Drosophila melanogaster

99 known processes

Lrrk (Dmel_CG5483)

Leucine-rich repeat kinase

(Aliases: dLRRK,Dmel\CG5483,CG5483,LRRK,CT17358,lrrk)

Lrrk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuromuscular junction development GO:0007528 149 0.922
synaptic transmission GO:0007268 288 0.884
cellular protein modification process GO:0006464 438 0.543
cilium assembly GO:0042384 38 0.458
protein modification by small protein conjugation or removal GO:0070647 106 0.457
Human
adult locomotory behavior GO:0008344 76 0.443
negative regulation of nervous system development GO:0051961 92 0.442
dna metabolic process GO:0006259 227 0.441
sperm mitochondrion organization GO:0030382 7 0.394
tube development GO:0035295 244 0.394
regulation of cellular component biogenesis GO:0044087 201 0.366
synaptic growth at neuromuscular junction GO:0051124 119 0.341
regulation of neuron projection development GO:0010975 69 0.323
Human Mouse
adult behavior GO:0030534 137 0.319
establishment of organelle localization GO:0051656 122 0.317
cell growth GO:0016049 108 0.306
Worm
organelle localization GO:0051640 148 0.289
signal release GO:0023061 49 0.289
Human
synapse organization GO:0050808 196 0.283
protein modification process GO:0036211 438 0.263
regulation of synaptic transmission GO:0050804 69 0.259
single organism cellular localization GO:1902580 180 0.246
regionalization GO:0003002 416 0.244
negative regulation of cell communication GO:0010648 223 0.243
purine nucleotide metabolic process GO:0006163 146 0.223
Human
aromatic compound catabolic process GO:0019439 166 0.207
Human
homeostatic process GO:0042592 199 0.203
Human Mouse
ribose phosphate metabolic process GO:0019693 145 0.202
Human
locomotory behavior GO:0007626 176 0.202
Mouse
regulation of neurotransmitter levels GO:0001505 38 0.201
Human
ribonucleotide metabolic process GO:0009259 145 0.196
Human
developmental growth GO:0048589 280 0.193
Worm
cation transmembrane transport GO:0098655 88 0.188
ribonucleoside metabolic process GO:0009119 127 0.187
Human
growth GO:0040007 359 0.186
Worm
cellular response to dna damage stimulus GO:0006974 223 0.184
vesicle localization GO:0051648 55 0.184
glycosyl compound metabolic process GO:1901657 127 0.173
Human
synapse assembly GO:0007416 143 0.173
nucleotide metabolic process GO:0009117 161 0.171
Human
synaptic vesicle transport GO:0048489 50 0.171
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.171
Human
purine ribonucleotide metabolic process GO:0009150 145 0.170
Human
regulation of nervous system development GO:0051960 248 0.168
catabolic process GO:0009056 409 0.166
Human Mouse
nucleobase containing compound catabolic process GO:0034655 165 0.157
Human
nucleoside catabolic process GO:0009164 112 0.155
Human
macromolecular complex assembly GO:0065003 256 0.143
organic substance catabolic process GO:1901575 308 0.142
Human Mouse
regulation of growth GO:0040008 233 0.139
purine nucleotide catabolic process GO:0006195 109 0.138
Human
dendrite development GO:0016358 204 0.137
Human Mouse
purine nucleoside monophosphate metabolic process GO:0009126 50 0.133
regulation of secretion by cell GO:1903530 39 0.131
Human
synaptic vesicle localization GO:0097479 53 0.128
ribonucleoside triphosphate catabolic process GO:0009203 108 0.124
Human
organelle fission GO:0048285 340 0.124
protein localization GO:0008104 284 0.121
Human Mouse Worm
brain development GO:0007420 120 0.121
Human
axonogenesis GO:0007409 290 0.119
Worm
purine nucleoside triphosphate metabolic process GO:0009144 119 0.118
Human
purine containing compound metabolic process GO:0072521 155 0.116
Human
cellular macromolecule localization GO:0070727 220 0.115
Human Mouse Worm
regulation of localization GO:0032879 275 0.115
cellular catabolic process GO:0044248 372 0.113
Human Mouse
regulation of dendrite morphogenesis GO:0048814 28 0.112
Human Mouse
neuron neuron synaptic transmission GO:0007270 14 0.111
Mouse
regulation of multicellular organismal development GO:2000026 414 0.111
purine nucleoside metabolic process GO:0042278 127 0.111
Human
positive regulation of signal transduction GO:0009967 223 0.108
Human Mouse
nucleoside triphosphate metabolic process GO:0009141 120 0.106
Human
cell death GO:0008219 279 0.105
Human
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.104
tube morphogenesis GO:0035239 191 0.104
nucleoside triphosphate catabolic process GO:0009143 108 0.104
Human
response to organonitrogen compound GO:0010243 75 0.104
Human
nuclear division GO:0000280 332 0.103
regulation of neurogenesis GO:0050767 158 0.101
Human Mouse
cellular component assembly involved in morphogenesis GO:0010927 151 0.101
regulation of cell projection organization GO:0031344 92 0.101
Human Mouse
regulation of vesicle mediated transport GO:0060627 59 0.101
programmed cell death GO:0012501 257 0.100
Human
ribonucleoside triphosphate metabolic process GO:0009199 119 0.100
Human
regulation of phosphorus metabolic process GO:0051174 210 0.099
Human Mouse
organophosphate catabolic process GO:0046434 112 0.097
Human
death GO:0016265 284 0.095
Human
exocytosis GO:0006887 28 0.093
Human
establishment of vesicle localization GO:0051650 51 0.092
negative regulation of gene expression epigenetic GO:0045814 77 0.090
response to oxygen containing compound GO:1901700 200 0.089
Human
positive regulation of cellular component organization GO:0051130 156 0.089
regulation of cellular protein metabolic process GO:0032268 243 0.088
Human Mouse
positive regulation of cell communication GO:0010647 250 0.087
Human Mouse
organophosphate metabolic process GO:0019637 195 0.084
Human
mitochondrion organization GO:0007005 65 0.084
regulation of transport GO:0051049 181 0.083
protein ubiquitination GO:0016567 70 0.081
Human
regulation of cellular amino acid metabolic process GO:0006521 0 0.081
cellular nitrogen compound catabolic process GO:0044270 165 0.078
Human
chromosome segregation GO:0007059 157 0.076
ribonucleotide catabolic process GO:0009261 109 0.075
Human
negative regulation of signal transduction GO:0009968 206 0.075
cellular protein localization GO:0034613 160 0.075
Human Mouse Worm
positive regulation of biosynthetic process GO:0009891 316 0.073
cellular response to oxygen containing compound GO:1901701 79 0.072
Human
ribonucleoside monophosphate metabolic process GO:0009161 51 0.072
single organism membrane organization GO:0044802 93 0.072
organonitrogen compound metabolic process GO:1901564 318 0.071
Human
response to organic substance GO:0010033 284 0.071
Human
small molecule metabolic process GO:0044281 305 0.071
Human
positive regulation of multicellular organismal process GO:0051240 143 0.070
negative regulation of cellular metabolic process GO:0031324 382 0.070
Human Mouse
synaptic vesicle endocytosis GO:0048488 28 0.069
nucleoside monophosphate metabolic process GO:0009123 52 0.068
heterocycle catabolic process GO:0046700 166 0.068
Human
nucleoside phosphate metabolic process GO:0006753 162 0.068
Human
dorsal ventral pattern formation GO:0009953 133 0.068
transmembrane transport GO:0055085 139 0.067
regulation of programmed cell death GO:0043067 152 0.067
Human
cell division GO:0051301 248 0.067
regulation of protein ubiquitination GO:0031396 22 0.066
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.066
cell migration GO:0016477 238 0.066
Human
negative regulation of multicellular organismal process GO:0051241 142 0.066
positive regulation of cellular biosynthetic process GO:0031328 316 0.066
ribonucleoside catabolic process GO:0042454 112 0.066
Human
embryonic development via the syncytial blastoderm GO:0001700 148 0.066
single organism intracellular transport GO:1902582 207 0.066
Human
mrna metabolic process GO:0016071 124 0.065
atp metabolic process GO:0046034 49 0.065
axon guidance GO:0007411 233 0.065
Worm
establishment of localization in cell GO:0051649 402 0.064
cellular macromolecular complex assembly GO:0034622 153 0.063
organelle fusion GO:0048284 46 0.063
synaptic vesicle recycling GO:0036465 28 0.063
skin development GO:0043588 65 0.063
cellular macromolecule catabolic process GO:0044265 136 0.060
Mouse
purine ribonucleoside catabolic process GO:0046130 112 0.059
Human
cellular homeostasis GO:0019725 80 0.059
regulation of protein modification process GO:0031399 112 0.058
Human Mouse
cellular amino acid metabolic process GO:0006520 61 0.058
multicellular organismal aging GO:0010259 140 0.058
Human
protein modification by small protein removal GO:0070646 28 0.058
inositol lipid mediated signaling GO:0048017 4 0.058
meiotic cell cycle process GO:1903046 132 0.057
negative regulation of signaling GO:0023057 219 0.057
establishment of synaptic vesicle localization GO:0097480 50 0.056
cell motility GO:0048870 251 0.056
Human
regulation of neuron differentiation GO:0045664 103 0.056
Human Mouse
phosphorylation GO:0016310 294 0.056
meiotic chromosome segregation GO:0045132 59 0.055
positive regulation of neurogenesis GO:0050769 41 0.055
regulation of apoptotic process GO:0042981 130 0.055
phosphatidylinositol mediated signaling GO:0048015 4 0.055
central nervous system development GO:0007417 201 0.053
Human
single organism catabolic process GO:0044712 228 0.053
Human
positive regulation of signaling GO:0023056 243 0.052
Human Mouse
negative regulation of gene expression GO:0010629 387 0.052
Human
intracellular transport GO:0046907 228 0.052
Human
microtubule based transport GO:0010970 42 0.052
apoptotic process GO:0006915 159 0.051
membrane organization GO:0061024 112 0.050
regulation of organelle organization GO:0033043 196 0.050
chemotaxis GO:0006935 249 0.050
Worm
posttranscriptional regulation of gene expression GO:0010608 145 0.050
chromatin assembly GO:0031497 48 0.049
regulation of catabolic process GO:0009894 170 0.049
Human Mouse
purine ribonucleoside metabolic process GO:0046128 127 0.049
Human
cilium organization GO:0044782 41 0.049
purine containing compound catabolic process GO:0072523 112 0.048
Human
neurotransmitter transport GO:0006836 37 0.048
Human
epidermis development GO:0008544 65 0.048
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.048
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.048
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.047
protein complex biogenesis GO:0070271 201 0.047
anatomical structure homeostasis GO:0060249 97 0.047
Mouse
nucleoside metabolic process GO:0009116 127 0.046
Human
carbohydrate derivative metabolic process GO:1901135 217 0.045
Human
purine ribonucleotide catabolic process GO:0009154 109 0.045
Human
intracellular protein transport GO:0006886 104 0.044
Human
positive regulation of nervous system development GO:0051962 69 0.043
cellular response to chemical stimulus GO:0070887 199 0.043
Human
positive regulation of secretion by cell GO:1903532 20 0.043
intracellular signal transduction GO:0035556 300 0.043
Human Mouse
regulation of anatomical structure morphogenesis GO:0022603 242 0.043
Human Mouse
positive regulation of phosphorus metabolic process GO:0010562 139 0.043
Human Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.042
Human
meiotic nuclear division GO:0007126 151 0.042
regulation of response to dna damage stimulus GO:2001020 23 0.042
carbohydrate derivative catabolic process GO:1901136 118 0.042
Human
regulation of protein localization GO:0032880 76 0.041
Human
endosomal transport GO:0016197 44 0.040
inorganic cation transmembrane transport GO:0098662 61 0.040
negative regulation of neurogenesis GO:0050768 53 0.040
regulation of cellular response to stress GO:0080135 89 0.040
Human
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.040
spermatogenesis GO:0007283 200 0.040
mapk cascade GO:0000165 107 0.039
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.039
Human
positive regulation of response to stimulus GO:0048584 323 0.039
Human Mouse
organonitrogen compound catabolic process GO:1901565 128 0.039
Human
purine nucleoside catabolic process GO:0006152 112 0.039
Human
nucleobase containing small molecule metabolic process GO:0055086 174 0.039
Human
regulation of anatomical structure size GO:0090066 163 0.039
Mouse
positive regulation of jun kinase activity GO:0043507 4 0.038
regulation of protein metabolic process GO:0051246 256 0.037
Human Mouse
sister chromatid segregation GO:0000819 92 0.037
cation homeostasis GO:0055080 51 0.037
necrotic cell death GO:0070265 1 0.037
forebrain development GO:0030900 2 0.037
Human
organic cyclic compound catabolic process GO:1901361 168 0.036
Human
organic substance transport GO:0071702 257 0.035
Human
dendrite morphogenesis GO:0048813 199 0.035
Human Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.035
cellular ion homeostasis GO:0006873 39 0.034
positive regulation of organelle organization GO:0010638 65 0.034
regulation of molecular function GO:0065009 217 0.033
Human
regulation of synapse assembly GO:0051963 94 0.033
regulation of developmental growth GO:0048638 174 0.033
ion transport GO:0006811 145 0.033
cytoplasmic transport GO:0016482 130 0.033
Human
vesicle mediated transport GO:0016192 381 0.033
positive regulation of nucleic acid templated transcription GO:1903508 266 0.032
positive regulation of cellular component biogenesis GO:0044089 80 0.032
regulation of phosphate metabolic process GO:0019220 210 0.032
Human Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
neurotransmitter secretion GO:0007269 35 0.031
Human
rna processing GO:0006396 147 0.031
metal ion homeostasis GO:0055065 44 0.030
establishment or maintenance of cell polarity GO:0007163 167 0.030
nucleotide catabolic process GO:0009166 109 0.030
Human
protein modification by small protein conjugation GO:0032446 79 0.030
Human
male gamete generation GO:0048232 201 0.030
cell projection assembly GO:0030031 94 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.029
cellular response to endogenous stimulus GO:0071495 80 0.029
Human
negative regulation of growth GO:0045926 84 0.029
regulation of cell development GO:0060284 215 0.029
Human Mouse
protein phosphorylation GO:0006468 169 0.029
gene silencing GO:0016458 138 0.029
negative regulation of cellular component organization GO:0051129 108 0.029
Human
regulation of cellular localization GO:0060341 136 0.028
negative regulation of cell development GO:0010721 62 0.028
atp catabolic process GO:0006200 38 0.028
developmental cell growth GO:0048588 52 0.028
Worm
regulation of gene expression epigenetic GO:0040029 128 0.028
regulation of protein kinase activity GO:0045859 51 0.027
Human
digestive system development GO:0055123 149 0.027
organic acid metabolic process GO:0006082 103 0.027
embryo development ending in birth or egg hatching GO:0009792 152 0.027
peptidyl amino acid modification GO:0018193 105 0.026
positive regulation of cell migration GO:0030335 2 0.026
eye development GO:0001654 323 0.026
dorsal closure GO:0007391 79 0.026
positive regulation of programmed cell death GO:0043068 62 0.026
Human
head development GO:0060322 135 0.026
Human
spermatid differentiation GO:0048515 114 0.026
female meiotic division GO:0007143 70 0.026
proteolysis GO:0006508 192 0.025
Mouse
negative regulation of phosphorylation GO:0042326 35 0.025
Mouse
regulation of cellular catabolic process GO:0031329 157 0.025
Human Mouse
epithelial cell development GO:0002064 274 0.025
glycosyl compound catabolic process GO:1901658 112 0.025
Human
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.025
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.024
Human
positive regulation of cell development GO:0010720 61 0.024
protein complex assembly GO:0006461 200 0.024
organelle assembly GO:0070925 198 0.024
ribonucleoside monophosphate catabolic process GO:0009158 39 0.024
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.023
positive regulation of intracellular signal transduction GO:1902533 116 0.023
Human Mouse
mitochondrion degradation GO:0000422 8 0.023
regulation of synapse organization GO:0050807 110 0.023
positive regulation of protein modification process GO:0031401 58 0.023
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.023
positive regulation of cell motility GO:2000147 3 0.023
aging GO:0007568 143 0.023
Human
cellular protein complex assembly GO:0043623 71 0.022
establishment of protein localization GO:0045184 163 0.022
Human
positive regulation of developmental process GO:0051094 143 0.022
cytokinesis GO:0000910 90 0.022
regulation of endocytosis GO:0030100 37 0.021
modification dependent macromolecule catabolic process GO:0043632 79 0.021
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
Human
regulation of nucleoside metabolic process GO:0009118 50 0.021
Human
negative regulation of response to stimulus GO:0048585 258 0.021
Human
regulation of cell death GO:0010941 173 0.021
Human
regulation of protein catabolic process GO:0042176 55 0.021
Mouse
regulation of phosphorylation GO:0042325 147 0.020
Human Mouse
regulation of synaptic vesicle endocytosis GO:1900242 7 0.020
calcium ion transport GO:0006816 24 0.020
localization of cell GO:0051674 257 0.020
Human
enzyme linked receptor protein signaling pathway GO:0007167 179 0.020
regulation of response to stress GO:0080134 200 0.020
Human
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.020
positive regulation of transcription dna templated GO:0045893 266 0.019
response to organic cyclic compound GO:0014070 89 0.019
Human
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.019
macromolecule catabolic process GO:0009057 161 0.018
Mouse
regulation of microtubule cytoskeleton organization GO:0070507 41 0.018
negative regulation of cell differentiation GO:0045596 143 0.018
protein polymerization GO:0051258 42 0.018
negative regulation of organelle organization GO:0010639 56 0.018
Human
cation transport GO:0006812 110 0.018
stress activated mapk cascade GO:0051403 52 0.018
dna packaging GO:0006323 91 0.018
nitrogen compound transport GO:0071705 85 0.018
cellular divalent inorganic cation homeostasis GO:0072503 23 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
Human
epithelium migration GO:0090132 148 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
Human
ion transmembrane transport GO:0034220 122 0.018
chromatin modification GO:0016568 147 0.018
protein deubiquitination GO:0016579 17 0.017
negative regulation of developmental process GO:0051093 201 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.017
Mouse
vesicle organization GO:0016050 44 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
Human Mouse
membrane fusion GO:0061025 42 0.017
synaptic vesicle exocytosis GO:0016079 16 0.017
Human
cellular response to organic substance GO:0071310 132 0.017
Human
organ growth GO:0035265 56 0.017
response to endogenous stimulus GO:0009719 119 0.017
Human
peptidyl tyrosine phosphorylation GO:0018108 24 0.017
Mouse
actin filament bundle assembly GO:0051017 26 0.017
regulation of dna metabolic process GO:0051052 34 0.017
cellular response to nutrient levels GO:0031669 62 0.017
positive regulation of apoptotic signaling pathway GO:2001235 4 0.016
terminal button organization GO:0072553 19 0.016
microtubule polymerization or depolymerization GO:0031109 39 0.016
modification dependent protein catabolic process GO:0019941 78 0.016
Mouse
oxidation reduction process GO:0055114 123 0.016
Human
camera type eye morphogenesis GO:0048593 2 0.016
microtubule based movement GO:0007018 51 0.016
response to nitrogen compound GO:1901698 90 0.016
Human
purine nucleoside triphosphate catabolic process GO:0009146 108 0.016
Human
nucleoside monophosphate catabolic process GO:0009125 39 0.016
autophagy GO:0006914 108 0.016
Human Mouse
endomembrane system organization GO:0010256 119 0.016
regulation of cell differentiation GO:0045595 302 0.016
Human Mouse
negative regulation of cellular catabolic process GO:0031330 34 0.016
Human
translation GO:0006412 69 0.015
meiotic cell cycle GO:0051321 171 0.015
response to oxidative stress GO:0006979 86 0.015
Human Worm
imaginal disc pattern formation GO:0007447 91 0.015
eye morphogenesis GO:0048592 260 0.015
sensory organ morphogenesis GO:0090596 260 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
mrna catabolic process GO:0006402 33 0.015
protein localization to organelle GO:0033365 82 0.015
Human
positive regulation of catabolic process GO:0009896 105 0.015
Human Mouse
regulation of response to oxidative stress GO:1902882 4 0.015
Human
hindbrain development GO:0030902 2 0.015
spinal cord development GO:0021510 1 0.015
positive regulation of molecular function GO:0044093 136 0.014
Human
positive regulation of synapse assembly GO:0051965 29 0.014
actin filament based process GO:0030029 220 0.014
steroid biosynthetic process GO:0006694 16 0.014
developmental growth involved in morphogenesis GO:0060560 65 0.014
Worm
regulation of meiosis GO:0040020 3 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
heterochromatin organization GO:0070828 25 0.014
regulation of purine nucleotide catabolic process GO:0033121 48 0.014
Human
mitotic spindle organization GO:0007052 220 0.014
small rna loading onto risc GO:0070922 6 0.014
regulation of protein polymerization GO:0032271 28 0.013
regulation of synaptic plasticity GO:0048167 14 0.013
regulation of synaptic activity GO:0060025 9 0.013
ras protein signal transduction GO:0007265 88 0.013
blastoderm segmentation GO:0007350 159 0.013
microtubule depolymerization GO:0007019 25 0.013
gene silencing by rna GO:0031047 57 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
Human Mouse
production of small rna involved in gene silencing by rna GO:0070918 15 0.013
regulation of erbb signaling pathway GO:1901184 42 0.013
regulation of synaptic vesicle transport GO:1902803 10 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
Human
regulation of wnt signaling pathway GO:0030111 68 0.013
mrna processing GO:0006397 104 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.013
Human
regulation of ras protein signal transduction GO:0046578 93 0.013
purine nucleoside monophosphate catabolic process GO:0009128 38 0.013
axon extension GO:0048675 32 0.013
Worm
protein targeting GO:0006605 64 0.012
Human
imaginal disc derived appendage development GO:0048737 399 0.012
metal ion transport GO:0030001 74 0.012
stress activated protein kinase signaling cascade GO:0031098 55 0.012
response to temperature stimulus GO:0009266 106 0.012
neuromuscular synaptic transmission GO:0007274 67 0.012
apoptotic signaling pathway GO:0097190 27 0.012
cytoskeleton dependent intracellular transport GO:0030705 44 0.012
columnar cuboidal epithelial cell development GO:0002066 249 0.012
regulation of cellular component size GO:0032535 98 0.012
cellular ketone metabolic process GO:0042180 24 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
Human Mouse
reproductive system development GO:0061458 74 0.012
regulation of synaptic vesicle exocytosis GO:2000300 3 0.012
Human
response to radiation GO:0009314 155 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
regulation of protein complex assembly GO:0043254 42 0.012
regulation of cell substrate adhesion GO:0010810 2 0.012
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
positive regulation of protein complex assembly GO:0031334 22 0.012
oxoacid metabolic process GO:0043436 103 0.012
regulation of hemocyte proliferation GO:0035206 37 0.011
ion homeostasis GO:0050801 55 0.011
Human
negative regulation of catabolic process GO:0009895 36 0.011
Human
regulation of actin filament bundle assembly GO:0032231 8 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.011
Mouse
posttranscriptional gene silencing GO:0016441 46 0.011
secretion GO:0046903 109 0.011
Human
ameboidal type cell migration GO:0001667 151 0.011
germline stem cell asymmetric division GO:0098728 15 0.011
positive regulation of macromolecule metabolic process GO:0010604 405 0.011
Human Mouse
actin cytoskeleton organization GO:0030036 206 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
regulation of insulin receptor signaling pathway GO:0046626 17 0.011
mitotic nuclear division GO:0007067 213 0.011
positive regulation of neuron differentiation GO:0045666 26 0.011
regulation of organ growth GO:0046620 42 0.011
sensory perception of smell GO:0007608 80 0.011
neuron projection guidance GO:0097485 241 0.011
Worm
regulation of jnk cascade GO:0046328 40 0.011
embryonic pattern specification GO:0009880 174 0.011
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.010
periodic partitioning GO:0007365 29 0.010
regulation of membrane potential GO:0042391 35 0.010
Human Mouse
negative regulation of multi organism process GO:0043901 29 0.010
actin filament organization GO:0007015 126 0.010
camera type eye development GO:0043010 4 0.010
dna conformation change GO:0071103 105 0.010

Lrrk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
parkinson s disease DOID:14330 0 0.023
Human
synucleinopathy DOID:0050890 0 0.023
Human
central nervous system disease DOID:331 0 0.023
Human
disease of anatomical entity DOID:7 0 0.023
Human
neurodegenerative disease DOID:1289 0 0.023
Human
nervous system disease DOID:863 0 0.023
Human