Drosophila melanogaster

39 known processes

Cdk4 (Dmel_CG5072)

Cyclin-dependent kinase 4

(Aliases: l(2)k06503,dCdk4,Pk53C,CG5072,l(2)sh0671,DmCdk4,cdk,CDK4/6,Cdk4/6,l(2)0671,l(2)05428,CDK4,cdk4/6,cdk4,l(2)s4639,Pk?7,8-6,Dmel\CG5072)

Cdk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic g2 m transition checkpoint GO:0044818 70 0.931
mitotic dna damage checkpoint GO:0044773 74 0.861
mitotic cell cycle phase transition GO:0044772 138 0.833
Human Worm
mitotic dna integrity checkpoint GO:0044774 75 0.688
regulation of cell cycle phase transition GO:1901987 130 0.608
Human Worm
growth GO:0040007 359 0.534
regulation of phosphorus metabolic process GO:0051174 210 0.533
cellular response to organic substance GO:0071310 132 0.455
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.447
Worm
mitotic g2 dna damage checkpoint GO:0007095 69 0.444
negative regulation of cell cycle phase transition GO:1901988 103 0.441
cell cycle g1 s phase transition GO:0044843 31 0.433
Human Worm
epithelial cell development GO:0002064 274 0.396
Human
regulation of cell cycle GO:0051726 291 0.385
Human Mouse Worm
eye morphogenesis GO:0048592 260 0.378
neuronal stem cell division GO:0036445 35 0.347
cell division GO:0051301 248 0.330
regulation of phosphorylation GO:0042325 147 0.313
regulation of growth GO:0040008 233 0.313
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.306
cell cycle phase transition GO:0044770 140 0.305
Human Worm
neuroblast division GO:0055057 35 0.305
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.303
regulation of phosphate metabolic process GO:0019220 210 0.302
immune system process GO:0002376 347 0.295
Human Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.283
regulation of cell differentiation GO:0045595 302 0.280
Human
regulation of nervous system development GO:0051960 248 0.272
regulation of developmental growth GO:0048638 174 0.268
regulation of imaginal disc derived wing size GO:0044719 20 0.268
somatic stem cell division GO:0048103 37 0.267
positive regulation of cell cycle g2 m phase transition GO:1902751 2 0.251
Human
developmental growth GO:0048589 280 0.248
phosphorylation GO:0016310 294 0.239
Human Mouse
positive regulation of gene expression GO:0010628 290 0.234
Mouse
regulation of epithelial cell proliferation GO:0050678 4 0.232
Human
reproductive structure development GO:0048608 74 0.231
Worm
positive regulation of lipid catabolic process GO:0050996 1 0.230
negative regulation of cell cycle process GO:0010948 109 0.229
Human
digestive system development GO:0055123 149 0.223
positive regulation of phosphorylation GO:0042327 87 0.212
regulation of multicellular organism growth GO:0040014 40 0.212
macromolecule catabolic process GO:0009057 161 0.210
regulation of cell cycle process GO:0010564 181 0.210
Human Worm
cellular response to endogenous stimulus GO:0071495 80 0.209
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 2 0.199
Human
regulation of cell cycle g1 s phase transition GO:1902806 23 0.197
Worm
localization of cell GO:0051674 257 0.197
negative regulation of mitotic cell cycle GO:0045930 109 0.195
tube morphogenesis GO:0035239 191 0.195
mitochondrion organization GO:0007005 65 0.193
neural precursor cell proliferation GO:0061351 75 0.191
dna replication GO:0006260 48 0.187
regulation of mitotic cell cycle phase transition GO:1901990 130 0.183
Human Worm
regulation of wnt signaling pathway GO:0030111 68 0.181
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.180
mitotic cell cycle checkpoint GO:0007093 88 0.180
negative regulation of response to stimulus GO:0048585 258 0.179
Human
positive regulation of biosynthetic process GO:0009891 316 0.178
positive regulation of protein metabolic process GO:0051247 128 0.172
establishment of localization in cell GO:0051649 402 0.172
cell migration GO:0016477 238 0.171
anterior posterior pattern specification GO:0009952 136 0.161
protein modification process GO:0036211 438 0.159
Human Mouse
positive regulation of developmental process GO:0051094 143 0.158
forebrain development GO:0030900 2 0.149
negative regulation of developmental growth GO:0048640 64 0.148
organic acid transport GO:0015849 18 0.147
camera type eye morphogenesis GO:0048593 2 0.144
limb development GO:0060173 1 0.137
cell proliferation GO:0008283 299 0.137
stem cell differentiation GO:0048863 117 0.135
Mouse
periodic partitioning GO:0007365 29 0.134
regulation of protein phosphorylation GO:0001932 64 0.134
hematopoietic or lymphoid organ development GO:0048534 57 0.132
Human Mouse
gonad development GO:0008406 50 0.132
Worm
positive regulation of multicellular organismal process GO:0051240 143 0.131
regulation of protein serine threonine kinase activity GO:0071900 25 0.129
regulation of cellular ketone metabolic process GO:0010565 3 0.127
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.125
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.122
chromosome organization GO:0051276 360 0.121
regulation of protein kinase activity GO:0045859 51 0.119
response to organic substance GO:0010033 284 0.119
g2 dna damage checkpoint GO:0031572 69 0.118
dna packaging GO:0006323 91 0.117
g1 s transition of mitotic cell cycle GO:0000082 31 0.115
Human Worm
cellular amine metabolic process GO:0044106 12 0.115
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.114
ion transport GO:0006811 145 0.113
cytoplasmic transport GO:0016482 130 0.111
gastrulation involving germ band extension GO:0010004 36 0.109
positive regulation of molecular function GO:0044093 136 0.107
asymmetric neuroblast division GO:0055059 33 0.106
positive regulation of protein phosphorylation GO:0001934 34 0.104
positive regulation of nucleic acid templated transcription GO:1903508 266 0.104
anatomical structure homeostasis GO:0060249 97 0.103
positive regulation of rna biosynthetic process GO:1902680 266 0.103
dna double strand break processing GO:0000729 3 0.101
regulation of immune system process GO:0002682 176 0.099
Human
protein catabolic process GO:0030163 101 0.098
cell cell signaling involved in cell fate commitment GO:0045168 210 0.098
positive regulation of protein kinase activity GO:0045860 25 0.097
eggshell chorion gene amplification GO:0007307 9 0.095
posttranscriptional regulation of gene expression GO:0010608 145 0.094
response to x ray GO:0010165 8 0.090
protein maturation GO:0051604 71 0.090
positive regulation of phosphate metabolic process GO:0045937 139 0.089
negative regulation of cell differentiation GO:0045596 143 0.089
Human
single organism biosynthetic process GO:0044711 206 0.088
cellular protein modification process GO:0006464 438 0.088
Human Mouse
mitotic nuclear division GO:0007067 213 0.088
Worm
cell cycle dna replication GO:0044786 23 0.086
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.085
positive regulation of growth GO:0045927 75 0.085
nuclear division GO:0000280 332 0.085
Worm
positive regulation of transport GO:0051050 92 0.083
positive regulation of cellular protein metabolic process GO:0032270 118 0.083
nuclear dna replication GO:0033260 1 0.082
asymmetric stem cell division GO:0098722 49 0.081
gland development GO:0048732 191 0.080
regulation of intracellular signal transduction GO:1902531 236 0.080
positive regulation of rna metabolic process GO:0051254 271 0.079
protein phosphorylation GO:0006468 169 0.078
Human Mouse
regulation of multicellular organismal development GO:2000026 414 0.077
Human
regulation of immune response GO:0050776 118 0.077
negative regulation of wnt signaling pathway GO:0030178 28 0.074
negative regulation of phosphorylation GO:0042326 35 0.074
positive regulation of catalytic activity GO:0043085 118 0.073
gastrulation with mouth forming first GO:0001703 36 0.072
immune response GO:0006955 246 0.070
olfactory learning GO:0008355 56 0.070
regulation of kinase activity GO:0043549 53 0.070
neutral lipid catabolic process GO:0046461 3 0.069
body morphogenesis GO:0010171 2 0.069
Worm
cell motility GO:0048870 251 0.069
intracellular transport GO:0046907 228 0.068
protein palmitoylation GO:0018345 2 0.067
transcription from rna polymerase ii promoter GO:0006366 368 0.066
cellular response to oxygen containing compound GO:1901701 79 0.065
chemosensory behavior GO:0007635 106 0.065
cellular response to dna damage stimulus GO:0006974 223 0.064
positive regulation of cell cycle GO:0045787 43 0.063
Human Worm
organelle fission GO:0048285 340 0.062
Worm
negative regulation of cell cycle GO:0045786 116 0.062
Human
purine nucleotide metabolic process GO:0006163 146 0.062
stem cell division GO:0017145 69 0.062
response to external biotic stimulus GO:0043207 293 0.061
Human
wnt signaling pathway GO:0016055 98 0.061
regionalization GO:0003002 416 0.061
stem cell proliferation GO:0072089 88 0.061
positive regulation of programmed cell death GO:0043068 62 0.061
embryonic morphogenesis GO:0048598 206 0.060
cellular response to nitrogen compound GO:1901699 51 0.060
g2 m transition of mitotic cell cycle GO:0000086 19 0.060
Human
regulation of protein modification process GO:0031399 112 0.059
hindbrain development GO:0030902 2 0.059
protein localization GO:0008104 284 0.059
response to endogenous stimulus GO:0009719 119 0.059
chromatin modification GO:0016568 147 0.058
organic substance transport GO:0071702 257 0.058
ensheathment of neurons GO:0007272 10 0.057
single organism intracellular transport GO:1902582 207 0.057
urogenital system development GO:0001655 72 0.056
regulation of transferase activity GO:0051338 58 0.056
positive regulation of phosphorus metabolic process GO:0010562 139 0.055
homeostatic process GO:0042592 199 0.054
Human
signal transduction by phosphorylation GO:0023014 107 0.054
ubiquitin dependent protein catabolic process GO:0006511 78 0.054
response to organonitrogen compound GO:0010243 75 0.054
cellular response to chemical stimulus GO:0070887 199 0.054
modification dependent macromolecule catabolic process GO:0043632 79 0.053
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.053
response to ionizing radiation GO:0010212 32 0.052
cellular response to hormone stimulus GO:0032870 44 0.052
response to insulin GO:0032868 29 0.052
protein ubiquitination GO:0016567 70 0.052
positive regulation of cellular component organization GO:0051130 156 0.052
response to nitrogen compound GO:1901698 90 0.052
neuroblast proliferation GO:0007405 74 0.051
rna capping GO:0036260 1 0.051
regulation of sister chromatid cohesion GO:0007063 2 0.051
dna damage checkpoint GO:0000077 78 0.051
tube development GO:0035295 244 0.050
negative regulation of multicellular organismal process GO:0051241 142 0.050
Human
regulation of response to stress GO:0080134 200 0.050
Human
regulation of cellular protein metabolic process GO:0032268 243 0.050
regulation of anatomical structure size GO:0090066 163 0.050
sex differentiation GO:0007548 81 0.049
Worm
morphogenesis of a branching epithelium GO:0061138 45 0.049
regulation of mapk cascade GO:0043408 92 0.049
dna metabolic process GO:0006259 227 0.047
regulation of cell division GO:0051302 72 0.047
positive regulation of response to stimulus GO:0048584 323 0.047
negative regulation of cellular metabolic process GO:0031324 382 0.046
positive regulation of kinase activity GO:0033674 25 0.046
taxis GO:0042330 304 0.046
nucleoside phosphate metabolic process GO:0006753 162 0.045
meiosis i GO:0007127 59 0.045
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.045
cellular protein catabolic process GO:0044257 83 0.044
peptidyl threonine phosphorylation GO:0018107 2 0.044
cell activation GO:0001775 9 0.044
Mouse
peptidyl threonine modification GO:0018210 3 0.044
morphogenesis of a branching structure GO:0001763 45 0.043
negative regulation of signaling GO:0023057 219 0.043
response to abiotic stimulus GO:0009628 341 0.043
positive regulation of cell migration GO:0030335 2 0.042
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.041
cellular ketone metabolic process GO:0042180 24 0.041
development of primary female sexual characteristics GO:0046545 12 0.041
digestive tract development GO:0048565 149 0.041
post embryonic appendage morphogenesis GO:0035120 385 0.040
neuron fate specification GO:0048665 12 0.040
neuron projection guidance GO:0097485 241 0.040
eye development GO:0001654 323 0.040
nucleoside catabolic process GO:0009164 112 0.040
chromosome segregation GO:0007059 157 0.039
regulation of cellular amino acid metabolic process GO:0006521 0 0.039
intracellular protein transport GO:0006886 104 0.039
positive regulation of protein modification process GO:0031401 58 0.039
positive regulation of immune response GO:0050778 63 0.039
epithelial cell differentiation GO:0030855 322 0.039
Human
dna dependent dna replication GO:0006261 17 0.039
olfactory behavior GO:0042048 97 0.039
germ cell migration GO:0008354 43 0.038
gastrulation GO:0007369 70 0.038
purine nucleoside triphosphate metabolic process GO:0009144 119 0.038
cation transport GO:0006812 110 0.038
amino acid transport GO:0006865 12 0.037
epithelial tube morphogenesis GO:0060562 88 0.037
peptidyl amino acid modification GO:0018193 105 0.037
death GO:0016265 284 0.037
maintenance of gastrointestinal epithelium GO:0030277 3 0.037
phosphorylation of rna polymerase ii c terminal domain GO:0070816 1 0.036
morphogenesis of an epithelium GO:0002009 276 0.036
cellular amide metabolic process GO:0043603 80 0.035
synapse assembly GO:0007416 143 0.035
modification dependent protein catabolic process GO:0019941 78 0.035
regulation of molecular function GO:0065009 217 0.035
spinal cord patterning GO:0021511 1 0.035
regulation of canonical wnt signaling pathway GO:0060828 15 0.035
embryo development ending in birth or egg hatching GO:0009792 152 0.034
Worm
carboxylic acid transport GO:0046942 18 0.034
asymmetric cell division GO:0008356 37 0.034
chromatin organization GO:0006325 207 0.034
defense response to bacterium GO:0042742 178 0.034
synaptic growth at neuromuscular junction GO:0051124 119 0.033
regulation of cysteine type endopeptidase activity GO:2000116 27 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.033
response to peptide hormone GO:0043434 29 0.033
positive regulation of signal transduction GO:0009967 223 0.033
regulation of protein stability GO:0031647 43 0.033
positive regulation of stem cell differentiation GO:2000738 3 0.032
positive regulation of developmental growth GO:0048639 62 0.032
hemopoiesis GO:0030097 46 0.032
Human Mouse
cellular macromolecule localization GO:0070727 220 0.031
nephron morphogenesis GO:0072028 3 0.031
cellular response to peptide hormone stimulus GO:0071375 28 0.031
endomitotic cell cycle GO:0007113 7 0.030
protein complex assembly GO:0006461 200 0.030
limb morphogenesis GO:0035108 1 0.030
segment polarity determination GO:0007367 25 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.029
columnar cuboidal epithelial cell development GO:0002066 249 0.029
Human
positive regulation of feeding behavior GO:2000253 8 0.029
dna integrity checkpoint GO:0031570 81 0.029
reproductive system development GO:0061458 74 0.029
Worm
cellular response to peptide GO:1901653 28 0.029
dna endoreduplication GO:0042023 22 0.029
immune effector process GO:0002252 98 0.028
regulation of proteolysis GO:0030162 87 0.028
cellular macromolecule catabolic process GO:0044265 136 0.028
mapk cascade GO:0000165 107 0.027
purine ribonucleotide metabolic process GO:0009150 145 0.027
regulation of protein import into nucleus GO:0042306 28 0.027
carboxylic acid metabolic process GO:0019752 92 0.027
proteolysis GO:0006508 192 0.027
cell cycle g2 m phase transition GO:0044839 22 0.027
Human
development of primary sexual characteristics GO:0045137 50 0.027
Worm
lateral inhibition GO:0046331 206 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.026
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.026
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.026
inositol lipid mediated signaling GO:0048017 4 0.026
organic substance catabolic process GO:1901575 308 0.026
purine containing compound metabolic process GO:0072521 155 0.026
vesicle mediated transport GO:0016192 381 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.025
amine metabolic process GO:0009308 12 0.025
meiotic cell cycle phase transition GO:0044771 4 0.025
response to radiation GO:0009314 155 0.025
synapse organization GO:0050808 196 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.025
regulation of catalytic activity GO:0050790 185 0.025
regulation of intracellular transport GO:0032386 64 0.025
regulation of insulin receptor signaling pathway GO:0046626 17 0.025
compound eye development GO:0048749 307 0.025
enzyme linked receptor protein signaling pathway GO:0007167 179 0.024
synaptonemal complex organization GO:0070193 5 0.024
innate immune response GO:0045087 144 0.024
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.024
Human Worm
negative regulation of programmed cell death GO:0043069 72 0.024
programmed cell death GO:0012501 257 0.024
glycosyl compound metabolic process GO:1901657 127 0.023
positive regulation of signaling GO:0023056 243 0.023
tissue morphogenesis GO:0048729 297 0.023
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.023
Human
cellular lipid metabolic process GO:0044255 83 0.023
negative regulation of growth GO:0045926 84 0.023
protein heterooligomerization GO:0051291 4 0.023
positive regulation of proteolysis GO:0045862 52 0.023
purine nucleoside triphosphate catabolic process GO:0009146 108 0.023
establishment of organelle localization GO:0051656 122 0.022
axis specification GO:0009798 167 0.022
somatic muscle development GO:0007525 66 0.022
regulation of neural precursor cell proliferation GO:2000177 35 0.022
cell junction organization GO:0034330 57 0.022
retina development in camera type eye GO:0060041 4 0.022
male gonad development GO:0008584 9 0.022
sex comb development GO:0045498 8 0.022
negative regulation of cell proliferation GO:0008285 69 0.022
Human
segmentation GO:0035282 207 0.021
neurological system process GO:0050877 358 0.021
synaptic transmission dopaminergic GO:0001963 2 0.021
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.021
response to biotic stimulus GO:0009607 294 0.021
Human
regulation of cell development GO:0060284 215 0.021
endocytosis GO:0006897 310 0.021
negative regulation of epithelial cell proliferation GO:0050680 4 0.021
Human
response to bacterium GO:0009617 198 0.021
response to organic cyclic compound GO:0014070 89 0.021
protein processing GO:0016485 68 0.021
regulation of dna replication GO:0006275 13 0.021
protein complex biogenesis GO:0070271 201 0.021
regulation of autophagy GO:0010506 62 0.020
positive regulation of transferase activity GO:0051347 26 0.020
branching morphogenesis of an epithelial tube GO:0048754 45 0.020
fatty acid beta oxidation GO:0006635 6 0.020
multicellular organismal aging GO:0010259 140 0.020
development of primary male sexual characteristics GO:0046546 9 0.020
cell cycle arrest GO:0007050 4 0.020
Human
smoothened signaling pathway GO:0007224 49 0.020
cell aging GO:0007569 2 0.020
Human
appendage morphogenesis GO:0035107 397 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.020
apoptotic process involved in morphogenesis GO:0060561 3 0.019
regulation of neuron differentiation GO:0045664 103 0.019
response to oxygen containing compound GO:1901700 200 0.019
larval development GO:0002164 104 0.019
Worm
secretion by cell GO:0032940 101 0.019
negative regulation of gene expression GO:0010629 387 0.019
somatic stem cell maintenance GO:0035019 14 0.019
positive regulation of macromolecule metabolic process GO:0010604 405 0.019
Mouse
proteasomal protein catabolic process GO:0010498 59 0.019
cellular response to oxygen levels GO:0071453 30 0.019
ribonucleoside catabolic process GO:0042454 112 0.019
transmission of nerve impulse GO:0019226 12 0.019
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.019
peripheral nervous system development GO:0007422 52 0.019
dna recombination GO:0006310 32 0.019
negative regulation of chromosome segregation GO:0051985 14 0.019
response to other organism GO:0051707 293 0.019
Human
positive regulation of cell communication GO:0010647 250 0.019
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.019
regulation of protein catabolic process GO:0042176 55 0.019
positive regulation of cell motility GO:2000147 3 0.018
negative regulation of cell communication GO:0010648 223 0.018
catabolic process GO:0009056 409 0.018
negative regulation of intracellular signal transduction GO:1902532 57 0.018
defense response GO:0006952 300 0.018
cuticle development GO:0042335 86 0.018
meiotic nuclear division GO:0007126 151 0.018
Worm
histone modification GO:0016570 106 0.018
connective tissue development GO:0061448 3 0.018
regulation of intracellular protein transport GO:0033157 46 0.018
lipid localization GO:0010876 54 0.018
regulation of synapse assembly GO:0051963 94 0.017
apoptotic process GO:0006915 159 0.017
phagocytosis GO:0006909 215 0.017
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
cellular catabolic process GO:0044248 372 0.016
spindle organization GO:0007051 253 0.016
negative regulation of proteolysis GO:0045861 31 0.016
ribonucleotide metabolic process GO:0009259 145 0.016
immune system development GO:0002520 57 0.016
Human Mouse
glial cell development GO:0021782 27 0.016
positive regulation of transcription dna templated GO:0045893 266 0.016
germarium derived oocyte fate determination GO:0007294 26 0.016
hemocyte differentiation GO:0042386 38 0.016
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.016
sensory organ morphogenesis GO:0090596 260 0.016
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 9 0.015
negative regulation of developmental process GO:0051093 201 0.015
Human
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.015
cellular response to organonitrogen compound GO:0071417 36 0.015
eye antennal disc morphogenesis GO:0007455 34 0.015
negative regulation of phosphate metabolic process GO:0045936 45 0.015
phosphatidylinositol mediated signaling GO:0048015 4 0.015
single organism cellular localization GO:1902580 180 0.015
regulation of mitosis GO:0007088 56 0.015
nephron epithelium morphogenesis GO:0072088 3 0.015
dorsal ventral axis specification GO:0009950 66 0.015
axonogenesis GO:0007409 290 0.015
macromolecular complex assembly GO:0065003 256 0.015
kidney development GO:0001822 3 0.015
mesenchymal cell development GO:0014031 1 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.015
positive regulation of apoptotic process GO:0043065 47 0.015
regulation of macroautophagy GO:0016241 15 0.015
chromosome separation GO:0051304 42 0.015
protein targeting GO:0006605 64 0.014
regulation of innate immune response GO:0045088 71 0.014
positive regulation of intracellular transport GO:0032388 42 0.014
single organism catabolic process GO:0044712 228 0.014
camera type eye development GO:0043010 4 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
Human Worm
neuronal action potential GO:0019228 10 0.014
regulation of cell death GO:0010941 173 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.014
establishment of protein localization GO:0045184 163 0.014
immune response activating signal transduction GO:0002757 2 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
negative regulation of canonical wnt signaling pathway GO:0090090 6 0.014
organonitrogen compound metabolic process GO:1901564 318 0.014
transmembrane transport GO:0055085 139 0.014
regulation of cellular response to stress GO:0080135 89 0.014
Human
response to nutrient levels GO:0031667 114 0.014
associative learning GO:0008306 65 0.014
retina morphogenesis in camera type eye GO:0060042 2 0.013
regulation of smoothened signaling pathway GO:0008589 28 0.013
cell fate specification GO:0001708 71 0.013
positive regulation of cell death GO:0010942 69 0.013
response to wounding GO:0009611 94 0.013
imaginal disc derived wing morphogenesis GO:0007476 337 0.013
spinal cord dorsal ventral patterning GO:0021513 1 0.013
negative regulation of protein modification process GO:0031400 29 0.013
negative regulation of dna dependent dna replication GO:2000104 2 0.013
negative regulation of dna replication GO:0008156 7 0.013
open tracheal system development GO:0007424 204 0.013
regulation of organ growth GO:0046620 42 0.013
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.013
regulation of immune effector process GO:0002697 52 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
positive regulation of protein transport GO:0051222 37 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
negative regulation of dna metabolic process GO:0051053 12 0.012
single organism nuclear import GO:1902593 51 0.012
chemotaxis GO:0006935 249 0.012
cellular polysaccharide metabolic process GO:0044264 11 0.012
response to metal ion GO:0010038 23 0.012
positive regulation of organ growth GO:0046622 12 0.012
cell growth GO:0016049 108 0.012
cellular lipid catabolic process GO:0044242 16 0.012
organic acid metabolic process GO:0006082 103 0.012
nitrogen compound transport GO:0071705 85 0.012
negative regulation of signal transduction GO:0009968 206 0.012
response to hypoxia GO:0001666 53 0.012
oocyte maturation GO:0001556 3 0.012
genitalia development GO:0048806 26 0.012
Worm
dna amplification GO:0006277 11 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.012
stress activated mapk cascade GO:0051403 52 0.012
cellular response to insulin stimulus GO:0032869 28 0.012
regulation of cell growth GO:0001558 43 0.012
regulation of chromatin binding GO:0035561 3 0.012
respiratory system development GO:0060541 213 0.012
monocarboxylic acid catabolic process GO:0072329 10 0.012
eye antennal disc development GO:0035214 60 0.011
insulin like growth factor receptor signaling pathway GO:0048009 5 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
gliogenesis GO:0042063 80 0.011
Human
defense response to other organism GO:0098542 225 0.011
regulation of phosphatase activity GO:0010921 3 0.011
positive regulation of wnt signaling pathway GO:0030177 25 0.011
nephron epithelium development GO:0072009 3 0.011
cell recognition GO:0008037 102 0.011
spermatogenesis GO:0007283 200 0.011
anion transmembrane transport GO:0098656 26 0.011
telencephalon development GO:0021537 2 0.011
enteroendocrine cell differentiation GO:0035883 1 0.011
Human

Cdk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.559
disease of cellular proliferation DOID:14566 0 0.559
organ system cancer DOID:0050686 0 0.203
musculoskeletal system cancer DOID:0060100 0 0.043
large intestine cancer DOID:5672 0 0.037
gastrointestinal system cancer DOID:3119 0 0.037
intestinal cancer DOID:10155 0 0.037
colorectal cancer DOID:9256 0 0.037
connective tissue cancer DOID:201 0 0.016
thoracic cancer DOID:5093 0 0.014