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.025
cell division GO:0051301 248 0.025
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
Human
protein acylation GO:0043543 42 0.025
rna processing GO:0006396 147 0.025
sperm individualization GO:0007291 48 0.025
regulation of protein localization GO:0032880 76 0.025
chromatin silencing GO:0006342 76 0.024
organic hydroxy compound metabolic process GO:1901615 83 0.024
regulation of hydrolase activity GO:0051336 97 0.024
Fly
pigment biosynthetic process GO:0046148 36 0.024
mitotic g2 m transition checkpoint GO:0044818 70 0.024
fat soluble vitamin biosynthetic process GO:0042362 1 0.024
negative regulation of transcription dna templated GO:0045892 237 0.024
negative regulation of biosynthetic process GO:0009890 277 0.024
spindle organization GO:0007051 253 0.024
aging GO:0007568 143 0.024
regulation of wnt signaling pathway GO:0030111 68 0.024
pole cell development GO:0007277 26 0.024
cellular macromolecule catabolic process GO:0044265 136 0.024
gastrulation with mouth forming first GO:0001703 36 0.023
negative regulation of protein metabolic process GO:0051248 85 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.023
mitotic cell cycle checkpoint GO:0007093 88 0.023
regulation of developmental growth GO:0048638 174 0.023
neural retina development GO:0003407 4 0.023
protein import GO:0017038 55 0.023
stress activated mapk cascade GO:0051403 52 0.023
regulation of phosphorylation GO:0042325 147 0.023
chromatin modification GO:0016568 147 0.023
protein modification by small protein conjugation or removal GO:0070647 106 0.023
peripheral nervous system development GO:0007422 52 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.023
Human
gland development GO:0048732 191 0.023
Mouse
negative regulation of immune response GO:0050777 39 0.022
regulation of synapse organization GO:0050807 110 0.022
telencephalon development GO:0021537 2 0.022
detection of light stimulus GO:0009583 58 0.022
positive regulation of innate immune response GO:0045089 38 0.022
digestive system development GO:0055123 149 0.022
Zebrafish
oocyte dorsal ventral axis specification GO:0007310 34 0.022
positive regulation of catabolic process GO:0009896 105 0.022
cellular response to chemical stimulus GO:0070887 199 0.022
Human
macroautophagy GO:0016236 42 0.022
regionalization GO:0003002 416 0.022
Zebrafish
peptidyl lysine modification GO:0018205 57 0.022
positive regulation of cellular protein metabolic process GO:0032270 118 0.021
Fly
regulation of growth GO:0040008 233 0.021
response to endogenous stimulus GO:0009719 119 0.021
positive regulation of rna biosynthetic process GO:1902680 266 0.021
Human
segment polarity determination GO:0007367 25 0.021
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.020
protein import into nucleus GO:0006606 51 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
Mouse
synaptic growth at neuromuscular junction GO:0051124 119 0.020
positive regulation of catalytic activity GO:0043085 118 0.020
Fly
spindle assembly GO:0051225 80 0.020
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.020
organic cyclic compound catabolic process GO:1901361 168 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
positive regulation of apoptotic signaling pathway GO:2001235 4 0.020
ectopic germ cell programmed cell death GO:0035234 8 0.020
regulation of cell cycle g1 s phase transition GO:1902806 23 0.020
connective tissue development GO:0061448 3 0.020
response to oxidative stress GO:0006979 86 0.020
male gamete generation GO:0048232 201 0.020
dorsal ventral axis specification GO:0009950 66 0.020
respiratory system development GO:0060541 213 0.020
Fly
positive regulation of rna metabolic process GO:0051254 271 0.019
Human
appendage development GO:0048736 401 0.019
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.019
Mouse
embryonic morphogenesis GO:0048598 206 0.019
Zebrafish
regulation of nuclear division GO:0051783 58 0.019
response to lipid GO:0033993 38 0.019
Rat
enzyme linked receptor protein signaling pathway GO:0007167 179 0.019
negative regulation of cellular component organization GO:0051129 108 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.019
Human
interspecies interaction between organisms GO:0044419 16 0.019
forebrain development GO:0030900 2 0.019
positive regulation of apoptotic process GO:0043065 47 0.019
Fly
positive regulation of growth GO:0045927 75 0.019
positive regulation of hydrolase activity GO:0051345 78 0.019
Fly
embryonic pattern specification GO:0009880 174 0.019
Zebrafish
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
sensory organ morphogenesis GO:0090596 260 0.019
detection of abiotic stimulus GO:0009582 66 0.019
compound eye retinal cell programmed cell death GO:0046667 23 0.019
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.019
cellular response to sterol depletion GO:0071501 3 0.019
establishment of tissue polarity GO:0007164 87 0.018
regulation of proteolysis GO:0030162 87 0.018
Fly
positive regulation of cell cycle GO:0045787 43 0.018
regulation of mapk cascade GO:0043408 92 0.018
regulation of reactive oxygen species metabolic process GO:2000377 8 0.018
apoptotic cell clearance GO:0043277 14 0.018
alternative mrna splicing via spliceosome GO:0000380 60 0.018
neuron maturation GO:0042551 31 0.018
Fly
vesicle mediated transport GO:0016192 381 0.018
Fly
myotube cell development GO:0014904 3 0.018
spermatid development GO:0007286 98 0.018
mitotic nuclear division GO:0007067 213 0.017
cellular response to nutrient levels GO:0031669 62 0.017
locomotory behavior GO:0007626 176 0.017
regulation of apoptotic process GO:0042981 130 0.017
Zebrafish Fly
cellular amino acid metabolic process GO:0006520 61 0.017
positive regulation of intracellular transport GO:0032388 42 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.017
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.017
cellular nitrogen compound catabolic process GO:0044270 165 0.017
ncrna metabolic process GO:0034660 43 0.017
mating behavior GO:0007617 106 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
Zebrafish
mrna metabolic process GO:0016071 124 0.017
exocrine system development GO:0035272 162 0.017
cellular response to nitrogen compound GO:1901699 51 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.017
Human
protein processing GO:0016485 68 0.017
germ line stem cell maintenance GO:0030718 50 0.016
nucleobase containing compound transport GO:0015931 56 0.016
regulation of epithelial cell differentiation GO:0030856 4 0.016
peptidyl lysine acetylation GO:0018394 39 0.016
response to copper ion GO:0046688 4 0.016
imaginal disc fusion GO:0046528 19 0.016
regulation of protein transport GO:0051223 57 0.016
limb development GO:0060173 1 0.016
cation transport GO:0006812 110 0.016
Mouse
spermatogenesis GO:0007283 200 0.016
positive regulation of developmental growth GO:0048639 62 0.016
positive regulation of developmental process GO:0051094 143 0.016
camera type eye development GO:0043010 4 0.016
cell cycle arrest GO:0007050 4 0.016
centrosome duplication GO:0051298 121 0.016
negative regulation of innate immune response GO:0045824 30 0.016
covalent chromatin modification GO:0016569 106 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.015
regulation of ras gtpase activity GO:0032318 38 0.015
positive regulation of cell migration GO:0030335 2 0.015
regulation of response to extracellular stimulus GO:0032104 18 0.015
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.015
cellular response to ethanol GO:0071361 4 0.015
regulation of anatomical structure morphogenesis GO:0022603 242 0.015
vitamin metabolic process GO:0006766 2 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
endomembrane system organization GO:0010256 119 0.015
appendage morphogenesis GO:0035107 397 0.015
retina development in camera type eye GO:0060041 4 0.015
molting cycle chitin based cuticle GO:0007591 56 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
membrane depolarization GO:0051899 4 0.015
response to ethanol GO:0045471 59 0.015
morphogenesis of an epithelium GO:0002009 276 0.015
Zebrafish Mouse
negative regulation of growth GO:0045926 84 0.015
negative regulation of cell differentiation GO:0045596 143 0.015
negative regulation of cell death GO:0060548 81 0.015
Zebrafish
regulation of synapse structure and activity GO:0050803 128 0.015
muscle cell differentiation GO:0042692 103 0.015

ird5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.077
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.016