Drosophila melanogaster

95 known processes

Su(dx) (Dmel_CG4244)

Suppressor of deltex

(Aliases: Dmel\CG4244,Su(Dx),Su(deltex),su(dx),CG4244,anon-WO0073329.4,anon-WO0073329.2,anon-WO0073329.1)

Su(dx) biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
enzyme linked receptor protein signaling pathway GO:0007167 179 0.563
Fly
regulation of growth GO:0040008 233 0.411
Fly
cellular response to endogenous stimulus GO:0071495 80 0.359
Fly
regulation of catabolic process GO:0009894 170 0.312
Mouse
small molecule metabolic process GO:0044281 305 0.306
death GO:0016265 284 0.302
Human
imaginal disc derived appendage development GO:0048737 399 0.287
cellular protein modification process GO:0006464 438 0.272
Human Mouse Fly
epithelial cell differentiation GO:0030855 322 0.244
regulation of cellular catabolic process GO:0031329 157 0.227
phosphorylation GO:0016310 294 0.212
Mouse
protein modification process GO:0036211 438 0.212
Human Mouse Fly
positive regulation of catabolic process GO:0009896 105 0.206
Mouse
establishment or maintenance of cell polarity GO:0007163 167 0.188
endosomal transport GO:0016197 44 0.185
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.183
developmental growth GO:0048589 280 0.180
positive regulation of cellular catabolic process GO:0031331 95 0.177
actin filament based process GO:0030029 220 0.170
protein localization GO:0008104 284 0.152
growth GO:0040007 359 0.140
Fly
axon guidance GO:0007411 233 0.127
male gamete generation GO:0048232 201 0.127
regulation of protein metabolic process GO:0051246 256 0.124
Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.122
regulation of erbb signaling pathway GO:1901184 42 0.122
organonitrogen compound metabolic process GO:1901564 318 0.120
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.120
Human Mouse
single organism intracellular transport GO:1902582 207 0.116
stem cell differentiation GO:0048863 117 0.110
establishment of organelle localization GO:0051656 122 0.109
organic substance catabolic process GO:1901575 308 0.105
Human Mouse Fly
autophagy GO:0006914 108 0.103
regulation of intracellular signal transduction GO:1902531 236 0.101
Mouse
oxoacid metabolic process GO:0043436 103 0.101
regulation of developmental growth GO:0048638 174 0.098
protein targeting GO:0006605 64 0.096
positive regulation of cellular component organization GO:0051130 156 0.095
single organism cellular localization GO:1902580 180 0.094
regulation of phosphorylation GO:0042325 147 0.094
Mouse
cytokinesis GO:0000910 90 0.094
body morphogenesis GO:0010171 2 0.090
spermatid development GO:0007286 98 0.090
vesicle mediated transport GO:0016192 381 0.089
immune response regulating signaling pathway GO:0002764 2 0.087
ribonucleoside triphosphate catabolic process GO:0009203 108 0.087
organelle fission GO:0048285 340 0.086
lipid metabolic process GO:0006629 121 0.085
cellular macromolecule localization GO:0070727 220 0.085
spermatogenesis GO:0007283 200 0.083
proteolysis GO:0006508 192 0.082
Human Mouse Fly
single organism catabolic process GO:0044712 228 0.082
programmed cell death GO:0012501 257 0.081
Human
actin cytoskeleton organization GO:0030036 206 0.081
digestive system development GO:0055123 149 0.081
Fly
embryonic development via the syncytial blastoderm GO:0001700 148 0.080
Fly
lipid modification GO:0030258 24 0.080
tissue migration GO:0090130 155 0.079
organelle assembly GO:0070925 198 0.078
regulation of nervous system development GO:0051960 248 0.077
oocyte development GO:0048599 124 0.077
spermatid differentiation GO:0048515 114 0.075
regulation of molecular function GO:0065009 217 0.075
Human Mouse
regulation of immune system process GO:0002682 176 0.075
Human Mouse
cell death GO:0008219 279 0.074
Human
macromolecular complex assembly GO:0065003 256 0.074
cell projection assembly GO:0030031 94 0.073
organelle localization GO:0051640 148 0.073
epidermal growth factor receptor signaling pathway GO:0007173 58 0.072
regulation of cellular component biogenesis GO:0044087 201 0.070
response to external biotic stimulus GO:0043207 293 0.067
Human Mouse
cellular response to peptide hormone stimulus GO:0071375 28 0.066
determination of adult lifespan GO:0008340 137 0.066
endocytosis GO:0006897 310 0.065
cellular response to organonitrogen compound GO:0071417 36 0.064
appendage development GO:0048736 401 0.063
embryo development ending in birth or egg hatching GO:0009792 152 0.062
Fly
regulation of catalytic activity GO:0050790 185 0.061
negative regulation of developmental process GO:0051093 201 0.060
carbohydrate derivative catabolic process GO:1901136 118 0.059
pigment metabolic process GO:0042440 84 0.059
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.059
cellular lipid metabolic process GO:0044255 83 0.058
regionalization GO:0003002 416 0.058
protein complex assembly GO:0006461 200 0.058
protein transport GO:0015031 155 0.057
Human
cellular catabolic process GO:0044248 372 0.057
Human Mouse Fly
regulation of phosphate metabolic process GO:0019220 210 0.055
Mouse
wing disc morphogenesis GO:0007472 344 0.054
negative regulation of multicellular organismal process GO:0051241 142 0.054
single organism membrane organization GO:0044802 93 0.054
asymmetric protein localization GO:0008105 33 0.054
ribose phosphate metabolic process GO:0019693 145 0.054
cellular response to peptide GO:1901653 28 0.054
regulation of autophagy GO:0010506 62 0.053
membrane organization GO:0061024 112 0.053
cellular response to hormone stimulus GO:0032870 44 0.051
nucleoside catabolic process GO:0009164 112 0.050
ribonucleoside catabolic process GO:0042454 112 0.050
bmp signaling pathway GO:0030509 27 0.050
Fly
catabolic process GO:0009056 409 0.049
Human Mouse Fly
cellular ketone metabolic process GO:0042180 24 0.049
response to growth factor GO:0070848 31 0.049
Fly
regulation of cell cycle GO:0051726 291 0.048
cell motility GO:0048870 251 0.048
protein phosphorylation GO:0006468 169 0.048
single organism biosynthetic process GO:0044711 206 0.048
actin filament organization GO:0007015 126 0.047
cellular protein localization GO:0034613 160 0.047
positive regulation of catalytic activity GO:0043085 118 0.047
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.047
Fly
intracellular signal transduction GO:0035556 300 0.046
Mouse
cellular nitrogen compound catabolic process GO:0044270 165 0.046
cell proliferation GO:0008283 299 0.046
Mouse
establishment of protein localization GO:0045184 163 0.045
Human
histone modification GO:0016570 106 0.045
defense response to bacterium GO:0042742 178 0.044
ameboidal type cell migration GO:0001667 151 0.044
regulation of bmp signaling pathway GO:0030510 23 0.043
Fly
negative regulation of signal transduction GO:0009968 206 0.043
transcription from rna polymerase ii promoter GO:0006366 368 0.042
Human Mouse
response to peptide hormone GO:0043434 29 0.041
nucleotide metabolic process GO:0009117 161 0.041
organophosphate metabolic process GO:0019637 195 0.041
ribonucleotide metabolic process GO:0009259 145 0.041
regulation of actin cytoskeleton organization GO:0032956 42 0.041
nucleoside triphosphate metabolic process GO:0009141 120 0.041
cell division GO:0051301 248 0.040
positive regulation of molecular function GO:0044093 136 0.040
intracellular transport GO:0046907 228 0.040
cellular response to growth factor stimulus GO:0071363 30 0.040
Fly
establishment of localization in cell GO:0051649 402 0.040
negative regulation of response to stimulus GO:0048585 258 0.040
tube development GO:0035295 244 0.039
Fly
purine ribonucleotide metabolic process GO:0009150 145 0.039
purine containing compound metabolic process GO:0072521 155 0.039
regulation of cellular protein metabolic process GO:0032268 243 0.039
Mouse
insulin receptor signaling pathway GO:0008286 25 0.039
positive regulation of biosynthetic process GO:0009891 316 0.039
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.039
post embryonic appendage morphogenesis GO:0035120 385 0.039
adult behavior GO:0030534 137 0.038
erbb signaling pathway GO:0038127 58 0.038
hematopoietic progenitor cell differentiation GO:0002244 1 0.038
actin filament bundle organization GO:0061572 28 0.038
peptidyl amino acid modification GO:0018193 105 0.037
developmental maturation GO:0021700 172 0.037
purine nucleoside triphosphate metabolic process GO:0009144 119 0.037
regulation of proteolysis GO:0030162 87 0.037
carboxylic acid metabolic process GO:0019752 92 0.037
mitotic nuclear division GO:0007067 213 0.036
nucleoside phosphate catabolic process GO:1901292 110 0.036
regulation of localization GO:0032879 275 0.035
cellular response to chemical stimulus GO:0070887 199 0.035
Fly
cellularization GO:0007349 90 0.035
cellular protein complex assembly GO:0043623 71 0.035
nucleoside triphosphate catabolic process GO:0009143 108 0.035
purine containing compound catabolic process GO:0072523 112 0.035
single organism behavior GO:0044708 391 0.035
cellular amine metabolic process GO:0044106 12 0.034
response to extracellular stimulus GO:0009991 116 0.034
negative regulation of phosphate metabolic process GO:0045936 45 0.034
Mouse
nuclear division GO:0000280 332 0.034
epithelial cell migration GO:0010631 148 0.034
digestive tract development GO:0048565 149 0.034
Fly
developmental programmed cell death GO:0010623 138 0.034
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.033
Fly
regulation of anatomical structure morphogenesis GO:0022603 242 0.033
purine nucleoside catabolic process GO:0006152 112 0.033
regulation of phosphorus metabolic process GO:0051174 210 0.033
Mouse
oocyte differentiation GO:0009994 145 0.033
axonogenesis GO:0007409 290 0.033
formation of organ boundary GO:0010160 30 0.032
synaptic growth at neuromuscular junction GO:0051124 119 0.032
glycosyl compound catabolic process GO:1901658 112 0.032
regulation of cell development GO:0060284 215 0.032
lipid catabolic process GO:0016042 21 0.032
monocarboxylic acid catabolic process GO:0072329 10 0.032
negative regulation of biosynthetic process GO:0009890 277 0.032
Human Mouse
actin cytoskeleton reorganization GO:0031532 22 0.032
regulation of transport GO:0051049 181 0.031
Human
axon development GO:0061564 297 0.030
positive regulation of phosphorus metabolic process GO:0010562 139 0.030
negative regulation of cellular metabolic process GO:0031324 382 0.030
Human Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.030
mitochondrion organization GO:0007005 65 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.029
purine nucleoside metabolic process GO:0042278 127 0.029
response to peptide GO:1901652 29 0.029
nuclear migration GO:0007097 20 0.029
cellular macromolecular complex assembly GO:0034622 153 0.028
regulation of programmed cell death GO:0043067 152 0.028
Human
purine nucleoside triphosphate catabolic process GO:0009146 108 0.028
positive regulation of cellular protein metabolic process GO:0032270 118 0.028
anion transport GO:0006820 41 0.027
chemotaxis GO:0006935 249 0.027
compound eye morphogenesis GO:0001745 249 0.027
negative regulation of nervous system development GO:0051961 92 0.026
purine nucleotide metabolic process GO:0006163 146 0.026
organophosphate catabolic process GO:0046434 112 0.026
regulation of cellular response to insulin stimulus GO:1900076 17 0.026
negative regulation of gene expression GO:0010629 387 0.026
Human Mouse Fly
cell migration GO:0016477 238 0.026
regulation of protein kinase activity GO:0045859 51 0.026
phagocytosis GO:0006909 215 0.026
purine ribonucleoside metabolic process GO:0046128 127 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
oocyte construction GO:0007308 112 0.025
regulation of cell division GO:0051302 72 0.025
hematopoietic or lymphoid organ development GO:0048534 57 0.025
purine nucleotide catabolic process GO:0006195 109 0.025
localization of cell GO:0051674 257 0.025
protein catabolic process GO:0030163 101 0.025
Human Mouse Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.024
regulation of small gtpase mediated signal transduction GO:0051056 93 0.024
response to transforming growth factor beta GO:0071559 18 0.024
Fly
nucleobase containing small molecule metabolic process GO:0055086 174 0.024
regulation of actin filament based process GO:0032970 42 0.024
response to organic substance GO:0010033 284 0.024
Fly
regulation of hemocyte proliferation GO:0035206 37 0.024
larval development GO:0002164 104 0.023
circadian behavior GO:0048512 76 0.023
response to oxygen containing compound GO:1901700 200 0.023
synaptic transmission GO:0007268 288 0.023
epithelial cell development GO:0002064 274 0.023
negative regulation of growth GO:0045926 84 0.023
positive regulation of proteolysis GO:0045862 52 0.023
regulation of cell shape GO:0008360 113 0.023
purine ribonucleoside catabolic process GO:0046130 112 0.023
regulation of cell morphogenesis GO:0022604 163 0.023
nucleoside metabolic process GO:0009116 127 0.023
neuromuscular junction development GO:0007528 149 0.022
purine ribonucleotide catabolic process GO:0009154 109 0.022
epithelium migration GO:0090132 148 0.022
cellular response to oxygen containing compound GO:1901701 79 0.022
protein complex biogenesis GO:0070271 201 0.022
regulation of protein catabolic process GO:0042176 55 0.022
Mouse
regulation of immune response GO:0050776 118 0.022
carbohydrate derivative metabolic process GO:1901135 217 0.022
actin filament bundle assembly GO:0051017 26 0.022
positive regulation of gtp catabolic process GO:0033126 43 0.021
lipid storage GO:0019915 38 0.021
developmental pigmentation GO:0048066 68 0.021
cellular response to organic substance GO:0071310 132 0.021
Fly
endomembrane system organization GO:0010256 119 0.020
cellular response to insulin stimulus GO:0032869 28 0.020
chromosome organization GO:0051276 360 0.020
sister chromatid segregation GO:0000819 92 0.020
regulation of cell proliferation GO:0042127 163 0.020
Mouse
nephron development GO:0072006 3 0.020
cell adhesion GO:0007155 136 0.020
notch signaling pathway GO:0007219 120 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
Mouse
nucleoside phosphate metabolic process GO:0006753 162 0.020
response to hormone GO:0009725 45 0.019
protein localization to organelle GO:0033365 82 0.019
protein processing GO:0016485 68 0.019
positive regulation of cell death GO:0010942 69 0.019
neuron projection guidance GO:0097485 241 0.019
actin polymerization or depolymerization GO:0008154 31 0.019
immune system process GO:0002376 347 0.019
Human Mouse
regulation of anatomical structure size GO:0090066 163 0.019
positive regulation of response to stimulus GO:0048584 323 0.018
centrosome organization GO:0051297 163 0.018
positive regulation of phosphate metabolic process GO:0045937 139 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
Mouse
maternal determination of anterior posterior axis embryo GO:0008358 74 0.018
guanosine containing compound metabolic process GO:1901068 74 0.018
locomotory behavior GO:0007626 176 0.018
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.018
metal ion transport GO:0030001 74 0.018
Human
response to insulin GO:0032868 29 0.018
anterior posterior axis specification embryo GO:0008595 103 0.018
ras protein signal transduction GO:0007265 88 0.018
organic acid metabolic process GO:0006082 103 0.018
aging GO:0007568 143 0.018
epidermal cell differentiation GO:0009913 51 0.018
biological adhesion GO:0022610 138 0.017
gtp metabolic process GO:0046039 72 0.017
response to nutrient levels GO:0031667 114 0.017
regulation of cellular response to growth factor stimulus GO:0090287 13 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
Mouse
regulation of cell cycle process GO:0010564 181 0.017
regulation of cellular component size GO:0032535 98 0.017
regulation of rho gtpase activity GO:0032319 20 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.017
Human Mouse
regulation of microtubule based process GO:0032886 49 0.017
glycosyl compound metabolic process GO:1901657 127 0.017
oocyte anterior posterior axis specification GO:0007314 72 0.017
cell growth GO:0016049 108 0.017
cellular response to nutrient levels GO:0031669 62 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.016
response to bacterium GO:0009617 198 0.016
microtubule polymerization or depolymerization GO:0031109 39 0.016
stem cell proliferation GO:0072089 88 0.016
regulation of organ morphogenesis GO:2000027 78 0.016
protein localization to membrane GO:0072657 19 0.016
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.016
Fly
regulation of protein modification process GO:0031399 112 0.016
Mouse
regulation of response to stress GO:0080134 200 0.016
Human Mouse
organ growth GO:0035265 56 0.016
oocyte axis specification GO:0007309 108 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
kidney epithelium development GO:0072073 3 0.015
negative regulation of phosphorus metabolic process GO:0010563 45 0.015
Mouse
negative regulation of cell communication GO:0010648 223 0.015
negative regulation of cellular biosynthetic process GO:0031327 277 0.015
Human Mouse
chromosome segregation GO:0007059 157 0.015
regulation of rho protein signal transduction GO:0035023 20 0.015
developmental growth involved in morphogenesis GO:0060560 65 0.015
microtubule depolymerization GO:0007019 25 0.015
regulation of rac gtpase activity GO:0032314 1 0.015
regulation of cell differentiation GO:0045595 302 0.015
positive regulation of growth GO:0045927 75 0.015
taxis GO:0042330 304 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
Mouse
regulation of synapse structure and activity GO:0050803 128 0.015
regulation of cytoskeleton organization GO:0051493 89 0.015
organic substance transport GO:0071702 257 0.015
Human
regulation of protein phosphorylation GO:0001932 64 0.015
stem cell development GO:0048864 79 0.014
plasma membrane organization GO:0007009 26 0.014
ion transport GO:0006811 145 0.014
Human
cellular response to nitrogen compound GO:1901699 51 0.014
hemopoiesis GO:0030097 46 0.014
exocytosis GO:0006887 28 0.014
positive regulation of developmental growth GO:0048639 62 0.014
negative regulation of cell fate commitment GO:0010454 17 0.014
spindle organization GO:0007051 253 0.014
ovarian follicle cell migration GO:0007297 121 0.014
regulation of protein stability GO:0031647 43 0.014
defense response GO:0006952 300 0.014
Human Mouse
negative regulation of signaling GO:0023057 219 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
striated muscle tissue development GO:0014706 27 0.014
regulation of lipid metabolic process GO:0019216 15 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.014
regulation of protein complex assembly GO:0043254 42 0.013
negative regulation of cytoskeleton organization GO:0051494 30 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
positive regulation of organelle organization GO:0010638 65 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
actomyosin structure organization GO:0031032 56 0.013
maintenance of location GO:0051235 73 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
Human Mouse Fly
nucleotide catabolic process GO:0009166 109 0.013
skin development GO:0043588 65 0.013
locomotor rhythm GO:0045475 56 0.012
amine metabolic process GO:0009308 12 0.012
nephron morphogenesis GO:0072028 3 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
substrate adhesion dependent cell spreading GO:0034446 2 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
negative regulation of ras protein signal transduction GO:0046580 13 0.012
ovarian follicle cell development GO:0030707 248 0.012
muscle system process GO:0003012 21 0.012
positive regulation of lipid biosynthetic process GO:0046889 3 0.012
multi organism reproductive behavior GO:0044705 121 0.012
regulation of nucleoside metabolic process GO:0009118 50 0.012
inorganic ion transmembrane transport GO:0098660 73 0.012
Human
response to endogenous stimulus GO:0009719 119 0.012
Fly
organic cyclic compound catabolic process GO:1901361 168 0.012
tripartite regional subdivision GO:0007351 103 0.012
lipid biosynthetic process GO:0008610 46 0.012
regulation of intracellular transport GO:0032386 64 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
Mouse
regulation of cellular protein catabolic process GO:1903362 44 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.011
tissue morphogenesis GO:0048729 297 0.011
response to other organism GO:0051707 293 0.011
Human Mouse
regulation of organ growth GO:0046620 42 0.011
positive regulation of actin filament polymerization GO:0030838 11 0.011
lipid localization GO:0010876 54 0.011
monocarboxylic acid transport GO:0015718 3 0.011
blastoderm segmentation GO:0007350 159 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.011
Fly
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
defense response to gram negative bacterium GO:0050829 94 0.011
nephron tubule morphogenesis GO:0072078 3 0.011
renal tubule morphogenesis GO:0061333 44 0.011
protein secretion GO:0009306 45 0.011
compound eye development GO:0048749 307 0.011
response to axon injury GO:0048678 12 0.011
response to biotic stimulus GO:0009607 294 0.011
Human Mouse
syncytium formation by plasma membrane fusion GO:0000768 43 0.010
intracellular protein transport GO:0006886 104 0.010
positive regulation of nucleic acid templated transcription GO:1903508 266 0.010
Mouse
imaginal disc pattern formation GO:0007447 91 0.010
macromolecule catabolic process GO:0009057 161 0.010
Human Mouse Fly
positive regulation of phosphorylation GO:0042327 87 0.010
spinal cord development GO:0021510 1 0.010
regulation of stress activated mapk cascade GO:0032872 41 0.010
Mouse
regulation of vesicle mediated transport GO:0060627 59 0.010
regulation of cell migration GO:0030334 22 0.010
positive regulation of binding GO:0051099 4 0.010
rho protein signal transduction GO:0007266 14 0.010
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.010
aromatic compound catabolic process GO:0019439 166 0.010
response to abiotic stimulus GO:0009628 341 0.010

Su(dx) disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.030
disease of cellular proliferation DOID:14566 0 0.030
disease of anatomical entity DOID:7 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016
organ system cancer DOID:0050686 0 0.013
nervous system disease DOID:863 0 0.011