Drosophila melanogaster

143 known processes

E(z) (Dmel_CG6502)

Enhancer of zeste

(Aliases: E(Z),l(3)ds12,l(3)67Fa,l(3)B12,Dmel\CG6502,E[z],CG6502,Ez,pco/E(z),Su(z)301,pco,EZ,E(z)1,l(3)SG17,l(3)1902)

E(z) biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.999
dna metabolic process GO:0006259 227 0.999
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.996
chromosome organization GO:0051276 360 0.995
germarium derived egg chamber formation GO:0007293 101 0.986
meiotic cell cycle GO:0051321 171 0.972
chromosome segregation GO:0007059 157 0.967
meiotic nuclear division GO:0007126 151 0.964
dna repair GO:0006281 54 0.949
negative regulation of cellular biosynthetic process GO:0031327 277 0.932
chromatin organization GO:0006325 207 0.918
regulation of cell cycle process GO:0010564 181 0.909
Mouse
death GO:0016265 284 0.887
Worm
chromatin silencing GO:0006342 76 0.878
mrna metabolic process GO:0016071 124 0.857
ovarian follicle cell development GO:0030707 248 0.847
dna packaging GO:0006323 91 0.818
gene silencing GO:0016458 138 0.817
columnar cuboidal epithelial cell development GO:0002066 249 0.804
dna conformation change GO:0071103 105 0.804
cell cycle phase transition GO:0044770 140 0.801
Mouse
sister chromatid segregation GO:0000819 92 0.757
regulation of response to gamma radiation GO:2001228 4 0.670
small molecule metabolic process GO:0044281 305 0.667
Human
nucleobase containing compound catabolic process GO:0034655 165 0.660
Human
regulation of cell differentiation GO:0045595 302 0.624
Human Mouse
ribose phosphate metabolic process GO:0019693 145 0.620
Human
epithelial cell differentiation GO:0030855 322 0.619
Mouse
protein modification process GO:0036211 438 0.612
tube development GO:0035295 244 0.598
negative regulation of gene expression GO:0010629 387 0.592
covalent chromatin modification GO:0016569 106 0.570
nuclear division GO:0000280 332 0.560
negative regulation of response to stimulus GO:0048585 258 0.551
Human
negative regulation of cellular metabolic process GO:0031324 382 0.535
cell death GO:0008219 279 0.513
Worm
meiotic cell cycle process GO:1903046 132 0.511
ovarian follicle cell stalk formation GO:0030713 17 0.496
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.495
regulation of cell cycle phase transition GO:1901987 130 0.491
Mouse
double strand break repair GO:0006302 26 0.484
chromatin modification GO:0016568 147 0.482
cellular catabolic process GO:0044248 372 0.478
Human
dna recombination GO:0006310 32 0.474
negative regulation of transcription dna templated GO:0045892 237 0.470
regulation of localization GO:0032879 275 0.450
regulation of mitotic cell cycle GO:0007346 190 0.442
Mouse
regulation of cell development GO:0060284 215 0.409
Human Mouse
immune system process GO:0002376 347 0.396
regulation of small gtpase mediated signal transduction GO:0051056 93 0.382
Human
organelle fission GO:0048285 340 0.369
negative regulation of biosynthetic process GO:0009890 277 0.367
negative regulation of rna biosynthetic process GO:1902679 240 0.362
single organism catabolic process GO:0044712 228 0.353
Human
female meiotic division GO:0007143 70 0.328
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.327
Human
germarium derived female germ line cyst encapsulation GO:0030708 8 0.327
macromolecule catabolic process GO:0009057 161 0.319
regulation of phosphate metabolic process GO:0019220 210 0.301
Human Mouse
negative regulation of gene expression epigenetic GO:0045814 77 0.298
Human
cellular protein modification process GO:0006464 438 0.296
organic substance catabolic process GO:1901575 308 0.295
Human
purine ribonucleoside catabolic process GO:0046130 112 0.293
Human
nucleoside metabolic process GO:0009116 127 0.286
Human
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.283
purine containing compound catabolic process GO:0072523 112 0.276
Human
purine nucleotide catabolic process GO:0006195 109 0.256
Human
spermatogenesis GO:0007283 200 0.254
regulation of cell proliferation GO:0042127 163 0.253
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.252
Human Mouse
protein localization GO:0008104 284 0.241
Mouse
mitotic cell cycle phase transition GO:0044772 138 0.241
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.238
regulation of catabolic process GO:0009894 170 0.231
Human
nucleotide metabolic process GO:0009117 161 0.230
Human
rna processing GO:0006396 147 0.225
regulation of dna metabolic process GO:0051052 34 0.218
purine containing compound metabolic process GO:0072521 155 0.214
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.213
Human Mouse
male gamete generation GO:0048232 201 0.212
instar larval development GO:0002168 55 0.212
macromolecule methylation GO:0043414 45 0.211
cellular component assembly involved in morphogenesis GO:0010927 151 0.210
carbohydrate derivative metabolic process GO:1901135 217 0.209
Human
cellular response to dna damage stimulus GO:0006974 223 0.208
apoptotic process GO:0006915 159 0.204
Worm
epithelial cell development GO:0002064 274 0.202
histone ubiquitination GO:0016574 4 0.195
response to organic substance GO:0010033 284 0.194
germarium derived oocyte differentiation GO:0030706 29 0.193
organic cyclic compound catabolic process GO:1901361 168 0.190
Human
homeostatic process GO:0042592 199 0.187
male meiosis GO:0007140 52 0.187
regulation of meiosis GO:0040020 3 0.183
cellular macromolecule catabolic process GO:0044265 136 0.182
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.181
methylation GO:0032259 47 0.175
ribonucleotide metabolic process GO:0009259 145 0.167
Human
histone modification GO:0016570 106 0.167
regulation of anatomical structure morphogenesis GO:0022603 242 0.166
Human
protein targeting to nucleus GO:0044744 51 0.164
protein import GO:0017038 55 0.164
purine nucleotide metabolic process GO:0006163 146 0.160
Human
chromatin mediated maintenance of transcription GO:0048096 7 0.160
growth GO:0040007 359 0.158
Mouse
dorsal vessel heart proper cell fate commitment GO:0035053 2 0.157
chorion containing eggshell formation GO:0007304 105 0.156
nucleoside phosphate catabolic process GO:1901292 110 0.154
Human
organophosphate metabolic process GO:0019637 195 0.154
Human
nucleoside phosphate metabolic process GO:0006753 162 0.146
Human
catabolic process GO:0009056 409 0.137
Human
mitotic dna damage checkpoint GO:0044773 74 0.134
organ growth GO:0035265 56 0.127
aromatic compound catabolic process GO:0019439 166 0.124
Human
ribonucleoside triphosphate catabolic process GO:0009203 108 0.124
Human
negative regulation of signal transduction GO:0009968 206 0.123
Human
regulation of protein transport GO:0051223 57 0.123
ribonucleoside triphosphate metabolic process GO:0009199 119 0.121
Human
embryo development ending in birth or egg hatching GO:0009792 152 0.119
eggshell chorion assembly GO:0007306 66 0.118
germarium derived oocyte fate determination GO:0007294 26 0.112
phosphorylation GO:0016310 294 0.112
Human Mouse
oocyte differentiation GO:0009994 145 0.110
regulation of meiotic cell cycle GO:0051445 9 0.109
ribonucleoside catabolic process GO:0042454 112 0.108
Human
axonogenesis GO:0007409 290 0.108
regulation of molecular function GO:0065009 217 0.106
Human
memory GO:0007613 94 0.106
cell proliferation GO:0008283 299 0.103
Mouse
regulation of multicellular organismal development GO:2000026 414 0.103
Human Mouse Worm
mrna processing GO:0006397 104 0.102
sister chromatid cohesion GO:0007062 18 0.097
positive regulation of gene expression GO:0010628 290 0.096
single organism biosynthetic process GO:0044711 206 0.095
regulation of phosphorylation GO:0042325 147 0.094
Human Mouse
regulation of mapk cascade GO:0043408 92 0.093
Human
purine nucleoside triphosphate metabolic process GO:0009144 119 0.092
Human
glycosyl compound metabolic process GO:1901657 127 0.090
Human
carbohydrate derivative catabolic process GO:1901136 118 0.090
Human
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.089
Mouse
muscle structure development GO:0061061 224 0.086
regulation of cell death GO:0010941 173 0.086
purine nucleoside catabolic process GO:0006152 112 0.086
Human
ncrna metabolic process GO:0034660 43 0.085
intracellular signal transduction GO:0035556 300 0.085
Human
axon guidance GO:0007411 233 0.085
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.084
Human
posttranscriptional gene silencing by rna GO:0035194 45 0.083
regulation of cellular protein metabolic process GO:0032268 243 0.080
Human Mouse
reproductive structure development GO:0048608 74 0.077
nuclear import GO:0051170 51 0.076
sex differentiation GO:0007548 81 0.074
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.074
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.073
Human
dna methylation or demethylation GO:0044728 4 0.073
Mouse
stem cell proliferation GO:0072089 88 0.072
organophosphate catabolic process GO:0046434 112 0.072
Human
purine nucleoside metabolic process GO:0042278 127 0.071
Human
negative regulation of cell cycle GO:0045786 116 0.071
Mouse
nuclear transport GO:0051169 72 0.071
cellular nitrogen compound catabolic process GO:0044270 165 0.071
Human
protein alkylation GO:0008213 43 0.070
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.069
purine ribonucleoside metabolic process GO:0046128 127 0.069
Human
larval development GO:0002164 104 0.066
Worm
anterior posterior pattern specification GO:0009952 136 0.065
positive regulation of response to stimulus GO:0048584 323 0.065
Human
protein modification by small protein conjugation or removal GO:0070647 106 0.065
negative regulation of cell proliferation GO:0008285 69 0.065
protein localization to nucleus GO:0034504 55 0.063
negative regulation of cell differentiation GO:0045596 143 0.062
Mouse
development of primary sexual characteristics GO:0045137 50 0.062
digestive tract morphogenesis GO:0048546 127 0.061
intracellular transport GO:0046907 228 0.061
protein import into nucleus GO:0006606 51 0.059
eggshell formation GO:0030703 105 0.059
gliogenesis GO:0042063 80 0.059
Mouse
cellular response to chemical stimulus GO:0070887 199 0.059
Mouse
chromosome condensation GO:0030261 41 0.058
negative regulation of mapk cascade GO:0043409 23 0.057
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.056
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.056
rna interference GO:0016246 27 0.056
purine ribonucleotide metabolic process GO:0009150 145 0.056
Human
positive regulation of molecular function GO:0044093 136 0.056
Human
regulation of intracellular signal transduction GO:1902531 236 0.056
Human
regulation of apoptotic process GO:0042981 130 0.056
regulation of gene silencing GO:0060968 63 0.056
neuron projection guidance GO:0097485 241 0.055
mitotic sister chromatid segregation GO:0000070 87 0.053
mesenchymal cell development GO:0014031 1 0.053
Human
protein transport GO:0015031 155 0.053
meiosis i GO:0007127 59 0.053
dendrite regeneration GO:0031104 2 0.053
gland development GO:0048732 191 0.052
regulation of wnt signaling pathway GO:0030111 68 0.052
positive regulation of transcription dna templated GO:0045893 266 0.051
oocyte morphogenesis GO:0048601 3 0.051
gene silencing by rna GO:0031047 57 0.050
mitotic sister chromatid separation GO:0051306 30 0.049
regulation of ras protein signal transduction GO:0046578 93 0.049
Human
organic substance transport GO:0071702 257 0.049
cellular macromolecular complex assembly GO:0034622 153 0.048
axon development GO:0061564 297 0.046
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.046
modification dependent protein catabolic process GO:0019941 78 0.046
fertilization GO:0009566 26 0.046
regulation of cellular localization GO:0060341 136 0.046
signal transduction by phosphorylation GO:0023014 107 0.045
Human
determination of adult lifespan GO:0008340 137 0.044
Worm
muscle cell development GO:0055001 50 0.044
multi organism behavior GO:0051705 175 0.044
regulation of cell cycle GO:0051726 291 0.044
Mouse
mitotic cell cycle embryonic GO:0045448 38 0.043
chromosome separation GO:0051304 42 0.043
programmed cell death GO:0012501 257 0.042
Worm
organonitrogen compound metabolic process GO:1901564 318 0.041
Human
negative regulation of response to gamma radiation GO:2001229 4 0.041
purine ribonucleotide catabolic process GO:0009154 109 0.040
Human
multicellular organism growth GO:0035264 46 0.040
negative regulation of rna metabolic process GO:0051253 251 0.040
oxoacid metabolic process GO:0043436 103 0.039
positive regulation of signaling GO:0023056 243 0.038
Human
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 2 0.038
actin cytoskeleton organization GO:0030036 206 0.038
ubiquitin dependent protein catabolic process GO:0006511 78 0.037
positive regulation of multicellular organismal process GO:0051240 143 0.037
Human
wnt signaling pathway GO:0016055 98 0.037
taxis GO:0042330 304 0.036
regulation of cellular response to stress GO:0080135 89 0.036
meiotic chromosome segregation GO:0045132 59 0.036
regulation of organelle organization GO:0033043 196 0.036
negative regulation of neuroblast proliferation GO:0007406 27 0.035
nucleocytoplasmic transport GO:0006913 72 0.035
positive regulation of protein metabolic process GO:0051247 128 0.035
Human
regulation of transport GO:0051049 181 0.034
localization of cell GO:0051674 257 0.034
aging GO:0007568 143 0.033
Worm
autophagic cell death GO:0048102 83 0.033
macromolecular complex assembly GO:0065003 256 0.033
tissue death GO:0016271 102 0.033
oocyte fate determination GO:0030716 27 0.033
dna replication GO:0006260 48 0.033
ribonucleotide catabolic process GO:0009261 109 0.033
Human
regulation of neurogenesis GO:0050767 158 0.032
Mouse
regulation of intracellular protein transport GO:0033157 46 0.032
genitalia development GO:0048806 26 0.032
organonitrogen compound catabolic process GO:1901565 128 0.032
Human
negative regulation of cell communication GO:0010648 223 0.032
Human
response to abiotic stimulus GO:0009628 341 0.031
reactive oxygen species biosynthetic process GO:1903409 0 0.031
regulation of establishment of protein localization GO:0070201 61 0.031
positive regulation of cellular catabolic process GO:0031331 95 0.031
Human
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.030
regulation of canonical wnt signaling pathway GO:0060828 15 0.030
regulation of response to stress GO:0080134 200 0.030
endocytosis GO:0006897 310 0.030
single organism intracellular transport GO:1902582 207 0.030
dendrite development GO:0016358 204 0.030
multicellular organismal aging GO:0010259 140 0.029
Worm
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.029
purine nucleoside monophosphate catabolic process GO:0009128 38 0.029
ribonucleoside metabolic process GO:0009119 127 0.029
Human
regulation of nucleotide metabolic process GO:0006140 62 0.028
Human
protein complex biogenesis GO:0070271 201 0.028
negative regulation of terminal cell fate specification open tracheal system GO:0035155 2 0.028
regulation of cellular catabolic process GO:0031329 157 0.028
Human
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.028
regulation of cell cycle g1 s phase transition GO:1902806 23 0.028
Mouse
regulation of chromosome segregation GO:0051983 32 0.028
trunk segmentation GO:0035290 8 0.027
dorsal closure leading edge cell differentiation GO:0046663 2 0.027
regulation of ral protein signal transduction GO:0032485 1 0.026
cell cycle arrest GO:0007050 4 0.026
nucleoside triphosphate metabolic process GO:0009141 120 0.026
Human
atp catabolic process GO:0006200 38 0.026
regulation of nuclear division GO:0051783 58 0.026
spindle organization GO:0007051 253 0.026
nucleoside monophosphate metabolic process GO:0009123 52 0.026
regulation of trichome morphogenesis GO:2000039 3 0.026
germ line cyst encapsulation GO:0048138 8 0.026
dna geometric change GO:0032392 16 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
Human
positive regulation of cell cycle GO:0045787 43 0.025
body morphogenesis GO:0010171 2 0.025
regulation of cell morphogenesis GO:0022604 163 0.025
Human
proteasomal protein catabolic process GO:0010498 59 0.024
response to radiation GO:0009314 155 0.024
rna splicing GO:0008380 83 0.024
positive regulation of mitotic cell cycle GO:0045931 34 0.024
oocyte fate commitment GO:0048600 2 0.024
regeneration GO:0031099 16 0.024
Mouse
establishment of localization in cell GO:0051649 402 0.024
molting cycle GO:0042303 56 0.024
central nervous system development GO:0007417 201 0.024
Mouse
negative regulation of wnt signaling pathway GO:0030178 28 0.023
establishment of protein localization GO:0045184 163 0.023
metaphase anaphase transition of cell cycle GO:0044784 28 0.023
positive regulation of protein phosphorylation GO:0001934 34 0.023
Human
mitotic spindle organization GO:0007052 220 0.022
meiotic spindle checkpoint GO:0044779 1 0.022
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.022
positive regulation of viral entry into host cell GO:0046598 2 0.022
mapk cascade GO:0000165 107 0.022
Human
posttranscriptional gene silencing GO:0016441 46 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.022
negative regulation of phosphatase activity GO:0010923 3 0.021
female germ line cyst encapsulation GO:0048139 8 0.021
positive regulation of calcium ion transmembrane transporter activity GO:1901021 2 0.021
regulation of phosphatase activity GO:0010921 3 0.021
embryonic morphogenesis GO:0048598 206 0.021
segmentation GO:0035282 207 0.021
cellular protein localization GO:0034613 160 0.020
Mouse
regulation of protein modification process GO:0031399 112 0.020
Human Mouse
negative regulation of filopodium assembly GO:0051490 3 0.020
cognition GO:0050890 141 0.020
regulation of ruffle assembly GO:1900027 1 0.020
modification dependent macromolecule catabolic process GO:0043632 79 0.020
response to organic cyclic compound GO:0014070 89 0.020
regulation of rac gtpase activity GO:0032314 1 0.020
regulation of catalytic activity GO:0050790 185 0.020
Human
mitotic nuclear division GO:0007067 213 0.020
negative regulation of dna templated transcription initiation GO:2000143 1 0.020
stem cell differentiation GO:0048863 117 0.019
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.019
pole cell formation GO:0007279 19 0.019
regulation of nucleocytoplasmic transport GO:0046822 35 0.019
lateral inhibition GO:0046331 206 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
Human Mouse
ras protein signal transduction GO:0007265 88 0.019
purine nucleoside monophosphate metabolic process GO:0009126 50 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
Human
digestive system development GO:0055123 149 0.018
g2 m transition of mitotic cell cycle GO:0000086 19 0.018
histone lysine methylation GO:0034968 32 0.018
histolysis GO:0007559 102 0.017
multicellular organismal reproductive behavior GO:0033057 110 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
Human
negative regulation of signaling GO:0023057 219 0.017
Human
histone h4 acetylation involved in response to dna damage stimulus GO:2000776 1 0.017
oocyte development GO:0048599 124 0.017
specification of segmental identity antennal segment GO:0007383 2 0.017
negative regulation of mitotic cell cycle GO:0045930 109 0.017
Mouse
dna alkylation GO:0006305 4 0.017
Mouse
regulation of purine nucleotide metabolic process GO:1900542 62 0.017
Human
border follicle cell delamination GO:0030709 3 0.017
protein catabolic process GO:0030163 101 0.017
tissue morphogenesis GO:0048729 297 0.017
protein modification by small protein conjugation GO:0032446 79 0.016
striated muscle cell differentiation GO:0051146 90 0.016
Mouse
glycosyl compound catabolic process GO:1901658 112 0.016
Human
single organism nuclear import GO:1902593 51 0.016
eye development GO:0001654 323 0.016
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051436 2 0.016
regulation of neuroblast proliferation GO:1902692 34 0.016
response to uv b GO:0010224 1 0.016
negative regulation of mitochondrial fusion GO:0010637 2 0.015
regulation of nucleoside metabolic process GO:0009118 50 0.015
Human
positive regulation of cellular component organization GO:0051130 156 0.015
Human
positive regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0090282 1 0.015
regulation of calcium ion transmembrane transport GO:1903169 2 0.015
nucleotide catabolic process GO:0009166 109 0.015
Human
vesicle mediated transport GO:0016192 381 0.015
regulation of sister chromatid segregation GO:0033045 28 0.015
anterior posterior axis specification follicular epithelium GO:0030714 2 0.015
cellular protein catabolic process GO:0044257 83 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.015
meiotic nuclear envelope disassembly GO:0051078 2 0.015
negative regulation of mrna 3 end processing GO:0031441 3 0.015
cytoskeletal anchoring at plasma membrane GO:0007016 1 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
regulation of proteasomal protein catabolic process GO:0061136 39 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
positive regulation of cell maturation GO:1903431 2 0.014
karyosome formation GO:0030717 22 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.014
Human
organic acid metabolic process GO:0006082 103 0.014
heart development GO:0007507 82 0.014
protein ubiquitination GO:0016567 70 0.014
dna templated transcriptional start site selection GO:0001173 1 0.014
mitotic chromosome condensation GO:0007076 22 0.014
immune system development GO:0002520 57 0.014
female germ line cyst formation GO:0048135 42 0.014
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 1 0.014
response to external biotic stimulus GO:0043207 293 0.014
innate immune response GO:0045087 144 0.014
response to red light GO:0010114 2 0.014
cell maturation GO:0048469 144 0.014
nitric oxide metabolic process GO:0046209 1 0.014
protein dna complex assembly GO:0065004 63 0.014
cardiovascular system development GO:0072358 82 0.014
positive regulation of store operated calcium channel activity GO:1901341 1 0.014
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded GO:0008070 2 0.014
response to ionizing radiation GO:0010212 32 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.013
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
regulation of mitotic cell cycle phase transition GO:1901990 130 0.013
Mouse
regulation of ran gtpase activity GO:0032316 1 0.013
regulation of transcription by chromatin organization GO:0034401 3 0.013
purine nucleoside triphosphate catabolic process GO:0009146 108 0.013
Human
regulation of protein localization to nucleus GO:1900180 29 0.013
brain development GO:0007420 120 0.013
Mouse
regulation of epithelial cell proliferation GO:0050678 4 0.013
regulation of cytokinesis actomyosin contractile ring assembly GO:2000431 2 0.013
release of cytoplasmic sequestered nf kappab GO:0008588 1 0.013
trichome morphogenesis GO:0010090 3 0.013
microtubule sliding GO:0051012 3 0.013
organelle assembly GO:0070925 198 0.013
morphogenesis of an epithelium GO:0002009 276 0.012
protein complex assembly GO:0006461 200 0.012
chromatin assembly or disassembly GO:0006333 52 0.012
regulation of striated muscle contraction GO:0006942 2 0.012
phagocytosis GO:0006909 215 0.012
regulation of endocrine process GO:0044060 2 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
Human
regulation of sphingolipid biosynthetic process GO:0090153 2 0.012
regulation of hemocyte proliferation GO:0035206 37 0.012
regulation of response to dna damage stimulus GO:2001020 23 0.012
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
Human
nitrogen compound transport GO:0071705 85 0.012
regulation of viral entry into host cell GO:0046596 2 0.012
transposition GO:0032196 13 0.012
synaptic vesicle budding from presynaptic membrane GO:0016185 1 0.012
regulation of neuron differentiation GO:0045664 103 0.012
regulation of programmed cell death GO:0043067 152 0.012
negative regulation of phosphorus metabolic process GO:0010563 45 0.012
positive regulation of organelle organization GO:0010638 65 0.012
cell morphogenesis involved in malpighian tubule morphogenesis GO:0061336 1 0.011
neurological system process GO:0050877 358 0.011
response to other organism GO:0051707 293 0.011
positive regulation of intracellular transport GO:0032388 42 0.011
regulation of mitotic sister chromatid segregation GO:0033047 28 0.011
regulation of viral genome replication GO:0045069 4 0.011
regulation of mitotic sister chromatid separation GO:0010965 28 0.011
positive regulation of neuron projection regeneration GO:0070572 3 0.011
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.011
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.011
positive regulation of pole plasm oskar mrna localization GO:0045856 2 0.011
centripetally migrating follicle cell migration GO:0060269 1 0.011
long term strengthening of neuromuscular junction GO:0042062 2 0.011
digestive tract development GO:0048565 149 0.011
positive regulation of protein modification process GO:0031401 58 0.011
Human
embryonic pattern specification GO:0009880 174 0.011
cell cell junction maintenance GO:0045217 1 0.011
positive regulation of developmental process GO:0051094 143 0.011
Human
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.011
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.011
cell cycle checkpoint GO:0000075 95 0.011
maintenance of mitotic sister chromatid cohesion GO:0034088 1 0.011
border follicle cell migration GO:0007298 113 0.010
nurse cell nucleus anchoring GO:0007302 1 0.010
cell aging GO:0007569 2 0.010
protein modification by small protein removal GO:0070646 28 0.010
cell activation GO:0001775 9 0.010
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 1 0.010
negative regulation of developmental process GO:0051093 201 0.010
Mouse Worm

E(z) disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.200
cancer DOID:162 0 0.092
organ system cancer DOID:0050686 0 0.092
gonadal dysgenesis DOID:14447 0 0.026
chromosomal disease DOID:0080014 0 0.026
thyroid carcinoma DOID:3963 0 0.021
thyroid cancer DOID:1781 0 0.021
follicular thyroid carcinoma DOID:3962 0 0.021
endocrine gland cancer DOID:170 0 0.021
pancreatic carcinoma DOID:4905 0 0.020
pancreatic cancer DOID:1793 0 0.020
tuberous sclerosis DOID:13515 0 0.016
vascular disease DOID:178 0 0.016
cardiovascular system disease DOID:1287 0 0.016
artery disease DOID:0050828 0 0.016
disease of anatomical entity DOID:7 0 0.016
aortic disease DOID:520 0 0.016
benign neoplasm DOID:0060072 0 0.013
organ system benign neoplasm DOID:0060085 0 0.013
skin benign neoplasm DOID:3165 0 0.013
integumentary system benign neoplasm DOID:0060121 0 0.013
hair follicle neoplasm DOID:5375 0 0.013
pilomatrixoma DOID:5374 0 0.013
leopard syndrome DOID:14291 0 0.013
hajdu cheney syndrome DOID:2736 0 0.013
alagille syndrome DOID:9245 0 0.011
liver disease DOID:409 0 0.011
hepatobiliary disease DOID:3118 0 0.011
gastrointestinal system disease DOID:77 0 0.011
disease of metabolism DOID:0014667 0 0.011
hemochromatosis DOID:2352 0 0.011
inherited metabolic disorder DOID:655 0 0.011
metal metabolism disorder DOID:896 0 0.011