Drosophila melanogaster

111 known processes

Timp (Dmel_CG6281)

Tissue inhibitor of metalloproteases

(Aliases: DTIMP,TIMP,CG6281,timp,Dmel\CG6281,Dtimp,dTIMP)

Timp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of tube length open tracheal system GO:0035159 24 0.884
regulation of tube architecture open tracheal system GO:0035152 68 0.778
regulation of defense response GO:0031347 102 0.643
dorsal trunk growth open tracheal system GO:0035001 7 0.625
cellular response to light stimulus GO:0071482 37 0.581
regulation of immune system process GO:0002682 176 0.504
regulation of tube size open tracheal system GO:0035151 43 0.484
cellular response to abiotic stimulus GO:0071214 58 0.453
open tracheal system development GO:0007424 204 0.391
regulation of immune response GO:0050776 118 0.282
cellular response to radiation GO:0071478 52 0.280
immune effector process GO:0002252 98 0.273
cell adhesion GO:0007155 136 0.271
molting cycle chitin based cuticle GO:0007591 56 0.268
extracellular matrix disassembly GO:0022617 4 0.261
anatomical structure homeostasis GO:0060249 97 0.251
response to fibroblast growth factor GO:0071774 10 0.240
regulation of tube size GO:0035150 46 0.240
extracellular structure organization GO:0043062 46 0.227
tracheal outgrowth open tracheal system GO:0007426 18 0.219
regulation of response to stress GO:0080134 200 0.198
immune system process GO:0002376 347 0.192
negative regulation of cell communication GO:0010648 223 0.175
positive regulation of defense response GO:0031349 59 0.171
cellular component disassembly GO:0022411 46 0.165
catabolic process GO:0009056 409 0.163
Human
positive regulation of response to stimulus GO:0048584 323 0.162
activation of innate immune response GO:0002218 4 0.158
negative regulation of signaling GO:0023057 219 0.154
gland morphogenesis GO:0022612 145 0.152
regeneration GO:0031099 16 0.150
biological adhesion GO:0022610 138 0.150
positive regulation of cellular biosynthetic process GO:0031328 316 0.133
regulation of innate immune response GO:0045088 71 0.132
positive regulation of immune response GO:0050778 63 0.127
imaginal disc derived appendage morphogenesis GO:0035114 395 0.125
negative regulation of multicellular organismal process GO:0051241 142 0.125
Human
response to light stimulus GO:0009416 124 0.122
response to wounding GO:0009611 94 0.108
respiratory system development GO:0060541 213 0.107
growth GO:0040007 359 0.104
molting cycle GO:0042303 56 0.101
developmental growth GO:0048589 280 0.096
positive regulation of immune system process GO:0002684 68 0.086
defense response GO:0006952 300 0.086
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.084
cellular metal ion homeostasis GO:0006875 31 0.068
regulation of anatomical structure size GO:0090066 163 0.067
cell recognition GO:0008037 102 0.066
lateral inhibition GO:0046331 206 0.066
negative regulation of signal transduction GO:0009968 206 0.059
positive regulation of biosynthetic process GO:0009891 316 0.059
homeostatic process GO:0042592 199 0.056
regulation of cell differentiation GO:0045595 302 0.054
Mouse
negative regulation of response to stimulus GO:0048585 258 0.053
post embryonic appendage morphogenesis GO:0035120 385 0.053
salivary gland development GO:0007431 162 0.053
mapk cascade GO:0000165 107 0.052
Mouse
positive regulation of developmental process GO:0051094 143 0.052
melanin metabolic process GO:0006582 47 0.050
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.049
substrate adhesion dependent cell spreading GO:0034446 2 0.049
muscle cell development GO:0055001 50 0.049
small molecule metabolic process GO:0044281 305 0.049
Mouse
developmental growth involved in morphogenesis GO:0060560 65 0.049
response to organic cyclic compound GO:0014070 89 0.049
innate immune response GO:0045087 144 0.048
salivary gland morphogenesis GO:0007435 145 0.048
regulation of phosphorus metabolic process GO:0051174 210 0.048
Mouse
sterol homeostasis GO:0055092 4 0.048
immune response GO:0006955 246 0.046
extracellular matrix organization GO:0030198 32 0.045
positive regulation of immune effector process GO:0002699 28 0.043
circadian sleep wake cycle process GO:0022410 24 0.043
response to lipopolysaccharide GO:0032496 4 0.043
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.042
histolysis GO:0007559 102 0.042
response to high light intensity GO:0009644 1 0.042
heart process GO:0003015 37 0.041
proteolysis GO:0006508 192 0.041
regulation of cell proliferation GO:0042127 163 0.041
Human Mouse
positive regulation of phosphate metabolic process GO:0045937 139 0.040
regulation of response to wounding GO:1903034 19 0.040
organic cyclic compound catabolic process GO:1901361 168 0.040
response to radiation GO:0009314 155 0.039
cellular response to endogenous stimulus GO:0071495 80 0.039
regulation of circadian rhythm GO:0042752 49 0.039
regulation of proteolysis GO:0030162 87 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.039
cellular response to light intensity GO:0071484 1 0.039
regulation of phosphorylation GO:0042325 147 0.038
Mouse
response to organic substance GO:0010033 284 0.037
Mouse
instar larval development GO:0002168 55 0.037
positive regulation of cell migration GO:0030335 2 0.037
microtubule organizing center organization GO:0031023 168 0.037
gland development GO:0048732 191 0.036
exocrine system development GO:0035272 162 0.036
carboxylic acid metabolic process GO:0019752 92 0.035
death GO:0016265 284 0.035
protein modification process GO:0036211 438 0.035
cellular catabolic process GO:0044248 372 0.035
Human
positive regulation of signaling GO:0023056 243 0.035
regulation of mapk cascade GO:0043408 92 0.034
Mouse
wing disc morphogenesis GO:0007472 344 0.034
positive regulation of phosphorus metabolic process GO:0010562 139 0.033
organelle assembly GO:0070925 198 0.032
organic substance catabolic process GO:1901575 308 0.032
Human
learning or memory GO:0007611 141 0.032
catecholamine biosynthetic process GO:0042423 3 0.032
cellular homeostasis GO:0019725 80 0.031
imaginal disc derived appendage development GO:0048737 399 0.031
centrosome organization GO:0051297 163 0.030
dopamine biosynthetic process GO:0042416 3 0.030
regulation of multicellular organismal development GO:2000026 414 0.030
Human Mouse
kidney development GO:0001822 3 0.030
regulation of response to external stimulus GO:0032101 115 0.029
negative regulation of rna metabolic process GO:0051253 251 0.029
endocytosis GO:0006897 310 0.029
regulation of cellular protein metabolic process GO:0032268 243 0.029
indole containing compound biosynthetic process GO:0042435 4 0.028
cell cell signaling involved in cell fate commitment GO:0045168 210 0.028
tissue death GO:0016271 102 0.028
connective tissue development GO:0061448 3 0.027
single organism catabolic process GO:0044712 228 0.026
centrosome duplication GO:0051298 121 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
myotube cell development GO:0014904 3 0.026
programmed cell death GO:0012501 257 0.026
regulation of immune effector process GO:0002697 52 0.025
establishment or maintenance of cell polarity GO:0007163 167 0.025
cuticle pigmentation GO:0048067 22 0.025
cellular response to high light intensity GO:0071486 1 0.025
establishment of localization in cell GO:0051649 402 0.025
cellular chemical homeostasis GO:0055082 40 0.024
salivary gland cell autophagic cell death GO:0035071 83 0.024
cellular response to growth factor stimulus GO:0071363 30 0.024
positive regulation of innate immune response GO:0045089 38 0.024
cellular response to organic substance GO:0071310 132 0.024
Mouse
fluid transport GO:0042044 19 0.023
rhythmic process GO:0048511 106 0.023
aromatic compound catabolic process GO:0019439 166 0.023
extrinsic apoptotic signaling pathway GO:0097191 1 0.023
negative regulation of cell differentiation GO:0045596 143 0.023
carbohydrate derivative biosynthetic process GO:1901137 85 0.022
response to endogenous stimulus GO:0009719 119 0.022
phosphorylation GO:0016310 294 0.022
Mouse
cellular component assembly involved in morphogenesis GO:0010927 151 0.022
pigment metabolic process GO:0042440 84 0.022
positive regulation of protein metabolic process GO:0051247 128 0.022
regulation of tube diameter open tracheal system GO:0035158 11 0.022
regionalization GO:0003002 416 0.022
cellular protein modification process GO:0006464 438 0.022
muscle attachment GO:0016203 36 0.022
cellular ion homeostasis GO:0006873 39 0.021
protein phosphorylation GO:0006468 169 0.021
positive regulation of cell communication GO:0010647 250 0.021
production of molecular mediator of immune response GO:0002440 46 0.021
purine nucleoside catabolic process GO:0006152 112 0.021
negative regulation of cellular response to growth factor stimulus GO:0090288 6 0.020
purine ribonucleotide metabolic process GO:0009150 145 0.020
Mouse
imaginal disc growth GO:0007446 37 0.020
protein transport GO:0015031 155 0.020
vesicle mediated transport GO:0016192 381 0.020
organic substance transport GO:0071702 257 0.020
epiboly GO:0090504 2 0.019
cation homeostasis GO:0055080 51 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.019
single organism behavior GO:0044708 391 0.019
body morphogenesis GO:0010171 2 0.019
cell death GO:0008219 279 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
establishment of protein localization GO:0045184 163 0.018
memory GO:0007613 94 0.018
appendage morphogenesis GO:0035107 397 0.018
phagocytosis GO:0006909 215 0.018
regulation of multi organism process GO:0043900 131 0.018
Human
aging GO:0007568 143 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.018
gene silencing GO:0016458 138 0.018
melanization defense response GO:0035006 45 0.017
epithelial structure maintenance GO:0010669 17 0.017
macromolecule catabolic process GO:0009057 161 0.017
Human
regulation of wnt signaling pathway GO:0030111 68 0.017
regulation of anatomical structure morphogenesis GO:0022603 242 0.017
localization of cell GO:0051674 257 0.017
Human
response to ecdysone GO:0035075 34 0.017
nucleotide metabolic process GO:0009117 161 0.017
Mouse
regulation of cell substrate adhesion GO:0010810 2 0.017
oxoacid metabolic process GO:0043436 103 0.017
imaginal disc eversion GO:0007561 4 0.017
developmental programmed cell death GO:0010623 138 0.017
cardiovascular system development GO:0072358 82 0.017
steroid catabolic process GO:0006706 1 0.017
positive regulation of signal transduction GO:0009967 223 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
skeletal muscle organ development GO:0060538 48 0.016
positive regulation of protein kinase activity GO:0045860 25 0.016
organonitrogen compound metabolic process GO:1901564 318 0.016
Mouse
response to abiotic stimulus GO:0009628 341 0.016
terminal branching open tracheal system GO:0007430 17 0.015
protein localization GO:0008104 284 0.015
imaginal disc fusion GO:0046528 19 0.015
regulation of protein modification process GO:0031399 112 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
regulation of establishment of protein localization GO:0070201 61 0.015
dephosphorylation GO:0016311 51 0.015
cell aging GO:0007569 2 0.015
organonitrogen compound biosynthetic process GO:1901566 117 0.015
positive regulation of response to biotic stimulus GO:0002833 31 0.014
response to bacterium GO:0009617 198 0.014
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.014
cell proliferation GO:0008283 299 0.014
Human Mouse
heterocycle catabolic process GO:0046700 166 0.014
sensory perception GO:0007600 196 0.014
sensory organ morphogenesis GO:0090596 260 0.014
positive regulation of cell motility GO:2000147 3 0.014
axis specification GO:0009798 167 0.014
response to growth factor GO:0070848 31 0.014
organic hydroxy compound metabolic process GO:1901615 83 0.014
cellular amide metabolic process GO:0043603 80 0.014
myofibril assembly GO:0030239 36 0.014
positive regulation of growth GO:0045927 75 0.014
mitochondrion organization GO:0007005 65 0.014
rhythmic behavior GO:0007622 76 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
cellular response to organic cyclic compound GO:0071407 32 0.013
wound healing GO:0042060 75 0.013
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
Mouse
autophagic cell death GO:0048102 83 0.013
camera type eye morphogenesis GO:0048593 2 0.013
cellular ketone metabolic process GO:0042180 24 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
encapsulation of foreign target GO:0035010 38 0.013
muscle tissue morphogenesis GO:0060415 2 0.013
long term memory GO:0007616 62 0.013
aromatic amino acid family metabolic process GO:0009072 3 0.013
cellular response to dna damage stimulus GO:0006974 223 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
regulation of synaptic transmission GO:0050804 69 0.013
basement membrane organization GO:0071711 10 0.013
organic acid metabolic process GO:0006082 103 0.013
intracellular signal transduction GO:0035556 300 0.013
Mouse
regulation of neural precursor cell proliferation GO:2000177 35 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
regulation of localization GO:0032879 275 0.012
Human
epithelial cell migration open tracheal system GO:0007427 32 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
phenol containing compound metabolic process GO:0018958 57 0.012
leg disc morphogenesis GO:0007478 80 0.012
regulation of cell division GO:0051302 72 0.012
mitotic cytokinesis GO:0000281 50 0.012
immune response activating signal transduction GO:0002757 2 0.012
regulation of hydrolase activity GO:0051336 97 0.012
positive regulation of response to external stimulus GO:0032103 44 0.012
tissue homeostasis GO:0001894 36 0.012
epiboly involved in wound healing GO:0090505 2 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
hindbrain development GO:0030902 2 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
negative regulation of stem cell proliferation GO:2000647 30 0.012
antifungal humoral response GO:0019732 12 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
primary amino compound biosynthetic process GO:1901162 2 0.011
neuron recognition GO:0008038 101 0.011
regulation of cell death GO:0010941 173 0.011
imaginal disc fusion thorax closure GO:0046529 19 0.011
jnk cascade GO:0007254 50 0.011
salivary gland histolysis GO:0035070 88 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
peptide metabolic process GO:0006518 80 0.011
regulation of response to biotic stimulus GO:0002831 63 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
muscle organ development GO:0007517 127 0.011
fibroblast growth factor receptor signaling pathway GO:0008543 10 0.011
larval development GO:0002164 104 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
Mouse
serotonin metabolic process GO:0042428 2 0.011
protein catabolic process GO:0030163 101 0.011
Human
dorsal ventral pattern formation GO:0009953 133 0.011
negative regulation of developmental process GO:0051093 201 0.011
Human
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
skeletal muscle fiber development GO:0048741 3 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.010
Mouse
regulation of nervous system development GO:0051960 248 0.010
Mouse
cellular response to biotic stimulus GO:0071216 4 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.010
neural precursor cell proliferation GO:0061351 75 0.010
protein secretion GO:0009306 45 0.010
segmentation GO:0035282 207 0.010
cytoskeleton dependent cytokinesis GO:0061640 81 0.010
striated muscle myosin thick filament assembly GO:0071688 3 0.010
regulation of kinase activity GO:0043549 53 0.010
regulation of protein metabolic process GO:0051246 256 0.010
regulation of cell adhesion GO:0030155 27 0.010

Timp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.017
bone disease DOID:0080001 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016
artery disease DOID:0050828 0 0.011
vascular disease DOID:178 0 0.011
cardiovascular system disease DOID:1287 0 0.011