Drosophila melanogaster

134 known processes

Pink1 (Dmel_CG4523)

PTEN-induced putative kinase 1

(Aliases: PINK,Dmel\CG4523,CG4523,dPink1,pink1,BEST:GH23468,dPINK1,PINK1)

Pink1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrial fusion GO:0008053 7 0.998
regulation of mitochondrial fission GO:0090140 7 0.981
locomotory behavior GO:0007626 176 0.976
response to oxidative stress GO:0006979 86 0.975
mitochondrion organization GO:0007005 65 0.968
single organism membrane fusion GO:0044801 42 0.962
actin filament based process GO:0030029 220 0.947
homeostatic process GO:0042592 199 0.944
Zebrafish
secretion GO:0046903 109 0.924
Mouse
sperm mitochondrion organization GO:0030382 7 0.901
positive regulation of mitochondrion organization GO:0010822 8 0.890
membrane organization GO:0061024 112 0.849
response to organic substance GO:0010033 284 0.832
Zebrafish
cellular homeostasis GO:0019725 80 0.775
regulation of organelle organization GO:0033043 196 0.757
single organism intracellular transport GO:1902582 207 0.740
regulation of mitochondrial fusion GO:0010635 5 0.727
spermatid development GO:0007286 98 0.725
protein complex assembly GO:0006461 200 0.714
Human
aging GO:0007568 143 0.703
synaptic transmission GO:0007268 288 0.702
chemical homeostasis GO:0048878 92 0.698
cation transmembrane transport GO:0098655 88 0.691
intracellular transport GO:0046907 228 0.681
negative regulation of gene expression GO:0010629 387 0.676
Mouse
single organism membrane organization GO:0044802 93 0.669
autophagy GO:0006914 108 0.665
programmed cell death GO:0012501 257 0.635
cellular component assembly involved in morphogenesis GO:0010927 151 0.635
macromolecular complex assembly GO:0065003 256 0.633
Human
tube development GO:0035295 244 0.614
Zebrafish
adult locomotory behavior GO:0008344 76 0.614
membrane fusion GO:0061025 42 0.582
response to abiotic stimulus GO:0009628 341 0.573
Human Mouse
actin filament organization GO:0007015 126 0.570
mitochondrial fission GO:0000266 8 0.564
energy derivation by oxidation of organic compounds GO:0015980 32 0.557
Mouse
regulation of transport GO:0051049 181 0.555
Mouse
organelle assembly GO:0070925 198 0.533
metal ion homeostasis GO:0055065 44 0.525
transmembrane transport GO:0055085 139 0.508
inorganic ion transmembrane transport GO:0098660 73 0.494
regulation of membrane potential GO:0042391 35 0.482
Human
vesicle mediated transport GO:0016192 381 0.478
ion transport GO:0006811 145 0.476
Mouse
organelle localization GO:0051640 148 0.472
establishment of localization in cell GO:0051649 402 0.471
Mouse
muscle structure development GO:0061061 224 0.468
regulation of protein metabolic process GO:0051246 256 0.462
Human Mouse
death GO:0016265 284 0.443
spermatogenesis GO:0007283 200 0.426
actin cytoskeleton organization GO:0030036 206 0.426
cuticle development GO:0042335 86 0.425
mitochondrion degradation GO:0000422 8 0.420
cell death GO:0008219 279 0.409
sperm individualization GO:0007291 48 0.393
organonitrogen compound metabolic process GO:1901564 318 0.375
developmental pigmentation GO:0048066 68 0.372
response to monosaccharide GO:0034284 4 0.368
cellular chemical homeostasis GO:0055082 40 0.366
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.363
organic hydroxy compound metabolic process GO:1901615 83 0.360
cation homeostasis GO:0055080 51 0.358
regulation of cellular response to stress GO:0080135 89 0.355
Human Mouse
cellular response to chemical stimulus GO:0070887 199 0.353
Human Zebrafish Mouse Worm
phenol containing compound metabolic process GO:0018958 57 0.352
protein complex biogenesis GO:0070271 201 0.346
Human
cellular response to oxidative stress GO:0034599 28 0.345
Human Mouse Worm
atp metabolic process GO:0046034 49 0.342
cellular protein complex assembly GO:0043623 71 0.341
ion transmembrane transport GO:0034220 122 0.338
negative regulation of signaling GO:0023057 219 0.329
Human Mouse
small molecule metabolic process GO:0044281 305 0.327
phosphorylation GO:0016310 294 0.321
protein modification by small protein conjugation or removal GO:0070647 106 0.310
regulation of autophagy GO:0010506 62 0.304
organelle fusion GO:0048284 46 0.298
positive regulation of biosynthetic process GO:0009891 316 0.288
Mouse
spermatid differentiation GO:0048515 114 0.282
organelle fission GO:0048285 340 0.276
epithelial cell differentiation GO:0030855 322 0.270
inorganic cation transmembrane transport GO:0098662 61 0.264
response to glucose GO:0009749 2 0.264
regulation of intracellular signal transduction GO:1902531 236 0.262
Human Mouse
regulation of cellular localization GO:0060341 136 0.254
Mouse
response to reactive oxygen species GO:0000302 24 0.254
Human
oxidation reduction process GO:0055114 123 0.251
Mouse
muscle cell differentiation GO:0042692 103 0.246
kidney development GO:0001822 3 0.242
neuron neuron synaptic transmission GO:0007270 14 0.241
Mouse
regulation of molecular function GO:0065009 217 0.239
Mouse
negative regulation of cell communication GO:0010648 223 0.238
Human Mouse
regulation of localization GO:0032879 275 0.234
Mouse
regulation of response to oxidative stress GO:1902882 4 0.233
Human
male gamete generation GO:0048232 201 0.231
cellular lipid metabolic process GO:0044255 83 0.229
synaptic transmission dopaminergic GO:0001963 2 0.225
Mouse
organic acid metabolic process GO:0006082 103 0.218
mapk cascade GO:0000165 107 0.217
macroautophagy GO:0016236 42 0.211
organic substance transport GO:0071702 257 0.209
Mouse
mitochondrion morphogenesis GO:0070584 8 0.209
regulation of cellular response to oxidative stress GO:1900407 4 0.207
Human
regulation of cellular amine metabolic process GO:0033238 3 0.201
regulation of secretion GO:0051046 44 0.198
Mouse
cellular response to endogenous stimulus GO:0071495 80 0.195
reactive oxygen species metabolic process GO:0072593 22 0.189
Human Zebrafish Mouse
striated muscle cell differentiation GO:0051146 90 0.188
developmental maturation GO:0021700 172 0.188
adult behavior GO:0030534 137 0.184
generation of precursor metabolites and energy GO:0006091 42 0.184
Mouse
proteolysis GO:0006508 192 0.182
negative regulation of cellular response to oxidative stress GO:1900408 1 0.179
Human
regulation of protein complex disassembly GO:0043244 29 0.169
signal transduction by phosphorylation GO:0023014 107 0.168
somatic muscle development GO:0007525 66 0.166
apoptotic process GO:0006915 159 0.162
cell division GO:0051301 248 0.162
neurological system process GO:0050877 358 0.157
cellular catabolic process GO:0044248 372 0.156
intracellular signal transduction GO:0035556 300 0.154
Human Mouse
bmp signaling pathway GO:0030509 27 0.151
negative regulation of programmed cell death GO:0043069 72 0.147
response to metal ion GO:0010038 23 0.146
cellular response to organic substance GO:0071310 132 0.145
Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 405 0.144
Human Mouse
stress activated protein kinase signaling cascade GO:0031098 55 0.143
regulation of cell death GO:0010941 173 0.143
single organism biosynthetic process GO:0044711 206 0.143
regulation of mitochondrion organization GO:0010821 12 0.142
digestive tract development GO:0048565 149 0.140
regulation of cytoskeleton organization GO:0051493 89 0.139
organophosphate metabolic process GO:0019637 195 0.138
actomyosin structure organization GO:0031032 56 0.136
regulation of transmembrane transport GO:0034762 27 0.135
eggshell formation GO:0030703 105 0.135
cellular macromolecular complex assembly GO:0034622 153 0.133
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.132
regulation of anatomical structure morphogenesis GO:0022603 242 0.131
stress activated mapk cascade GO:0051403 52 0.130
regulation of response to stress GO:0080134 200 0.129
Human Mouse
single organism cellular localization GO:1902580 180 0.128
response to ionizing radiation GO:0010212 32 0.125
cation transport GO:0006812 110 0.125
Mouse
negative regulation of cytoskeleton organization GO:0051494 30 0.122
regulation of vesicle mediated transport GO:0060627 59 0.122
negative regulation of response to stimulus GO:0048585 258 0.121
Human Mouse
positive regulation of signaling GO:0023056 243 0.118
Human Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.118
regulation of neuron death GO:1901214 26 0.117
regulation of secretion by cell GO:1903530 39 0.117
Mouse
brain development GO:0007420 120 0.117
larval development GO:0002164 104 0.116
establishment of organelle localization GO:0051656 122 0.115
cellular response to starvation GO:0009267 61 0.115
response to radiation GO:0009314 155 0.115
regulation of growth GO:0040008 233 0.111
epithelial cell development GO:0002064 274 0.110
positive regulation of cellular protein metabolic process GO:0032270 118 0.110
Human Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.108
ovarian follicle cell development GO:0030707 248 0.108
response to organonitrogen compound GO:0010243 75 0.108
embryo development ending in birth or egg hatching GO:0009792 152 0.107
regulation of stress activated mapk cascade GO:0032872 41 0.106
cell projection assembly GO:0030031 94 0.106
regulation of catalytic activity GO:0050790 185 0.105
regulation of intracellular transport GO:0032386 64 0.105
multicellular organismal aging GO:0010259 140 0.104
lipid metabolic process GO:0006629 121 0.103
divalent inorganic cation homeostasis GO:0072507 29 0.103
cognition GO:0050890 141 0.100
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.099
Mouse
protein modification by small protein conjugation GO:0032446 79 0.098
positive regulation of cellular biosynthetic process GO:0031328 316 0.098
Mouse
endocytosis GO:0006897 310 0.097
response to oxygen containing compound GO:1901700 200 0.095
Human
response to hexose GO:0009746 3 0.094
posttranscriptional regulation of gene expression GO:0010608 145 0.093
Mouse
cellular ion homeostasis GO:0006873 39 0.092
cellular protein modification process GO:0006464 438 0.091
regulation of cellular protein metabolic process GO:0032268 243 0.089
Human Mouse
molting cycle chitin based cuticle GO:0007591 56 0.089
regulation of actin cytoskeleton organization GO:0032956 42 0.088
protein localization GO:0008104 284 0.088
ameboidal type cell migration GO:0001667 151 0.084
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.083
Human
positive regulation of molecular function GO:0044093 136 0.081
Mouse
positive regulation of cell communication GO:0010647 250 0.080
Human Mouse
regulation of proteolysis GO:0030162 87 0.079
negative regulation of cell death GO:0060548 81 0.079
regulation of anatomical structure size GO:0090066 163 0.079
catabolic process GO:0009056 409 0.078
regulation of cellular component biogenesis GO:0044087 201 0.078
Human
adult chitin containing cuticle pigmentation GO:0048085 16 0.077
cellular macromolecule localization GO:0070727 220 0.076
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.076
regulation of phosphate metabolic process GO:0019220 210 0.076
Human Mouse
regulation of programmed cell death GO:0043067 152 0.076
central nervous system development GO:0007417 201 0.074
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.074
negative regulation of organelle organization GO:0010639 56 0.074
positive regulation of signal transduction GO:0009967 223 0.073
Human
cellular response to hexose stimulus GO:0071331 1 0.073
regulation of cellular component movement GO:0051270 42 0.073
positive regulation of multicellular organismal process GO:0051240 143 0.073
divalent inorganic cation transport GO:0072511 30 0.073
synaptic vesicle transport GO:0048489 50 0.072
regulation of endocytosis GO:0030100 37 0.071
oxoacid metabolic process GO:0043436 103 0.071
regulation of cell cycle GO:0051726 291 0.070
wing disc morphogenesis GO:0007472 344 0.069
negative regulation of cell cycle process GO:0010948 109 0.069
epithelial cell migration GO:0010631 148 0.069
single organism behavior GO:0044708 391 0.068
neurotransmitter transport GO:0006836 37 0.068
regulation of microtubule based process GO:0032886 49 0.067
determination of adult lifespan GO:0008340 137 0.066
regulation of dna metabolic process GO:0051052 34 0.066
nitrogen compound transport GO:0071705 85 0.066
Mouse
macromolecular complex disassembly GO:0032984 37 0.064
negative regulation of insulin secretion GO:0046676 1 0.064
negative regulation of signal transduction GO:0009968 206 0.063
Human Mouse
cellular response to organonitrogen compound GO:0071417 36 0.063
secretion by cell GO:0032940 101 0.063
Mouse
regulation of mapk cascade GO:0043408 92 0.063
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.063
Zebrafish
electron transport chain GO:0022900 14 0.062
Mouse
positive regulation of proteolysis GO:0045862 52 0.061
amine metabolic process GO:0009308 12 0.061
response to organic cyclic compound GO:0014070 89 0.061
carboxylic acid metabolic process GO:0019752 92 0.061
cellular cation homeostasis GO:0030003 38 0.059
dopamine metabolic process GO:0042417 7 0.059
neuromuscular synaptic transmission GO:0007274 67 0.059
negative regulation of protein metabolic process GO:0051248 85 0.058
synaptic vesicle localization GO:0097479 53 0.058
response to lipid GO:0033993 38 0.058
response to osmotic stress GO:0006970 14 0.057
regulation of cell differentiation GO:0045595 302 0.057
response to bacterium GO:0009617 198 0.057
ribonucleotide metabolic process GO:0009259 145 0.056
regulation of phosphorus metabolic process GO:0051174 210 0.054
Human Mouse
learning or memory GO:0007611 141 0.053
nucleobase containing small molecule metabolic process GO:0055086 174 0.053
ribonucleoside metabolic process GO:0009119 127 0.053
plasma membrane organization GO:0007009 26 0.053
carbohydrate derivative metabolic process GO:1901135 217 0.052
cytoplasmic transport GO:0016482 130 0.052
nucleoside phosphate metabolic process GO:0006753 162 0.051
cellular divalent inorganic cation homeostasis GO:0072503 23 0.051
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.051
intrinsic apoptotic signaling pathway GO:0097193 16 0.051
Human Mouse
regulation of developmental pigmentation GO:0048070 24 0.051
embryonic development via the syncytial blastoderm GO:0001700 148 0.050
regulation of reactive oxygen species metabolic process GO:2000377 8 0.050
Human Zebrafish Mouse
anatomical structure homeostasis GO:0060249 97 0.050
cellular amino acid metabolic process GO:0006520 61 0.050
cellular respiration GO:0045333 26 0.050
Mouse
purine nucleoside metabolic process GO:0042278 127 0.050
regulation of phosphorylation GO:0042325 147 0.049
Human
myofibril assembly GO:0030239 36 0.049
positive regulation of transport GO:0051050 92 0.049
Mouse
purine containing compound metabolic process GO:0072521 155 0.049
necrotic cell death GO:0070265 1 0.048
cellular response to nutrient levels GO:0031669 62 0.048
mitochondrial transport GO:0006839 8 0.047
cellular response to carbohydrate stimulus GO:0071322 4 0.047
nucleotide metabolic process GO:0009117 161 0.046
organic substance catabolic process GO:1901575 308 0.046
response to nitrogen compound GO:1901698 90 0.045
neuromuscular junction development GO:0007528 149 0.045
sleep GO:0030431 49 0.045
regulation of proteasomal protein catabolic process GO:0061136 39 0.045
chitin based cuticle development GO:0040003 49 0.045
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.044
protein localization to organelle GO:0033365 82 0.044
regulation of catabolic process GO:0009894 170 0.043
nucleoside monophosphate metabolic process GO:0009123 52 0.042
dna metabolic process GO:0006259 227 0.042
digestive tract morphogenesis GO:0048546 127 0.042
microtubule based transport GO:0010970 42 0.041
macromolecule catabolic process GO:0009057 161 0.041
intracellular protein transport GO:0006886 104 0.041
positive regulation of phosphorus metabolic process GO:0010562 139 0.041
Human Mouse
regulation of bmp signaling pathway GO:0030510 23 0.041
cellular response to nitrogen compound GO:1901699 51 0.041
molting cycle GO:0042303 56 0.040
heart process GO:0003015 37 0.040
localization of cell GO:0051674 257 0.040
regulation of jnk cascade GO:0046328 40 0.040
cellular response to mechanical stimulus GO:0071260 2 0.040
vesicle localization GO:0051648 55 0.040
positive regulation of catabolic process GO:0009896 105 0.040
jnk cascade GO:0007254 50 0.038
actin polymerization or depolymerization GO:0008154 31 0.038
response to oxygen radical GO:0000305 3 0.038
regulation of protein depolymerization GO:1901879 27 0.038
response to starvation GO:0042594 97 0.038
response to heat GO:0009408 63 0.038
purine nucleoside triphosphate metabolic process GO:0009144 119 0.038
negative regulation of molecular function GO:0044092 51 0.037
negative regulation of phosphate metabolic process GO:0045936 45 0.037
positive regulation of autophagy GO:0010508 21 0.037
columnar cuboidal epithelial cell development GO:0002066 249 0.037
regulation of actin filament based process GO:0032970 42 0.037
striated muscle myosin thick filament assembly GO:0071688 3 0.037
cellular response to abiotic stimulus GO:0071214 58 0.036
morphogenesis of an epithelium GO:0002009 276 0.036
response to endogenous stimulus GO:0009719 119 0.036
regulation of phosphatase activity GO:0010921 3 0.036
synapse organization GO:0050808 196 0.036
cellular response to extracellular stimulus GO:0031668 64 0.036
ion homeostasis GO:0050801 55 0.036
regulation of terminal button organization GO:2000331 11 0.035
establishment of protein localization GO:0045184 163 0.035
purine nucleoside monophosphate metabolic process GO:0009126 50 0.035
mitotic nuclear division GO:0007067 213 0.035
actin filament based movement GO:0030048 26 0.034
cytoskeleton dependent intracellular transport GO:0030705 44 0.034
protein phosphorylation GO:0006468 169 0.034
phagocytosis GO:0006909 215 0.033
glycosyl compound metabolic process GO:1901657 127 0.033
purine ribonucleotide metabolic process GO:0009150 145 0.033
ribonucleoside monophosphate metabolic process GO:0009161 51 0.033
actin filament bundle organization GO:0061572 28 0.033
eggshell chorion assembly GO:0007306 66 0.033
protein catabolic process GO:0030163 101 0.033
negative regulation of phosphorus metabolic process GO:0010563 45 0.033
growth GO:0040007 359 0.033
Worm
immune system process GO:0002376 347 0.033
Zebrafish
regulation of ion transmembrane transport GO:0034765 27 0.032
negative regulation of cellular component organization GO:0051129 108 0.031
endomembrane system organization GO:0010256 119 0.031
protein ubiquitination GO:0016567 70 0.031
regionalization GO:0003002 416 0.031
cellular response to hydrogen peroxide GO:0070301 7 0.031
Human
ribose phosphate metabolic process GO:0019693 145 0.031
negative regulation of peptide secretion GO:0002792 1 0.031
response to light stimulus GO:0009416 124 0.030
purine ribonucleotide catabolic process GO:0009154 109 0.030
protein modification process GO:0036211 438 0.030
purine ribonucleoside metabolic process GO:0046128 127 0.030
spindle organization GO:0007051 253 0.030
positive regulation of response to stimulus GO:0048584 323 0.029
Human
cellular response to oxygen containing compound GO:1901701 79 0.029
Human
cell migration GO:0016477 238 0.029
response to inorganic substance GO:0010035 44 0.029
Human
l glutamate import GO:0051938 1 0.029
nuclear division GO:0000280 332 0.029
muscle system process GO:0003012 21 0.029
microtubule depolymerization GO:0007019 25 0.028
cytokinesis GO:0000910 90 0.028
positive regulation of intracellular signal transduction GO:1902533 116 0.028
Human
regulation of synaptic transmission GO:0050804 69 0.028
Mouse
locomotor rhythm GO:0045475 56 0.028
phagocytosis engulfment GO:0006911 11 0.028
apoptotic cell clearance GO:0043277 14 0.028
cellular response to external stimulus GO:0071496 66 0.027
negative regulation of neuron death GO:1901215 18 0.027
skeletal muscle adaptation GO:0043501 1 0.027
regulation of cell cycle process GO:0010564 181 0.027
purine nucleotide metabolic process GO:0006163 146 0.027
negative regulation of cellular catabolic process GO:0031330 34 0.026
nucleus organization GO:0006997 45 0.026
regulation of transmembrane transporter activity GO:0022898 6 0.026
tissue migration GO:0090130 155 0.026
startle response GO:0001964 16 0.026
regulation of cellular component size GO:0032535 98 0.026
single organism carbohydrate metabolic process GO:0044723 72 0.025
circulatory system process GO:0003013 37 0.025
regulation of protein localization GO:0032880 76 0.025
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.024
cell maturation GO:0048469 144 0.024
regulation of mitochondrial membrane potential GO:0051881 2 0.024
Human
response to hydrogen peroxide GO:0042542 11 0.024
Human
imaginal disc derived appendage development GO:0048737 399 0.024
protein processing GO:0016485 68 0.024
organophosphate biosynthetic process GO:0090407 46 0.024
heterocycle catabolic process GO:0046700 166 0.024
sensory perception of mechanical stimulus GO:0050954 72 0.023
response to mechanical stimulus GO:0009612 28 0.023
defense response GO:0006952 300 0.023
cellular response to peptide hormone stimulus GO:0071375 28 0.023
response to insulin GO:0032868 29 0.023
negative regulation of apoptotic process GO:0043066 63 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.023
regulation of neurogenesis GO:0050767 158 0.023
regulation of necrotic cell death GO:0010939 1 0.023
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.023
histolysis GO:0007559 102 0.023
cardiovascular system development GO:0072358 82 0.022
chemotaxis GO:0006935 249 0.022
Worm
cellular response to monosaccharide stimulus GO:0071326 2 0.022
positive regulation of catalytic activity GO:0043085 118 0.022
cellular protein localization GO:0034613 160 0.022
cellular calcium ion homeostasis GO:0006874 21 0.022
appendage morphogenesis GO:0035107 397 0.022
biological adhesion GO:0022610 138 0.022
regulation of immune system process GO:0002682 176 0.022
regulation of multi organism process GO:0043900 131 0.022
nucleoside triphosphate metabolic process GO:0009141 120 0.021
positive regulation of cell death GO:0010942 69 0.021
Human
establishment of vesicle localization GO:0051650 51 0.021
renal system development GO:0072001 72 0.021
zinc ion homeostasis GO:0055069 6 0.021
negative regulation of intracellular signal transduction GO:1902532 57 0.021
Human Mouse
glycosyl compound catabolic process GO:1901658 112 0.020
muscle contraction GO:0006936 13 0.020
positive regulation of phosphorylation GO:0042327 87 0.020
Human
protein transport GO:0015031 155 0.020
regulation of nervous system development GO:0051960 248 0.020
positive regulation of organelle organization GO:0010638 65 0.020
hydrogen ion transmembrane transport GO:1902600 5 0.019
purine nucleoside biosynthetic process GO:0042451 3 0.019
microtubule polymerization or depolymerization GO:0031109 39 0.019
tube morphogenesis GO:0035239 191 0.019
response to superoxide GO:0000303 3 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
signal release GO:0023061 49 0.019
organic acid transport GO:0015849 18 0.019
regulation of hormone levels GO:0010817 40 0.019
cellular response to hormone stimulus GO:0032870 44 0.019
cellular component disassembly GO:0022411 46 0.018
protein maturation GO:0051604 71 0.018
response to peptide hormone GO:0043434 29 0.018
modification dependent macromolecule catabolic process GO:0043632 79 0.018
digestive system development GO:0055123 149 0.018
heart contraction GO:0060047 26 0.018
purine nucleoside triphosphate catabolic process GO:0009146 108 0.018
regulation of protein phosphorylation GO:0001932 64 0.018
Human
cellular response to reactive oxygen species GO:0034614 14 0.018
Human
regulation of transferase activity GO:0051338 58 0.018
lipid homeostasis GO:0055088 33 0.018
salivary gland morphogenesis GO:0007435 145 0.017
cellular response to dna damage stimulus GO:0006974 223 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
circadian rhythm GO:0007623 105 0.017
positive regulation of ion transmembrane transporter activity GO:0032414 4 0.017
learning GO:0007612 75 0.017
cellular response to peptide GO:1901653 28 0.017
ribonucleoside triphosphate metabolic process GO:0009199 119 0.017
cellular nitrogen compound catabolic process GO:0044270 165 0.017
ubiquitin dependent protein catabolic process GO:0006511 78 0.017
single organism catabolic process GO:0044712 228 0.017
cell proliferation GO:0008283 299 0.017
maintenance of location GO:0051235 73 0.017
positive regulation of apoptotic process GO:0043065 47 0.017
Human
cellular amine metabolic process GO:0044106 12 0.017
negative regulation of cell cycle GO:0045786 116 0.017
dendrite development GO:0016358 204 0.016
regulation of cell development GO:0060284 215 0.016
regulation of apoptotic process GO:0042981 130 0.016
negative regulation of mitochondrion organization GO:0010823 2 0.016
regulation of microtubule depolymerization GO:0031114 24 0.016
protein depolymerization GO:0051261 31 0.016
exocytosis GO:0006887 28 0.016
pigment metabolic process GO:0042440 84 0.016
signal transduction in response to dna damage GO:0042770 3 0.016
regulation of actin filament length GO:0030832 27 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.015
purine nucleoside catabolic process GO:0006152 112 0.015
developmental growth GO:0048589 280 0.015
Worm
oxidative phosphorylation GO:0006119 9 0.015
respiratory system development GO:0060541 213 0.015
regulation of cell proliferation GO:0042127 163 0.015
rhythmic behavior GO:0007622 76 0.015
organophosphate catabolic process GO:0046434 112 0.015
positive regulation of intracellular transport GO:0032388 42 0.015
regulation of protein modification process GO:0031399 112 0.015
Human Mouse
negative regulation of apoptotic signaling pathway GO:2001234 5 0.015
Human Mouse
regulation of cysteine type endopeptidase activity GO:2000116 27 0.015
regulation of eye pigmentation GO:0048073 7 0.015
positive regulation of neuron apoptotic process GO:0043525 1 0.015
sarcomere organization GO:0045214 26 0.015
regulation of cuticle pigmentation GO:0048079 16 0.015
metal ion transport GO:0030001 74 0.014
regulation of hydrolase activity GO:0051336 97 0.014
forebrain development GO:0030900 2 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
regulation of establishment of protein localization GO:0070201 61 0.014
post embryonic appendage morphogenesis GO:0035120 385 0.014
carbohydrate metabolic process GO:0005975 82 0.014
cellular macromolecule catabolic process GO:0044265 136 0.014
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.014
negative regulation of multi organism process GO:0043901 29 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
regulation of compound eye pigmentation GO:0048076 7 0.014

Pink1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
synucleinopathy DOID:0050890 0 0.706
Human
central nervous system disease DOID:331 0 0.706
Human
disease of anatomical entity DOID:7 0 0.706
Human
neurodegenerative disease DOID:1289 0 0.706
Human
nervous system disease DOID:863 0 0.706
Human
parkinson s disease DOID:14330 0 0.659
Human
cancer DOID:162 0 0.064
disease of cellular proliferation DOID:14566 0 0.064
organ system cancer DOID:0050686 0 0.018