Drosophila melanogaster

104 known processes

Ubp64E (Dmel_CG5486)

Ubiquitin-specific protease 64E

(Aliases: E(var)3-64E,Dmel\CG5486,UBP,D-Ubp-64E,E-var(3)64E,E(var)1,ubp64E,BcDNA:LD12764,ubp64,D-UBP-64E,Ubp64,CG5486)

Ubp64E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gene expression GO:0010629 387 0.421
protein modification by small protein conjugation or removal GO:0070647 106 0.175
regulation of gene expression epigenetic GO:0040029 128 0.132
protein ubiquitination GO:0016567 70 0.121
spermatogenesis GO:0007283 200 0.114
intracellular signal transduction GO:0035556 300 0.108
Mouse
cellular macromolecule localization GO:0070727 220 0.098
regulation of response to stress GO:0080134 200 0.096
Mouse
protein modification process GO:0036211 438 0.086
cellular protein modification process GO:0006464 438 0.086
imaginal disc derived appendage development GO:0048737 399 0.072
response to other organism GO:0051707 293 0.069
modification dependent macromolecule catabolic process GO:0043632 79 0.066
negative regulation of rna biosynthetic process GO:1902679 240 0.064
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.064
appendage morphogenesis GO:0035107 397 0.062
muscle structure development GO:0061061 224 0.060
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.059
regulation of organelle organization GO:0033043 196 0.059
regulation of multicellular organismal development GO:2000026 414 0.059
cellular macromolecule catabolic process GO:0044265 136 0.058
chromosome organization GO:0051276 360 0.057
response to biotic stimulus GO:0009607 294 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.054
response to bacterium GO:0009617 198 0.053
regulation of cell proliferation GO:0042127 163 0.052
single organism intracellular transport GO:1902582 207 0.050
nuclear division GO:0000280 332 0.047
transcription from rna polymerase ii promoter GO:0006366 368 0.046
regulation of cell differentiation GO:0045595 302 0.046
mitotic spindle organization GO:0007052 220 0.046
response to external biotic stimulus GO:0043207 293 0.046
immune system process GO:0002376 347 0.044
defense response to bacterium GO:0042742 178 0.042
antimicrobial humoral response GO:0019730 99 0.042
humoral immune response GO:0006959 117 0.042
intracellular transport GO:0046907 228 0.041
protein localization GO:0008104 284 0.041
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.040
positive regulation of nucleic acid templated transcription GO:1903508 266 0.040
appendage development GO:0048736 401 0.039
imaginal disc derived appendage morphogenesis GO:0035114 395 0.038
modification dependent protein catabolic process GO:0019941 78 0.037
cell cell signaling involved in cell fate commitment GO:0045168 210 0.037
negative regulation of immune system process GO:0002683 50 0.036
lateral inhibition GO:0046331 206 0.036
cellular catabolic process GO:0044248 372 0.036
cellular macromolecular complex assembly GO:0034622 153 0.036
macromolecule catabolic process GO:0009057 161 0.035
programmed cell death GO:0012501 257 0.035
Human Mouse
cell proliferation GO:0008283 299 0.035
pigment metabolic process GO:0042440 84 0.035
regulation of cellular component biogenesis GO:0044087 201 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.035
regulation of cellular protein metabolic process GO:0032268 243 0.035
Human
negative regulation of transcription dna templated GO:0045892 237 0.034
mrna metabolic process GO:0016071 124 0.034
single organism cellular localization GO:1902580 180 0.034
positive regulation of signal transduction GO:0009967 223 0.034
catabolic process GO:0009056 409 0.034
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.034
organic substance transport GO:0071702 257 0.033
regulation of cell development GO:0060284 215 0.033
immune response GO:0006955 246 0.031
ubiquitin dependent protein catabolic process GO:0006511 78 0.031
death GO:0016265 284 0.031
Human Mouse
cell death GO:0008219 279 0.030
Human Mouse
negative regulation of biosynthetic process GO:0009890 277 0.030
protein modification by small protein conjugation GO:0032446 79 0.030
cytoplasmic transport GO:0016482 130 0.029
positive regulation of response to stimulus GO:0048584 323 0.029
regulation of multi organism process GO:0043900 131 0.029
posttranscriptional gene silencing GO:0016441 46 0.028
imaginal disc derived wing morphogenesis GO:0007476 337 0.028
spermatid differentiation GO:0048515 114 0.028
gene silencing by rna GO:0031047 57 0.028
dendrite development GO:0016358 204 0.027
male gamete generation GO:0048232 201 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.027
regulation of notch signaling pathway GO:0008593 100 0.027
vesicle mediated transport GO:0016192 381 0.027
negative regulation of multicellular organismal process GO:0051241 142 0.026
negative regulation of nervous system development GO:0051961 92 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.026
organic substance catabolic process GO:1901575 308 0.026
protein complex assembly GO:0006461 200 0.025
macromolecular complex assembly GO:0065003 256 0.025
aromatic compound catabolic process GO:0019439 166 0.025
regulation of immune system process GO:0002682 176 0.025
negative regulation of protein metabolic process GO:0051248 85 0.025
Human
cellular protein catabolic process GO:0044257 83 0.025
negative regulation of cell proliferation GO:0008285 69 0.025
regulation of cellular response to stress GO:0080135 89 0.025
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.025
positive regulation of intracellular signal transduction GO:1902533 116 0.024
posttranscriptional regulation of gene expression GO:0010608 145 0.024
cellular protein localization GO:0034613 160 0.024
negative regulation of signal transduction GO:0009968 206 0.023
Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.023
protein depolymerization GO:0051261 31 0.023
small gtpase mediated signal transduction GO:0007264 88 0.023
establishment of protein localization GO:0045184 163 0.023
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
Human
chromatin organization GO:0006325 207 0.023
regionalization GO:0003002 416 0.022
spermatid development GO:0007286 98 0.022
regulation of cellular catabolic process GO:0031329 157 0.022
neurological system process GO:0050877 358 0.022
positive regulation of rna metabolic process GO:0051254 271 0.021
establishment of localization in cell GO:0051649 402 0.021
translation GO:0006412 69 0.021
post embryonic appendage morphogenesis GO:0035120 385 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.021
positive regulation of signaling GO:0023056 243 0.021
muscle tissue development GO:0060537 30 0.020
defense response GO:0006952 300 0.020
notch signaling pathway GO:0007219 120 0.020
mitotic nuclear division GO:0007067 213 0.020
positive regulation of cell communication GO:0010647 250 0.020
taxis GO:0042330 304 0.020
positive regulation of transcription dna templated GO:0045893 266 0.020
regulation of localization GO:0032879 275 0.020
tube morphogenesis GO:0035239 191 0.019
defense response to other organism GO:0098542 225 0.019
regulation of cell death GO:0010941 173 0.019
Human Mouse
nuclear transport GO:0051169 72 0.019
regulation of catabolic process GO:0009894 170 0.019
organelle fission GO:0048285 340 0.019
anterior posterior pattern specification GO:0009952 136 0.019
positive regulation of multicellular organismal process GO:0051240 143 0.019
axon development GO:0061564 297 0.019
protein complex biogenesis GO:0070271 201 0.018
negative regulation of developmental process GO:0051093 201 0.018
chromosome segregation GO:0007059 157 0.018
regulation of cell cycle GO:0051726 291 0.018
Human
tripartite regional subdivision GO:0007351 103 0.018
regulation of microtubule cytoskeleton organization GO:0070507 41 0.018
secretion GO:0046903 109 0.017
cytoskeleton dependent cytokinesis GO:0061640 81 0.017
negative regulation of cell communication GO:0010648 223 0.017
Mouse
nucleocytoplasmic transport GO:0006913 72 0.017
regulation of small gtpase mediated signal transduction GO:0051056 93 0.017
regulation of programmed cell death GO:0043067 152 0.017
Human Mouse
regulation of molecular function GO:0065009 217 0.017
Human
rna interference GO:0016246 27 0.017
regulation of immune response GO:0050776 118 0.016
phagocytosis GO:0006909 215 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
positive regulation of macromolecule metabolic process GO:0010604 405 0.016
gene silencing GO:0016458 138 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
rrna processing GO:0006364 3 0.016
regulation of immune effector process GO:0002697 52 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.016
positive regulation of rna biosynthetic process GO:1902680 266 0.015
myoblast fusion GO:0007520 43 0.015
phosphorylation GO:0016310 294 0.015
protein processing GO:0016485 68 0.015
Human
intracellular mrna localization GO:0008298 66 0.015
positive regulation of gene expression GO:0010628 290 0.014
muscle organ development GO:0007517 127 0.014
skeletal muscle organ development GO:0060538 48 0.014
axonogenesis GO:0007409 290 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
oocyte axis specification GO:0007309 108 0.014
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.014
eye morphogenesis GO:0048592 260 0.014
cellular protein complex disassembly GO:0043624 35 0.014
endocytosis GO:0006897 310 0.014
cytoplasm organization GO:0007028 64 0.014
positive regulation of cell motility GO:2000147 3 0.014
endomembrane system organization GO:0010256 119 0.014
mitotic cytokinesis GO:0000281 50 0.013
organophosphate metabolic process GO:0019637 195 0.013
response to organic substance GO:0010033 284 0.013
positive regulation of cell death GO:0010942 69 0.013
protein complex disassembly GO:0043241 36 0.013
ras protein signal transduction GO:0007265 88 0.013
regulation of neurogenesis GO:0050767 158 0.013
regulation of defense response to bacterium GO:1900424 30 0.013
regulation of anatomical structure size GO:0090066 163 0.013
intracellular protein transport GO:0006886 104 0.013
establishment or maintenance of cell polarity GO:0007163 167 0.013
regulation of proteasomal protein catabolic process GO:0061136 39 0.013
photoreceptor cell differentiation GO:0046530 170 0.012
protein catabolic process GO:0030163 101 0.012
pole plasm rna localization GO:0007316 52 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
sterol homeostasis GO:0055092 4 0.012
regulation of protein metabolic process GO:0051246 256 0.012
Human
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
segmentation GO:0035282 207 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
covalent chromatin modification GO:0016569 106 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
regulation of nervous system development GO:0051960 248 0.012
biological adhesion GO:0022610 138 0.012
positive regulation of biosynthetic process GO:0009891 316 0.012
macromolecular complex disassembly GO:0032984 37 0.012
mrna catabolic process GO:0006402 33 0.012
regulation of embryonic development GO:0045995 68 0.012
g protein coupled receptor signaling pathway GO:0007186 136 0.012
regulation of cellular component size GO:0032535 98 0.012
spindle organization GO:0007051 253 0.011
striated muscle myosin thick filament assembly GO:0071688 3 0.011
antibacterial peptide production GO:0002778 22 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
Human Mouse
maternal determination of anterior posterior axis embryo GO:0008358 74 0.011
compound eye morphogenesis GO:0001745 249 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
tissue morphogenesis GO:0048729 297 0.011
homeostatic process GO:0042592 199 0.011
body morphogenesis GO:0010171 2 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
oocyte anterior posterior axis specification GO:0007314 72 0.011
regulation of cellular protein catabolic process GO:1903362 44 0.011
muscle cell differentiation GO:0042692 103 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.011
regulation of reproductive process GO:2000241 54 0.011
developmental maturation GO:0021700 172 0.011
negative regulation of notch signaling pathway GO:0045746 41 0.011
cell adhesion GO:0007155 136 0.011
chromatin modification GO:0016568 147 0.011
single organism membrane organization GO:0044802 93 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
nucleus organization GO:0006997 45 0.011
microtubule organizing center organization GO:0031023 168 0.010
sister chromatid segregation GO:0000819 92 0.010
regulation of proteolysis GO:0030162 87 0.010
Human
heterocycle catabolic process GO:0046700 166 0.010
positive regulation of mapk cascade GO:0043410 63 0.010
cellular response to chemical stimulus GO:0070887 199 0.010
negative regulation of signaling GO:0023057 219 0.010
Mouse
developmental programmed cell death GO:0010623 138 0.010
oocyte differentiation GO:0009994 145 0.010
actin filament polymerization GO:0030041 27 0.010
growth GO:0040007 359 0.010
Human
centrosome organization GO:0051297 163 0.010
pole plasm oskar mrna localization GO:0045451 46 0.010
apoptotic process GO:0006915 159 0.010
Human Mouse
organic acid metabolic process GO:0006082 103 0.010
substrate adhesion dependent cell spreading GO:0034446 2 0.010
protein transport GO:0015031 155 0.010
regulation of intracellular signal transduction GO:1902531 236 0.010
Mouse
positive regulation of organelle organization GO:0010638 65 0.010
cell division GO:0051301 248 0.010

Ubp64E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
renal tubular transport disease DOID:447 0 0.070
kidney disease DOID:557 0 0.070
disease of anatomical entity DOID:7 0 0.070
urinary system disease DOID:18 0 0.070
bartter disease DOID:445 0 0.017
nervous system disease DOID:863 0 0.013