Drosophila melanogaster

13 known processes

Tm2 (Dmel_CG4843)

Tropomyosin 2

(Aliases: Ifm-TmI,Tm1,CG4843,Dmel\CG4843,DROTROPI1,Ifm(3)3,Ifm(3)5,Tm127,dro Tm,mTmI,Tm,TmI,l(3)nc99Eb,Tn-H)

Tm2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
striated muscle cell development GO:0055002 50 0.995
Human Zebrafish
sarcomere organization GO:0045214 26 0.989
Human
muscle cell development GO:0055001 50 0.983
Human Zebrafish
skeletal muscle adaptation GO:0043501 1 0.955
actin filament based process GO:0030029 220 0.950
Human Zebrafish Rat Worm
myofibril assembly GO:0030239 36 0.942
Human Zebrafish
muscle tissue morphogenesis GO:0060415 2 0.927
Human Mouse
actomyosin structure organization GO:0031032 56 0.868
Human Zebrafish Rat
striated muscle myosin thick filament assembly GO:0071688 3 0.862
actin filament based movement GO:0030048 26 0.842
Rat
actin cytoskeleton organization GO:0030036 206 0.811
Human Zebrafish Rat Worm
myotube differentiation GO:0014902 46 0.792
mesoderm development GO:0007498 78 0.758
striated muscle cell differentiation GO:0051146 90 0.688
Human Zebrafish
muscle thin filament assembly GO:0071689 5 0.642
muscle cell differentiation GO:0042692 103 0.639
Human Zebrafish
skeletal myofibril assembly GO:0014866 6 0.618
blood circulation GO:0008015 26 0.604
Human Zebrafish Mouse Rat
heart process GO:0003015 37 0.600
Human Zebrafish Mouse Rat
regulation of blood circulation GO:1903522 21 0.592
Mouse
skeletal muscle organ development GO:0060538 48 0.545
muscle tissue development GO:0060537 30 0.537
Human Zebrafish Mouse
skeletal muscle myosin thick filament assembly GO:0030241 3 0.530
muscle structure development GO:0061061 224 0.500
Human Zebrafish Mouse
regulation of heart contraction GO:0008016 21 0.464
Mouse
striated muscle tissue development GO:0014706 27 0.436
Human Zebrafish Mouse
regulation of system process GO:0044057 36 0.401
Mouse
muscle organ development GO:0007517 127 0.331
Human Mouse
striated muscle adaptation GO:0014888 1 0.302
actin mediated cell contraction GO:0070252 21 0.300
Rat
organelle assembly GO:0070925 198 0.279
Human Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 151 0.268
Human Zebrafish
cellular ion homeostasis GO:0006873 39 0.243
heart contraction GO:0060047 26 0.231
Human Zebrafish Mouse Rat
myosin filament assembly GO:0031034 5 0.225
circulatory system process GO:0003013 37 0.210
Human Zebrafish Mouse Rat
cellular macromolecular complex assembly GO:0034622 153 0.199
Rat Worm
body morphogenesis GO:0010171 2 0.184
Worm
atp metabolic process GO:0046034 49 0.182
Human Rat
protein complex assembly GO:0006461 200 0.168
Rat Worm
heart development GO:0007507 82 0.152
positive regulation of atp catabolic process GO:1903291 3 0.148
Rat
metal ion homeostasis GO:0055065 44 0.143
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.134
Human Rat
heart morphogenesis GO:0003007 32 0.130
Human Mouse
skeletal muscle fiber development GO:0048741 3 0.129
cation homeostasis GO:0055080 51 0.124
cellular protein complex assembly GO:0043623 71 0.123
Rat Worm
multi multicellular organism process GO:0044706 123 0.119
Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.116
Mouse Worm
multicellular organismal reproductive behavior GO:0033057 110 0.115
Worm
purine ribonucleotide catabolic process GO:0009154 109 0.103
Human Rat
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.102
Human Rat
protein complex biogenesis GO:0070271 201 0.099
Rat Worm
adult somatic muscle development GO:0007527 14 0.099
regulation of heart rate GO:0002027 11 0.099
Mouse
myotube cell development GO:0014904 3 0.097
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.096
Rat
atp catabolic process GO:0006200 38 0.093
Human Rat
negative regulation of cellular catabolic process GO:0031330 34 0.092
ion homeostasis GO:0050801 55 0.091
cardiac muscle tissue development GO:0048738 9 0.087
Human Zebrafish Mouse
positive regulation of nucleotide catabolic process GO:0030813 46 0.087
Rat
ribose phosphate metabolic process GO:0019693 145 0.086
Human Rat
purine ribonucleotide metabolic process GO:0009150 145 0.083
Human Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.083
Human Rat
purine ribonucleoside metabolic process GO:0046128 127 0.082
Human Rat
ribonucleoside monophosphate catabolic process GO:0009158 39 0.080
Human Rat
cellular cation homeostasis GO:0030003 38 0.078
nucleobase containing small molecule metabolic process GO:0055086 174 0.076
Human Rat
nucleoside triphosphate metabolic process GO:0009141 120 0.073
Human Rat
glycosyl compound metabolic process GO:1901657 127 0.072
Human Rat
ribonucleoside monophosphate metabolic process GO:0009161 51 0.072
Human Rat
muscle contraction GO:0006936 13 0.072
Human Zebrafish Mouse Rat
cytokinesis GO:0000910 90 0.071
Worm
myosin filament organization GO:0031033 5 0.070
actin filament organization GO:0007015 126 0.069
Rat Worm
heterocycle catabolic process GO:0046700 166 0.064
Human Rat
ribonucleoside catabolic process GO:0042454 112 0.061
Human Rat
vesicle mediated transport GO:0016192 381 0.061
purine ribonucleoside catabolic process GO:0046130 112 0.059
Human Rat
purine nucleoside monophosphate catabolic process GO:0009128 38 0.058
Human Rat
axonal fasciculation GO:0007413 12 0.056
small molecule metabolic process GO:0044281 305 0.055
Human Rat
cytoskeleton dependent cytokinesis GO:0061640 81 0.054
oviposition GO:0018991 19 0.054
Worm
muscle fiber development GO:0048747 12 0.053
epithelial tube morphogenesis GO:0060562 88 0.052
nucleoside triphosphate catabolic process GO:0009143 108 0.052
Human Rat
striated muscle contraction GO:0006941 5 0.052
Human Zebrafish Mouse Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.051
Human Rat
glycolytic process GO:0006096 6 0.050
nucleobase containing compound catabolic process GO:0034655 165 0.050
Human Rat
camera type eye development GO:0043010 4 0.050
carbohydrate derivative catabolic process GO:1901136 118 0.048
Human Rat
mitotic cytokinesis GO:0000281 50 0.048
nucleoside phosphate metabolic process GO:0006753 162 0.048
Human Rat
endocytosis GO:0006897 310 0.047
alditol phosphate metabolic process GO:0052646 2 0.047
purine nucleotide metabolic process GO:0006163 146 0.047
Human Rat
aging GO:0007568 143 0.046
ribonucleoside triphosphate metabolic process GO:0009199 119 0.046
Human Rat
somatic muscle development GO:0007525 66 0.045
purine nucleoside catabolic process GO:0006152 112 0.045
Human Rat
purine nucleotide catabolic process GO:0006195 109 0.045
Human Rat
establishment of nucleus localization GO:0040023 26 0.044
purine nucleoside metabolic process GO:0042278 127 0.043
Human Rat
response to heat GO:0009408 63 0.043
aromatic compound catabolic process GO:0019439 166 0.043
Human Rat
actin cytoskeleton reorganization GO:0031532 22 0.043
muscle organ morphogenesis GO:0048644 7 0.041
Human Mouse
positive regulation of catabolic process GO:0009896 105 0.040
Rat
ribonucleoside metabolic process GO:0009119 127 0.039
Human Rat
skeletal muscle tissue development GO:0007519 13 0.039
multi organism reproductive behavior GO:0044705 121 0.038
Worm
regulation of multicellular organismal development GO:2000026 414 0.038
cellular metal ion homeostasis GO:0006875 31 0.038
muscle system process GO:0003012 21 0.036
Human Zebrafish Mouse Rat
cellular homeostasis GO:0019725 80 0.036
cell recognition GO:0008037 102 0.036
kidney development GO:0001822 3 0.035
growth GO:0040007 359 0.035
nucleoside catabolic process GO:0009164 112 0.034
Human Rat
gonad development GO:0008406 50 0.034
Worm
neuron recognition GO:0008038 101 0.034
positive regulation of protein import into nucleus GO:0042307 21 0.034
regionalization GO:0003002 416 0.034
immune system development GO:0002520 57 0.034
organophosphate metabolic process GO:0019637 195 0.033
Human Rat
cellular chemical homeostasis GO:0055082 40 0.033
nucleotide metabolic process GO:0009117 161 0.033
Human Rat
positive regulation of phosphorus metabolic process GO:0010562 139 0.033
Rat
organic cyclic compound catabolic process GO:1901361 168 0.033
Human Rat
positive regulation of transcription factor import into nucleus GO:0042993 19 0.033
ribonucleotide catabolic process GO:0009261 109 0.033
Human Rat
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.032
ribonucleoside triphosphate catabolic process GO:0009203 108 0.032
Human Rat
adult behavior GO:0030534 137 0.031
appendage morphogenesis GO:0035107 397 0.031
response to anesthetic GO:0072347 9 0.031
positive regulation of actin filament polymerization GO:0030838 11 0.031
regulation of cytoskeleton organization GO:0051493 89 0.031
Rat Worm
muscle adaptation GO:0043500 1 0.031
organonitrogen compound metabolic process GO:1901564 318 0.030
Human Rat
divalent inorganic cation homeostasis GO:0072507 29 0.030
regulation of cellular localization GO:0060341 136 0.029
organonitrogen compound catabolic process GO:1901565 128 0.029
Human Rat
nucleoside monophosphate metabolic process GO:0009123 52 0.029
Human Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.029
Rat
regulation of organelle organization GO:0033043 196 0.028
Rat Worm
positive regulation of cellular catabolic process GO:0031331 95 0.028
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.028
Human Rat
sex differentiation GO:0007548 81 0.028
Worm
larval somatic muscle development GO:0007526 19 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.028
Rat
regulation of muscle system process GO:0090257 6 0.028
cellular response to chemical stimulus GO:0070887 199 0.027
Human
calcium ion homeostasis GO:0055074 23 0.027
tissue morphogenesis GO:0048729 297 0.027
Human Mouse
multi organism behavior GO:0051705 175 0.027
Worm
maintenance of location GO:0051235 73 0.027
development of primary sexual characteristics GO:0045137 50 0.027
Worm
cellular nitrogen compound catabolic process GO:0044270 165 0.026
Human Rat
protein modification process GO:0036211 438 0.026
glycosyl compound catabolic process GO:1901658 112 0.026
Human Rat
purine nucleoside triphosphate metabolic process GO:0009144 119 0.025
Human Rat
actin filament polymerization GO:0030041 27 0.025
Rat Worm
nucleoside phosphate catabolic process GO:1901292 110 0.025
Human Rat
negative regulation of sequestering of calcium ion GO:0051283 2 0.025
hematopoietic progenitor cell differentiation GO:0002244 1 0.025
embryonic morphogenesis GO:0048598 206 0.025
actin polymerization or depolymerization GO:0008154 31 0.025
Rat Worm
regulation of actin filament length GO:0030832 27 0.024
Rat Worm
nucleoside monophosphate catabolic process GO:0009125 39 0.024
Human Rat
cellular protein complex disassembly GO:0043624 35 0.023
Rat Worm
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.023
Rat
regulation of actin filament polymerization GO:0030833 25 0.023
Rat Worm
macromolecular complex assembly GO:0065003 256 0.023
Rat Worm
anatomical structure homeostasis GO:0060249 97 0.023
organophosphate catabolic process GO:0046434 112 0.023
Human Rat
ribonucleotide metabolic process GO:0009259 145 0.023
Human Rat
negative regulation of cellular metabolic process GO:0031324 382 0.022
regulation of purine nucleotide metabolic process GO:1900542 62 0.022
Human Rat
single organism catabolic process GO:0044712 228 0.022
Human Rat
cell division GO:0051301 248 0.022
Worm
chemical homeostasis GO:0048878 92 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
Human Rat
regulation of tube length open tracheal system GO:0035159 24 0.021
sequestering of calcium ion GO:0051208 5 0.020
macromolecule catabolic process GO:0009057 161 0.020
protein depolymerization GO:0051261 31 0.020
Rat Worm
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
negative regulation of catabolic process GO:0009895 36 0.020
microtubule organizing center organization GO:0031023 168 0.020
localization of cell GO:0051674 257 0.019
Rat
mitotic chromosome condensation GO:0007076 22 0.019
stem cell differentiation GO:0048863 117 0.019
regulation of anatomical structure morphogenesis GO:0022603 242 0.019
positive regulation of nfat protein import into nucleus GO:0051533 16 0.019
epithelial cell development GO:0002064 274 0.018
positive regulation of cellular component organization GO:0051130 156 0.018
Rat
regulation of catalytic activity GO:0050790 185 0.018
Human Rat
regulation of sarcomere organization GO:0060297 2 0.018
larval development GO:0002164 104 0.018
Worm
phagocytosis GO:0006909 215 0.018
organelle localization GO:0051640 148 0.018
organic substance catabolic process GO:1901575 308 0.018
Human Rat
cellular calcium ion homeostasis GO:0006874 21 0.018
negative regulation of cellular component organization GO:0051129 108 0.017
Rat Worm
tube development GO:0035295 244 0.017
Worm
regulation of molecular function GO:0065009 217 0.017
Human Rat Worm
embryonic development via the syncytial blastoderm GO:0001700 148 0.017
regulation of cell morphogenesis GO:0022604 163 0.017
multicellular organism growth GO:0035264 46 0.017
synapse organization GO:0050808 196 0.017
oxoacid metabolic process GO:0043436 103 0.017
cytosolic calcium ion transport GO:0060401 2 0.017
positive regulation of protein transport GO:0051222 37 0.017
single organism nuclear import GO:1902593 51 0.017
regulation of cell cycle GO:0051726 291 0.017
ovulation GO:0030728 4 0.017
Worm
purine containing compound catabolic process GO:0072523 112 0.017
Human Rat
morphogenesis of an epithelium GO:0002009 276 0.016
cytoplasmic transport GO:0016482 130 0.016
positive regulation of nucleoside metabolic process GO:0045979 47 0.016
Rat
positive regulation of transport GO:0051050 92 0.016
regulation of sequestering of calcium ion GO:0051282 3 0.016
circulatory system development GO:0072359 82 0.016
regulation of cellular catabolic process GO:0031329 157 0.015
Human Rat
regulation of actin polymerization or depolymerization GO:0008064 27 0.015
Rat Worm
imaginal disc derived appendage development GO:0048737 399 0.015
regulation of establishment of protein localization GO:0070201 61 0.015
cellular divalent inorganic cation homeostasis GO:0072503 23 0.015
positive regulation of intracellular transport GO:0032388 42 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
Human Rat
protein polymerization GO:0051258 42 0.015
Rat Worm
regulation of intracellular protein transport GO:0033157 46 0.015
tube morphogenesis GO:0035239 191 0.015
centrosome organization GO:0051297 163 0.015
establishment of localization in cell GO:0051649 402 0.015
catabolic process GO:0009056 409 0.014
Human Rat
cellular catabolic process GO:0044248 372 0.014
Human Rat
regulation of cellular component size GO:0032535 98 0.014
Rat Worm
lipid storage GO:0019915 38 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of growth GO:0040008 233 0.014
anterior posterior pattern specification GO:0009952 136 0.014
chromosome condensation GO:0030261 41 0.014
stem cell development GO:0048864 79 0.014
cell aging GO:0007569 2 0.014
nuclear import GO:0051170 51 0.013
outflow tract morphogenesis GO:0003151 4 0.013
negative regulation of cell cycle GO:0045786 116 0.013
protein targeting to nucleus GO:0044744 51 0.013
neuroblast proliferation GO:0007405 74 0.013
nucleotide catabolic process GO:0009166 109 0.013
Human Rat
purine nucleoside monophosphate metabolic process GO:0009126 50 0.013
Human Rat
intracellular transport GO:0046907 228 0.013
intracellular signal transduction GO:0035556 300 0.013
regulation of muscle contraction GO:0006937 5 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
negative regulation of homeostatic process GO:0032845 2 0.012
regulation of transcription factor import into nucleus GO:0042990 22 0.012
protein catabolic process GO:0030163 101 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
Rat
regulation of nucleotide catabolic process GO:0030811 48 0.012
Human Rat
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of cell shape GO:0008360 113 0.012
homeostatic process GO:0042592 199 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
Rat
response to metal ion GO:0010038 23 0.012
positive regulation of endocytosis GO:0045807 22 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
cell adhesion GO:0007155 136 0.011
Rat
protein localization to nucleus GO:0034504 55 0.011
negative regulation of cytoskeleton organization GO:0051494 30 0.011
Rat Worm
mitotic nuclear division GO:0007067 213 0.011
phosphorylation GO:0016310 294 0.011
purine containing compound metabolic process GO:0072521 155 0.011
Human Rat
response to ionizing radiation GO:0010212 32 0.011
organelle fission GO:0048285 340 0.011
regulation of cell differentiation GO:0045595 302 0.011
positive regulation of gene expression GO:0010628 290 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
negative regulation of phosphorus metabolic process GO:0010563 45 0.011
positive regulation of molecular function GO:0044093 136 0.011
Rat
establishment of organelle localization GO:0051656 122 0.011
calcium ion transport into cytosol GO:0060402 2 0.011
reactive oxygen species metabolic process GO:0072593 22 0.011
renal system development GO:0072001 72 0.010
positive regulation of intracellular protein transport GO:0090316 30 0.010
epithelial cell morphogenesis GO:0003382 25 0.010
regulation of phosphatase activity GO:0010921 3 0.010
formation of anatomical boundary GO:0048859 37 0.010

Tm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.315
Human
muscular disease DOID:0080000 0 0.315
Human
cardiomyopathy DOID:0050700 0 0.315
Human
disease of anatomical entity DOID:7 0 0.315
Human
myopathy DOID:423 0 0.315
Human
cardiovascular system disease DOID:1287 0 0.315
Human
musculoskeletal system disease DOID:17 0 0.315
Human
muscle tissue disease DOID:66 0 0.315
Human
intrinsic cardiomyopathy DOID:0060036 0 0.058
Human
dilated cardiomyopathy DOID:12930 0 0.058
Human
nervous system disease DOID:863 0 0.017
neurodegenerative disease DOID:1289 0 0.017
central nervous system disease DOID:331 0 0.017