Drosophila melanogaster

0 known processes

Pen (Dmel_CG4799)

Pendulin

(Aliases: Dalpha2,Dimp-alpha2,OHO31,oho31,Kpna2,DPend,2.1,alpha2,Kap-alpha2,Dmel\CG4799,Rch1,pen,l(2)k14401,anon-WO0140519.258,imp alpha2,CG4799,Oho31,pen-2,alpha2A-Kap,Kap alpha2,Imp-alpha2,IMPalpha2,importin alpha2/pendulin,oho-31,l(2)144/1,imp-alpha2,bs29g06.y1)

Pen biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oocyte construction GO:0007308 112 0.937
oocyte development GO:0048599 124 0.814
mrna processing GO:0006397 104 0.773
pole plasm mrna localization GO:0019094 49 0.736
oocyte axis specification GO:0007309 108 0.721
mrna metabolic process GO:0016071 124 0.712
anterior posterior pattern specification GO:0009952 136 0.706
immune response GO:0006955 246 0.614
cell fate determination GO:0001709 91 0.537
cell maturation GO:0048469 144 0.514
maternal determination of anterior posterior axis embryo GO:0008358 74 0.503
oocyte anterior posterior axis specification GO:0007314 72 0.501
muscle structure development GO:0061061 224 0.478
blastoderm segmentation GO:0007350 159 0.403
response to abiotic stimulus GO:0009628 341 0.402
Fly
oocyte differentiation GO:0009994 145 0.389
regionalization GO:0003002 416 0.386
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.384
immune system process GO:0002376 347 0.375
embryonic pattern specification GO:0009880 174 0.375
negative regulation of cellular metabolic process GO:0031324 382 0.334
gravitaxis GO:0042332 26 0.331
segmentation GO:0035282 207 0.328
defense response GO:0006952 300 0.300
negative regulation of translation GO:0017148 28 0.266
mrna catabolic process GO:0006402 33 0.259
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.251
salivary gland morphogenesis GO:0007435 145 0.246
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.243
male gamete generation GO:0048232 201 0.225
embryonic axis specification GO:0000578 107 0.219
epithelial cell migration open tracheal system GO:0007427 32 0.217
dendrite development GO:0016358 204 0.210
negative regulation of gene expression GO:0010629 387 0.202
skeletal muscle organ development GO:0060538 48 0.200
single organism behavior GO:0044708 391 0.191
response to gravity GO:0009629 26 0.190
embryonic morphogenesis GO:0048598 206 0.189
taxis GO:0042330 304 0.187
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.187
digestive system development GO:0055123 149 0.187
developmental maturation GO:0021700 172 0.183
enzyme linked receptor protein signaling pathway GO:0007167 179 0.180
actin filament based process GO:0030029 220 0.174
response to organic substance GO:0010033 284 0.173
rna processing GO:0006396 147 0.169
gene silencing GO:0016458 138 0.168
response to other organism GO:0051707 293 0.164
mrna splicing via spliceosome GO:0000398 73 0.161
spermatogenesis GO:0007283 200 0.154
imaginal disc derived appendage morphogenesis GO:0035114 395 0.152
negative regulation of cellular protein metabolic process GO:0032269 85 0.151
positive regulation of rna metabolic process GO:0051254 271 0.147
anterior posterior axis specification embryo GO:0008595 103 0.134
cell death GO:0008219 279 0.134
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.129
rna splicing GO:0008380 83 0.126
growth GO:0040007 359 0.126
negative regulation of cellular biosynthetic process GO:0031327 277 0.121
nuclear transcribed mrna catabolic process GO:0000956 24 0.114
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.111
positive regulation of mrna metabolic process GO:1903313 5 0.111
positive regulation of gene expression GO:0010628 290 0.109
regulation of defense response GO:0031347 102 0.108
regulation of multicellular organismal development GO:2000026 414 0.108
exocrine system development GO:0035272 162 0.105
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.103
tripartite regional subdivision GO:0007351 103 0.101
regulation of cell differentiation GO:0045595 302 0.099
pole plasm assembly GO:0007315 61 0.097
oocyte dorsal ventral axis specification GO:0007310 34 0.097
negative regulation of nervous system development GO:0051961 92 0.095
interspecies interaction between organisms GO:0044419 16 0.095
actin polymerization or depolymerization GO:0008154 31 0.093
cellular response to chemical stimulus GO:0070887 199 0.091
positive regulation of macromolecule metabolic process GO:0010604 405 0.090
regulation of cysteine type endopeptidase activity GO:2000116 27 0.085
rna catabolic process GO:0006401 37 0.084
epithelial cell migration GO:0010631 148 0.084
defense response to bacterium GO:0042742 178 0.084
response to bacterium GO:0009617 198 0.083
cell proliferation GO:0008283 299 0.082
cellular response to organic substance GO:0071310 132 0.082
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.081
striated muscle cell differentiation GO:0051146 90 0.081
defense response to other organism GO:0098542 225 0.081
asymmetric cell division GO:0008356 37 0.079
cellular component assembly involved in morphogenesis GO:0010927 151 0.079
response to external biotic stimulus GO:0043207 293 0.075
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 4 0.075
anterior posterior axis specification GO:0009948 109 0.074
germarium derived oocyte fate determination GO:0007294 26 0.072
germ line cyst formation GO:0048134 44 0.071
muscle cell differentiation GO:0042692 103 0.070
somatic muscle development GO:0007525 66 0.070
apoptotic process GO:0006915 159 0.065
rna splicing via transesterification reactions GO:0000375 73 0.065
programmed cell death GO:0012501 257 0.064
regulation of mrna processing GO:0050684 71 0.062
regulation of apoptotic process GO:0042981 130 0.061
positive regulation of nucleic acid templated transcription GO:1903508 266 0.060
lipid storage GO:0019915 38 0.060
kidney epithelium development GO:0072073 3 0.060
regulation of translation GO:0006417 56 0.057
fusome organization GO:0045478 13 0.056
regulation of protein metabolic process GO:0051246 256 0.055
imaginal disc derived appendage development GO:0048737 399 0.052
death GO:0016265 284 0.051
cellularization GO:0007349 90 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.051
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.050
regulation of mrna splicing via spliceosome GO:0048024 64 0.049
regulation of mrna catabolic process GO:0061013 5 0.049
regulation of mrna metabolic process GO:1903311 72 0.048
organic cyclic compound catabolic process GO:1901361 168 0.047
regulation of cellular protein metabolic process GO:0032268 243 0.047
cellular macromolecular complex assembly GO:0034622 153 0.047
regulation of dendrite development GO:0050773 37 0.046
regulation of oocyte development GO:0060281 27 0.046
negative regulation of response to stimulus GO:0048585 258 0.044
ovarian fusome organization GO:0030723 11 0.043
defense response to gram negative bacterium GO:0050829 94 0.043
protein maturation GO:0051604 71 0.043
gland morphogenesis GO:0022612 145 0.043
appendage development GO:0048736 401 0.043
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.043
negative regulation of cell proliferation GO:0008285 69 0.042
morphogenesis of an epithelium GO:0002009 276 0.042
gland development GO:0048732 191 0.042
salivary gland development GO:0007431 162 0.042
pole plasm oskar mrna localization GO:0045451 46 0.040
macromolecular complex assembly GO:0065003 256 0.039
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
striated muscle cell development GO:0055002 50 0.038
cellular protein complex assembly GO:0043623 71 0.038
negative regulation of biosynthetic process GO:0009890 277 0.038
regulation of response to stress GO:0080134 200 0.037
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.037
negative regulation of protein metabolic process GO:0051248 85 0.036
posttranscriptional regulation of gene expression GO:0010608 145 0.036
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.036
chorion containing eggshell formation GO:0007304 105 0.035
dendrite morphogenesis GO:0048813 199 0.035
multi organism behavior GO:0051705 175 0.035
regulation of cellular catabolic process GO:0031329 157 0.035
cellular macromolecule localization GO:0070727 220 0.034
Mouse Worm Fly
regulation of programmed cell death GO:0043067 152 0.033
regulation of localization GO:0032879 275 0.033
Fly
heart process GO:0003015 37 0.033
muscle attachment GO:0016203 36 0.033
protein processing GO:0016485 68 0.033
actin cytoskeleton organization GO:0030036 206 0.032
cell motility GO:0048870 251 0.032
positive regulation of cellular biosynthetic process GO:0031328 316 0.032
alternative mrna splicing via spliceosome GO:0000380 60 0.032
photoreceptor cell axon guidance GO:0072499 23 0.032
response to ethanol GO:0045471 59 0.032
mrna 3 end processing GO:0031124 28 0.031
larval development GO:0002164 104 0.031
negative regulation of nucleic acid templated transcription GO:1903507 240 0.031
germarium derived female germ line cyst formation GO:0030727 42 0.031
oocyte microtubule cytoskeleton organization GO:0016325 35 0.030
heterocycle catabolic process GO:0046700 166 0.030
axis specification GO:0009798 167 0.030
protein localization GO:0008104 284 0.030
Mouse Worm Fly
ameboidal type cell migration GO:0001667 151 0.029
cellular nitrogen compound catabolic process GO:0044270 165 0.029
organic substance catabolic process GO:1901575 308 0.028
axon guidance GO:0007411 233 0.028
negative regulation of rna biosynthetic process GO:1902679 240 0.028
tissue migration GO:0090130 155 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
rna 3 end processing GO:0031123 45 0.027
negative regulation of cell cycle GO:0045786 116 0.027
Fly
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.026
regulation of actin filament polymerization GO:0030833 25 0.026
muscle organ development GO:0007517 127 0.026
renal system development GO:0072001 72 0.026
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.026
kidney development GO:0001822 3 0.026
developmental programmed cell death GO:0010623 138 0.026
organic substance transport GO:0071702 257 0.026
Mouse Worm Fly
tissue morphogenesis GO:0048729 297 0.025
cellular ketone metabolic process GO:0042180 24 0.025
digestive tract development GO:0048565 149 0.025
female germ line stem cell asymmetric division GO:0048132 14 0.025
response to endogenous stimulus GO:0009719 119 0.025
positive regulation of response to stimulus GO:0048584 323 0.025
response to biotic stimulus GO:0009607 294 0.025
autophagic cell death GO:0048102 83 0.025
positive regulation of biosynthetic process GO:0009891 316 0.025
tube morphogenesis GO:0035239 191 0.025
aging GO:0007568 143 0.024
dna biosynthetic process GO:0071897 24 0.024
negative regulation of cell death GO:0060548 81 0.024
epithelial cell development GO:0002064 274 0.024
asymmetric protein localization GO:0008105 33 0.024
translation GO:0006412 69 0.024
regulation of cell death GO:0010941 173 0.024
epithelial cell differentiation GO:0030855 322 0.024
negative regulation of synapse assembly GO:0051964 39 0.024
biological adhesion GO:0022610 138 0.024
regulation of rna splicing GO:0043484 69 0.024
ventral cord development GO:0007419 16 0.024
nucleobase containing compound catabolic process GO:0034655 165 0.023
cell adhesion GO:0007155 136 0.023
regulation of catalytic activity GO:0050790 185 0.023
meiotic chromosome condensation GO:0010032 3 0.023
female germ line cyst formation GO:0048135 42 0.023
body morphogenesis GO:0010171 2 0.023
positive regulation of cell communication GO:0010647 250 0.022
organ growth GO:0035265 56 0.022
proteolysis GO:0006508 192 0.022
myotube cell development GO:0014904 3 0.022
positive regulation of apoptotic process GO:0043065 47 0.022
cellular catabolic process GO:0044248 372 0.021
neuron projection guidance GO:0097485 241 0.021
single organism cell adhesion GO:0098602 47 0.021
epithelial tube morphogenesis GO:0060562 88 0.021
protein complex biogenesis GO:0070271 201 0.021
regulation of proteolysis GO:0030162 87 0.020
regulation of nervous system development GO:0051960 248 0.020
histolysis GO:0007559 102 0.020
germarium derived oocyte differentiation GO:0030706 29 0.020
positive regulation of mrna catabolic process GO:0061014 5 0.020
actin filament polymerization GO:0030041 27 0.020
protein complex assembly GO:0006461 200 0.020
mitotic cell cycle phase transition GO:0044772 138 0.019
Fly
protein modification by small protein conjugation or removal GO:0070647 106 0.019
cellular response to endogenous stimulus GO:0071495 80 0.019
aromatic compound catabolic process GO:0019439 166 0.019
phosphorylation GO:0016310 294 0.019
axon development GO:0061564 297 0.019
regulation of actin polymerization or depolymerization GO:0008064 27 0.019
regulation of endopeptidase activity GO:0052548 36 0.018
homeostatic process GO:0042592 199 0.018
ribose phosphate metabolic process GO:0019693 145 0.018
multi organism reproductive behavior GO:0044705 121 0.018
spermatid development GO:0007286 98 0.018
microtubule polymerization or depolymerization GO:0031109 39 0.018
regulation of cell cycle GO:0051726 291 0.018
Fly
protein phosphorylation GO:0006468 169 0.018
ribonucleoprotein complex assembly GO:0022618 23 0.017
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.017
central nervous system development GO:0007417 201 0.017
macromolecule catabolic process GO:0009057 161 0.017
regulation of embryonic development GO:0045995 68 0.017
tube development GO:0035295 244 0.017
intracellular receptor signaling pathway GO:0030522 19 0.016
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.016
salivary gland cell autophagic cell death GO:0035071 83 0.016
protein polymerization GO:0051258 42 0.016
regulation of synapse structure and activity GO:0050803 128 0.016
pole plasm rna localization GO:0007316 52 0.016
karyosome formation GO:0030717 22 0.016
oocyte fate determination GO:0030716 27 0.016
lipid localization GO:0010876 54 0.015
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.015
cellular macromolecule catabolic process GO:0044265 136 0.015
regulation of synapse organization GO:0050807 110 0.015
cytoplasm organization GO:0007028 64 0.015
salivary gland histolysis GO:0035070 88 0.015
skeletal muscle fiber development GO:0048741 3 0.015
positive regulation of defense response GO:0031349 59 0.015
establishment of protein localization GO:0045184 163 0.015
Mouse Worm Fly
morphogenesis of a branching structure GO:0001763 45 0.015
camera type eye development GO:0043010 4 0.015
transcription from rna polymerase ii promoter GO:0006366 368 0.015
maintenance of location GO:0051235 73 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.014
Worm
positive regulation of rna biosynthetic process GO:1902680 266 0.014
muscle tissue development GO:0060537 30 0.014
regulation of protein polymerization GO:0032271 28 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
regulation of catabolic process GO:0009894 170 0.014
response to oxidative stress GO:0006979 86 0.014
positive regulation of peptidase activity GO:0010952 29 0.014
positive regulation of proteolysis GO:0045862 52 0.014
positive regulation of signal transduction GO:0009967 223 0.014
cellular amino acid metabolic process GO:0006520 61 0.013
regulation of immune response GO:0050776 118 0.013
positive regulation of developmental growth GO:0048639 62 0.013
positive regulation of growth GO:0045927 75 0.013
regulation of hydrolase activity GO:0051336 97 0.013
regulation of meiosis GO:0040020 3 0.013
germarium derived egg chamber formation GO:0007293 101 0.013
motor neuron axon guidance GO:0008045 58 0.013
sensory organ morphogenesis GO:0090596 260 0.013
positive regulation of neuron apoptotic process GO:0043525 1 0.013
startle response GO:0001964 16 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
positive regulation of catabolic process GO:0009896 105 0.012
nephron development GO:0072006 3 0.012
muscle fiber development GO:0048747 12 0.012
negative regulation of cell communication GO:0010648 223 0.012
tissue death GO:0016271 102 0.012
negative regulation of growth GO:0045926 84 0.012
positive regulation of immune response GO:0050778 63 0.012
regulation of anatomical structure morphogenesis GO:0022603 242 0.012
regulation of cell proliferation GO:0042127 163 0.012
regulation of phosphatase activity GO:0010921 3 0.012
larval behavior GO:0030537 42 0.012
regulation of molecular function GO:0065009 217 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
innate immune response GO:0045087 144 0.011
single organism cellular localization GO:1902580 180 0.011
Mouse Worm Fly
regulation of cell fate specification GO:0042659 27 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.011
organelle assembly GO:0070925 198 0.011
ovarian nurse cell to oocyte transport GO:0007300 27 0.011
peptidyl tyrosine phosphorylation GO:0018108 24 0.011
catabolic process GO:0009056 409 0.011
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.011
regulation of peptidase activity GO:0052547 39 0.011
response to hormone GO:0009725 45 0.011
mitotic nuclear division GO:0007067 213 0.011
positive regulation of cell cycle process GO:0090068 28 0.011
negative regulation of programmed cell death GO:0043069 72 0.011
regulation of cellular component size GO:0032535 98 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
specification of symmetry GO:0009799 13 0.010
rna localization GO:0006403 115 0.010
positive regulation of signaling GO:0023056 243 0.010
chromosome condensation GO:0030261 41 0.010
regulation of phosphorylation GO:0042325 147 0.010
multicellular organismal signaling GO:0035637 12 0.010

Pen disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
musculoskeletal system disease DOID:17 0 0.044
myopathy DOID:423 0 0.010
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010