Drosophila melanogaster

10 known processes

Hsp23 (Dmel_CG4463)

Heat shock protein 23

(Aliases: CG4463,23,hsp23,Hsp-23,HSP23/IAP,DmHsp23,HSP23,hsp23/22,hsp 23,hsp 23K,Dmel\CG4463,small hsp locus 67B,hsp 22K)

Hsp23 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
appendage development GO:0048736 401 0.655
Fly
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.622
Rat
imaginal disc derived appendage development GO:0048737 399 0.548
Fly
imaginal disc derived appendage morphogenesis GO:0035114 395 0.546
Fly
wing disc morphogenesis GO:0007472 344 0.539
Fly
response to temperature stimulus GO:0009266 106 0.459
response to heat GO:0009408 63 0.370
Rat Fly
post embryonic appendage morphogenesis GO:0035120 385 0.327
Fly
response to hydrogen peroxide GO:0042542 11 0.326
Mouse Rat
appendage morphogenesis GO:0035107 397 0.317
Fly
apoptotic process involved in morphogenesis GO:0060561 3 0.294
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.253
Fly
glutathione metabolic process GO:0006749 37 0.209
defense response to bacterium GO:0042742 178 0.182
Fly
growth GO:0040007 359 0.179
Rat
defense response GO:0006952 300 0.168
Fly
response to fungus GO:0009620 50 0.161
Fly
epithelial cell differentiation GO:0030855 322 0.153
response to endogenous stimulus GO:0009719 119 0.146
Rat
response to bacterium GO:0009617 198 0.119
Fly
cellular response to ionizing radiation GO:0071479 15 0.119
heat shock mediated polytene chromosome puffing GO:0035080 7 0.115
response to other organism GO:0051707 293 0.112
Fly
cellular amide metabolic process GO:0043603 80 0.108
negative regulation of cellular metabolic process GO:0031324 382 0.107
Mouse Rat
defense response to other organism GO:0098542 225 0.106
Fly
response to extracellular stimulus GO:0009991 116 0.102
Fly
regulation of growth GO:0040008 233 0.097
Rat
cellular modified amino acid metabolic process GO:0006575 45 0.089
response to cold GO:0009409 13 0.088
negative regulation of biosynthetic process GO:0009890 277 0.086
response to abiotic stimulus GO:0009628 341 0.083
regulation of protein metabolic process GO:0051246 256 0.079
Mouse
response to reactive oxygen species GO:0000302 24 0.076
Mouse Rat
macromolecular complex assembly GO:0065003 256 0.075
Human Mouse
behavioral response to starvation GO:0042595 6 0.075
Fly
cold acclimation GO:0009631 8 0.074
chemotaxis GO:0006935 249 0.071
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.069
Mouse
cellular protein complex assembly GO:0043623 71 0.067
Mouse
intracellular signal transduction GO:0035556 300 0.067
Mouse Rat
peptide metabolic process GO:0006518 80 0.067
establishment of localization in cell GO:0051649 402 0.065
Human
taxis GO:0042330 304 0.065
actin cytoskeleton organization GO:0030036 206 0.063
camera type eye morphogenesis GO:0048593 2 0.063
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.062
camera type eye development GO:0043010 4 0.061
Mouse
sensory perception GO:0007600 196 0.061
Human
cellular response to gamma radiation GO:0071480 10 0.059
stress activated mapk cascade GO:0051403 52 0.058
Rat
positive regulation of macromolecule metabolic process GO:0010604 405 0.057
Mouse
regulation of response to external stimulus GO:0032101 115 0.056
intracellular transport GO:0046907 228 0.056
Human
response to nutrient levels GO:0031667 114 0.056
Fly
negative regulation of response to stimulus GO:0048585 258 0.055
Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.055
transcription from rna polymerase ii promoter GO:0006366 368 0.055
regulation of cell death GO:0010941 173 0.055
Human Mouse Rat
negative regulation of endopeptidase activity GO:0010951 11 0.054
Mouse
detection of abiotic stimulus GO:0009582 66 0.054
positive regulation of cell motility GO:2000147 3 0.054
multicellular organismal aging GO:0010259 140 0.054
Fly
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.054
death GO:0016265 284 0.054
Human Mouse Rat
regulation of cellular protein metabolic process GO:0032268 243 0.053
Mouse
phosphorylation GO:0016310 294 0.053
Mouse Rat
enzyme linked receptor protein signaling pathway GO:0007167 179 0.052
response to external biotic stimulus GO:0043207 293 0.051
Fly
response to radiation GO:0009314 155 0.051
regulation of cell growth GO:0001558 43 0.051
Rat
regulation of cysteine type endopeptidase activity GO:2000116 27 0.050
Mouse
regulation of programmed cell death GO:0043067 152 0.049
Human Mouse Rat
sulfur compound metabolic process GO:0006790 59 0.048
epithelial cell development GO:0002064 274 0.047
regulation of intracellular signal transduction GO:1902531 236 0.047
Mouse
cell growth GO:0016049 108 0.047
Rat
negative regulation of cellular response to oxidative stress GO:1900408 1 0.046
Mouse
response to biotic stimulus GO:0009607 294 0.045
Fly
actin filament based process GO:0030029 220 0.045
negative regulation of cell death GO:0060548 81 0.045
Human Mouse Rat
aging GO:0007568 143 0.043
Rat Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.043
sensory perception of light stimulus GO:0050953 12 0.043
Human
regulation of behavior GO:0050795 75 0.043
translation GO:0006412 69 0.042
apoptotic process GO:0006915 159 0.042
Human Mouse Rat
cellular response to radiation GO:0071478 52 0.041
programmed cell death GO:0012501 257 0.041
Human Mouse Rat
negative regulation of cellular biosynthetic process GO:0031327 277 0.041
regulation of response to stress GO:0080134 200 0.041
Mouse
positive regulation of response to external stimulus GO:0032103 44 0.041
detection of stimulus GO:0051606 156 0.041
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.041
Mouse
defense response to fungus GO:0050832 48 0.040
Fly
regulation of response to oxidative stress GO:1902882 4 0.040
Mouse
regulation of apoptotic process GO:0042981 130 0.040
Human Mouse Rat
negative regulation of cell communication GO:0010648 223 0.040
Mouse
regulation of multicellular organismal development GO:2000026 414 0.039
eye morphogenesis GO:0048592 260 0.039
response to ionizing radiation GO:0010212 32 0.038
cellular protein modification process GO:0006464 438 0.038
Mouse
negative regulation of peptidase activity GO:0010466 11 0.037
Mouse
positive regulation of cell migration GO:0030335 2 0.037
cellular response to heat GO:0034605 24 0.037
rna localization GO:0006403 115 0.037
detection of external stimulus GO:0009581 66 0.037
muscle system process GO:0003012 21 0.036
Rat
protein phosphorylation GO:0006468 169 0.036
Mouse
signal transduction by phosphorylation GO:0023014 107 0.035
Rat
protein complex assembly GO:0006461 200 0.035
Human Mouse
regulation of intracellular transport GO:0032386 64 0.034
Human
oxoacid metabolic process GO:0043436 103 0.033
negative regulation of apoptotic process GO:0043066 63 0.033
Human Mouse Rat
response to organic cyclic compound GO:0014070 89 0.033
Rat
dna damage checkpoint GO:0000077 78 0.033
tissue homeostasis GO:0001894 36 0.032
response to organic substance GO:0010033 284 0.032
Rat
cellular amino acid metabolic process GO:0006520 61 0.032
regulation of translation GO:0006417 56 0.032
regulation of phosphorus metabolic process GO:0051174 210 0.032
Mouse
negative regulation of growth GO:0045926 84 0.032
Rat
response to oxygen containing compound GO:1901700 200 0.031
Mouse Rat
regulation of cellular response to stress GO:0080135 89 0.031
Mouse
regulation of cell cycle phase transition GO:1901987 130 0.031
reactive oxygen species metabolic process GO:0072593 22 0.031
Rat
response to hypoxia GO:0001666 53 0.030
protein complex biogenesis GO:0070271 201 0.030
Human Mouse
muscle organ development GO:0007517 127 0.030
Mouse
microtubule polymerization or depolymerization GO:0031109 39 0.030
Rat
negative regulation of gene expression GO:0010629 387 0.030
Mouse
negative regulation of response to oxidative stress GO:1902883 1 0.029
Mouse
regulation of system process GO:0044057 36 0.029
Rat
muscle structure development GO:0061061 224 0.029
Mouse
regulation of transport GO:0051049 181 0.029
Human
response to oxidative stress GO:0006979 86 0.029
Mouse Rat Fly
negative regulation of transcription dna templated GO:0045892 237 0.029
columnar cuboidal epithelial cell development GO:0002066 249 0.028
stress activated protein kinase signaling cascade GO:0031098 55 0.028
Rat
regulation of cell differentiation GO:0045595 302 0.028
biological adhesion GO:0022610 138 0.028
response to alcohol GO:0097305 95 0.027
Rat
autophagy GO:0006914 108 0.027
cell cycle checkpoint GO:0000075 95 0.027
response to light stimulus GO:0009416 124 0.027
spermatogenesis GO:0007283 200 0.027
muscle contraction GO:0006936 13 0.027
Rat
male courtship behavior GO:0008049 63 0.026
rna processing GO:0006396 147 0.026
regulation of molecular function GO:0065009 217 0.026
Mouse
actin filament organization GO:0007015 126 0.026
negative regulation of signal transduction GO:0009968 206 0.025
Mouse
regulation of anatomical structure morphogenesis GO:0022603 242 0.025
visual perception GO:0007601 9 0.025
Human
response to nitrogen compound GO:1901698 90 0.025
anatomical structure homeostasis GO:0060249 97 0.025
response to starvation GO:0042594 97 0.024
Fly
mitotic dna integrity checkpoint GO:0044774 75 0.024
organonitrogen compound metabolic process GO:1901564 318 0.024
homeostatic process GO:0042592 199 0.023
multicellular organismal homeostasis GO:0048871 41 0.023
cellular macromolecular complex assembly GO:0034622 153 0.023
Mouse
determination of adult lifespan GO:0008340 137 0.023
Fly
negative regulation of programmed cell death GO:0043069 72 0.023
Human Mouse Rat
sensory organ morphogenesis GO:0090596 260 0.023
organic acid metabolic process GO:0006082 103 0.023
regulation of cell cycle process GO:0010564 181 0.023
posttranscriptional regulation of gene expression GO:0010608 145 0.022
g2 dna damage checkpoint GO:0031572 69 0.022
cell cycle phase transition GO:0044770 140 0.022
regulation of chemotaxis GO:0050920 12 0.022
positive regulation of biosynthetic process GO:0009891 316 0.022
Mouse
response to wounding GO:0009611 94 0.022
mitotic g2 dna damage checkpoint GO:0007095 69 0.022
jak stat cascade GO:0007259 49 0.021
mitotic g2 m transition checkpoint GO:0044818 70 0.021
cellular response to organic substance GO:0071310 132 0.021
negative regulation of protein metabolic process GO:0051248 85 0.021
Mouse
neurological system process GO:0050877 358 0.020
Human
regulation of reactive oxygen species metabolic process GO:2000377 8 0.020
Rat
regulation of epithelial cell migration GO:0010632 12 0.020
regulation of localization GO:0032879 275 0.020
Human
cellular response to oxidative stress GO:0034599 28 0.020
Mouse
polytene chromosome puffing GO:0035079 7 0.019
negative regulation of transferase activity GO:0051348 18 0.019
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.019
ameboidal type cell migration GO:0001667 151 0.019
regulation of defense response GO:0031347 102 0.019
amine metabolic process GO:0009308 12 0.019
response to gamma radiation GO:0010332 17 0.019
regionalization GO:0003002 416 0.019
mitotic nuclear division GO:0007067 213 0.019
mitotic cell cycle checkpoint GO:0007093 88 0.018
cell maturation GO:0048469 144 0.018
positive regulation of cellular protein metabolic process GO:0032270 118 0.018
negative regulation of cell cycle GO:0045786 116 0.018
positive regulation of signal transduction GO:0009967 223 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
cellular response to abiotic stimulus GO:0071214 58 0.018
single organism behavior GO:0044708 391 0.018
negative regulation of intracellular signal transduction GO:1902532 57 0.018
Mouse
cell adhesion GO:0007155 136 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
Mouse
regulation of transferase activity GO:0051338 58 0.017
Mouse
regulation of proteolysis GO:0030162 87 0.017
Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.017
small molecule metabolic process GO:0044281 305 0.017
synapse organization GO:0050808 196 0.017
negative regulation of kinase activity GO:0033673 16 0.017
Mouse
pole plasm rna localization GO:0007316 52 0.017
dna integrity checkpoint GO:0031570 81 0.017
spermatid development GO:0007286 98 0.017
positive regulation of developmental process GO:0051094 143 0.017
positive regulation of signaling GO:0023056 243 0.017
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
single organismal cell cell adhesion GO:0016337 45 0.016
cellular amine metabolic process GO:0044106 12 0.016
oocyte axis specification GO:0007309 108 0.016
negative regulation of cell cycle phase transition GO:1901988 103 0.016
negative regulation of signaling GO:0023057 219 0.016
Mouse
developmental programmed cell death GO:0010623 138 0.016
Mouse
carboxylic acid metabolic process GO:0019752 92 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
mitotic dna damage checkpoint GO:0044773 74 0.016
somatic muscle development GO:0007525 66 0.016
histolysis GO:0007559 102 0.016
positive regulation of response to stimulus GO:0048584 323 0.016
regulation of hydrolase activity GO:0051336 97 0.016
Mouse
negative regulation of rna metabolic process GO:0051253 251 0.016
body morphogenesis GO:0010171 2 0.016
positive regulation of multi organism process GO:0043902 40 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
Mouse
embryonic morphogenesis GO:0048598 206 0.016
mesenchymal cell differentiation GO:0048762 1 0.016
single organism cell adhesion GO:0098602 47 0.016
regulation of catalytic activity GO:0050790 185 0.015
Mouse
larval development GO:0002164 104 0.015
open tracheal system development GO:0007424 204 0.015
regulation of protein modification process GO:0031399 112 0.015
Mouse
mitotic cell cycle phase transition GO:0044772 138 0.015
positive regulation of cellular biosynthetic process GO:0031328 316 0.015
Mouse
forebrain development GO:0030900 2 0.015
dorsal ventral pattern formation GO:0009953 133 0.014
negative regulation of phosphate metabolic process GO:0045936 45 0.014
Mouse
negative regulation of cell differentiation GO:0045596 143 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.014
embryonic pattern specification GO:0009880 174 0.014
response to lipopolysaccharide GO:0032496 4 0.014
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.014
cell death GO:0008219 279 0.014
Human Mouse Rat
positive regulation of multicellular organismal process GO:0051240 143 0.014
Mouse
response to organonitrogen compound GO:0010243 75 0.014
proteolysis GO:0006508 192 0.014
Mouse
response to methotrexate GO:0031427 11 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
axis specification GO:0009798 167 0.014
salivary gland cell autophagic cell death GO:0035071 83 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.013
spinal cord development GO:0021510 1 0.013
positive regulation of apoptotic signaling pathway GO:2001235 4 0.013
wound healing GO:0042060 75 0.013
positive regulation of chemotaxis GO:0050921 2 0.013
oocyte differentiation GO:0009994 145 0.013
response to virus GO:0009615 28 0.013
regulation of cell cycle GO:0051726 291 0.013
detection of light stimulus GO:0009583 58 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
salivary gland histolysis GO:0035070 88 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
mapk cascade GO:0000165 107 0.013
Rat
limb development GO:0060173 1 0.012
cytoplasmic transport GO:0016482 130 0.012
regulation of multi organism process GO:0043900 131 0.012
chromosome organization GO:0051276 360 0.012
regulation of autophagy GO:0010506 62 0.012
protein processing GO:0016485 68 0.012
Mouse
negative regulation of mitotic cell cycle GO:0045930 109 0.012
response to uv GO:0009411 24 0.012
leg disc morphogenesis GO:0007478 80 0.012
cellular response to extracellular stimulus GO:0031668 64 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
organic substance transport GO:0071702 257 0.012
negative regulation of defense response GO:0031348 35 0.012
regulation of cell development GO:0060284 215 0.012
compound eye development GO:0048749 307 0.012
phosphatidylethanolamine metabolic process GO:0046337 1 0.012
tissue death GO:0016271 102 0.012
mushroom body development GO:0016319 70 0.012
regulation of phosphorylation GO:0042325 147 0.012
Mouse
pigment biosynthetic process GO:0046148 36 0.012
limb morphogenesis GO:0035108 1 0.012
cellular response to nitrogen compound GO:1901699 51 0.012
response to organophosphorus GO:0046683 2 0.012
developmental maturation GO:0021700 172 0.011
cellular biogenic amine catabolic process GO:0042402 1 0.011
positive regulation of cell death GO:0010942 69 0.011
imaginal disc derived leg morphogenesis GO:0007480 80 0.011
epithelium migration GO:0090132 148 0.011
macromolecule catabolic process GO:0009057 161 0.011
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 2 0.011
Mouse
memory GO:0007613 94 0.011
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.011
cell cycle arrest GO:0007050 4 0.011
embryonic organ development GO:0048568 50 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.011
Mouse
positive regulation of cell communication GO:0010647 250 0.011
gtp metabolic process GO:0046039 72 0.011
positive regulation of melanization defense response GO:0035008 1 0.011
negative regulation of molecular function GO:0044092 51 0.011
Mouse
innate immune response GO:0045087 144 0.011
apoptotic signaling pathway GO:0097190 27 0.011
Mouse
catabolic process GO:0009056 409 0.011
pole plasm oskar mrna localization GO:0045451 46 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
response to growth factor GO:0070848 31 0.011
regulation of body fluid levels GO:0050878 14 0.010
cellular response to oxygen containing compound GO:1901701 79 0.010
response to endoplasmic reticulum stress GO:0034976 28 0.010
phagocytosis GO:0006909 215 0.010
regulation of defense response to bacterium GO:1900424 30 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
adult behavior GO:0030534 137 0.010
negative regulation of developmental process GO:0051093 201 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
regulation of small gtpase mediated signal transduction GO:0051056 93 0.010
salivary gland morphogenesis GO:0007435 145 0.010

Hsp23 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
neuromuscular disease DOID:440 0 0.529
Human
charcot marie tooth disease type 2 DOID:0050539 0 0.529
Human
disease of anatomical entity DOID:7 0 0.529
Human
charcot marie tooth disease DOID:10595 0 0.529
Human
nervous system disease DOID:863 0 0.529
Human
neuropathy DOID:870 0 0.529
Human
motor neuron disease DOID:231 0 0.358
Human
central nervous system disease DOID:331 0 0.358
Human
neurodegenerative disease DOID:1289 0 0.358
Human
musculoskeletal system disease DOID:17 0 0.103
cardiovascular system disease DOID:1287 0 0.103
muscular disease DOID:0080000 0 0.098
muscle tissue disease DOID:66 0 0.098
myopathy DOID:423 0 0.067
heart disease DOID:114 0 0.067
cardiomyopathy DOID:0050700 0 0.067
intrinsic cardiomyopathy DOID:0060036 0 0.067
sensory system disease DOID:0050155 0 0.066
eye and adnexa disease DOID:1492 0 0.066
eye disease DOID:5614 0 0.066
dilated cardiomyopathy DOID:12930 0 0.025
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012