Drosophila melanogaster

66 known processes

up (Dmel_CG7107)

upheld

(Aliases: BcDNA:LD08591,DmTpnT,upheld2,FBgn0004169,wupB,Tn-T,int,dro TnT,TpnT,tnT,CG7107,Dmel\CG7107,TnT)

up biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sarcomere organization GO:0045214 26 0.988
myofibril assembly GO:0030239 36 0.973
cellular component assembly involved in morphogenesis GO:0010927 151 0.899
striated muscle cell differentiation GO:0051146 90 0.809
skeletal muscle adaptation GO:0043501 1 0.806
Mouse
regulation of actin filament depolymerization GO:0030834 3 0.784
muscle structure development GO:0061061 224 0.781
muscle cell development GO:0055001 50 0.772
muscle cell differentiation GO:0042692 103 0.740
actomyosin structure organization GO:0031032 56 0.716
negative regulation of actin filament depolymerization GO:0030835 2 0.557
protein complex biogenesis GO:0070271 201 0.510
Worm
actin filament based process GO:0030029 220 0.486
organelle assembly GO:0070925 198 0.477
adult somatic muscle development GO:0007527 14 0.416
muscle thin filament assembly GO:0071689 5 0.384
striated muscle cell development GO:0055002 50 0.381
tube development GO:0035295 244 0.361
Zebrafish
actin filament organization GO:0007015 126 0.333
brain development GO:0007420 120 0.333
molting cycle GO:0042303 56 0.244
mesoderm development GO:0007498 78 0.242
skeletal muscle organ development GO:0060538 48 0.223
organic substance catabolic process GO:1901575 308 0.222
Human Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.218
Human
striated muscle tissue development GO:0014706 27 0.216
Human Zebrafish Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.212
Human
protein complex assembly GO:0006461 200 0.204
Worm
metal ion homeostasis GO:0055065 44 0.183
somatic muscle development GO:0007525 66 0.172
Worm
striated muscle myosin thick filament assembly GO:0071688 3 0.172
Worm
vesicle mediated transport GO:0016192 381 0.172
Worm
regulation of cellular catabolic process GO:0031329 157 0.171
Human
cellular protein complex assembly GO:0043623 71 0.169
Worm
localization of cell GO:0051674 257 0.162
Zebrafish
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.157
Human
nucleoside triphosphate catabolic process GO:0009143 108 0.151
Human
actin cytoskeleton organization GO:0030036 206 0.148
purine nucleoside metabolic process GO:0042278 127 0.147
Human
adult behavior GO:0030534 137 0.144
muscle organ development GO:0007517 127 0.142
catabolic process GO:0009056 409 0.137
Human Worm
skeletal muscle myosin thick filament assembly GO:0030241 3 0.120
body morphogenesis GO:0010171 2 0.114
cellular macromolecular complex assembly GO:0034622 153 0.112
Worm
purine nucleotide catabolic process GO:0006195 109 0.112
Human
ion homeostasis GO:0050801 55 0.111
nucleoside triphosphate metabolic process GO:0009141 120 0.106
Human
skeletal muscle tissue development GO:0007519 13 0.105
nucleoside phosphate metabolic process GO:0006753 162 0.102
Human
ribose phosphate metabolic process GO:0019693 145 0.101
Human
purine ribonucleotide metabolic process GO:0009150 145 0.100
Human
cation homeostasis GO:0055080 51 0.099
endocytosis GO:0006897 310 0.097
Worm
response to oxygen containing compound GO:1901700 200 0.095
circulatory system development GO:0072359 82 0.092
Human Zebrafish Mouse
tissue morphogenesis GO:0048729 297 0.089
Human Zebrafish Mouse
glycosyl compound metabolic process GO:1901657 127 0.083
Human
cellular catabolic process GO:0044248 372 0.082
Human
carbohydrate derivative metabolic process GO:1901135 217 0.080
Human
cellular nitrogen compound catabolic process GO:0044270 165 0.079
Human
organonitrogen compound catabolic process GO:1901565 128 0.078
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.078
Human
muscle tissue morphogenesis GO:0060415 2 0.077
Human Zebrafish Mouse
purine containing compound metabolic process GO:0072521 155 0.077
Human
macromolecular complex assembly GO:0065003 256 0.074
Worm
actin filament capping GO:0051693 2 0.073
actin filament based movement GO:0030048 26 0.073
Human
muscle organ morphogenesis GO:0048644 7 0.070
actin filament depolymerization GO:0030042 5 0.068
heart process GO:0003015 37 0.068
Human Zebrafish Mouse
ribonucleotide catabolic process GO:0009261 109 0.067
Human
cellular response to reactive oxygen species GO:0034614 14 0.067
negative regulation of protein depolymerization GO:1901880 23 0.066
ribonucleoside monophosphate metabolic process GO:0009161 51 0.065
Human
anatomical structure homeostasis GO:0060249 97 0.064
regulation of localization GO:0032879 275 0.060
nucleotide metabolic process GO:0009117 161 0.060
Human
positive regulation of catalytic activity GO:0043085 118 0.059
Human
regulation of protein depolymerization GO:1901879 27 0.058
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.058
Human
protein depolymerization GO:0051261 31 0.053
myotube differentiation GO:0014902 46 0.053
regulation of hydrolase activity GO:0051336 97 0.052
Human
cellular homeostasis GO:0019725 80 0.052
protein modification process GO:0036211 438 0.052
cellular metal ion homeostasis GO:0006875 31 0.051
cardiac muscle tissue development GO:0048738 9 0.051
Human Zebrafish Mouse
posttranscriptional regulation of gene expression GO:0010608 145 0.051
regulation of molecular function GO:0065009 217 0.050
Human
heart contraction GO:0060047 26 0.050
Human Zebrafish Mouse
cardiocyte differentiation GO:0035051 29 0.050
regulation of actin filament length GO:0030832 27 0.049
positive regulation of cellular component organization GO:0051130 156 0.049
regulation of cellular localization GO:0060341 136 0.049
phagocytosis GO:0006909 215 0.049
negative regulation of protein polymerization GO:0032272 7 0.049
phosphorylation GO:0016310 294 0.048
regulation of cell death GO:0010941 173 0.047
organonitrogen compound metabolic process GO:1901564 318 0.045
Human
nucleoside monophosphate metabolic process GO:0009123 52 0.045
Human
muscle contraction GO:0006936 13 0.044
Human Zebrafish Mouse Worm
purine nucleoside triphosphate metabolic process GO:0009144 119 0.044
Human
digestive tract development GO:0048565 149 0.043
small molecule metabolic process GO:0044281 305 0.041
Human
cardiovascular system development GO:0072358 82 0.041
Human Zebrafish Mouse
organophosphate metabolic process GO:0019637 195 0.041
Human
positive regulation of phosphorus metabolic process GO:0010562 139 0.041
Human
positive regulation of transport GO:0051050 92 0.040
carbohydrate derivative catabolic process GO:1901136 118 0.040
Human
chemical homeostasis GO:0048878 92 0.040
purine ribonucleoside metabolic process GO:0046128 127 0.040
Human
regulation of vesicle mediated transport GO:0060627 59 0.039
actin filament bundle organization GO:0061572 28 0.039
ribonucleoside triphosphate catabolic process GO:0009203 108 0.039
Human
regulation of cellular component biogenesis GO:0044087 201 0.039
organophosphate catabolic process GO:0046434 112 0.039
Human
response to abiotic stimulus GO:0009628 341 0.039
reproductive behavior GO:0019098 122 0.039
regulation of cellular component movement GO:0051270 42 0.037
actin polymerization or depolymerization GO:0008154 31 0.037
cellular divalent inorganic cation homeostasis GO:0072503 23 0.037
regulation of apoptotic process GO:0042981 130 0.036
homeostatic process GO:0042592 199 0.036
imaginal disc derived appendage development GO:0048737 399 0.036
regulation of cytoskeleton organization GO:0051493 89 0.035
striated muscle adaptation GO:0014888 1 0.034
Mouse
negative regulation of cytoskeleton organization GO:0051494 30 0.034
regulation of actin cytoskeleton organization GO:0032956 42 0.033
positive regulation of cellular catabolic process GO:0031331 95 0.033
Human
ribonucleoside catabolic process GO:0042454 112 0.033
Human
positive regulation of catabolic process GO:0009896 105 0.032
Human
regulation of cell differentiation GO:0045595 302 0.032
regulation of purine nucleotide metabolic process GO:1900542 62 0.032
Human
positive regulation of organelle organization GO:0010638 65 0.032
positive regulation of protein import into nucleus GO:0042307 21 0.032
ribonucleoside metabolic process GO:0009119 127 0.031
Human
ribonucleotide metabolic process GO:0009259 145 0.031
Human
purine nucleoside catabolic process GO:0006152 112 0.030
Human
biological adhesion GO:0022610 138 0.029
regulation of catabolic process GO:0009894 170 0.029
Human
response to organic substance GO:0010033 284 0.029
calcium ion homeostasis GO:0055074 23 0.028
nucleobase containing compound catabolic process GO:0034655 165 0.028
Human
mapk cascade GO:0000165 107 0.028
regulation of cell migration GO:0030334 22 0.028
single organism catabolic process GO:0044712 228 0.028
Human
skeletal muscle fiber development GO:0048741 3 0.028
purine nucleotide metabolic process GO:0006163 146 0.028
Human
ribonucleoside triphosphate metabolic process GO:0009199 119 0.028
Human
multicellular organismal reproductive behavior GO:0033057 110 0.027
positive regulation of biosynthetic process GO:0009891 316 0.027
growth GO:0040007 359 0.027
muscle tissue development GO:0060537 30 0.027
Human Zebrafish Mouse
organelle fission GO:0048285 340 0.027
oviposition GO:0018991 19 0.027
primary amino compound metabolic process GO:1901160 2 0.026
adult locomotory behavior GO:0008344 76 0.026
larval development GO:0002164 104 0.025
Worm
nucleobase containing small molecule metabolic process GO:0055086 174 0.025
Human
cellular response to chemical stimulus GO:0070887 199 0.025
striated muscle contraction GO:0006941 5 0.025
Zebrafish
regulation of catalytic activity GO:0050790 185 0.025
Human
regulation of organelle organization GO:0033043 196 0.025
nucleoside catabolic process GO:0009164 112 0.025
Human
ovulation GO:0030728 4 0.024
Worm
regulation of multicellular organismal development GO:2000026 414 0.023
aromatic compound catabolic process GO:0019439 166 0.023
Human
muscle adaptation GO:0043500 1 0.023
Mouse
central nervous system development GO:0007417 201 0.023
morphogenesis of an epithelium GO:0002009 276 0.023
Zebrafish
cell adhesion GO:0007155 136 0.023
response to endogenous stimulus GO:0009719 119 0.023
positive regulation of atp catabolic process GO:1903291 3 0.023
Human
cellular chemical homeostasis GO:0055082 40 0.022
alditol phosphate metabolic process GO:0052646 2 0.022
purine ribonucleoside catabolic process GO:0046130 112 0.021
Human
regulation of locomotion GO:0040012 42 0.021
organic cyclic compound catabolic process GO:1901361 168 0.021
Human
catecholamine biosynthetic process GO:0042423 3 0.020
secretion GO:0046903 109 0.020
response to reactive oxygen species GO:0000302 24 0.020
positive regulation of nucleoside metabolic process GO:0045979 47 0.020
Human
multi multicellular organism process GO:0044706 123 0.020
heterocycle catabolic process GO:0046700 166 0.020
Human
regulation of protein complex disassembly GO:0043244 29 0.020
macromolecule catabolic process GO:0009057 161 0.019
Worm
regulation of protein polymerization GO:0032271 28 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
Human
nucleoside monophosphate catabolic process GO:0009125 39 0.019
Human
regulation of immune system process GO:0002682 176 0.018
single organism carbohydrate metabolic process GO:0044723 72 0.018
stem cell differentiation GO:0048863 117 0.018
Zebrafish
actin filament bundle assembly GO:0051017 26 0.018
regulation of sarcomere organization GO:0060297 2 0.018
purine nucleoside monophosphate metabolic process GO:0009126 50 0.018
Human
cellular protein modification process GO:0006464 438 0.018
response to hypoxia GO:0001666 53 0.018
positive regulation of signal transduction GO:0009967 223 0.018
negative regulation of actin filament polymerization GO:0030837 7 0.017
regulation of transport GO:0051049 181 0.017
carbohydrate metabolic process GO:0005975 82 0.017
regulation of actin polymerization or depolymerization GO:0008064 27 0.017
cell division GO:0051301 248 0.016
purine ribonucleotide catabolic process GO:0009154 109 0.016
Human
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
skeletal myofibril assembly GO:0014866 6 0.015
camera type eye development GO:0043010 4 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
Human
response to organic cyclic compound GO:0014070 89 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.015
Human
cellular response to oxygen containing compound GO:1901701 79 0.015
purine nucleoside monophosphate catabolic process GO:0009128 38 0.015
Human
protein secretion GO:0009306 45 0.015
autophagy GO:0006914 108 0.015
nucleoside phosphate catabolic process GO:1901292 110 0.015
Human
positive regulation of nucleotide catabolic process GO:0030813 46 0.015
Human
cellular response to organic substance GO:0071310 132 0.014
gonad development GO:0008406 50 0.014
mitotic nuclear division GO:0007067 213 0.014
wing disc morphogenesis GO:0007472 344 0.014
atp catabolic process GO:0006200 38 0.014
Human
immune system process GO:0002376 347 0.014
Zebrafish
response to oxygen levels GO:0070482 59 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
protein localization GO:0008104 284 0.014
negative regulation of organelle organization GO:0010639 56 0.013
heart development GO:0007507 82 0.013
Human Zebrafish Mouse
myotube cell development GO:0014904 3 0.013
protein phosphorylation GO:0006468 169 0.013
atp metabolic process GO:0046034 49 0.013
Human
head development GO:0060322 135 0.013
establishment of localization in cell GO:0051649 402 0.013
stress activated mapk cascade GO:0051403 52 0.013
cell motility GO:0048870 251 0.013
Zebrafish
protein transport GO:0015031 155 0.012
negative regulation of protein complex disassembly GO:0043242 23 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.012
Human
neurological system process GO:0050877 358 0.012
positive regulation of molecular function GO:0044093 136 0.012
Human
cardiac muscle cell differentiation GO:0055007 4 0.012
oxoacid metabolic process GO:0043436 103 0.012
muscle system process GO:0003012 21 0.012
Human Zebrafish Mouse Worm
reproductive system development GO:0061458 74 0.012
regulation of intracellular protein transport GO:0033157 46 0.012
regulation of response to stress GO:0080134 200 0.012
cellular cation homeostasis GO:0030003 38 0.012
response to lipopolysaccharide GO:0032496 4 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
positive regulation of cell death GO:0010942 69 0.011
circulatory system process GO:0003013 37 0.011
Human Zebrafish Mouse
pharynx development GO:0060465 1 0.011
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
sex differentiation GO:0007548 81 0.011
cellular macromolecule localization GO:0070727 220 0.011
regulation of secretion GO:0051046 44 0.011
digestive system development GO:0055123 149 0.011
cellular response to oxidative stress GO:0034599 28 0.011
regulation of phosphatase activity GO:0010921 3 0.011
regulation of anatomical structure size GO:0090066 163 0.011
regulation of growth GO:0040008 233 0.011
purine containing compound catabolic process GO:0072523 112 0.011
Human
embryo development ending in birth or egg hatching GO:0009792 152 0.011
establishment of protein localization GO:0045184 163 0.011
positive regulation of actin filament bundle assembly GO:0032233 3 0.010
myosin filament assembly GO:0031034 5 0.010
Worm
negative regulation of gene expression GO:0010629 387 0.010
regulation of protein complex assembly GO:0043254 42 0.010
positive regulation of signaling GO:0023056 243 0.010
ribonucleoside monophosphate catabolic process GO:0009158 39 0.010
Human
kidney development GO:0001822 3 0.010
Zebrafish

up disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.304
Human
muscular disease DOID:0080000 0 0.304
Human
heart disease DOID:114 0 0.304
Human
cardiomyopathy DOID:0050700 0 0.304
Human
disease of anatomical entity DOID:7 0 0.304
Human
cardiovascular system disease DOID:1287 0 0.304
Human
musculoskeletal system disease DOID:17 0 0.304
Human
muscle tissue disease DOID:66 0 0.304
Human
dilated cardiomyopathy DOID:12930 0 0.147
Human
intrinsic cardiomyopathy DOID:0060036 0 0.147
Human
nervous system disease DOID:863 0 0.012