Drosophila melanogaster

60 known processes

Sirt2 (Dmel_CG5085)

CG5085 gene product from transcript CG5085-RA

(Aliases: dSIRT2,D.mel2,Dmel\CG5085,CG5085)

Sirt2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.107
organic substance catabolic process GO:1901575 308 0.092
cellular protein modification process GO:0006464 438 0.085
protein modification process GO:0036211 438 0.071
small molecule metabolic process GO:0044281 305 0.070
anterior posterior pattern specification GO:0009952 136 0.069
epithelial cell development GO:0002064 274 0.066
columnar cuboidal epithelial cell development GO:0002066 249 0.063
mitotic cell cycle phase transition GO:0044772 138 0.063
establishment of localization in cell GO:0051649 402 0.057
Rat
positive regulation of cellular biosynthetic process GO:0031328 316 0.057
organelle fission GO:0048285 340 0.054
protein modification by small protein conjugation or removal GO:0070647 106 0.050
regulation of cell cycle phase transition GO:1901987 130 0.049
positive regulation of lipid catabolic process GO:0050996 1 0.048
catabolic process GO:0009056 409 0.047
response to oxygen containing compound GO:1901700 200 0.046
regionalization GO:0003002 416 0.044
positive regulation of catabolic process GO:0009896 105 0.043
locomotory behavior GO:0007626 176 0.042
developmental growth GO:0048589 280 0.041
response to abiotic stimulus GO:0009628 341 0.041
negative regulation of mitotic cell cycle GO:0045930 109 0.041
cellular macromolecule catabolic process GO:0044265 136 0.039
regulation of protein metabolic process GO:0051246 256 0.038
cell migration GO:0016477 238 0.038
ion transport GO:0006811 145 0.038
positive regulation of biosynthetic process GO:0009891 316 0.037
blastoderm segmentation GO:0007350 159 0.037
cellular catabolic process GO:0044248 372 0.036
mitotic g2 m transition checkpoint GO:0044818 70 0.036
compound eye morphogenesis GO:0001745 249 0.036
regulation of catalytic activity GO:0050790 185 0.036
localization of cell GO:0051674 257 0.036
regulation of cell cycle process GO:0010564 181 0.035
negative regulation of cell cycle phase transition GO:1901988 103 0.035
programmed cell death GO:0012501 257 0.034
Rat
regulation of localization GO:0032879 275 0.034
Rat
tripartite regional subdivision GO:0007351 103 0.033
nuclear division GO:0000280 332 0.033
regulation of phosphorylation GO:0042325 147 0.033
Rat
positive regulation of rna biosynthetic process GO:1902680 266 0.032
single organism intracellular transport GO:1902582 207 0.032
positive regulation of rna metabolic process GO:0051254 271 0.031
covalent chromatin modification GO:0016569 106 0.031
regulation of mitotic cell cycle GO:0007346 190 0.031
negative regulation of cell cycle process GO:0010948 109 0.031
regulation of mitotic cell cycle phase transition GO:1901990 130 0.030
cell motility GO:0048870 251 0.030
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.029
jak stat cascade GO:0007259 49 0.029
developmental maturation GO:0021700 172 0.029
negative regulation of transcription dna templated GO:0045892 237 0.027
organelle assembly GO:0070925 198 0.027
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
positive regulation of gene expression GO:0010628 290 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.025
cilium organization GO:0044782 41 0.025
protein modification by small protein conjugation GO:0032446 79 0.025
regulation of anatomical structure size GO:0090066 163 0.025
growth GO:0040007 359 0.025
chromatin remodeling GO:0006338 72 0.025
axis specification GO:0009798 167 0.025
wing disc morphogenesis GO:0007472 344 0.025
cell cycle phase transition GO:0044770 140 0.025
dna damage checkpoint GO:0000077 78 0.025
segmentation GO:0035282 207 0.025
cellular response to chemical stimulus GO:0070887 199 0.024
modification dependent macromolecule catabolic process GO:0043632 79 0.024
vesicle mediated transport GO:0016192 381 0.024
response to organic substance GO:0010033 284 0.024
positive regulation of nucleic acid templated transcription GO:1903508 266 0.024
phagocytosis GO:0006909 215 0.024
regulation of cellular protein metabolic process GO:0032268 243 0.024
taxis GO:0042330 304 0.024
regulation of cell cycle GO:0051726 291 0.023
respiratory system development GO:0060541 213 0.023
anterior posterior axis specification GO:0009948 109 0.023
regulation of neuron differentiation GO:0045664 103 0.023
positive regulation of macromolecule metabolic process GO:0010604 405 0.023
regulation of nurse cell apoptotic process GO:0045477 9 0.023
telencephalon development GO:0021537 2 0.023
chromatin modification GO:0016568 147 0.023
ovarian follicle cell development GO:0030707 248 0.023
learning or memory GO:0007611 141 0.022
macromolecule catabolic process GO:0009057 161 0.022
proteolysis GO:0006508 192 0.022
endocytosis GO:0006897 310 0.022
embryonic axis specification GO:0000578 107 0.022
regulation of molecular function GO:0065009 217 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.022
cellular response to organic substance GO:0071310 132 0.022
phosphorylation GO:0016310 294 0.022
Rat
modification dependent protein catabolic process GO:0019941 78 0.022
regulation of cell death GO:0010941 173 0.022
Rat
negative regulation of developmental process GO:0051093 201 0.021
Rat
regulation of catabolic process GO:0009894 170 0.021
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.021
single organism behavior GO:0044708 391 0.021
regulation of nervous system development GO:0051960 248 0.021
Rat
negative regulation of gene expression GO:0010629 387 0.021
female meiotic division GO:0007143 70 0.021
organonitrogen compound metabolic process GO:1901564 318 0.021
embryonic pattern specification GO:0009880 174 0.020
mitotic cell cycle embryonic GO:0045448 38 0.020
positive regulation of transcription dna templated GO:0045893 266 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
epithelial cell migration GO:0010631 148 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.020
axon development GO:0061564 297 0.020
transmembrane transport GO:0055085 139 0.020
protein ubiquitination GO:0016567 70 0.020
regulation of neurogenesis GO:0050767 158 0.019
Rat
regulation of immune system process GO:0002682 176 0.019
protein catabolic process GO:0030163 101 0.019
adult locomotory behavior GO:0008344 76 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
immune response regulating signaling pathway GO:0002764 2 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
Rat
positive regulation of signal transduction GO:0009967 223 0.019
gtp catabolic process GO:0006184 72 0.018
mitotic g2 dna damage checkpoint GO:0007095 69 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.018
mitotic dna damage checkpoint GO:0044773 74 0.018
meiotic cell cycle process GO:1903046 132 0.018
single organism membrane organization GO:0044802 93 0.018
forebrain development GO:0030900 2 0.018
spermatogenesis GO:0007283 200 0.018
positive regulation of response to stimulus GO:0048584 323 0.018
amine metabolic process GO:0009308 12 0.017
regulation of multi organism process GO:0043900 131 0.017
epithelial cell differentiation GO:0030855 322 0.017
regulation of cell size GO:0008361 63 0.017
microtubule based movement GO:0007018 51 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
g2 dna damage checkpoint GO:0031572 69 0.017
ubiquitin dependent protein catabolic process GO:0006511 78 0.016
peptide metabolic process GO:0006518 80 0.016
positive regulation of cell motility GO:2000147 3 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.016
response to wounding GO:0009611 94 0.016
central nervous system development GO:0007417 201 0.016
Rat
antimicrobial humoral response GO:0019730 99 0.016
organonitrogen compound catabolic process GO:1901565 128 0.016
adult behavior GO:0030534 137 0.016
cation transport GO:0006812 110 0.016
gene silencing GO:0016458 138 0.016
synaptic transmission GO:0007268 288 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
intracellular protein transmembrane transport GO:0065002 4 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
chromatin organization GO:0006325 207 0.015
sex differentiation GO:0007548 81 0.015
negative regulation of cellular metabolic process GO:0031324 382 0.015
Rat
small gtpase mediated signal transduction GO:0007264 88 0.015
positive regulation of signaling GO:0023056 243 0.015
Rat
regulation of protein modification process GO:0031399 112 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
camera type eye morphogenesis GO:0048593 2 0.015
aromatic compound catabolic process GO:0019439 166 0.015
eye development GO:0001654 323 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
acylglycerol catabolic process GO:0046464 3 0.014
establishment of protein localization GO:0045184 163 0.014
developmental programmed cell death GO:0010623 138 0.014
protein localization GO:0008104 284 0.014
protein phosphorylation GO:0006468 169 0.014
cellular protein catabolic process GO:0044257 83 0.014
gliogenesis GO:0042063 80 0.013
Rat
single organism biosynthetic process GO:0044711 206 0.013
protein modification by small protein removal GO:0070646 28 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
Rat
tissue migration GO:0090130 155 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.013
Rat
anterior posterior axis specification embryo GO:0008595 103 0.013
eye photoreceptor cell differentiation GO:0001754 145 0.013
positive regulation of cell communication GO:0010647 250 0.013
Rat
regulation of cellular component size GO:0032535 98 0.013
male gamete generation GO:0048232 201 0.013
positive regulation of cell death GO:0010942 69 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
apoptotic process GO:0006915 159 0.013
Rat
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.013
positive regulation of developmental process GO:0051094 143 0.013
heterocycle catabolic process GO:0046700 166 0.013
inositol lipid mediated signaling GO:0048017 4 0.013
negative regulation of cell cycle GO:0045786 116 0.013
glycerolipid catabolic process GO:0046503 3 0.013
response to endogenous stimulus GO:0009719 119 0.013
positive regulation of phosphorylation GO:0042327 87 0.012
dna integrity checkpoint GO:0031570 81 0.012
chromosome segregation GO:0007059 157 0.012
cellular amine metabolic process GO:0044106 12 0.012
circulatory system process GO:0003013 37 0.012
head development GO:0060322 135 0.012
intracellular signal transduction GO:0035556 300 0.012
Rat
positive regulation of programmed cell death GO:0043068 62 0.012
cilium assembly GO:0042384 38 0.012
organophosphate metabolic process GO:0019637 195 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
peroxisome organization GO:0007031 14 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
brain development GO:0007420 120 0.012
response to peptide hormone GO:0043434 29 0.012
dna replication checkpoint GO:0000076 8 0.012
translation GO:0006412 69 0.011
positive regulation of lipid metabolic process GO:0045834 4 0.011
response to lipopolysaccharide GO:0032496 4 0.011
regulation of cell proliferation GO:0042127 163 0.011
Rat
neurological system process GO:0050877 358 0.011
Rat
mitotic dna integrity checkpoint GO:0044774 75 0.011
positive regulation of cell migration GO:0030335 2 0.011
negative regulation of multicellular organismal process GO:0051241 142 0.011
Rat
monocarboxylic acid transport GO:0015718 3 0.011
organophosphate catabolic process GO:0046434 112 0.011
regulation of nucleotide metabolic process GO:0006140 62 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
memory GO:0007613 94 0.011
larval development GO:0002164 104 0.011
camera type eye development GO:0043010 4 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
cell aging GO:0007569 2 0.011
response to endoplasmic reticulum stress GO:0034976 28 0.011
appendage development GO:0048736 401 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
post embryonic appendage morphogenesis GO:0035120 385 0.011
regulation of lipid transport GO:0032368 3 0.011
cellularization GO:0007349 90 0.011
cognition GO:0050890 141 0.011
carbohydrate derivative biosynthetic process GO:1901137 85 0.011
positive regulation of molecular function GO:0044093 136 0.011
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
regulation of cell differentiation GO:0045595 302 0.011
Rat
cell growth GO:0016049 108 0.011
ion transmembrane transport GO:0034220 122 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
Rat
response to nitrogen compound GO:1901698 90 0.010
regulation of autophagy GO:0010506 62 0.010
heart contraction GO:0060047 26 0.010
negative regulation of cellular biosynthetic process GO:0031327 277 0.010
immune response activating signal transduction GO:0002757 2 0.010
eggshell formation GO:0030703 105 0.010
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.010
negative regulation of rna biosynthetic process GO:1902679 240 0.010
protein transport GO:0015031 155 0.010
axon guidance GO:0007411 233 0.010
regulation of protein catabolic process GO:0042176 55 0.010
photoreceptor cell differentiation GO:0046530 170 0.010

Sirt2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
nervous system disease DOID:863 0 0.038
diabetes mellitus DOID:9351 0 0.025
disease of metabolism DOID:0014667 0 0.025
carbohydrate metabolism disease DOID:0050013 0 0.025
glucose metabolism disease DOID:4194 0 0.025
acquired metabolic disease DOID:0060158 0 0.025
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
central nervous system disease DOID:331 0 0.014
neurodegenerative disease DOID:1289 0 0.014
thoracic cancer DOID:5093 0 0.011
organ system cancer DOID:0050686 0 0.011
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011