Drosophila melanogaster

25 known processes

Gem3 (Dmel_CG6539)

Gemin3

(Aliases: Dmel\CG6539,BcDNA:LD05563,CG6539,dGem3,Dhh1,DHH1,l(3)rL562,BcDNA.LD05563,DmRH22)

Gem3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
open tracheal system development GO:0007424 204 0.601
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.484
locomotory behavior GO:0007626 176 0.408
regulation of developmental growth GO:0048638 174 0.394
single organism behavior GO:0044708 391 0.369
adult locomotory behavior GO:0008344 76 0.325
synaptic transmission GO:0007268 288 0.306
muscle structure development GO:0061061 224 0.285
cell maturation GO:0048469 144 0.235
response to alcohol GO:0097305 95 0.230
regulation of cellular component biogenesis GO:0044087 201 0.225
homeostatic process GO:0042592 199 0.215
negative regulation of cellular component organization GO:0051129 108 0.205
reproductive behavior GO:0019098 122 0.201
mitochondrion organization GO:0007005 65 0.201
cellular response to dna damage stimulus GO:0006974 223 0.191
regulation of multicellular organismal development GO:2000026 414 0.181
adult behavior GO:0030534 137 0.178
regulation of synapse assembly GO:0051963 94 0.170
organonitrogen compound metabolic process GO:1901564 318 0.165
growth GO:0040007 359 0.156
synapse organization GO:0050808 196 0.156
ion transport GO:0006811 145 0.156
columnar cuboidal epithelial cell development GO:0002066 249 0.155
neuromuscular junction development GO:0007528 149 0.147
negative regulation of synapse assembly GO:0051964 39 0.131
negative regulation of multicellular organismal process GO:0051241 142 0.130
mating behavior GO:0007617 106 0.128
rna polyadenylation GO:0043631 12 0.123
regulation of peptidase activity GO:0052547 39 0.119
compound eye photoreceptor cell differentiation GO:0001751 140 0.115
regulation of organelle organization GO:0033043 196 0.113
regulation of nervous system development GO:0051960 248 0.112
negative regulation of nervous system development GO:0051961 92 0.102
negative regulation of developmental process GO:0051093 201 0.100
protein modification by small protein conjugation or removal GO:0070647 106 0.099
synaptic growth at neuromuscular junction GO:0051124 119 0.098
positive regulation of signal transduction GO:0009967 223 0.098
negative regulation of cell cycle phase transition GO:1901988 103 0.095
regulation of cell differentiation GO:0045595 302 0.094
response to temperature stimulus GO:0009266 106 0.093
mitotic g2 dna damage checkpoint GO:0007095 69 0.092
positive regulation of response to stimulus GO:0048584 323 0.091
regulation of synapse organization GO:0050807 110 0.088
regulation of notch signaling pathway GO:0008593 100 0.086
regulation of protein complex disassembly GO:0043244 29 0.085
mitotic nuclear division GO:0007067 213 0.085
cytoplasmic transport GO:0016482 130 0.085
cellular response to abiotic stimulus GO:0071214 58 0.084
response to abiotic stimulus GO:0009628 341 0.081
male mating behavior GO:0060179 70 0.081
cellular protein modification process GO:0006464 438 0.080
developmental growth GO:0048589 280 0.078
dna repair GO:0006281 54 0.078
developmental maturation GO:0021700 172 0.077
compound eye morphogenesis GO:0001745 249 0.074
negative regulation of cell cycle GO:0045786 116 0.073
synapse assembly GO:0007416 143 0.071
positive regulation of developmental growth GO:0048639 62 0.070
regulation of growth GO:0040008 233 0.068
transcription from rna polymerase ii promoter GO:0006366 368 0.066
Mouse
taxis GO:0042330 304 0.065
negative regulation of response to stimulus GO:0048585 258 0.063
notch signaling pathway GO:0007219 120 0.062
organelle fission GO:0048285 340 0.062
positive regulation of biosynthetic process GO:0009891 316 0.060
sensory organ morphogenesis GO:0090596 260 0.059
regulation of molecular function GO:0065009 217 0.059
response to radiation GO:0009314 155 0.059
morphogenesis of an epithelium GO:0002009 276 0.058
protein polymerization GO:0051258 42 0.057
macromolecular complex assembly GO:0065003 256 0.056
divalent inorganic cation transport GO:0072511 30 0.056
positive regulation of nucleic acid templated transcription GO:1903508 266 0.056
small molecule metabolic process GO:0044281 305 0.056
positive regulation of signaling GO:0023056 243 0.055
central nervous system development GO:0007417 201 0.055
mitotic cell cycle phase transition GO:0044772 138 0.054
response to organic cyclic compound GO:0014070 89 0.053
regulation of mitotic cell cycle GO:0007346 190 0.052
chromosome organization GO:0051276 360 0.052
proteolysis GO:0006508 192 0.052
positive regulation of cell communication GO:0010647 250 0.051
regulation of cellular protein metabolic process GO:0032268 243 0.050
nitrogen compound transport GO:0071705 85 0.049
wing disc morphogenesis GO:0007472 344 0.048
ubiquitin dependent protein catabolic process GO:0006511 78 0.048
protein modification by small protein conjugation GO:0032446 79 0.048
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.047
cellular catabolic process GO:0044248 372 0.047
regulation of synapse structure and activity GO:0050803 128 0.046
multi organism behavior GO:0051705 175 0.046
response to ecdysone GO:0035075 34 0.046
imaginal disc fusion GO:0046528 19 0.046
neuromuscular synaptic transmission GO:0007274 67 0.045
intracellular signal transduction GO:0035556 300 0.045
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.044
Mouse
mrna polyadenylation GO:0006378 11 0.044
regulation of mitotic cell cycle phase transition GO:1901990 130 0.042
positive regulation of multicellular organismal process GO:0051240 143 0.042
positive regulation of cellular component organization GO:0051130 156 0.042
cation transport GO:0006812 110 0.041
catabolic process GO:0009056 409 0.041
response to inorganic substance GO:0010035 44 0.041
regulation of proteolysis GO:0030162 87 0.040
head development GO:0060322 135 0.039
dna metabolic process GO:0006259 227 0.039
eye morphogenesis GO:0048592 260 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.038
metal ion transport GO:0030001 74 0.038
embryo development ending in birth or egg hatching GO:0009792 152 0.038
carbohydrate derivative metabolic process GO:1901135 217 0.037
organic substance transport GO:0071702 257 0.037
epithelial cell differentiation GO:0030855 322 0.036
positive regulation of rna biosynthetic process GO:1902680 266 0.036
ovarian follicle cell development GO:0030707 248 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.035
Mouse
single organism biosynthetic process GO:0044711 206 0.035
Mouse
positive regulation of developmental process GO:0051094 143 0.035
protein ubiquitination GO:0016567 70 0.035
epithelial cell development GO:0002064 274 0.034
regulation of phosphatase activity GO:0010921 3 0.034
neuron projection guidance GO:0097485 241 0.033
brain development GO:0007420 120 0.033
intracellular transport GO:0046907 228 0.033
actin filament organization GO:0007015 126 0.033
striated muscle myosin thick filament assembly GO:0071688 3 0.033
regulation of cytoplasmic transport GO:1903649 47 0.032
rna localization GO:0006403 115 0.032
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.032
Mouse
actin cytoskeleton organization GO:0030036 206 0.031
segmentation GO:0035282 207 0.030
ribose phosphate metabolic process GO:0019693 145 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.030
purine ribonucleotide metabolic process GO:0009150 145 0.030
multi organism reproductive behavior GO:0044705 121 0.029
regulation of catalytic activity GO:0050790 185 0.029
nucleocytoplasmic transport GO:0006913 72 0.029
regulation of cell development GO:0060284 215 0.029
ecdysone receptor mediated signaling pathway GO:0035076 11 0.028
regulation of intracellular transport GO:0032386 64 0.028
chromatin silencing GO:0006342 76 0.028
negative regulation of rna biosynthetic process GO:1902679 240 0.028
Mouse
single organism catabolic process GO:0044712 228 0.028
transmembrane transport GO:0055085 139 0.028
peptidyl lysine methylation GO:0018022 16 0.028
actin filament based process GO:0030029 220 0.027
muscle cell differentiation GO:0042692 103 0.027
positive regulation of multicellular organism growth GO:0040018 21 0.027
gene silencing GO:0016458 138 0.026
nuclear export GO:0051168 24 0.025
carbohydrate derivative biosynthetic process GO:1901137 85 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.024
Mouse
regulation of protein metabolic process GO:0051246 256 0.024
oocyte construction GO:0007308 112 0.024
regulation of cell cycle process GO:0010564 181 0.023
regulation of cell shape GO:0008360 113 0.023
striated muscle cell differentiation GO:0051146 90 0.023
negative regulation of mitotic cell cycle GO:0045930 109 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.023
cellular cation homeostasis GO:0030003 38 0.023
protein modification process GO:0036211 438 0.022
chromatin organization GO:0006325 207 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.022
response to light stimulus GO:0009416 124 0.022
negative regulation of notch signaling pathway GO:0045746 41 0.022
signal transduction in response to dna damage GO:0042770 3 0.022
tissue morphogenesis GO:0048729 297 0.021
oocyte axis specification GO:0007309 108 0.021
regulation of programmed cell death GO:0043067 152 0.021
Mouse
mrna transport GO:0051028 15 0.021
spermatogenesis GO:0007283 200 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
Mouse
regulation of hydrolase activity GO:0051336 97 0.021
regulation of dna metabolic process GO:0051052 34 0.021
compound eye development GO:0048749 307 0.021
tissue death GO:0016271 102 0.020
response to sterol GO:0036314 34 0.020
positive regulation of macromolecule metabolic process GO:0010604 405 0.020
mitotic cell cycle checkpoint GO:0007093 88 0.020
rhythmic process GO:0048511 106 0.019
rna transport GO:0050658 46 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.019
regulation of cell cycle GO:0051726 291 0.019
regionalization GO:0003002 416 0.019
cell cycle phase transition GO:0044770 140 0.019
axon development GO:0061564 297 0.019
chromosome segregation GO:0007059 157 0.019
response to ketone GO:1901654 34 0.019
regulation of gene expression epigenetic GO:0040029 128 0.019
modification dependent macromolecule catabolic process GO:0043632 79 0.019
chemical homeostasis GO:0048878 92 0.019
metal ion homeostasis GO:0055065 44 0.019
positive regulation of apoptotic signaling pathway GO:2001235 4 0.019
nuclear envelope organization GO:0006998 7 0.019
negative regulation of cell cycle process GO:0010948 109 0.019
cellular component assembly involved in morphogenesis GO:0010927 151 0.018
appendage development GO:0048736 401 0.018
microtubule organizing center organization GO:0031023 168 0.018
negative regulation of neuroblast proliferation GO:0007406 27 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
regulation of protein catabolic process GO:0042176 55 0.018
establishment of rna localization GO:0051236 47 0.018
negative regulation of growth GO:0045926 84 0.018
embryonic pattern specification GO:0009880 174 0.017
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.017
carbohydrate metabolic process GO:0005975 82 0.017
regulation of neuroblast proliferation GO:1902692 34 0.017
actin polymerization or depolymerization GO:0008154 31 0.017
negative regulation of gene expression GO:0010629 387 0.017
Mouse
negative regulation of proteolysis GO:0045861 31 0.016
response to heat GO:0009408 63 0.016
anatomical structure homeostasis GO:0060249 97 0.016
myofibril assembly GO:0030239 36 0.016
formation of anatomical boundary GO:0048859 37 0.016
regulation of cell cycle phase transition GO:1901987 130 0.016
ncrna metabolic process GO:0034660 43 0.016
blastoderm segmentation GO:0007350 159 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
eye photoreceptor cell differentiation GO:0001754 145 0.016
vesicle mediated transport GO:0016192 381 0.016
Worm
eggshell formation GO:0030703 105 0.016
eye development GO:0001654 323 0.016
cellular metal ion homeostasis GO:0006875 31 0.016
morphogenesis of a polarized epithelium GO:0001738 93 0.016
protein complex assembly GO:0006461 200 0.015
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.015
embryonic axis specification GO:0000578 107 0.015
negative regulation of cellular biosynthetic process GO:0031327 277 0.015
Mouse
larval locomotory behavior GO:0008345 27 0.015
wound healing GO:0042060 75 0.015
larval development GO:0002164 104 0.015
cellular protein complex assembly GO:0043623 71 0.015
appendage morphogenesis GO:0035107 397 0.015
cellular response to chemical stimulus GO:0070887 199 0.014
negative regulation of defense response GO:0031348 35 0.014
maintenance of location GO:0051235 73 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
tube morphogenesis GO:0035239 191 0.014
oocyte maturation GO:0001556 3 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
negative regulation of signaling GO:0023057 219 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
Mouse
rhabdomere development GO:0042052 38 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.014
proteasomal protein catabolic process GO:0010498 59 0.014
regulation of anatomical structure size GO:0090066 163 0.014
dna templated transcription elongation GO:0006354 18 0.013
phagocytosis GO:0006909 215 0.013
protein transport GO:0015031 155 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
Mouse
regulation of nucleocytoplasmic transport GO:0046822 35 0.013
regulation of cellular component size GO:0032535 98 0.013
molting cycle chitin based cuticle GO:0007591 56 0.013
regulation of localization GO:0032879 275 0.013
cellular response to organic cyclic compound GO:0071407 32 0.013
dna double strand break processing GO:0000729 3 0.013
connective tissue development GO:0061448 3 0.013
positive regulation of growth GO:0045927 75 0.013
cell proliferation GO:0008283 299 0.013
regulation of actin polymerization or depolymerization GO:0008064 27 0.012
regulation of protein modification process GO:0031399 112 0.012
multicellular organismal aging GO:0010259 140 0.012
axon guidance GO:0007411 233 0.012
aging GO:0007568 143 0.012
cellular lipid metabolic process GO:0044255 83 0.012
feeding behavior GO:0007631 50 0.012
single organism intracellular transport GO:1902582 207 0.012
chromatin modification GO:0016568 147 0.012
spermatid development GO:0007286 98 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
negative regulation of cellular metabolic process GO:0031324 382 0.011
Mouse
protein processing GO:0016485 68 0.011
peripheral nervous system development GO:0007422 52 0.011
cellular response to sterol depletion GO:0071501 3 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.011
purine nucleoside monophosphate catabolic process GO:0009128 38 0.011
mitotic g2 m transition checkpoint GO:0044818 70 0.011
neuron remodeling GO:0016322 29 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
divalent metal ion transport GO:0070838 26 0.011
calcium ion homeostasis GO:0055074 23 0.011
nuclear import GO:0051170 51 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.010
single organism cellular localization GO:1902580 180 0.010
nuclear transport GO:0051169 72 0.010
regulation of multicellular organism growth GO:0040014 40 0.010
nucleoside monophosphate catabolic process GO:0009125 39 0.010
establishment of tissue polarity GO:0007164 87 0.010
regulation of ion transport GO:0043269 39 0.010
actin filament polymerization GO:0030041 27 0.010
glycoprotein metabolic process GO:0009100 41 0.010
larval behavior GO:0030537 42 0.010
sarcomere organization GO:0045214 26 0.010
cellular protein catabolic process GO:0044257 83 0.010
negative regulation of cell communication GO:0010648 223 0.010

Gem3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.080
nervous system disease DOID:863 0 0.033
central nervous system disease DOID:331 0 0.014
neurodegenerative disease DOID:1289 0 0.010