Drosophila melanogaster

257 known processes

Pten (Dmel_CG5671)

CG5671 gene product from transcript CG5671-RB

(Aliases: DPTEN,pten,PTEN3,Dmel\CG5671,dpten,PTEN,CG5671,dPTEN,dPten)

Pten biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of growth GO:0040008 233 0.999
regulation of cell differentiation GO:0045595 302 0.991
multi organism reproductive behavior GO:0044705 121 0.988
Mouse
growth GO:0040007 359 0.985
sensory organ morphogenesis GO:0090596 260 0.984
lipid metabolic process GO:0006629 121 0.980
intracellular signal transduction GO:0035556 300 0.979
negative regulation of autophagy GO:0010507 16 0.979
regulation of apoptotic process GO:0042981 130 0.978
Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.973
Human
tissue migration GO:0090130 155 0.970
Mouse
defense response GO:0006952 300 0.968
regulation of developmental growth GO:0048638 174 0.965
macroautophagy GO:0016236 42 0.962
reproductive behavior GO:0019098 122 0.961
Mouse
carbohydrate derivative metabolic process GO:1901135 217 0.958
cell growth GO:0016049 108 0.955
regulation of protein metabolic process GO:0051246 256 0.955
Human Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.951
multi multicellular organism process GO:0044706 123 0.947
Mouse
compound eye morphogenesis GO:0001745 249 0.945
regulation of cellular component biogenesis GO:0044087 201 0.938
ribonucleoside metabolic process GO:0009119 127 0.935
gland development GO:0048732 191 0.933
ribose phosphate metabolic process GO:0019693 145 0.933
epithelial cell migration GO:0010631 148 0.932
Mouse
regulation of anatomical structure size GO:0090066 163 0.932
ion transport GO:0006811 145 0.931
positive regulation of developmental growth GO:0048639 62 0.927
cellular protein modification process GO:0006464 438 0.926
organophosphate metabolic process GO:0019637 195 0.922
Human Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.913
negative regulation of biosynthetic process GO:0009890 277 0.900
negative regulation of nucleic acid templated transcription GO:1903507 240 0.900
response to extracellular stimulus GO:0009991 116 0.897
neuromuscular junction development GO:0007528 149 0.894
autophagic vacuole assembly GO:0000045 2 0.892
positive regulation of growth GO:0045927 75 0.886
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.881
apoptotic signaling pathway GO:0097190 27 0.879
Mouse
compound eye photoreceptor development GO:0042051 78 0.879
autophagy GO:0006914 108 0.877
nucleoside triphosphate catabolic process GO:0009143 108 0.876
purine ribonucleoside metabolic process GO:0046128 127 0.875
negative regulation of growth GO:0045926 84 0.872
negative regulation of response to stimulus GO:0048585 258 0.869
regulation of cell growth GO:0001558 43 0.863
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.859
germarium derived female germ line cyst formation GO:0030727 42 0.855
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.850
defense response to other organism GO:0098542 225 0.847
positive regulation of response to stimulus GO:0048584 323 0.845
Mouse
stem cell development GO:0048864 79 0.842
regulation of neurogenesis GO:0050767 158 0.835
defense response to bacterium GO:0042742 178 0.834
regulation of catabolic process GO:0009894 170 0.832
synaptic growth at neuromuscular junction GO:0051124 119 0.831
stem cell differentiation GO:0048863 117 0.827
carbohydrate derivative catabolic process GO:1901136 118 0.825
eye development GO:0001654 323 0.821
single organism catabolic process GO:0044712 228 0.819
Human Mouse
ovarian follicle cell development GO:0030707 248 0.807
stem cell maintenance GO:0019827 67 0.804
nucleoside metabolic process GO:0009116 127 0.797
immune system process GO:0002376 347 0.790
positive regulation of cell growth GO:0030307 19 0.786
regulation of protein modification process GO:0031399 112 0.786
Human Mouse
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.779
ribonucleotide metabolic process GO:0009259 145 0.774
negative regulation of developmental growth GO:0048640 64 0.767
tube development GO:0035295 244 0.767
Zebrafish
positive regulation of nucleotide metabolic process GO:0045981 55 0.765
regulation of organelle organization GO:0033043 196 0.764
Human Mouse
negative regulation of synapse assembly GO:0051964 39 0.763
protein localization GO:0008104 284 0.759
negative regulation of gene expression GO:0010629 387 0.759
cell proliferation GO:0008283 299 0.756
regulation of cellular catabolic process GO:0031329 157 0.741
positive regulation of macromolecule metabolic process GO:0010604 405 0.738
Human Mouse
protein modification process GO:0036211 438 0.735
positive regulation of nucleic acid templated transcription GO:1903508 266 0.732
purine nucleotide catabolic process GO:0006195 109 0.731
hematopoietic or lymphoid organ development GO:0048534 57 0.729
Zebrafish
apoptotic process GO:0006915 159 0.726
programmed cell death GO:0012501 257 0.723
rhythmic process GO:0048511 106 0.722
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.719
regulation of nervous system development GO:0051960 248 0.719
protein transport GO:0015031 155 0.716
Worm
muscle structure development GO:0061061 224 0.713
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.712
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.709
developmental growth GO:0048589 280 0.707
multicellular organismal aging GO:0010259 140 0.707
Worm
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.703
metal ion homeostasis GO:0055065 44 0.702
ribonucleoside catabolic process GO:0042454 112 0.702
secondary metabolic process GO:0019748 75 0.697
phenol containing compound metabolic process GO:0018958 57 0.691
nucleotide metabolic process GO:0009117 161 0.690
cell death GO:0008219 279 0.684
tube morphogenesis GO:0035239 191 0.682
Zebrafish
immune response GO:0006955 246 0.681
eye photoreceptor cell differentiation GO:0001754 145 0.679
ovarian follicle cell migration GO:0007297 121 0.676
purine containing compound catabolic process GO:0072523 112 0.674
border follicle cell migration GO:0007298 113 0.673
compound eye development GO:0048749 307 0.665
regulation of neuron differentiation GO:0045664 103 0.663
purine nucleoside metabolic process GO:0042278 127 0.657
dendrite development GO:0016358 204 0.655
regulation of cell cycle GO:0051726 291 0.655
guanosine containing compound metabolic process GO:1901068 74 0.651
cellular response to chemical stimulus GO:0070887 199 0.646
regulation of establishment of planar polarity GO:0090175 22 0.646
multi organism behavior GO:0051705 175 0.642
Mouse
torc1 signaling GO:0038202 12 0.639
regulation of cellular component size GO:0032535 98 0.630
negative regulation of rna metabolic process GO:0051253 251 0.628
death GO:0016265 284 0.628
positive regulation of gtpase activity GO:0043547 43 0.623
regulation of kinase activity GO:0043549 53 0.621
Human
response to external biotic stimulus GO:0043207 293 0.620
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.619
multicellular organismal reproductive behavior GO:0033057 110 0.609
Mouse
nucleobase containing small molecule metabolic process GO:0055086 174 0.607
enzyme linked receptor protein signaling pathway GO:0007167 179 0.604
positive regulation of gtp catabolic process GO:0033126 43 0.603
photoreceptor cell differentiation GO:0046530 170 0.603
localization of cell GO:0051674 257 0.603
Human Mouse
regulation of epithelial cell proliferation GO:0050678 4 0.600
Mouse
cell motility GO:0048870 251 0.599
Human Mouse
purine containing compound metabolic process GO:0072521 155 0.596
regulation of cell proliferation GO:0042127 163 0.594
regulation of cell death GO:0010941 173 0.592
Mouse
guanosine containing compound catabolic process GO:1901069 74 0.585
single organism biosynthetic process GO:0044711 206 0.585
negative regulation of rna biosynthetic process GO:1902679 240 0.584
negative regulation of transcription dna templated GO:0045892 237 0.580
eggshell formation GO:0030703 105 0.579
regulation of synaptic transmission GO:0050804 69 0.578
Mouse
nucleotide catabolic process GO:0009166 109 0.575
purine nucleoside catabolic process GO:0006152 112 0.575
oocyte development GO:0048599 124 0.569
purine ribonucleotide catabolic process GO:0009154 109 0.566
oocyte maturation GO:0001556 3 0.565
negative regulation of signaling GO:0023057 219 0.554
Human Mouse
regulation of reactive oxygen species metabolic process GO:2000377 8 0.545
regulation of cellular protein metabolic process GO:0032268 243 0.537
Human Mouse
small molecule metabolic process GO:0044281 305 0.535
Human
chorion containing eggshell formation GO:0007304 105 0.534
homeostatic process GO:0042592 199 0.533
response to biotic stimulus GO:0009607 294 0.532
purine ribonucleoside catabolic process GO:0046130 112 0.517
glycosyl compound metabolic process GO:1901657 127 0.516
positive regulation of mitotic cell cycle GO:0045931 34 0.513
Human Mouse
cell migration GO:0016477 238 0.504
Human Mouse
dendrite morphogenesis GO:0048813 199 0.499
Mouse
nucleoside phosphate metabolic process GO:0006753 162 0.496
positive regulation of organelle organization GO:0010638 65 0.496
Human Mouse
regulation of programmed cell death GO:0043067 152 0.494
Mouse
epithelium migration GO:0090132 148 0.493
Mouse
epithelial cell development GO:0002064 274 0.493
peripheral nervous system development GO:0007422 52 0.493
entry into diapause GO:0055115 1 0.486
Worm
regulation of gtpase activity GO:0043087 44 0.483
negative regulation of developmental process GO:0051093 201 0.483
epithelial cell differentiation GO:0030855 322 0.482
regulation of multicellular organismal development GO:2000026 414 0.482
columnar cuboidal epithelial cell development GO:0002066 249 0.476
establishment of localization in cell GO:0051649 402 0.470
Worm
purine nucleoside triphosphate metabolic process GO:0009144 119 0.462
multicellular organism growth GO:0035264 46 0.454
ribonucleoside triphosphate metabolic process GO:0009199 119 0.446
response to other organism GO:0051707 293 0.443
response to nitrogen compound GO:1901698 90 0.438
tissue morphogenesis GO:0048729 297 0.435
regulation of tor signaling GO:0032006 21 0.433
regulation of synapse organization GO:0050807 110 0.430
germ line cyst formation GO:0048134 44 0.423
male gamete generation GO:0048232 201 0.420
blastoderm segmentation GO:0007350 159 0.418
regulation of macroautophagy GO:0016241 15 0.417
regulation of autophagy GO:0010506 62 0.415
actin cytoskeleton organization GO:0030036 206 0.411
eye morphogenesis GO:0048592 260 0.410
positive regulation of molecular function GO:0044093 136 0.410
Human Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.409
gtp catabolic process GO:0006184 72 0.408
lipid modification GO:0030258 24 0.405
Human Zebrafish
regulation of nucleotide catabolic process GO:0030811 48 0.395
rho protein signal transduction GO:0007266 14 0.394
regulation of cellular response to insulin stimulus GO:1900076 17 0.390
ribonucleoside triphosphate catabolic process GO:0009203 108 0.388
immune effector process GO:0002252 98 0.383
regulation of establishment of protein localization to plasma membrane GO:0090003 7 0.383
circulatory system process GO:0003013 37 0.380
cell type specific apoptotic process GO:0097285 38 0.379
Mouse
phosphatidylinositol mediated signaling GO:0048015 4 0.378
negative regulation of macroautophagy GO:0016242 6 0.372
regulation of cell development GO:0060284 215 0.367
regulation of phosphate metabolic process GO:0019220 210 0.365
Human
eye photoreceptor cell development GO:0042462 81 0.362
cellular cation homeostasis GO:0030003 38 0.362
positive regulation of protein modification process GO:0031401 58 0.359
Human Mouse
chromatin organization GO:0006325 207 0.358
organic substance transport GO:0071702 257 0.358
Worm
heart development GO:0007507 82 0.357
Mouse
inositol lipid mediated signaling GO:0048017 4 0.357
response to bacterium GO:0009617 198 0.351
central nervous system development GO:0007417 201 0.350
Mouse
positive regulation of developmental process GO:0051094 143 0.346
sex differentiation GO:0007548 81 0.345
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.344
cellular response to nutrient levels GO:0031669 62 0.343
positive regulation of catalytic activity GO:0043085 118 0.343
Human Mouse
blood circulation GO:0008015 26 0.341
cellular metal ion homeostasis GO:0006875 31 0.338
secretion by cell GO:0032940 101 0.338
embryonic morphogenesis GO:0048598 206 0.337
Zebrafish
appendage morphogenesis GO:0035107 397 0.337
regulation of catalytic activity GO:0050790 185 0.332
Human Mouse
positive regulation of cellular component biogenesis GO:0044089 80 0.325
adherens junction organization GO:0034332 27 0.324
Human
morphogenesis of a branching structure GO:0001763 45 0.321
ribonucleotide catabolic process GO:0009261 109 0.320
erbb signaling pathway GO:0038127 58 0.319
nucleoside catabolic process GO:0009164 112 0.318
nucleoside triphosphate metabolic process GO:0009141 120 0.317
organ growth GO:0035265 56 0.316
insulin receptor signaling pathway GO:0008286 25 0.316
cellular ion homeostasis GO:0006873 39 0.315
g1 s transition of mitotic cell cycle GO:0000082 31 0.307
Human
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.293
collateral sprouting GO:0048668 3 0.292
regionalization GO:0003002 416 0.290
actin filament based process GO:0030029 220 0.290
negative regulation of cellular component organization GO:0051129 108 0.288
negative regulation of programmed cell death GO:0043069 72 0.287
Mouse
phagocytosis GO:0006909 215 0.285
tor signaling GO:0031929 32 0.283
regulation of nucleotide metabolic process GO:0006140 62 0.277
purine nucleotide metabolic process GO:0006163 146 0.276
metal ion transport GO:0030001 74 0.276
epidermal growth factor receptor signaling pathway GO:0007173 58 0.275
positive regulation of multicellular organism growth GO:0040018 21 0.274
positive regulation of cellular biosynthetic process GO:0031328 316 0.273
regulation of nucleoside metabolic process GO:0009118 50 0.273
protein complex biogenesis GO:0070271 201 0.270
axon development GO:0061564 297 0.268
glycosyl compound catabolic process GO:1901658 112 0.266
purine nucleoside triphosphate catabolic process GO:0009146 108 0.263
positive regulation of establishment of protein localization to plasma membrane GO:0090004 3 0.263
regulation of ras gtpase activity GO:0032318 38 0.262
cellular homeostasis GO:0019725 80 0.261
negative regulation of nervous system development GO:0051961 92 0.261
melanotic encapsulation of foreign target GO:0035011 30 0.259
negative regulation of response to nutrient levels GO:0032108 6 0.259
spermatid development GO:0007286 98 0.254
oocyte microtubule cytoskeleton organization GO:0016325 35 0.253
reactive oxygen species metabolic process GO:0072593 22 0.244
cellular catabolic process GO:0044248 372 0.244
regulation of system process GO:0044057 36 0.243
Mouse
positive regulation of hydrolase activity GO:0051345 78 0.239
regulation of immune system process GO:0002682 176 0.239
positive regulation of transcription dna templated GO:0045893 266 0.236
appendage development GO:0048736 401 0.234
cell cycle g1 s phase transition GO:0044843 31 0.229
Human
meiotic nuclear division GO:0007126 151 0.225
response to reactive oxygen species GO:0000302 24 0.221
stem cell proliferation GO:0072089 88 0.220
wound healing GO:0042060 75 0.219
catabolic process GO:0009056 409 0.216
axonogenesis GO:0007409 290 0.215
Mouse
germarium derived egg chamber formation GO:0007293 101 0.214
regulation of imaginal disc growth GO:0045570 26 0.212
meiotic cell cycle process GO:1903046 132 0.211
biological adhesion GO:0022610 138 0.211
embryonic organ development GO:0048568 50 0.211
regulation of synapse structure and activity GO:0050803 128 0.209
single organism behavior GO:0044708 391 0.208
Mouse Worm
purine ribonucleotide metabolic process GO:0009150 145 0.206
regulation of phosphatidylinositol 3 kinase activity GO:0043551 2 0.206
dephosphorylation GO:0016311 51 0.204
positive regulation of protein metabolic process GO:0051247 128 0.203
Human Mouse
regulation of proteolysis GO:0030162 87 0.203
Human Mouse
gtp metabolic process GO:0046039 72 0.202
branching morphogenesis of an epithelial tube GO:0048754 45 0.200
heterocycle catabolic process GO:0046700 166 0.199
negative regulation of protein modification process GO:0031400 29 0.197
Human
eye antennal disc development GO:0035214 60 0.197
organonitrogen compound metabolic process GO:1901564 318 0.194
organonitrogen compound catabolic process GO:1901565 128 0.193
imaginal disc derived appendage morphogenesis GO:0035114 395 0.193
positive regulation of biosynthetic process GO:0009891 316 0.192
lipid catabolic process GO:0016042 21 0.191
germ line stem cell maintenance GO:0030718 50 0.191
regulation of cellular localization GO:0060341 136 0.191
Mouse Worm
positive regulation of cell size GO:0045793 21 0.190
positive regulation of protein localization to plasma membrane GO:1903078 3 0.190
regulation of insulin receptor signaling pathway GO:0046626 17 0.189
regulation of cellular amine metabolic process GO:0033238 3 0.189
body morphogenesis GO:0010171 2 0.188
female germ line cyst formation GO:0048135 42 0.185
negative regulation of kinase activity GO:0033673 16 0.184
Human
positive regulation of signaling GO:0023056 243 0.184
Mouse
response to oxygen containing compound GO:1901700 200 0.183
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.182
stem cell division GO:0017145 69 0.182
nucleoside phosphate catabolic process GO:1901292 110 0.182
neurological system process GO:0050877 358 0.181
Mouse Worm
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.178
dormancy process GO:0022611 2 0.175
Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.174
positive regulation of rna metabolic process GO:0051254 271 0.173
regulation of stress activated mapk cascade GO:0032872 41 0.171
oocyte differentiation GO:0009994 145 0.171
positive regulation of ras gtpase activity GO:0032320 36 0.168
positive regulation of cell death GO:0010942 69 0.163
Mouse
neuronal action potential GO:0019228 10 0.161
meiotic cell cycle GO:0051321 171 0.159
regulation of cellular amino acid metabolic process GO:0006521 0 0.156
regulation of phosphorus metabolic process GO:0051174 210 0.156
Human
negative regulation of cell communication GO:0010648 223 0.155
Human Mouse
regulation of behavior GO:0050795 75 0.154
Worm
nucleobase containing compound catabolic process GO:0034655 165 0.154
pigment metabolic process GO:0042440 84 0.152
protein targeting to nucleus GO:0044744 51 0.152
Worm
feeding behavior GO:0007631 50 0.151
synaptic transmission GO:0007268 288 0.150
Mouse
positive regulation of nucleoside metabolic process GO:0045979 47 0.150
organophosphate catabolic process GO:0046434 112 0.150
Human
compound eye photoreceptor cell differentiation GO:0001751 140 0.150
oxoacid metabolic process GO:0043436 103 0.149
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.149
protein localization to nucleus GO:0034504 55 0.149
Worm
negative regulation of cellular protein metabolic process GO:0032269 85 0.148
Human
epithelial tube morphogenesis GO:0060562 88 0.147
regulation of cellular ketone metabolic process GO:0010565 3 0.146
cellular macromolecule localization GO:0070727 220 0.144
intracellular protein transport GO:0006886 104 0.143
Worm
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.142
ameboidal type cell migration GO:0001667 151 0.141
Mouse
dna replication GO:0006260 48 0.138
cell cycle phase transition GO:0044770 140 0.138
Human Mouse
positive regulation of catabolic process GO:0009896 105 0.138
Human Mouse
regulation of map kinase activity GO:0043405 17 0.137
cellular lipid metabolic process GO:0044255 83 0.134
Human Zebrafish
larval development GO:0002164 104 0.131
regulation of multicellular organism growth GO:0040014 40 0.130
regulation of immune response GO:0050776 118 0.129
determination of adult lifespan GO:0008340 137 0.129
Worm
cation transport GO:0006812 110 0.129
positive regulation of nucleotide catabolic process GO:0030813 46 0.128
positive regulation of cellular catabolic process GO:0031331 95 0.127
Human Mouse
cellular response to extracellular stimulus GO:0031668 64 0.126
learning or memory GO:0007611 141 0.125
Mouse Worm
calcium ion homeostasis GO:0055074 23 0.125
regulation of gtp catabolic process GO:0033124 44 0.124
membrane organization GO:0061024 112 0.124
Mouse
camera type eye morphogenesis GO:0048593 2 0.124
muscle tissue development GO:0060537 30 0.122
Mouse
developmental programmed cell death GO:0010623 138 0.119
nucleocytoplasmic transport GO:0006913 72 0.119
Worm
heart process GO:0003015 37 0.118
regulation of mapk cascade GO:0043408 92 0.117
telencephalon development GO:0021537 2 0.117
Mouse
cellular chemical homeostasis GO:0055082 40 0.117
striated muscle cell differentiation GO:0051146 90 0.116
response to nutrient levels GO:0031667 114 0.116
morphogenesis of a branching epithelium GO:0061138 45 0.116
regulation of cyclase activity GO:0031279 13 0.115
cellular amine metabolic process GO:0044106 12 0.114
regulation of purine nucleotide metabolic process GO:1900542 62 0.113
positive regulation of signal transduction GO:0009967 223 0.113
Mouse
response to wounding GO:0009611 94 0.113
regulation of intracellular transport GO:0032386 64 0.112
Worm
regulation of protein catabolic process GO:0042176 55 0.112
Human Mouse
rhabdomere development GO:0042052 38 0.111
positive regulation of cell differentiation GO:0045597 64 0.108
brain development GO:0007420 120 0.107
Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.107
protein ubiquitination GO:0016567 70 0.107
Human Mouse
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.106
single organism carbohydrate metabolic process GO:0044723 72 0.105
Human
regulation of anatomical structure morphogenesis GO:0022603 242 0.105
imaginal disc derived appendage development GO:0048737 399 0.103
digestive tract development GO:0048565 149 0.103
Zebrafish
regulation of molecular function GO:0065009 217 0.102
Human Mouse
glial cell migration GO:0008347 31 0.100
actin filament organization GO:0007015 126 0.099
neuroblast proliferation GO:0007405 74 0.099
divalent metal ion transport GO:0070838 26 0.097
actin filament polymerization GO:0030041 27 0.096
regulation of cell size GO:0008361 63 0.095
regulation of phosphorylation GO:0042325 147 0.095
Human
regulation of response to stress GO:0080134 200 0.095
regulation of rap protein signal transduction GO:0032487 4 0.094
regulation of long term neuronal synaptic plasticity GO:0048169 1 0.094
regulation of organ morphogenesis GO:2000027 78 0.093
positive regulation of phosphate metabolic process GO:0045937 139 0.093
regulation of protein phosphorylation GO:0001932 64 0.092
Human
stress activated mapk cascade GO:0051403 52 0.092
intracellular transport GO:0046907 228 0.092
Worm
ion transmembrane transport GO:0034220 122 0.092
negative regulation of cellular catabolic process GO:0031330 34 0.092
response to starvation GO:0042594 97 0.091
secretion GO:0046903 109 0.090
regulation of purine nucleotide catabolic process GO:0033121 48 0.090
divalent inorganic cation homeostasis GO:0072507 29 0.090
positive regulation of protein phosphorylation GO:0001934 34 0.090
positive regulation of cell migration GO:0030335 2 0.090
positive regulation of phosphorus metabolic process GO:0010562 139 0.089
organic substance catabolic process GO:1901575 308 0.089
Human Mouse
regeneration GO:0031099 16 0.088
regulation of transport GO:0051049 181 0.087
Worm
regulation of lipid kinase activity GO:0043550 2 0.087
hemopoiesis GO:0030097 46 0.087
Zebrafish
response to oxidative stress GO:0006979 86 0.087
cellular divalent inorganic cation homeostasis GO:0072503 23 0.086
macromolecule catabolic process GO:0009057 161 0.085
Human Mouse
chemotaxis GO:0006935 249 0.085
Worm
positive regulation of protein kinase activity GO:0045860 25 0.084
tissue death GO:0016271 102 0.084
organelle fission GO:0048285 340 0.084
Human Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.083
heart contraction GO:0060047 26 0.081
aromatic compound catabolic process GO:0019439 166 0.080
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.080
positive regulation of multicellular organismal process GO:0051240 143 0.080
camera type eye development GO:0043010 4 0.080
circulatory system development GO:0072359 82 0.079
Zebrafish Mouse
spermatid differentiation GO:0048515 114 0.079
negative regulation of response to extracellular stimulus GO:0032105 6 0.077
cell maturation GO:0048469 144 0.077
photoreceptor cell development GO:0042461 96 0.076
cell aging GO:0007569 2 0.076
Mouse
establishment of protein localization to plasma membrane GO:0090002 9 0.075
regulation of cytoskeleton organization GO:0051493 89 0.075
regulation of circadian rhythm GO:0042752 49 0.075
anatomical structure homeostasis GO:0060249 97 0.075
cellular ketone metabolic process GO:0042180 24 0.075
cellular protein localization GO:0034613 160 0.075
larval midgut histolysis GO:0035069 22 0.074
cellular response to peptide hormone stimulus GO:0071375 28 0.074
immune system development GO:0002520 57 0.074
Zebrafish
cardiocyte differentiation GO:0035051 29 0.073
organic acid metabolic process GO:0006082 103 0.073
response to axon injury GO:0048678 12 0.073
negative regulation of signal transduction GO:0009968 206 0.073
Human Mouse
regulation of protein kinase activity GO:0045859 51 0.073
Human
positive regulation of proteolysis GO:0045862 52 0.072
Human Mouse
imaginal disc derived leg morphogenesis GO:0007480 80 0.072
positive regulation of neurogenesis GO:0050769 41 0.072
g protein coupled receptor signaling pathway GO:0007186 136 0.072
imaginal disc derived wing morphogenesis GO:0007476 337 0.071
cortical actin cytoskeleton organization GO:0030866 24 0.070
positive regulation of apoptotic process GO:0043065 47 0.070
Mouse
extrinsic apoptotic signaling pathway GO:0097191 1 0.070
negative regulation of multicellular organismal process GO:0051241 142 0.070
response to fungus GO:0009620 50 0.069
regulation of response to external stimulus GO:0032101 115 0.068
spermatogenesis GO:0007283 200 0.068
synapse organization GO:0050808 196 0.068
Mouse
oocyte construction GO:0007308 112 0.068
digestive system development GO:0055123 149 0.068
Zebrafish
cellular nitrogen compound catabolic process GO:0044270 165 0.068
response to lipid GO:0033993 38 0.067
digestive tract morphogenesis GO:0048546 127 0.067
Zebrafish
hemocyte migration GO:0035099 19 0.067
centrosome cycle GO:0007098 137 0.066
oviposition GO:0018991 19 0.066
positive regulation of cell communication GO:0010647 250 0.066
Mouse
protein heterooligomerization GO:0051291 4 0.065
regulation of transferase activity GO:0051338 58 0.065
Human Mouse
eye antennal disc morphogenesis GO:0007455 34 0.065
histolysis GO:0007559 102 0.064
regulation of cell motility GO:2000145 23 0.064
Human
protein catabolic process GO:0030163 101 0.064
Human Mouse
response to organic substance GO:0010033 284 0.063
response to peptide GO:1901652 29 0.063
striated muscle tissue development GO:0014706 27 0.062
Mouse
response to organonitrogen compound GO:0010243 75 0.062
positive regulation of cell motility GO:2000147 3 0.062
regulation of mitotic cell cycle GO:0007346 190 0.062
Human Mouse
morphogenesis of an epithelium GO:0002009 276 0.062
regulation of axon regeneration GO:0048679 4 0.062
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.061
Human
positive regulation of gene expression GO:0010628 290 0.061
wnt signaling pathway GO:0016055 98 0.060
Human
organic cyclic compound catabolic process GO:1901361 168 0.060
glycoprotein biosynthetic process GO:0009101 41 0.060
negative regulation of apoptotic signaling pathway GO:2001234 5 0.060
single organism cellular localization GO:1902580 180 0.060
Mouse Worm

Pten disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.217
Human
organ system cancer DOID:0050686 0 0.096
Human
cancer DOID:162 0 0.096
Human
endocrine gland cancer DOID:170 0 0.096
Human
disease of anatomical entity DOID:7 0 0.087