Drosophila melanogaster

0 known processes

Pdi (Dmel_CG6988)

Protein disulfide isomerase

(Aliases: CG6988,pdi,Dpdi,Dmel\CG6988,PDI,EP(3)1022,dpdi)

Pdi biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.101
protein modification process GO:0036211 438 0.091
Human
vesicle mediated transport GO:0016192 381 0.090
regulation of gene expression epigenetic GO:0040029 128 0.078
cellular protein modification process GO:0006464 438 0.072
Human
regulation of localization GO:0032879 275 0.070
modification dependent protein catabolic process GO:0019941 78 0.069
establishment of localization in cell GO:0051649 402 0.069
negative regulation of cellular metabolic process GO:0031324 382 0.068
anatomical structure homeostasis GO:0060249 97 0.065
wing disc morphogenesis GO:0007472 344 0.064
ion transmembrane transport GO:0034220 122 0.063
protein catabolic process GO:0030163 101 0.062
microtubule organizing center organization GO:0031023 168 0.057
intracellular transport GO:0046907 228 0.057
positive regulation of response to stimulus GO:0048584 323 0.057
male gamete generation GO:0048232 201 0.056
Mouse
spermatogenesis GO:0007283 200 0.055
Mouse
regulation of transport GO:0051049 181 0.052
neurological system process GO:0050877 358 0.052
catabolic process GO:0009056 409 0.049
peptide metabolic process GO:0006518 80 0.049
regulation of multicellular organismal development GO:2000026 414 0.049
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.049
cellular catabolic process GO:0044248 372 0.048
xenobiotic catabolic process GO:0042178 1 0.047
imaginal disc derived wing morphogenesis GO:0007476 337 0.045
cellular protein catabolic process GO:0044257 83 0.045
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.045
organic substance catabolic process GO:1901575 308 0.044
negative regulation of rna metabolic process GO:0051253 251 0.044
positive regulation of cellular component organization GO:0051130 156 0.043
negative regulation of cell cycle GO:0045786 116 0.043
single organism behavior GO:0044708 391 0.043
protein localization GO:0008104 284 0.043
imaginal disc derived appendage development GO:0048737 399 0.042
single organism intracellular transport GO:1902582 207 0.041
proteasomal protein catabolic process GO:0010498 59 0.041
regulation of cell differentiation GO:0045595 302 0.041
mrna metabolic process GO:0016071 124 0.041
endocytosis GO:0006897 310 0.041
exocrine system development GO:0035272 162 0.041
imaginal disc derived appendage morphogenesis GO:0035114 395 0.040
cellular macromolecule catabolic process GO:0044265 136 0.039
positive regulation of macromolecule metabolic process GO:0010604 405 0.039
camera type eye development GO:0043010 4 0.039
transcription from rna polymerase ii promoter GO:0006366 368 0.038
macromolecule catabolic process GO:0009057 161 0.038
cytoplasmic transport GO:0016482 130 0.037
regulation of molecular function GO:0065009 217 0.037
negative regulation of signaling GO:0023057 219 0.037
single organism biosynthetic process GO:0044711 206 0.036
peptidyl amino acid modification GO:0018193 105 0.036
Human
regulation of nervous system development GO:0051960 248 0.036
response to organic substance GO:0010033 284 0.036
regulation of behavior GO:0050795 75 0.036
regionalization GO:0003002 416 0.036
negative regulation of cell cycle process GO:0010948 109 0.035
negative regulation of gene expression GO:0010629 387 0.035
response to unfolded protein GO:0006986 9 0.035
ubiquitin dependent protein catabolic process GO:0006511 78 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.035
negative regulation of cell communication GO:0010648 223 0.035
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.034
cellular protein localization GO:0034613 160 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.033
cellular response to dna damage stimulus GO:0006974 223 0.033
peptidyl proline hydroxylation GO:0019511 1 0.033
Human
aggressive behavior GO:0002118 63 0.033
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.033
phagocytosis GO:0006909 215 0.032
immune system process GO:0002376 347 0.032
negative regulation of nervous system development GO:0051961 92 0.032
multicellular organismal reproductive behavior GO:0033057 110 0.032
organic substance transport GO:0071702 257 0.032
regulation of cell cycle GO:0051726 291 0.032
locomotory behavior GO:0007626 176 0.032
cellular response to chemical stimulus GO:0070887 199 0.032
Human
forebrain development GO:0030900 2 0.031
sensory perception of mechanical stimulus GO:0050954 72 0.031
lateral inhibition GO:0046331 206 0.031
regulation of imaginal disc derived wing size GO:0044719 20 0.031
centrosome duplication GO:0051298 121 0.031
negative regulation of nucleic acid templated transcription GO:1903507 240 0.031
endomembrane system organization GO:0010256 119 0.031
thioester metabolic process GO:0035383 3 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.030
dna conformation change GO:0071103 105 0.030
regulation of organelle organization GO:0033043 196 0.030
cellular response to unfolded protein GO:0034620 9 0.029
regulation of intracellular signal transduction GO:1902531 236 0.029
Human
negative regulation of rna biosynthetic process GO:1902679 240 0.029
oocyte development GO:0048599 124 0.029
cellular macromolecule localization GO:0070727 220 0.029
inorganic ion transmembrane transport GO:0098660 73 0.029
centrosome cycle GO:0007098 137 0.029
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.028
positive regulation of cell migration GO:0030335 2 0.028
chromosome organization GO:0051276 360 0.028
negative regulation of signal transduction GO:0009968 206 0.028
inter male aggressive behavior GO:0002121 60 0.028
developmental growth GO:0048589 280 0.028
chaeta development GO:0022416 97 0.027
negative regulation of transcription dna templated GO:0045892 237 0.027
salivary gland morphogenesis GO:0007435 145 0.027
regulation of catalytic activity GO:0050790 185 0.027
intracellular protein transport GO:0006886 104 0.027
cell proliferation GO:0008283 299 0.027
appendage morphogenesis GO:0035107 397 0.026
cuticle development GO:0042335 86 0.026
positive regulation of rna biosynthetic process GO:1902680 266 0.026
dendrite morphogenesis GO:0048813 199 0.026
vitamin biosynthetic process GO:0009110 1 0.026
positive regulation of signal transduction GO:0009967 223 0.025
golgi organization GO:0007030 66 0.025
kidney development GO:0001822 3 0.025
positive regulation of biosynthetic process GO:0009891 316 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
positive regulation of transcription dna templated GO:0045893 266 0.025
regulation of protein metabolic process GO:0051246 256 0.024
aging GO:0007568 143 0.024
regulation of cell development GO:0060284 215 0.024
sensory perception GO:0007600 196 0.024
gland development GO:0048732 191 0.023
pigment metabolic process involved in pigmentation GO:0043474 33 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.023
sister chromatid segregation GO:0000819 92 0.023
carbohydrate metabolic process GO:0005975 82 0.023
eye development GO:0001654 323 0.023
appendage development GO:0048736 401 0.023
axon development GO:0061564 297 0.023
dna metabolic process GO:0006259 227 0.023
centrosome organization GO:0051297 163 0.023
ion transport GO:0006811 145 0.023
maintenance of location GO:0051235 73 0.022
synaptic transmission GO:0007268 288 0.022
post embryonic appendage morphogenesis GO:0035120 385 0.022
regulation of chromatin silencing GO:0031935 36 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
regulation of anatomical structure size GO:0090066 163 0.022
multi organism behavior GO:0051705 175 0.022
sleep GO:0030431 49 0.021
response to glucose GO:0009749 2 0.021
negative regulation of cellular biosynthetic process GO:0031327 277 0.021
organonitrogen compound metabolic process GO:1901564 318 0.021
Human
positive regulation of cell communication GO:0010647 250 0.021
telencephalon development GO:0021537 2 0.021
regulation of cell proliferation GO:0042127 163 0.021
embryo development ending in birth or egg hatching GO:0009792 152 0.021
modification dependent macromolecule catabolic process GO:0043632 79 0.021
inorganic cation transmembrane transport GO:0098662 61 0.021
positive regulation of gene expression GO:0010628 290 0.021
cell cycle arrest GO:0007050 4 0.020
chromosome segregation GO:0007059 157 0.020
establishment of protein localization GO:0045184 163 0.020
regulation of catabolic process GO:0009894 170 0.020
regulation of response to external stimulus GO:0032101 115 0.020
oocyte differentiation GO:0009994 145 0.020
single organism carbohydrate metabolic process GO:0044723 72 0.020
chemotaxis GO:0006935 249 0.020
gene silencing GO:0016458 138 0.020
transmembrane transport GO:0055085 139 0.020
dendrite development GO:0016358 204 0.020
cellular ketone metabolic process GO:0042180 24 0.020
chemosensory behavior GO:0007635 106 0.020
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.020
cell aging GO:0007569 2 0.020
autophagy GO:0006914 108 0.019
olfactory behavior GO:0042048 97 0.019
water soluble vitamin metabolic process GO:0006767 1 0.019
stem cell differentiation GO:0048863 117 0.019
nuclear division GO:0000280 332 0.019
detection of stimulus involved in sensory perception GO:0050906 92 0.019
chromatin silencing GO:0006342 76 0.019
sensory perception of sound GO:0007605 56 0.019
multi multicellular organism process GO:0044706 123 0.019
mitotic sister chromatid segregation GO:0000070 87 0.019
salivary gland development GO:0007431 162 0.019
cellular component assembly involved in morphogenesis GO:0010927 151 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
dorsal ventral pattern formation GO:0009953 133 0.018
positive regulation of cell motility GO:2000147 3 0.018
axis specification GO:0009798 167 0.018
regulation of notch signaling pathway GO:0008593 100 0.018
developmental programmed cell death GO:0010623 138 0.018
developmental pigmentation GO:0048066 68 0.018
response to topologically incorrect protein GO:0035966 10 0.018
positive regulation of rna metabolic process GO:0051254 271 0.018
negative regulation of gene expression epigenetic GO:0045814 77 0.018
tissue death GO:0016271 102 0.017
small molecule metabolic process GO:0044281 305 0.017
Human
sterol homeostasis GO:0055092 4 0.017
organic acid metabolic process GO:0006082 103 0.017
Human
localization of cell GO:0051674 257 0.017
Mouse
protein maturation GO:0051604 71 0.017
carbohydrate derivative catabolic process GO:1901136 118 0.017
striated muscle cell differentiation GO:0051146 90 0.017
cell cycle phase transition GO:0044770 140 0.017
body morphogenesis GO:0010171 2 0.017
response to wounding GO:0009611 94 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
notch signaling pathway GO:0007219 120 0.017
regulation of response to stress GO:0080134 200 0.017
Human
protein processing GO:0016485 68 0.017
protein glycosylation GO:0006486 32 0.016
regulation of multi organism process GO:0043900 131 0.016
spindle organization GO:0007051 253 0.016
intracellular signal transduction GO:0035556 300 0.016
Human
response to other organism GO:0051707 293 0.016
vitamin metabolic process GO:0006766 2 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
reproductive behavior GO:0019098 122 0.016
central nervous system development GO:0007417 201 0.016
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
regulation of gene silencing GO:0060968 63 0.016
eye morphogenesis GO:0048592 260 0.016
regulation of dna metabolic process GO:0051052 34 0.016
response to abiotic stimulus GO:0009628 341 0.016
Human
epithelial cell differentiation GO:0030855 322 0.016
cellular response to organic substance GO:0071310 132 0.016
cellularization GO:0007349 90 0.016
small gtpase mediated signal transduction GO:0007264 88 0.016
positive regulation of intracellular signal transduction GO:1902533 116 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
response to monosaccharide GO:0034284 4 0.016
ras protein signal transduction GO:0007265 88 0.016
cell cell signaling involved in cell fate commitment GO:0045168 210 0.016
glutathione metabolic process GO:0006749 37 0.015
cation transmembrane transport GO:0098655 88 0.015
regulation of organ morphogenesis GO:2000027 78 0.015
response to hexose GO:0009746 3 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
positive regulation of transport GO:0051050 92 0.015
negative regulation of developmental process GO:0051093 201 0.015
mating behavior GO:0007617 106 0.015
small molecule biosynthetic process GO:0044283 37 0.015
digestive tract morphogenesis GO:0048546 127 0.015
single organism membrane organization GO:0044802 93 0.015
positive regulation of signaling GO:0023056 243 0.015
eye pigmentation GO:0048069 43 0.015
chromatin organization GO:0006325 207 0.015
regulation of cell substrate adhesion GO:0010810 2 0.015
regulation of cell cycle phase transition GO:1901987 130 0.014
regulation of cellular protein metabolic process GO:0032268 243 0.014
gland morphogenesis GO:0022612 145 0.014
regulation of sequestering of calcium ion GO:0051282 3 0.014
growth GO:0040007 359 0.014
substrate adhesion dependent cell spreading GO:0034446 2 0.014
salivary gland histolysis GO:0035070 88 0.014
lipid metabolic process GO:0006629 121 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
retina development in camera type eye GO:0060041 4 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
multi organism reproductive behavior GO:0044705 121 0.014
mitotic spindle organization GO:0007052 220 0.014
hindbrain development GO:0030902 2 0.014
regulation of cellular localization GO:0060341 136 0.014
protein secretion GO:0009306 45 0.014
open tracheal system development GO:0007424 204 0.014
regulation of immune system process GO:0002682 176 0.014
tube morphogenesis GO:0035239 191 0.014
intracellular protein transmembrane transport GO:0065002 4 0.014
regulation of neuron differentiation GO:0045664 103 0.014
cellular lipid metabolic process GO:0044255 83 0.014
muscle structure development GO:0061061 224 0.013
androgen metabolic process GO:0008209 1 0.013
mitotic cell cycle phase transition GO:0044772 138 0.013
regulation of rna splicing GO:0043484 69 0.013
regulation of synapse structure and activity GO:0050803 128 0.013
mitotic cytokinesis GO:0000281 50 0.013
regulation of intracellular transport GO:0032386 64 0.013
homeostatic process GO:0042592 199 0.013
regulation of autophagy GO:0010506 62 0.013
carbohydrate derivative biosynthetic process GO:1901137 85 0.013
response to mechanical stimulus GO:0009612 28 0.013
programmed cell death GO:0012501 257 0.013
Human
cellular response to nutrient levels GO:0031669 62 0.013
polyol biosynthetic process GO:0046173 3 0.013
regulation of cytoplasmic transport GO:1903649 47 0.013
mitotic nuclear division GO:0007067 213 0.013
cognition GO:0050890 141 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
Human
drinking behavior GO:0042756 2 0.013
regulation of mrna metabolic process GO:1903311 72 0.013
protein transport GO:0015031 155 0.013
regulation of proteolysis GO:0030162 87 0.013
oocyte dorsal ventral axis specification GO:0007310 34 0.013
response to axon injury GO:0048678 12 0.013
positive regulation of behavior GO:0048520 19 0.013
steroid catabolic process GO:0006706 1 0.013
multicellular organismal aging GO:0010259 140 0.013
carbohydrate biosynthetic process GO:0016051 17 0.013
rna splicing GO:0008380 83 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.013
immune response GO:0006955 246 0.013
regulation of steroid metabolic process GO:0019218 2 0.013
cardiocyte differentiation GO:0035051 29 0.013
single organism cell adhesion GO:0098602 47 0.013
mitotic spindle elongation GO:0000022 81 0.013
lipid localization GO:0010876 54 0.012
response to organic cyclic compound GO:0014070 89 0.012
regulation of endocytosis GO:0030100 37 0.012
negative regulation of catalytic activity GO:0043086 42 0.012
meiotic nuclear division GO:0007126 151 0.012
compound eye development GO:0048749 307 0.012
urogenital system development GO:0001655 72 0.012
negative regulation of translation GO:0017148 28 0.012
axon guidance GO:0007411 233 0.012
vesicle organization GO:0016050 44 0.012
positive regulation of response to external stimulus GO:0032103 44 0.012
endoplasmic reticulum organization GO:0007029 13 0.012
connective tissue development GO:0061448 3 0.012
neural retina development GO:0003407 4 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
cytoskeleton dependent cytokinesis GO:0061640 81 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
oxoacid metabolic process GO:0043436 103 0.012
Human
positive regulation of cell death GO:0010942 69 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
cytosolic calcium ion transport GO:0060401 2 0.012
acetylcholine metabolic process GO:0008291 2 0.012
morphogenesis of follicular epithelium GO:0016333 36 0.012
cellular modified amino acid metabolic process GO:0006575 45 0.012
Human
positive regulation of protein transport GO:0051222 37 0.012
salivary gland cell autophagic cell death GO:0035071 83 0.012
circulatory system development GO:0072359 82 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
sensory perception of pain GO:0019233 4 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.012
metal ion transport GO:0030001 74 0.012
positive regulation of cell development GO:0010720 61 0.012
death GO:0016265 284 0.012
Human
meiotic cell cycle GO:0051321 171 0.012
regulation of post mating oviposition GO:0048042 10 0.012
metaphase anaphase transition of cell cycle GO:0044784 28 0.012
respiratory system development GO:0060541 213 0.011
chromosome separation GO:0051304 42 0.011
limb development GO:0060173 1 0.011
mitotic g2 dna damage checkpoint GO:0007095 69 0.011
developmental maturation GO:0021700 172 0.011
response to decreased oxygen levels GO:0036293 58 0.011
Human
cellular homeostasis GO:0019725 80 0.011
histolysis GO:0007559 102 0.011
response to temperature stimulus GO:0009266 106 0.011
neuron projection guidance GO:0097485 241 0.011
negative regulation of neurogenesis GO:0050768 53 0.011
spindle elongation GO:0051231 83 0.011
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 2 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
positive regulation of molecular function GO:0044093 136 0.011
epithelial cell development GO:0002064 274 0.011
mesenchymal cell development GO:0014031 1 0.011
translation GO:0006412 69 0.011
pigment metabolic process GO:0042440 84 0.011
amine metabolic process GO:0009308 12 0.011
startle response GO:0001964 16 0.011
estrogen metabolic process GO:0008210 1 0.011
mapk cascade GO:0000165 107 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.011
positive regulation of developmental process GO:0051094 143 0.011
muscle organ development GO:0007517 127 0.011
negative regulation of sequestering of calcium ion GO:0051283 2 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
apoptotic cell clearance GO:0043277 14 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
negative regulation of molecular function GO:0044092 51 0.011
release of sequestered calcium ion into cytosol GO:0051209 1 0.011
humoral immune response GO:0006959 117 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
taxis GO:0042330 304 0.011
muscle cell differentiation GO:0042692 103 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
regulation of apoptotic process GO:0042981 130 0.011
Human
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.011
pole plasm assembly GO:0007315 61 0.010
cellular amide metabolic process GO:0043603 80 0.010
mitotic sister chromatid separation GO:0051306 30 0.010
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.010
axon regeneration GO:0031103 8 0.010
digestive system development GO:0055123 149 0.010
regulation of cell division GO:0051302 72 0.010
response to oxygen containing compound GO:1901700 200 0.010
regulation of protein transport GO:0051223 57 0.010
glycoprotein metabolic process GO:0009100 41 0.010
single organism catabolic process GO:0044712 228 0.010
renal system development GO:0072001 72 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
response to biotic stimulus GO:0009607 294 0.010
larval development GO:0002164 104 0.010
l glutamate import GO:0051938 1 0.010
antimicrobial humoral response GO:0019730 99 0.010
cytokinesis GO:0000910 90 0.010
protein localization to organelle GO:0033365 82 0.010
response to lipopolysaccharide GO:0032496 4 0.010
cardiac muscle cell differentiation GO:0055007 4 0.010
protein complex assembly GO:0006461 200 0.010

Pdi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
cancer DOID:162 0 0.038
disease of cellular proliferation DOID:14566 0 0.038
cardiovascular system disease DOID:1287 0 0.029
disease of metabolism DOID:0014667 0 0.029
lipid metabolism disorder DOID:3146 0 0.029
inherited metabolic disorder DOID:655 0 0.029
muscular disease DOID:0080000 0 0.027
musculoskeletal system disease DOID:17 0 0.027
organ system cancer DOID:0050686 0 0.021
urinary system disease DOID:18 0 0.017
nervous system disease DOID:863 0 0.013
kidney disease DOID:557 0 0.012
renal tubular transport disease DOID:447 0 0.012
muscle tissue disease DOID:66 0 0.011
cardiomyopathy DOID:0050700 0 0.010
myopathy DOID:423 0 0.010
heart disease DOID:114 0 0.010
intrinsic cardiomyopathy DOID:0060036 0 0.010
lower respiratory tract disease DOID:0050161 0 0.010
respiratory system disease DOID:1579 0 0.010