Drosophila melanogaster

113 known processes

Ppcs (Dmel_CG5629)

Phosphopantothenoylcysteine synthetase

(Aliases: CG5629,Dmel\CG5629,anon-WO0118547.401,BcDNA:GH03502,GH03502,dPPCS,PPCS)

Ppcs biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
columnar cuboidal epithelial cell development GO:0002066 249 0.908
cytoskeleton dependent cytokinesis GO:0061640 81 0.838
germarium derived egg chamber formation GO:0007293 101 0.813
ovarian follicle cell migration GO:0007297 121 0.759
organelle fission GO:0048285 340 0.620
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.605
cellular response to external stimulus GO:0071496 66 0.593
negative regulation of cellular metabolic process GO:0031324 382 0.556
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.542
ovarian follicle cell development GO:0030707 248 0.516
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.502
male gamete generation GO:0048232 201 0.427
adult behavior GO:0030534 137 0.411
negative regulation of cellular biosynthetic process GO:0031327 277 0.373
cytokinesis GO:0000910 90 0.373
regulation of cellular protein metabolic process GO:0032268 243 0.363
appendage development GO:0048736 401 0.349
microtubule depolymerization GO:0007019 25 0.321
rhythmic process GO:0048511 106 0.313
appendage morphogenesis GO:0035107 397 0.294
imaginal disc derived wing morphogenesis GO:0007476 337 0.280
macromolecular complex assembly GO:0065003 256 0.279
negative regulation of biosynthetic process GO:0009890 277 0.275
imaginal disc derived appendage morphogenesis GO:0035114 395 0.270
cell division GO:0051301 248 0.261
regulation of organelle organization GO:0033043 196 0.254
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.245
response to organic substance GO:0010033 284 0.239
tissue migration GO:0090130 155 0.225
central nervous system development GO:0007417 201 0.223
homeostatic process GO:0042592 199 0.217
germ line cyst formation GO:0048134 44 0.215
cognition GO:0050890 141 0.212
cellular response to nutrient levels GO:0031669 62 0.200
positive regulation of cellular biosynthetic process GO:0031328 316 0.199
positive regulation of macromolecule metabolic process GO:0010604 405 0.198
single organism behavior GO:0044708 391 0.197
epithelial cell development GO:0002064 274 0.189
circadian rhythm GO:0007623 105 0.186
positive regulation of rna metabolic process GO:0051254 271 0.177
cellular response to extracellular stimulus GO:0031668 64 0.176
spermatogenesis GO:0007283 200 0.176
regulation of protein complex disassembly GO:0043244 29 0.173
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.168
cell proliferation GO:0008283 299 0.166
response to extracellular stimulus GO:0009991 116 0.165
epithelial cell differentiation GO:0030855 322 0.164
regulation of protein metabolic process GO:0051246 256 0.163
cellular response to starvation GO:0009267 61 0.162
aging GO:0007568 143 0.162
negative regulation of cell differentiation GO:0045596 143 0.158
acylglycerol homeostasis GO:0055090 19 0.157
actin filament based process GO:0030029 220 0.155
regulation of multicellular organismal development GO:2000026 414 0.152
regulation of cell cycle process GO:0010564 181 0.151
regulation of cell cycle GO:0051726 291 0.151
protein modification process GO:0036211 438 0.144
morphogenesis of follicular epithelium GO:0016333 36 0.143
learning or memory GO:0007611 141 0.142
negative regulation of gene expression GO:0010629 387 0.137
chemical homeostasis GO:0048878 92 0.134
wing disc morphogenesis GO:0007472 344 0.130
female germ line cyst formation GO:0048135 42 0.129
organonitrogen compound metabolic process GO:1901564 318 0.126
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.124
localization of cell GO:0051674 257 0.121
cell migration GO:0016477 238 0.119
small molecule metabolic process GO:0044281 305 0.119
organic substance catabolic process GO:1901575 308 0.118
transcription from rna polymerase ii promoter GO:0006366 368 0.118
dna packaging GO:0006323 91 0.118
negative regulation of rna biosynthetic process GO:1902679 240 0.118
catabolic process GO:0009056 409 0.112
photoreceptor cell differentiation GO:0046530 170 0.111
lipid homeostasis GO:0055088 33 0.111
cellular protein modification process GO:0006464 438 0.111
dendrite morphogenesis GO:0048813 199 0.109
single organism membrane organization GO:0044802 93 0.109
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.107
regulation of cell differentiation GO:0045595 302 0.105
positive regulation of gene expression GO:0010628 290 0.105
imaginal disc derived appendage development GO:0048737 399 0.105
circadian behavior GO:0048512 76 0.102
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.099
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.098
determination of adult lifespan GO:0008340 137 0.097
response to alcohol GO:0097305 95 0.097
negative regulation of cytoskeleton organization GO:0051494 30 0.095
compound eye photoreceptor cell differentiation GO:0001751 140 0.093
membrane organization GO:0061024 112 0.092
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.092
gene silencing GO:0016458 138 0.089
response to ethanol GO:0045471 59 0.089
locomotory behavior GO:0007626 176 0.088
multicellular organismal aging GO:0010259 140 0.088
negative regulation of protein complex disassembly GO:0043242 23 0.087
oocyte construction GO:0007308 112 0.085
cellular macromolecular complex assembly GO:0034622 153 0.085
vesicle mediated transport GO:0016192 381 0.085
organic acid metabolic process GO:0006082 103 0.085
actin cytoskeleton organization GO:0030036 206 0.084
compound eye morphogenesis GO:0001745 249 0.084
intracellular transport GO:0046907 228 0.084
positive regulation of protein metabolic process GO:0051247 128 0.083
cellular response to organic substance GO:0071310 132 0.083
negative regulation of cell cycle GO:0045786 116 0.082
regulation of cell division GO:0051302 72 0.082
growth GO:0040007 359 0.081
germarium derived female germ line cyst formation GO:0030727 42 0.081
establishment of localization in cell GO:0051649 402 0.081
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.079
positive regulation of response to stimulus GO:0048584 323 0.079
apoptotic process GO:0006915 159 0.079
oxoacid metabolic process GO:0043436 103 0.079
oocyte axis specification GO:0007309 108 0.077
mitotic cytokinesis GO:0000281 50 0.075
hematopoietic or lymphoid organ development GO:0048534 57 0.074
cellular response to organic cyclic compound GO:0071407 32 0.074
compound eye development GO:0048749 307 0.074
response to abiotic stimulus GO:0009628 341 0.073
immune system development GO:0002520 57 0.072
single organism intracellular transport GO:1902582 207 0.072
regulation of protein depolymerization GO:1901879 27 0.071
cellular catabolic process GO:0044248 372 0.071
regionalization GO:0003002 416 0.070
macromolecule catabolic process GO:0009057 161 0.069
oocyte differentiation GO:0009994 145 0.069
regulation of cell death GO:0010941 173 0.068
chorion containing eggshell formation GO:0007304 105 0.068
stem cell differentiation GO:0048863 117 0.068
body morphogenesis GO:0010171 2 0.067
negative regulation of cellular component organization GO:0051129 108 0.066
protein complex assembly GO:0006461 200 0.065
lipid metabolic process GO:0006629 121 0.063
cellular macromolecule catabolic process GO:0044265 136 0.063
learning GO:0007612 75 0.063
positive regulation of developmental process GO:0051094 143 0.063
endocytosis GO:0006897 310 0.063
germarium derived oocyte fate determination GO:0007294 26 0.062
multi multicellular organism process GO:0044706 123 0.062
post embryonic appendage morphogenesis GO:0035120 385 0.062
dendrite development GO:0016358 204 0.061
cell fate determination GO:0001709 91 0.060
negative regulation of developmental process GO:0051093 201 0.060
dna conformation change GO:0071103 105 0.059
nuclear division GO:0000280 332 0.059
negative regulation of rna metabolic process GO:0051253 251 0.057
brain development GO:0007420 120 0.057
developmental growth GO:0048589 280 0.056
mitochondrial fusion GO:0008053 7 0.056
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.056
associative learning GO:0008306 65 0.056
regulation of catalytic activity GO:0050790 185 0.055
positive regulation of cellular component organization GO:0051130 156 0.055
death GO:0016265 284 0.055
regulation of cell proliferation GO:0042127 163 0.055
positive regulation of biosynthetic process GO:0009891 316 0.054
oocyte development GO:0048599 124 0.054
cellular response to chemical stimulus GO:0070887 199 0.053
response to oxygen containing compound GO:1901700 200 0.053
negative regulation of protein depolymerization GO:1901880 23 0.052
carboxylic acid metabolic process GO:0019752 92 0.052
cellular amine metabolic process GO:0044106 12 0.052
regulation of mitotic cell cycle GO:0007346 190 0.052
fusome organization GO:0045478 13 0.051
cytoplasmic transport GO:0016482 130 0.051
eye morphogenesis GO:0048592 260 0.050
adult locomotory behavior GO:0008344 76 0.050
negative regulation of microtubule depolymerization GO:0007026 21 0.050
chromosome organization GO:0051276 360 0.050
chromatin modification GO:0016568 147 0.049
embryo development ending in birth or egg hatching GO:0009792 152 0.049
amine metabolic process GO:0009308 12 0.048
dorsal appendage formation GO:0046843 47 0.046
negative regulation of cell proliferation GO:0008285 69 0.046
epithelium migration GO:0090132 148 0.046
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.046
regulation of programmed cell death GO:0043067 152 0.045
positive regulation of cell communication GO:0010647 250 0.045
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.045
ovarian follicle cell stalk formation GO:0030713 17 0.044
cell motility GO:0048870 251 0.044
sensory organ precursor cell fate determination GO:0016360 19 0.043
determination of left right symmetry GO:0007368 9 0.043
meiosis ii GO:0007135 23 0.042
regulation of localization GO:0032879 275 0.042
head development GO:0060322 135 0.041
regulation of catabolic process GO:0009894 170 0.040
protein catabolic process GO:0030163 101 0.040
negative regulation of cell communication GO:0010648 223 0.040
response to ionizing radiation GO:0010212 32 0.040
positive regulation of molecular function GO:0044093 136 0.040
positive regulation of rna biosynthetic process GO:1902680 266 0.040
chromatin remodeling GO:0006338 72 0.039
negative regulation of signaling GO:0023057 219 0.039
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.038
positive regulation of signaling GO:0023056 243 0.038
synaptic transmission dopaminergic GO:0001963 2 0.038
chromatin organization GO:0006325 207 0.038
negative regulation of nucleic acid templated transcription GO:1903507 240 0.037
anterior posterior pattern specification GO:0009952 136 0.037
positive regulation of catabolic process GO:0009896 105 0.037
enzyme linked receptor protein signaling pathway GO:0007167 179 0.037
meiotic cytokinesis GO:0033206 33 0.036
regulation of gene expression epigenetic GO:0040029 128 0.036
regulation of cellular amine metabolic process GO:0033238 3 0.036
negative regulation of cell cycle process GO:0010948 109 0.036
regulation of response to stress GO:0080134 200 0.035
cell type specific apoptotic process GO:0097285 38 0.035
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.035
programmed cell death GO:0012501 257 0.034
positive regulation of cellular catabolic process GO:0031331 95 0.034
negative regulation of transcription dna templated GO:0045892 237 0.033
macroautophagy GO:0016236 42 0.033
apoptotic signaling pathway GO:0097190 27 0.032
regulation of cellular amino acid metabolic process GO:0006521 0 0.032
cystoblast division GO:0007282 10 0.032
negative regulation of multicellular organismal process GO:0051241 142 0.032
regulation of phosphorus metabolic process GO:0051174 210 0.032
positive regulation of programmed cell death GO:0043068 62 0.031
regulation of neurogenesis GO:0050767 158 0.031
regulation of transferase activity GO:0051338 58 0.031
germarium derived oocyte differentiation GO:0030706 29 0.031
ovarian fusome organization GO:0030723 11 0.031
regulation of cytoskeleton organization GO:0051493 89 0.030
positive regulation of cellular protein metabolic process GO:0032270 118 0.030
regulation of epithelial cell proliferation GO:0050678 4 0.030
negative regulation of response to stimulus GO:0048585 258 0.030
nucleobase containing compound catabolic process GO:0034655 165 0.030
negative regulation of cell cycle phase transition GO:1901988 103 0.029
regulation of synapse structure and activity GO:0050803 128 0.029
dna metabolic process GO:0006259 227 0.029
regulation of transport GO:0051049 181 0.029
regulation of phosphorylation GO:0042325 147 0.029
extracellular structure organization GO:0043062 46 0.029
regulation of microtubule based process GO:0032886 49 0.029
regulation of immune system process GO:0002682 176 0.028
organelle fusion GO:0048284 46 0.028
digestive system development GO:0055123 149 0.028
regulation of multi organism process GO:0043900 131 0.028
cellular amino acid metabolic process GO:0006520 61 0.028
regulation of anatomical structure morphogenesis GO:0022603 242 0.028
negative regulation of cellular response to oxidative stress GO:1900408 1 0.028
epithelial cell migration GO:0010631 148 0.028
mitotic cell cycle phase transition GO:0044772 138 0.028
immune system process GO:0002376 347 0.027
molting cycle GO:0042303 56 0.027
organelle assembly GO:0070925 198 0.027
regulation of mitotic cell cycle phase transition GO:1901990 130 0.027
cellular component disassembly GO:0022411 46 0.026
regulation of developmental growth GO:0048638 174 0.026
erbb signaling pathway GO:0038127 58 0.026
positive regulation of nucleic acid templated transcription GO:1903508 266 0.026
oocyte anterior posterior axis specification GO:0007314 72 0.026
photoreceptor cell fate commitment GO:0046552 41 0.025
response to starvation GO:0042594 97 0.025
regulation of apoptotic process GO:0042981 130 0.025
negative regulation of programmed cell death GO:0043069 72 0.025
cell cycle arrest GO:0007050 4 0.025
proteolysis GO:0006508 192 0.025
protein complex biogenesis GO:0070271 201 0.025
regulation of phosphate metabolic process GO:0019220 210 0.025
single organism cellular localization GO:1902580 180 0.025
ameboidal type cell migration GO:0001667 151 0.025
response to endogenous stimulus GO:0009719 119 0.025
regulation of molecular function GO:0065009 217 0.025
segmentation GO:0035282 207 0.024
positive regulation of multicellular organismal process GO:0051240 143 0.024
response to nutrient levels GO:0031667 114 0.024
regulation of microtubule cytoskeleton organization GO:0070507 41 0.024
forebrain development GO:0030900 2 0.023
hindgut development GO:0061525 58 0.023
regulation of cellular component biogenesis GO:0044087 201 0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.023
embryonic axis specification GO:0000578 107 0.022
positive regulation of phosphorus metabolic process GO:0010562 139 0.022
negative regulation of protein metabolic process GO:0051248 85 0.022
larval development GO:0002164 104 0.022
macromolecular complex disassembly GO:0032984 37 0.022
multicellular organism growth GO:0035264 46 0.022
cellular response to ionizing radiation GO:0071479 15 0.022
embryonic pattern specification GO:0009880 174 0.022
muscle tissue morphogenesis GO:0060415 2 0.021
membrane fusion GO:0061025 42 0.021
regulation of protein modification process GO:0031399 112 0.021
mitotic nuclear division GO:0007067 213 0.021
phosphorylation GO:0016310 294 0.021
regulation of neuron death GO:1901214 26 0.021
actomyosin structure organization GO:0031032 56 0.020
muscle structure development GO:0061061 224 0.020
generation of precursor metabolites and energy GO:0006091 42 0.019
cellular response to nitrogen compound GO:1901699 51 0.019
apoptotic cell clearance GO:0043277 14 0.019
chromosome condensation GO:0030261 41 0.019
intracellular protein transport GO:0006886 104 0.019
regulation of spindle organization GO:0090224 17 0.019
tube development GO:0035295 244 0.019
hemopoiesis GO:0030097 46 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.019
positive regulation of hydrolase activity GO:0051345 78 0.018
cell cycle phase transition GO:0044770 140 0.018
oocyte dorsal ventral axis specification GO:0007310 34 0.018
phenol containing compound metabolic process GO:0018958 57 0.018
regulation of wnt signaling pathway GO:0030111 68 0.018
single organism biosynthetic process GO:0044711 206 0.018
regulation of proteolysis GO:0030162 87 0.018
regulation of cellular catabolic process GO:0031329 157 0.018
eye development GO:0001654 323 0.018
intracellular signal transduction GO:0035556 300 0.018
protein k48 linked ubiquitination GO:0070936 3 0.018
positive regulation of organelle organization GO:0010638 65 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
eye photoreceptor cell differentiation GO:0001754 145 0.017
telencephalon development GO:0021537 2 0.017
anterior posterior axis specification embryo GO:0008595 103 0.017
meiotic nuclear division GO:0007126 151 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
defense response GO:0006952 300 0.017
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.017
response to lipopolysaccharide GO:0032496 4 0.017
cellular response to endogenous stimulus GO:0071495 80 0.017
eye photoreceptor cell fate commitment GO:0042706 37 0.016
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
sensory organ morphogenesis GO:0090596 260 0.016
developmental maturation GO:0021700 172 0.016
negative regulation of molecular function GO:0044092 51 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
regulation of nuclear division GO:0051783 58 0.016
negative regulation of cell death GO:0060548 81 0.016
oocyte fate determination GO:0030716 27 0.015
morphogenesis of an epithelium GO:0002009 276 0.015
negative regulation of signal transduction GO:0009968 206 0.015
muscle cell development GO:0055001 50 0.015
blastoderm segmentation GO:0007350 159 0.015
rhythmic behavior GO:0007622 76 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
organic substance transport GO:0071702 257 0.015
response to oxidative stress GO:0006979 86 0.015
protein phosphorylation GO:0006468 169 0.015
response to nitrogen compound GO:1901698 90 0.014
neurological system process GO:0050877 358 0.014
protein processing GO:0016485 68 0.014
skeletal muscle fiber development GO:0048741 3 0.014
neuron apoptotic process GO:0051402 17 0.014
meiotic cell cycle process GO:1903046 132 0.014
axis specification GO:0009798 167 0.014
negative regulation of neuron apoptotic process GO:0043524 14 0.014
regulation of cell development GO:0060284 215 0.014
multi organism reproductive behavior GO:0044705 121 0.014
regulation of meiosis GO:0040020 3 0.014
protein depolymerization GO:0051261 31 0.014
cellular respiration GO:0045333 26 0.014
heterochromatin organization GO:0070828 25 0.014
response to other organism GO:0051707 293 0.014
response to organic cyclic compound GO:0014070 89 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
regulation of endocytosis GO:0030100 37 0.014
negative regulation of organelle organization GO:0010639 56 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.013
positive regulation of apoptotic signaling pathway GO:2001235 4 0.013
epidermal growth factor receptor signaling pathway GO:0007173 58 0.013
protein localization to organelle GO:0033365 82 0.013
regulation of secretion GO:0051046 44 0.013
positive regulation of cell death GO:0010942 69 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
cellular protein complex disassembly GO:0043624 35 0.013
regulation of chromosome organization GO:0033044 64 0.013
eggshell chorion assembly GO:0007306 66 0.013
negative regulation of mitotic cell cycle GO:0045930 109 0.013
positive regulation of signal transduction GO:0009967 223 0.013
carbohydrate metabolic process GO:0005975 82 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
circadian sleep wake cycle GO:0042745 28 0.013
spermatid differentiation GO:0048515 114 0.013
establishment of protein localization GO:0045184 163 0.013
rna processing GO:0006396 147 0.013
regulation of cellular response to oxidative stress GO:1900407 4 0.013
negative regulation of cell division GO:0051782 17 0.013
protein ubiquitination GO:0016567 70 0.012
protein maturation GO:0051604 71 0.012
muscle cell differentiation GO:0042692 103 0.012
positive regulation of multicellular organism growth GO:0040018 21 0.012
aromatic compound catabolic process GO:0019439 166 0.012
negative regulation of response to oxidative stress GO:1902883 1 0.012
triglyceride homeostasis GO:0070328 18 0.012
spindle organization GO:0007051 253 0.012
energy derivation by oxidation of organic compounds GO:0015980 32 0.012
contractile ring contraction GO:0036213 12 0.012
negative regulation of catalytic activity GO:0043086 42 0.012
skin development GO:0043588 65 0.012
response to ecdysone GO:0035075 34 0.012
cellular response to oxygen containing compound GO:1901701 79 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
establishment or maintenance of cell polarity GO:0007163 167 0.012
mrna processing GO:0006397 104 0.012
positive regulation of transport GO:0051050 92 0.012
gastrulation involving germ band extension GO:0010004 36 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
regulation of synaptic transmission GO:0050804 69 0.011
gland development GO:0048732 191 0.011
lipid storage GO:0019915 38 0.011
response to growth factor GO:0070848 31 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
spermatid development GO:0007286 98 0.011
camera type eye development GO:0043010 4 0.011
cellular protein complex assembly GO:0043623 71 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
cell death GO:0008219 279 0.011
nuclear transport GO:0051169 72 0.011
telomere maintenance GO:0000723 21 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
gonad development GO:0008406 50 0.011
cellular response to organonitrogen compound GO:0071417 36 0.011
eye antennal disc development GO:0035214 60 0.011
positive regulation of apoptotic process GO:0043065 47 0.011
formation of organ boundary GO:0010160 30 0.011
cellular ketone metabolic process GO:0042180 24 0.011
sex differentiation GO:0007548 81 0.011
phagocytosis GO:0006909 215 0.011
germ line stem cell maintenance GO:0030718 50 0.011
regulation of epidermal cell differentiation GO:0045604 3 0.011
respiratory system development GO:0060541 213 0.011
cellular macromolecule localization GO:0070727 220 0.010
stress activated mapk cascade GO:0051403 52 0.010
compound eye photoreceptor development GO:0042051 78 0.010
hindbrain development GO:0030902 2 0.010

Ppcs disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
parkinson s disease DOID:14330 0 0.048
synucleinopathy DOID:0050890 0 0.048
central nervous system disease DOID:331 0 0.048
disease of anatomical entity DOID:7 0 0.048
neurodegenerative disease DOID:1289 0 0.048
nervous system disease DOID:863 0 0.048
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014