Drosophila melanogaster

22 known processes

Pros35 (Dmel_CG4904)

Proteasome 35kD subunit

(Aliases: Prosalpha6,143314_at,PROS-35,Dmel\CG4904,PROS-Dm35,alpha_dm,pros35,anon-SAGE:Wang-116,Pros-35,Pros-Dm35,CG4904,pros 35)

Pros35 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spindle elongation GO:0051231 83 0.773
ubiquitin dependent protein catabolic process GO:0006511 78 0.538
modification dependent macromolecule catabolic process GO:0043632 79 0.532
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.464
proteolysis GO:0006508 192 0.455
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.431
cellular macromolecule catabolic process GO:0044265 136 0.407
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.385
mitotic spindle elongation GO:0000022 81 0.361
mitotic spindle organization GO:0007052 220 0.335
spindle organization GO:0007051 253 0.335
spindle assembly GO:0051225 80 0.315
mitotic cell cycle phase transition GO:0044772 138 0.278
cellular response to dna damage stimulus GO:0006974 223 0.273
response to biotic stimulus GO:0009607 294 0.269
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.251
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.240
dendrite morphogenesis GO:0048813 199 0.228
cellular protein catabolic process GO:0044257 83 0.227
protein catabolic process GO:0030163 101 0.225
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.210
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.207
cellular catabolic process GO:0044248 372 0.203
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.203
asymmetric protein localization GO:0008105 33 0.193
dna metabolic process GO:0006259 227 0.174
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.172
positive regulation of cellular protein metabolic process GO:0032270 118 0.162
transcription from rna polymerase ii promoter GO:0006366 368 0.153
catabolic process GO:0009056 409 0.149
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.146
protein complex biogenesis GO:0070271 201 0.146
macromolecular complex assembly GO:0065003 256 0.145
proteasomal protein catabolic process GO:0010498 59 0.144
regulation of mitotic cell cycle GO:0007346 190 0.144
spindle assembly involved in mitosis GO:0090307 50 0.143
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.139
regulation of proteasomal protein catabolic process GO:0061136 39 0.132
body morphogenesis GO:0010171 2 0.120
cell proliferation GO:0008283 299 0.119
proteasome assembly GO:0043248 2 0.113
death GO:0016265 284 0.110
microtubule organizing center organization GO:0031023 168 0.110
positive regulation of cellular component organization GO:0051130 156 0.110
protein complex assembly GO:0006461 200 0.109
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.106
positive regulation of macromolecule metabolic process GO:0010604 405 0.102
embryo development ending in birth or egg hatching GO:0009792 152 0.098
macromolecule catabolic process GO:0009057 161 0.093
centrosome organization GO:0051297 163 0.092
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.089
positive regulation of proteolysis GO:0045862 52 0.088
apoptotic process GO:0006915 159 0.087
dna templated transcription initiation GO:0006352 25 0.087
larval development GO:0002164 104 0.084
regulation of cell cycle phase transition GO:1901987 130 0.083
regulation of chromosome organization GO:0033044 64 0.083
dendrite development GO:0016358 204 0.078
positive regulation of nucleic acid templated transcription GO:1903508 266 0.077
lateral inhibition GO:0046331 206 0.076
positive regulation of rna biosynthetic process GO:1902680 266 0.076
small molecule metabolic process GO:0044281 305 0.074
nuclear division GO:0000280 332 0.074
steroid biosynthetic process GO:0006694 16 0.071
positive regulation of catalytic activity GO:0043085 118 0.071
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.071
protein dna complex assembly GO:0065004 63 0.069
dorsal appendage formation GO:0046843 47 0.068
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.067
regulation of cell shape GO:0008360 113 0.067
sterol homeostasis GO:0055092 4 0.067
response to external biotic stimulus GO:0043207 293 0.066
synapse assembly GO:0007416 143 0.064
chromosome organization GO:0051276 360 0.063
regulation of cell cycle GO:0051726 291 0.061
meiotic cell cycle GO:0051321 171 0.061
cell division GO:0051301 248 0.060
negative regulation of developmental process GO:0051093 201 0.060
male gamete generation GO:0048232 201 0.060
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.059
mitotic nuclear division GO:0007067 213 0.059
regulation of cellular protein metabolic process GO:0032268 243 0.058
regulation of cell cycle process GO:0010564 181 0.057
response to other organism GO:0051707 293 0.057
negative regulation of cell cycle GO:0045786 116 0.056
chaeta development GO:0022416 97 0.055
cellular macromolecular complex assembly GO:0034622 153 0.053
regulation of molecular function GO:0065009 217 0.053
positive regulation of transcription dna templated GO:0045893 266 0.053
regulation of cell morphogenesis GO:0022604 163 0.053
mrna metabolic process GO:0016071 124 0.053
cell migration GO:0016477 238 0.049
positive regulation of rna metabolic process GO:0051254 271 0.049
organic substance catabolic process GO:1901575 308 0.049
regulation of endopeptidase activity GO:0052548 36 0.047
organelle assembly GO:0070925 198 0.047
regulation of synapse structure and activity GO:0050803 128 0.046
imaginal disc derived appendage development GO:0048737 399 0.046
morphogenesis of an epithelium GO:0002009 276 0.046
regulation of cellular catabolic process GO:0031329 157 0.046
aging GO:0007568 143 0.045
intracellular signal transduction GO:0035556 300 0.043
chromatin silencing GO:0006342 76 0.043
positive regulation of peptidase activity GO:0010952 29 0.042
regulation of cell death GO:0010941 173 0.041
homeostatic process GO:0042592 199 0.040
cell cycle phase transition GO:0044770 140 0.040
positive regulation of cellular catabolic process GO:0031331 95 0.040
gland development GO:0048732 191 0.040
cell death GO:0008219 279 0.038
regulation of catalytic activity GO:0050790 185 0.037
chromatin modification GO:0016568 147 0.036
stem cell differentiation GO:0048863 117 0.036
mrna splicing via spliceosome GO:0000398 73 0.036
cell cell signaling involved in cell fate commitment GO:0045168 210 0.035
hormone metabolic process GO:0042445 33 0.035
regulation of tube architecture open tracheal system GO:0035152 68 0.035
vesicle mediated transport GO:0016192 381 0.035
response to inorganic substance GO:0010035 44 0.034
mitotic g2 m transition checkpoint GO:0044818 70 0.034
g2 dna damage checkpoint GO:0031572 69 0.033
hormone biosynthetic process GO:0042446 20 0.033
positive regulation of cell migration GO:0030335 2 0.032
regulation of cellular component biogenesis GO:0044087 201 0.032
programmed cell death GO:0012501 257 0.032
dna repair GO:0006281 54 0.032
positive regulation of biosynthetic process GO:0009891 316 0.031
positive regulation of protein metabolic process GO:0051247 128 0.031
positive regulation of molecular function GO:0044093 136 0.031
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.030
appendage development GO:0048736 401 0.030
multicellular organismal aging GO:0010259 140 0.030
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
regulation of mitotic cell cycle phase transition GO:1901990 130 0.030
positive regulation of catabolic process GO:0009896 105 0.030
mitotic dna damage checkpoint GO:0044773 74 0.030
axon development GO:0061564 297 0.030
posttranscriptional gene silencing GO:0016441 46 0.029
regulation of chromatin modification GO:1903308 28 0.029
regulation of protein acetylation GO:1901983 7 0.028
regulation of cell differentiation GO:0045595 302 0.028
epithelial cell migration GO:0010631 148 0.028
defense response GO:0006952 300 0.027
regulation of synapse assembly GO:0051963 94 0.027
mrna processing GO:0006397 104 0.027
negative regulation of biosynthetic process GO:0009890 277 0.027
heterocycle catabolic process GO:0046700 166 0.027
positive regulation of gene expression GO:0010628 290 0.027
regulation of embryonic development GO:0045995 68 0.027
positive regulation of cell communication GO:0010647 250 0.026
response to organic substance GO:0010033 284 0.026
positive regulation of protein modification process GO:0031401 58 0.026
cellular ketone metabolic process GO:0042180 24 0.026
positive regulation of cellular protein catabolic process GO:1903364 24 0.026
negative regulation of cellular biosynthetic process GO:0031327 277 0.026
molting cycle GO:0042303 56 0.026
gene silencing GO:0016458 138 0.025
organonitrogen compound metabolic process GO:1901564 318 0.025
endomembrane system organization GO:0010256 119 0.025
regulation of cellular protein catabolic process GO:1903362 44 0.025
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.025
ameboidal type cell migration GO:0001667 151 0.025
tube development GO:0035295 244 0.025
regionalization GO:0003002 416 0.024
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.023
nucleoside catabolic process GO:0009164 112 0.023
protein modification process GO:0036211 438 0.023
regulation of apoptotic process GO:0042981 130 0.023
dna damage checkpoint GO:0000077 78 0.023
gtp metabolic process GO:0046039 72 0.022
negative regulation of rna metabolic process GO:0051253 251 0.022
chromatin organization GO:0006325 207 0.022
negative regulation of gene expression GO:0010629 387 0.022
negative regulation of transcription dna templated GO:0045892 237 0.021
axonogenesis GO:0007409 290 0.021
regulation of protein modification process GO:0031399 112 0.021
regulation of multicellular organismal development GO:2000026 414 0.021
cellular hormone metabolic process GO:0034754 23 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
aromatic compound catabolic process GO:0019439 166 0.021
regulation of programmed cell death GO:0043067 152 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
imaginal disc derived appendage morphogenesis GO:0035114 395 0.020
regulation of cell development GO:0060284 215 0.020
pigmentation GO:0043473 75 0.020
double strand break repair GO:0006302 26 0.019
positive regulation of endopeptidase activity GO:0010950 26 0.019
organic acid metabolic process GO:0006082 103 0.019
humoral immune response GO:0006959 117 0.019
response to oxygen levels GO:0070482 59 0.019
negative regulation of cellular metabolic process GO:0031324 382 0.018
actin cytoskeleton organization GO:0030036 206 0.018
female germline ring canal formation GO:0007301 9 0.018
cell growth GO:0016049 108 0.018
cellular protein modification process GO:0006464 438 0.018
negative regulation of cell cycle process GO:0010948 109 0.018
wing disc morphogenesis GO:0007472 344 0.018
appendage morphogenesis GO:0035107 397 0.018
membrane fusion GO:0061025 42 0.017
establishment of protein localization to organelle GO:0072594 62 0.017
rna catabolic process GO:0006401 37 0.017
negative regulation of molecular function GO:0044092 51 0.017
basolateral protein localization GO:0061467 1 0.017
neuron projection guidance GO:0097485 241 0.017
epithelial cell differentiation GO:0030855 322 0.017
tissue morphogenesis GO:0048729 297 0.017
apical constriction involved in gastrulation GO:0003384 7 0.017
protein localization GO:0008104 284 0.017
endocytosis GO:0006897 310 0.017
cell cycle checkpoint GO:0000075 95 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.016
cell motility GO:0048870 251 0.016
regulation of protein metabolic process GO:0051246 256 0.016
regulation of mitotic sister chromatid separation GO:0010965 28 0.016
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
peroxisome organization GO:0007031 14 0.015
anatomical structure homeostasis GO:0060249 97 0.015
regulation of organelle organization GO:0033043 196 0.015
epidermis development GO:0008544 65 0.015
regulation of peptidase activity GO:0052547 39 0.015
positive regulation of hydrolase activity GO:0051345 78 0.015
biological adhesion GO:0022610 138 0.015
synaptic growth at neuromuscular junction GO:0051124 119 0.015
mitotic g2 dna damage checkpoint GO:0007095 69 0.015
cell junction organization GO:0034330 57 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
stem cell development GO:0048864 79 0.014
lipid biosynthetic process GO:0008610 46 0.014
chemotaxis GO:0006935 249 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
nuclear import GO:0051170 51 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
regulation of proteolysis GO:0030162 87 0.014
single organism cellular localization GO:1902580 180 0.014
eye pigmentation GO:0048069 43 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
positive regulation of signaling GO:0023056 243 0.014
spermatogenesis GO:0007283 200 0.014
meiotic nuclear division GO:0007126 151 0.014
imaginal disc derived wing morphogenesis GO:0007476 337 0.013
mitochondrion organization GO:0007005 65 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
phagocytosis GO:0006909 215 0.013
protein dna complex subunit organization GO:0071824 86 0.013
organic substance transport GO:0071702 257 0.013
muscle tissue morphogenesis GO:0060415 2 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
rna splicing GO:0008380 83 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
establishment of protein localization GO:0045184 163 0.012
cellular lipid metabolic process GO:0044255 83 0.012
eggshell formation GO:0030703 105 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
developmental pigmentation GO:0048066 68 0.012
regulation of anatomical structure morphogenesis GO:0022603 242 0.012
positive regulation of protein catabolic process GO:0045732 34 0.012
eye morphogenesis GO:0048592 260 0.012
regulation of immune system process GO:0002682 176 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.012
axon midline choice point recognition GO:0016199 26 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
ecdysteroid biosynthetic process GO:0045456 15 0.012
regulation of multi organism process GO:0043900 131 0.011
gliogenesis GO:0042063 80 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
response to wounding GO:0009611 94 0.011
gastrulation with mouth forming first GO:0001703 36 0.011
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.011
negative regulation of rna biosynthetic process GO:1902679 240 0.011
axon guidance GO:0007411 233 0.011
regulation of gtp catabolic process GO:0033124 44 0.011
instar larval development GO:0002168 55 0.011
segmentation GO:0035282 207 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
negative regulation of signal transduction GO:0009968 206 0.011
posttranscriptional gene silencing by rna GO:0035194 45 0.011
endosomal transport GO:0016197 44 0.011
positive regulation of cell motility GO:2000147 3 0.011
eye development GO:0001654 323 0.011
protein ubiquitination GO:0016567 70 0.011
response to hypoxia GO:0001666 53 0.011
lipid homeostasis GO:0055088 33 0.011
positive regulation of developmental process GO:0051094 143 0.011
dna recombination GO:0006310 32 0.011
morphogenesis of follicular epithelium GO:0016333 36 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
regulation of hydrolase activity GO:0051336 97 0.011
compound eye development GO:0048749 307 0.011
negative regulation of cell communication GO:0010648 223 0.010
ribonucleoside triphosphate catabolic process GO:0009203 108 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.010
ecdysteroid metabolic process GO:0045455 19 0.010
regulation of apoptotic signaling pathway GO:2001233 10 0.010
sister chromatid segregation GO:0000819 92 0.010
posttranscriptional regulation of gene expression GO:0010608 145 0.010
regulation of catabolic process GO:0009894 170 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
tube formation GO:0035148 21 0.010
determination of adult lifespan GO:0008340 137 0.010
mesoderm development GO:0007498 78 0.010
embryonic morphogenesis GO:0048598 206 0.010
stress activated mapk cascade GO:0051403 52 0.010

Pros35 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.078
disease of metabolism DOID:0014667 0 0.034
inherited metabolic disorder DOID:655 0 0.030
nervous system disease DOID:863 0 0.012