Drosophila melanogaster

5 known processes

Mlc1 (Dmel_CG5596)

Myosin alkali light chain 1

(Aliases: mlc,Mlci,Dmel\CG5596,LC1,MLC-ALK,ELC,MlcI,mlc1,mlcl,FBgn0002772,mlc-alk,CG5596,Mlc-1,DmMLC1,MLC1)

Mlc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
striated muscle cell differentiation GO:0051146 90 0.692
muscle cell differentiation GO:0042692 103 0.505
muscle thin filament assembly GO:0071689 5 0.242
muscle structure development GO:0061061 224 0.191
larval development GO:0002164 104 0.175
aging GO:0007568 143 0.170
myotube differentiation GO:0014902 46 0.160
striated muscle cell development GO:0055002 50 0.144
actin filament organization GO:0007015 126 0.138
phosphorylation GO:0016310 294 0.132
organophosphate metabolic process GO:0019637 195 0.129
skeletal muscle adaptation GO:0043501 1 0.113
striated muscle myosin thick filament assembly GO:0071688 3 0.108
cell division GO:0051301 248 0.104
growth GO:0040007 359 0.094
nucleoside triphosphate metabolic process GO:0009141 120 0.090
muscle cell development GO:0055001 50 0.086
ribonucleoside monophosphate catabolic process GO:0009158 39 0.084
regulation of cellular component size GO:0032535 98 0.083
actin filament based process GO:0030029 220 0.083
Fly
myotube cell development GO:0014904 3 0.077
cellular component assembly involved in morphogenesis GO:0010927 151 0.074
actin cytoskeleton organization GO:0030036 206 0.071
protein localization to organelle GO:0033365 82 0.068
single organism intracellular transport GO:1902582 207 0.067
nuclear transport GO:0051169 72 0.067
oviposition GO:0018991 19 0.066
Worm
establishment of localization in cell GO:0051649 402 0.064
multi multicellular organism process GO:0044706 123 0.063
Worm
cytokinesis GO:0000910 90 0.062
nucleoside triphosphate catabolic process GO:0009143 108 0.062
purine nucleoside triphosphate catabolic process GO:0009146 108 0.061
regulation of growth GO:0040008 233 0.060
nucleocytoplasmic transport GO:0006913 72 0.056
single organism nuclear import GO:1902593 51 0.055
protein targeting to nucleus GO:0044744 51 0.054
actomyosin structure organization GO:0031032 56 0.054
positive regulation of protein import into nucleus GO:0042307 21 0.054
positive regulation of phosphate metabolic process GO:0045937 139 0.052
glycerol 3 phosphate metabolic process GO:0006072 2 0.052
regulation of intracellular protein transport GO:0033157 46 0.051
actin filament based movement GO:0030048 26 0.050
Fly
cellular respiration GO:0045333 26 0.050
vesicle mediated transport GO:0016192 381 0.049
embryo development ending in birth or egg hatching GO:0009792 152 0.049
myofibril assembly GO:0030239 36 0.047
cellular protein complex assembly GO:0043623 71 0.046
chaeta development GO:0022416 97 0.045
mesoderm development GO:0007498 78 0.045
intracellular transport GO:0046907 228 0.043
regulation of actin filament depolymerization GO:0030834 3 0.043
anatomical structure homeostasis GO:0060249 97 0.042
nucleotide metabolic process GO:0009117 161 0.042
developmental growth GO:0048589 280 0.041
positive regulation of growth GO:0045927 75 0.040
regulation of cytoskeleton organization GO:0051493 89 0.040
centrosome organization GO:0051297 163 0.040
muscle tissue morphogenesis GO:0060415 2 0.039
cytoplasmic transport GO:0016482 130 0.039
positive regulation of nucleoside metabolic process GO:0045979 47 0.039
regulation of protein import into nucleus GO:0042306 28 0.038
muscle organ development GO:0007517 127 0.038
sarcomere organization GO:0045214 26 0.038
syncytium formation by plasma membrane fusion GO:0000768 43 0.038
nucleobase containing compound catabolic process GO:0034655 165 0.037
striated muscle tissue development GO:0014706 27 0.036
glycolytic process GO:0006096 6 0.035
negative regulation of actin filament depolymerization GO:0030835 2 0.035
cytoskeleton dependent cytokinesis GO:0061640 81 0.034
extracellular matrix disassembly GO:0022617 4 0.034
intracellular signal transduction GO:0035556 300 0.034
aromatic compound catabolic process GO:0019439 166 0.034
atp metabolic process GO:0046034 49 0.033
embryonic morphogenesis GO:0048598 206 0.033
ribonucleoside triphosphate catabolic process GO:0009203 108 0.031
hematopoietic progenitor cell differentiation GO:0002244 1 0.031
establishment of protein localization to organelle GO:0072594 62 0.031
cellular macromolecular complex assembly GO:0034622 153 0.031
regulation of transcription factor import into nucleus GO:0042990 22 0.030
peptidyl threonine phosphorylation GO:0018107 2 0.030
ribose phosphate metabolic process GO:0019693 145 0.029
protein targeting GO:0006605 64 0.029
protein localization to nucleus GO:0034504 55 0.029
muscle system process GO:0003012 21 0.029
cellular protein modification process GO:0006464 438 0.029
ribonucleoside monophosphate metabolic process GO:0009161 51 0.028
regulation of establishment of protein localization GO:0070201 61 0.028
ribonucleoside triphosphate metabolic process GO:0009199 119 0.028
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.028
development of primary sexual characteristics GO:0045137 50 0.027
regulation of actin filament polymerization GO:0030833 25 0.027
tissue morphogenesis GO:0048729 297 0.027
regulation of catabolic process GO:0009894 170 0.027
nuclear import GO:0051170 51 0.027
protein depolymerization GO:0051261 31 0.027
camera type eye development GO:0043010 4 0.027
purine containing compound metabolic process GO:0072521 155 0.027
regulation of anatomical structure size GO:0090066 163 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.026
posttranscriptional regulation of gene expression GO:0010608 145 0.026
organelle assembly GO:0070925 198 0.026
regulation of intracellular signal transduction GO:1902531 236 0.025
protein import into nucleus GO:0006606 51 0.025
cell motility GO:0048870 251 0.025
purine ribonucleotide metabolic process GO:0009150 145 0.025
protein catabolic process GO:0030163 101 0.025
protein transport GO:0015031 155 0.024
nucleoside monophosphate metabolic process GO:0009123 52 0.024
ribonucleotide catabolic process GO:0009261 109 0.024
carbohydrate derivative catabolic process GO:1901136 118 0.024
body morphogenesis GO:0010171 2 0.024
purine containing compound catabolic process GO:0072523 112 0.023
ribonucleoside catabolic process GO:0042454 112 0.023
small molecule metabolic process GO:0044281 305 0.023
nucleoside phosphate metabolic process GO:0006753 162 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.023
purine nucleotide catabolic process GO:0006195 109 0.023
positive regulation of atp catabolic process GO:1903291 3 0.022
purine nucleotide metabolic process GO:0006163 146 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
regulation of cytoplasmic transport GO:1903649 47 0.022
regulation of localization GO:0032879 275 0.022
cellular nitrogen compound catabolic process GO:0044270 165 0.022
protein complex biogenesis GO:0070271 201 0.022
stress fiber assembly GO:0043149 6 0.022
purine ribonucleoside catabolic process GO:0046130 112 0.021
regulation of phosphate metabolic process GO:0019220 210 0.021
protein complex assembly GO:0006461 200 0.021
nucleobase containing small molecule metabolic process GO:0055086 174 0.021
regulation of cell differentiation GO:0045595 302 0.021
syncytium formation GO:0006949 43 0.021
nucleoside monophosphate catabolic process GO:0009125 39 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.020
multicellular organism growth GO:0035264 46 0.020
muscle tissue development GO:0060537 30 0.020
purine nucleoside monophosphate metabolic process GO:0009126 50 0.020
nucleoside phosphate catabolic process GO:1901292 110 0.020
immune response GO:0006955 246 0.020
mitotic cytokinesis GO:0000281 50 0.020
protein polymerization GO:0051258 42 0.020
nadh metabolic process GO:0006734 1 0.020
localization of cell GO:0051674 257 0.019
purine nucleoside monophosphate catabolic process GO:0009128 38 0.019
cellular component disassembly GO:0022411 46 0.019
positive regulation of cell adhesion GO:0045785 10 0.019
positive regulation of hydrolase activity GO:0051345 78 0.019
cell migration GO:0016477 238 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
macromolecule catabolic process GO:0009057 161 0.018
immune system process GO:0002376 347 0.018
positive regulation of transcription factor import into nucleus GO:0042993 19 0.018
nucleus localization GO:0051647 34 0.018
stem cell differentiation GO:0048863 117 0.018
regulation of nucleocytoplasmic transport GO:0046822 35 0.017
pharynx development GO:0060465 1 0.017
purine nucleoside metabolic process GO:0042278 127 0.017
positive regulation of developmental process GO:0051094 143 0.017
regulation of protein complex disassembly GO:0043244 29 0.017
nucleoside metabolic process GO:0009116 127 0.017
skeletal muscle organ development GO:0060538 48 0.017
positive regulation of catabolic process GO:0009896 105 0.017
positive regulation of cellular catabolic process GO:0031331 95 0.016
ribonucleotide metabolic process GO:0009259 145 0.016
actin polymerization or depolymerization GO:0008154 31 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
actin filament capping GO:0051693 2 0.016
central nervous system development GO:0007417 201 0.016
nad metabolic process GO:0019674 1 0.016
regulation of actin filament length GO:0030832 27 0.016
catabolic process GO:0009056 409 0.016
regulation of actin polymerization or depolymerization GO:0008064 27 0.016
negative regulation of protein complex disassembly GO:0043242 23 0.015
actin mediated cell contraction GO:0070252 21 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.015
purine ribonucleotide catabolic process GO:0009154 109 0.015
single organism catabolic process GO:0044712 228 0.015
myosin filament assembly GO:0031034 5 0.015
macromolecular complex assembly GO:0065003 256 0.015
heterocycle catabolic process GO:0046700 166 0.014
response to oxygen containing compound GO:1901700 200 0.014
cell adhesion GO:0007155 136 0.014
positive regulation of nucleotide catabolic process GO:0030813 46 0.014
positive regulation of intracellular transport GO:0032388 42 0.014
single organism cellular localization GO:1902580 180 0.014
skeletal muscle fiber development GO:0048741 3 0.014
glycosyl compound catabolic process GO:1901658 112 0.014
regulation of cell morphogenesis GO:0022604 163 0.014
regulation of developmental growth GO:0048638 174 0.014
regulation of synapse structure and activity GO:0050803 128 0.014
defense response to bacterium GO:0042742 178 0.014
negative regulation of cellular component organization GO:0051129 108 0.013
positive regulation of nfat protein import into nucleus GO:0051533 16 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
mitotic nuclear division GO:0007067 213 0.013
intracellular protein transport GO:0006886 104 0.013
cellular catabolic process GO:0044248 372 0.013
cell aging GO:0007569 2 0.013
atp catabolic process GO:0006200 38 0.013
regulation of protein targeting GO:1903533 29 0.013
cell recognition GO:0008037 102 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.013
digestive tract development GO:0048565 149 0.013
regulation of catalytic activity GO:0050790 185 0.013
regulation of organelle organization GO:0033043 196 0.013
nfat protein import into nucleus GO:0051531 16 0.013
negative regulation of protein polymerization GO:0032272 7 0.013
regulation of protein transport GO:0051223 57 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
sex differentiation GO:0007548 81 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
regulation of cell shape GO:0008360 113 0.012
generation of precursor metabolites and energy GO:0006091 42 0.012
cardiac muscle cell differentiation GO:0055007 4 0.012
positive regulation of protein localization to nucleus GO:1900182 21 0.012
nucleoside catabolic process GO:0009164 112 0.012
positive regulation of stress fiber assembly GO:0051496 3 0.012
endocytosis GO:0006897 310 0.012
response to oxidative stress GO:0006979 86 0.012
reproductive structure development GO:0048608 74 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
regulation of protein localization to nucleus GO:1900180 29 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.012
regulation of protein localization GO:0032880 76 0.012
determination of adult lifespan GO:0008340 137 0.011
ovulation GO:0030728 4 0.011
muscle adaptation GO:0043500 1 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.011
establishment of protein localization GO:0045184 163 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
somatic muscle development GO:0007525 66 0.011
muscle contraction GO:0006936 13 0.011
regulation of multicellular organism growth GO:0040014 40 0.011
brain development GO:0007420 120 0.011
positive regulation of intracellular protein transport GO:0090316 30 0.011
phagocytosis GO:0006909 215 0.010
neurological system process GO:0050877 358 0.010
reproductive system development GO:0061458 74 0.010
sensory organ morphogenesis GO:0090596 260 0.010
regulation of purine nucleotide catabolic process GO:0033121 48 0.010
regulation of molecular function GO:0065009 217 0.010
organophosphate catabolic process GO:0046434 112 0.010

Mlc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.149
muscular disease DOID:0080000 0 0.149
heart disease DOID:114 0 0.149
cardiomyopathy DOID:0050700 0 0.149
disease of anatomical entity DOID:7 0 0.149
cardiovascular system disease DOID:1287 0 0.149
musculoskeletal system disease DOID:17 0 0.149
muscle tissue disease DOID:66 0 0.149
intrinsic cardiomyopathy DOID:0060036 0 0.055
dilated cardiomyopathy DOID:12930 0 0.035