Drosophila melanogaster

95 known processes

fbl (Dmel_CG5725)

fumble

(Aliases: PANK,Dmel\CG5725,dPANK,CG5725)

fbl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell division GO:0051301 248 0.863
organelle fission GO:0048285 340 0.817
meiotic cell cycle GO:0051321 171 0.597
meiotic cell cycle process GO:1903046 132 0.440
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.428
meiotic nuclear division GO:0007126 151 0.386
adult behavior GO:0030534 137 0.380
cytoskeleton dependent cytokinesis GO:0061640 81 0.374
imaginal disc derived appendage development GO:0048737 399 0.353
response to abiotic stimulus GO:0009628 341 0.351
organonitrogen compound metabolic process GO:1901564 318 0.328
Mouse
oxoacid metabolic process GO:0043436 103 0.319
cellular protein modification process GO:0006464 438 0.316
cell migration GO:0016477 238 0.286
spermatogenesis GO:0007283 200 0.281
imaginal disc derived appendage morphogenesis GO:0035114 395 0.277
appendage development GO:0048736 401 0.267
cellular lipid metabolic process GO:0044255 83 0.266
adult locomotory behavior GO:0008344 76 0.243
regulation of neurogenesis GO:0050767 158 0.231
cellular catabolic process GO:0044248 372 0.228
mitochondrion organization GO:0007005 65 0.209
Mouse
nuclear division GO:0000280 332 0.205
programmed cell death GO:0012501 257 0.190
Worm
organic acid metabolic process GO:0006082 103 0.190
central nervous system development GO:0007417 201 0.188
organic substance catabolic process GO:1901575 308 0.181
transmembrane transport GO:0055085 139 0.181
modification dependent macromolecule catabolic process GO:0043632 79 0.174
cell death GO:0008219 279 0.162
Worm
organonitrogen compound catabolic process GO:1901565 128 0.155
ion transmembrane transport GO:0034220 122 0.146
homeostatic process GO:0042592 199 0.139
regulation of multicellular organismal development GO:2000026 414 0.139
intracellular transport GO:0046907 228 0.134
aging GO:0007568 143 0.134
Worm
head development GO:0060322 135 0.134
catabolic process GO:0009056 409 0.134
single organism intracellular transport GO:1902582 207 0.129
meiotic cytokinesis GO:0033206 33 0.125
cytoplasmic transport GO:0016482 130 0.125
appendage morphogenesis GO:0035107 397 0.124
muscle structure development GO:0061061 224 0.118
macromolecule catabolic process GO:0009057 161 0.111
proteolysis GO:0006508 192 0.104
defense response GO:0006952 300 0.103
brain development GO:0007420 120 0.102
developmental growth GO:0048589 280 0.101
regulation of localization GO:0032879 275 0.101
small molecule metabolic process GO:0044281 305 0.100
Mouse
regulation of organelle organization GO:0033043 196 0.100
macromolecular complex disassembly GO:0032984 37 0.096
regulation of cellular catabolic process GO:0031329 157 0.091
nitrogen compound transport GO:0071705 85 0.090
establishment of localization in cell GO:0051649 402 0.089
imaginal disc derived wing morphogenesis GO:0007476 337 0.084
modification dependent protein catabolic process GO:0019941 78 0.083
organophosphate metabolic process GO:0019637 195 0.079
Mouse
ubiquitin dependent protein catabolic process GO:0006511 78 0.079
negative regulation of cellular metabolic process GO:0031324 382 0.077
single organism behavior GO:0044708 391 0.074
regulation of cell development GO:0060284 215 0.073
locomotory behavior GO:0007626 176 0.073
apoptotic process GO:0006915 159 0.072
Worm
chromosome organization GO:0051276 360 0.071
cytokinesis GO:0000910 90 0.070
response to oxygen containing compound GO:1901700 200 0.067
ion transport GO:0006811 145 0.067
regulation of nervous system development GO:0051960 248 0.067
eye development GO:0001654 323 0.066
response to organic substance GO:0010033 284 0.065
organic substance transport GO:0071702 257 0.065
cellular response to organic substance GO:0071310 132 0.065
multicellular organismal aging GO:0010259 140 0.063
Worm
secretion GO:0046903 109 0.061
regulation of catabolic process GO:0009894 170 0.060
vesicle mediated transport GO:0016192 381 0.059
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.058
positive regulation of cell communication GO:0010647 250 0.058
purine containing compound metabolic process GO:0072521 155 0.058
Mouse
carboxylic acid metabolic process GO:0019752 92 0.058
epithelial cell migration GO:0010631 148 0.057
regulation of transport GO:0051049 181 0.057
immune system process GO:0002376 347 0.056
regulation of protein metabolic process GO:0051246 256 0.055
organic anion transport GO:0015711 28 0.054
negative regulation of response to stimulus GO:0048585 258 0.053
cellular macromolecule catabolic process GO:0044265 136 0.053
mitotic nuclear division GO:0007067 213 0.052
regulation of cell cycle GO:0051726 291 0.052
forebrain development GO:0030900 2 0.051
negative regulation of developmental process GO:0051093 201 0.050
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.050
circadian sleep wake cycle sleep GO:0050802 23 0.050
death GO:0016265 284 0.049
Worm
single organism biosynthetic process GO:0044711 206 0.049
Mouse
determination of adult lifespan GO:0008340 137 0.049
Worm
carbohydrate derivative metabolic process GO:1901135 217 0.049
Mouse
cell motility GO:0048870 251 0.048
actin filament based process GO:0030029 220 0.048
negative regulation of cell differentiation GO:0045596 143 0.047
nucleobase containing compound catabolic process GO:0034655 165 0.047
aromatic compound catabolic process GO:0019439 166 0.046
positive regulation of multicellular organismal process GO:0051240 143 0.045
localization of cell GO:0051674 257 0.045
positive regulation of developmental process GO:0051094 143 0.045
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.042
mitotic cytokinesis GO:0000281 50 0.042
cellular amino acid metabolic process GO:0006520 61 0.042
cellular protein catabolic process GO:0044257 83 0.042
cellular amine metabolic process GO:0044106 12 0.042
tissue migration GO:0090130 155 0.040
sperm mitochondrion organization GO:0030382 7 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.040
cognition GO:0050890 141 0.039
sperm individualization GO:0007291 48 0.039
nucleobase containing small molecule metabolic process GO:0055086 174 0.038
Mouse
regulation of response to stress GO:0080134 200 0.037
actin cytoskeleton organization GO:0030036 206 0.037
oocyte development GO:0048599 124 0.036
regulation of cell differentiation GO:0045595 302 0.035
tube development GO:0035295 244 0.035
regulation of phosphorus metabolic process GO:0051174 210 0.035
spindle assembly GO:0051225 80 0.034
body morphogenesis GO:0010171 2 0.034
positive regulation of cellular protein metabolic process GO:0032270 118 0.034
positive regulation of signal transduction GO:0009967 223 0.033
spermatocyte division GO:0048137 13 0.033
regulation of cellular protein catabolic process GO:1903362 44 0.032
post embryonic appendage morphogenesis GO:0035120 385 0.032
ribonucleotide catabolic process GO:0009261 109 0.031
cytoskeleton dependent intracellular transport GO:0030705 44 0.031
positive regulation of cellular catabolic process GO:0031331 95 0.031
regulation of hemocyte proliferation GO:0035206 37 0.031
cellular response to endogenous stimulus GO:0071495 80 0.031
bmp signaling pathway GO:0030509 27 0.030
male meiosis cytokinesis GO:0007112 26 0.030
protein complex assembly GO:0006461 200 0.030
male gamete generation GO:0048232 201 0.029
ameboidal type cell migration GO:0001667 151 0.029
meiosis ii GO:0007135 23 0.029
positive regulation of signaling GO:0023056 243 0.029
lipid metabolic process GO:0006629 121 0.029
protein catabolic process GO:0030163 101 0.028
nucleotide metabolic process GO:0009117 161 0.028
Mouse
anion transport GO:0006820 41 0.028
chaeta development GO:0022416 97 0.028
positive regulation of catabolic process GO:0009896 105 0.028
carbohydrate derivative biosynthetic process GO:1901137 85 0.028
Mouse
purine nucleotide metabolic process GO:0006163 146 0.028
Mouse
protein localization GO:0008104 284 0.028
positive regulation of nervous system development GO:0051962 69 0.027
negative regulation of cellular component organization GO:0051129 108 0.027
protein modification by small protein conjugation or removal GO:0070647 106 0.027
protein phosphorylation GO:0006468 169 0.027
blastoderm segmentation GO:0007350 159 0.027
monocarboxylic acid transport GO:0015718 3 0.027
cardiovascular system development GO:0072358 82 0.026
regulation of cellular response to oxidative stress GO:1900407 4 0.026
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.026
regionalization GO:0003002 416 0.026
purine ribonucleotide metabolic process GO:0009150 145 0.026
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.026
single organism cellular localization GO:1902580 180 0.026
response to oxidative stress GO:0006979 86 0.025
compound eye development GO:0048749 307 0.025
axonogenesis GO:0007409 290 0.025
regulation of developmental growth GO:0048638 174 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.024
purine nucleotide catabolic process GO:0006195 109 0.024
embryonic pattern specification GO:0009880 174 0.024
embryonic development via the syncytial blastoderm GO:0001700 148 0.024
regulation of cell cycle process GO:0010564 181 0.024
organonitrogen compound biosynthetic process GO:1901566 117 0.024
Mouse
nucleoside phosphate metabolic process GO:0006753 162 0.023
Mouse
purine ribonucleotide catabolic process GO:0009154 109 0.023
connective tissue development GO:0061448 3 0.023
carbohydrate derivative catabolic process GO:1901136 118 0.023
cellular response to chemical stimulus GO:0070887 199 0.023
regulation of response to external stimulus GO:0032101 115 0.023
positive regulation of cellular protein catabolic process GO:1903364 24 0.023
immune system development GO:0002520 57 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
inorganic cation transmembrane transport GO:0098662 61 0.022
pigmentation GO:0043473 75 0.021
regulation of autophagy GO:0010506 62 0.021
neurological system process GO:0050877 358 0.021
negative regulation of multicellular organismal process GO:0051241 142 0.021
proteasomal protein catabolic process GO:0010498 59 0.021
regulation of proteolysis GO:0030162 87 0.021
positive regulation of macromolecule metabolic process GO:0010604 405 0.020
regulation of cellular response to stress GO:0080135 89 0.020
response to wounding GO:0009611 94 0.020
mitochondrial fission GO:0000266 8 0.020
response to other organism GO:0051707 293 0.020
cytokinetic process GO:0032506 27 0.019
positive regulation of protein metabolic process GO:0051247 128 0.019
spermatid development GO:0007286 98 0.019
Mouse
cellular respiration GO:0045333 26 0.019
Mouse
cation transport GO:0006812 110 0.019
response to symbiotic bacterium GO:0009609 2 0.019
regulation of proteasomal protein catabolic process GO:0061136 39 0.019
regulation of cell death GO:0010941 173 0.019
microtubule organizing center organization GO:0031023 168 0.018
centrosome organization GO:0051297 163 0.018
developmental maturation GO:0021700 172 0.018
synaptic transmission dopaminergic GO:0001963 2 0.018
response to hypoxia GO:0001666 53 0.018
enzyme linked receptor protein signaling pathway GO:0007167 179 0.018
protein modification by small protein conjugation GO:0032446 79 0.018
protein complex disassembly GO:0043241 36 0.018
organic cyclic compound catabolic process GO:1901361 168 0.018
epithelial cell differentiation GO:0030855 322 0.017
organelle fusion GO:0048284 46 0.017
meiosis i GO:0007127 59 0.017
cellular protein localization GO:0034613 160 0.017
regulation of protein modification process GO:0031399 112 0.017
reproductive system development GO:0061458 74 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
regulation of programmed cell death GO:0043067 152 0.017
growth GO:0040007 359 0.017
purine nucleoside catabolic process GO:0006152 112 0.017
response to alcohol GO:0097305 95 0.016
endocytosis GO:0006897 310 0.016
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
axon development GO:0061564 297 0.016
nucleus organization GO:0006997 45 0.016
regulation of protein depolymerization GO:1901879 27 0.016
regulation of cellular localization GO:0060341 136 0.016
nucleoside monophosphate metabolic process GO:0009123 52 0.016
nucleobase containing compound transport GO:0015931 56 0.016
regulation of organ morphogenesis GO:2000027 78 0.016
response to growth factor GO:0070848 31 0.015
lipid biosynthetic process GO:0008610 46 0.015
response to endogenous stimulus GO:0009719 119 0.015
peptidyl lysine acetylation GO:0018394 39 0.015
negative regulation of signaling GO:0023057 219 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.015
regulation of protein catabolic process GO:0042176 55 0.015
developmental cell growth GO:0048588 52 0.015
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.015
circulatory system development GO:0072359 82 0.015
gland morphogenesis GO:0022612 145 0.015
protein modification process GO:0036211 438 0.015
amine metabolic process GO:0009308 12 0.015
ribonucleoside metabolic process GO:0009119 127 0.015
Mouse
mitochondrial fusion GO:0008053 7 0.015
positive regulation of response to stimulus GO:0048584 323 0.014
wing disc morphogenesis GO:0007472 344 0.014
stem cell development GO:0048864 79 0.014
stem cell proliferation GO:0072089 88 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
secretion by cell GO:0032940 101 0.014
single organism catabolic process GO:0044712 228 0.014
cellular response to metal ion GO:0071248 6 0.014
biological adhesion GO:0022610 138 0.014
histone modification GO:0016570 106 0.014
epidermal growth factor receptor signaling pathway GO:0007173 58 0.014
cellular macromolecule localization GO:0070727 220 0.014
embryonic organ development GO:0048568 50 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
Mouse
protein ubiquitination GO:0016567 70 0.013
negative regulation of homeostatic process GO:0032845 2 0.013
positive regulation of organelle organization GO:0010638 65 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.013
establishment of protein localization GO:0045184 163 0.013
cellular protein complex disassembly GO:0043624 35 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.013
autophagy GO:0006914 108 0.013
heterocycle catabolic process GO:0046700 166 0.013
organic hydroxy compound metabolic process GO:1901615 83 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
negative regulation of cellular response to oxidative stress GO:1900408 1 0.013
protein transport GO:0015031 155 0.013
regulation of apoptotic process GO:0042981 130 0.012
negative regulation of cytoskeleton organization GO:0051494 30 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
Mouse
oocyte differentiation GO:0009994 145 0.012
regulation of spindle organization GO:0090224 17 0.012
cation transmembrane transport GO:0098655 88 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
sister chromatid segregation GO:0000819 92 0.012
organic acid transport GO:0015849 18 0.012
camera type eye development GO:0043010 4 0.012
actin filament organization GO:0007015 126 0.012
positive regulation of apoptotic signaling pathway GO:2001235 4 0.012
sensory perception of pain GO:0019233 4 0.012
regulation of catalytic activity GO:0050790 185 0.012
cellular response to oxidative stress GO:0034599 28 0.012
single organism carbohydrate metabolic process GO:0044723 72 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.011
telencephalon development GO:0021537 2 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of protein modification process GO:0031401 58 0.011
contractile ring contraction GO:0036213 12 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
electron transport chain GO:0022900 14 0.011
regulation of bmp signaling pathway GO:0030510 23 0.011
nucleoside metabolic process GO:0009116 127 0.011
Mouse
response to organic cyclic compound GO:0014070 89 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
sex differentiation GO:0007548 81 0.011
positive regulation of gene expression GO:0010628 290 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
regulation of phosphatase activity GO:0010921 3 0.011
response to oxygen levels GO:0070482 59 0.011
muscle organ development GO:0007517 127 0.011
atp metabolic process GO:0046034 49 0.011
regulation of circadian rhythm GO:0042752 49 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
gland development GO:0048732 191 0.011
protein complex biogenesis GO:0070271 201 0.011
stem cell differentiation GO:0048863 117 0.011
regulation of mitochondrial fission GO:0090140 7 0.011
cellularization GO:0007349 90 0.011
microtubule based transport GO:0010970 42 0.010
developmental growth involved in morphogenesis GO:0060560 65 0.010
positive regulation of cell development GO:0010720 61 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
small molecule biosynthetic process GO:0044283 37 0.010
cellular response to hexose stimulus GO:0071331 1 0.010
purine containing compound catabolic process GO:0072523 112 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.010
rna localization GO:0006403 115 0.010
circadian rhythm GO:0007623 105 0.010
centrosome cycle GO:0007098 137 0.010
regulation of response to oxidative stress GO:1902882 4 0.010
acid secretion GO:0046717 1 0.010
response to copper ion GO:0046688 4 0.010

fbl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.147
nervous system disease DOID:863 0 0.109
central nervous system disease DOID:331 0 0.044
neurodegenerative disease DOID:1289 0 0.044
parkinson s disease DOID:14330 0 0.014
synucleinopathy DOID:0050890 0 0.014