Drosophila melanogaster

15 known processes

Idh (Dmel_CG7176)

Isocitrate dehydrogenase

(Aliases: l(3)L3852,Idh-NADP,Dmel\CG7176,idh,IDH,CT22171,CG7176,isocitrate dehydrogenase,IDH-NADP)

Idh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 103 0.968
small molecule metabolic process GO:0044281 305 0.829
carboxylic acid metabolic process GO:0019752 92 0.822
nicotinamide nucleotide metabolic process GO:0046496 2 0.589
oxoacid metabolic process GO:0043436 103 0.546
monocarboxylic acid metabolic process GO:0032787 29 0.541
Yeast
cellular amino acid metabolic process GO:0006520 61 0.486
Yeast Mouse
organonitrogen compound metabolic process GO:1901564 318 0.404
Yeast Mouse
aging GO:0007568 143 0.386
fatty acid beta oxidation GO:0006635 6 0.320
Yeast
glutamate metabolic process GO:0006536 5 0.290
Yeast
lipid catabolic process GO:0016042 21 0.260
Yeast
pyridine nucleotide metabolic process GO:0019362 2 0.256
catabolic process GO:0009056 409 0.250
Yeast
pyridine containing compound metabolic process GO:0072524 3 0.233
cellular ketone metabolic process GO:0042180 24 0.225
oxidation reduction process GO:0055114 123 0.222
small molecule catabolic process GO:0044282 21 0.210
Yeast
lateral inhibition GO:0046331 206 0.201
organic substance catabolic process GO:1901575 308 0.182
Yeast
negative regulation of biosynthetic process GO:0009890 277 0.170
thioester metabolic process GO:0035383 3 0.162
organophosphate metabolic process GO:0019637 195 0.151
carboxylic acid catabolic process GO:0046395 16 0.143
Yeast
response to organic substance GO:0010033 284 0.134
Rat
cellular response to chemical stimulus GO:0070887 199 0.130
homeostatic process GO:0042592 199 0.120
single organism catabolic process GO:0044712 228 0.118
Yeast
cellular ion homeostasis GO:0006873 39 0.118
lipid metabolic process GO:0006629 121 0.111
Yeast
cellular catabolic process GO:0044248 372 0.109
Yeast
regulation of cellular ketone metabolic process GO:0010565 3 0.103
cellular lipid metabolic process GO:0044255 83 0.103
Yeast
establishment of localization in cell GO:0051649 402 0.095
acyl coa metabolic process GO:0006637 3 0.094
oxidoreduction coenzyme metabolic process GO:0006733 2 0.088
sulfur compound metabolic process GO:0006790 59 0.085
Mouse
single organism biosynthetic process GO:0044711 206 0.078
Yeast
spermatogenesis GO:0007283 200 0.077
multicellular organismal aging GO:0010259 140 0.071
cell cell signaling involved in cell fate commitment GO:0045168 210 0.070
organic acid transport GO:0015849 18 0.066
response to oxygen containing compound GO:1901700 200 0.062
single organism carbohydrate metabolic process GO:0044723 72 0.056
regulation of apoptotic process GO:0042981 130 0.054
epithelial cell differentiation GO:0030855 322 0.054
organic substance transport GO:0071702 257 0.048
endocytosis GO:0006897 310 0.047
nad metabolic process GO:0019674 1 0.046
ion transport GO:0006811 145 0.046
negative regulation of cellular biosynthetic process GO:0031327 277 0.045
positive regulation of cell communication GO:0010647 250 0.045
transition metal ion homeostasis GO:0055076 17 0.044
head development GO:0060322 135 0.043
nucleobase containing small molecule metabolic process GO:0055086 174 0.041
protein complex biogenesis GO:0070271 201 0.037
neurological system process GO:0050877 358 0.037
negative regulation of cellular metabolic process GO:0031324 382 0.037
regulation of localization GO:0032879 275 0.036
cellular cation homeostasis GO:0030003 38 0.035
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.035
hormone metabolic process GO:0042445 33 0.033
negative regulation of gene expression GO:0010629 387 0.033
response to hypoxia GO:0001666 53 0.032
vesicle mediated transport GO:0016192 381 0.032
programmed cell death GO:0012501 257 0.031
organic anion transport GO:0015711 28 0.030
synapse organization GO:0050808 196 0.030
organonitrogen compound catabolic process GO:1901565 128 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.030
carbohydrate metabolic process GO:0005975 82 0.029
single organism intracellular transport GO:1902582 207 0.029
energy derivation by oxidation of organic compounds GO:0015980 32 0.029
positive regulation of cell death GO:0010942 69 0.028
body morphogenesis GO:0010171 2 0.027
cellular amine metabolic process GO:0044106 12 0.027
chemical homeostasis GO:0048878 92 0.027
response to abiotic stimulus GO:0009628 341 0.027
positive regulation of signaling GO:0023056 243 0.026
maintenance of location GO:0051235 73 0.026
regulation of cellular amine metabolic process GO:0033238 3 0.026
response to endogenous stimulus GO:0009719 119 0.026
Rat
pyruvate metabolic process GO:0006090 7 0.025
intracellular transport GO:0046907 228 0.025
gland development GO:0048732 191 0.024
nucleotide metabolic process GO:0009117 161 0.024
response to nutrient levels GO:0031667 114 0.023
ion homeostasis GO:0050801 55 0.023
embryonic morphogenesis GO:0048598 206 0.023
forebrain development GO:0030900 2 0.023
positive regulation of multicellular organismal process GO:0051240 143 0.023
synapse assembly GO:0007416 143 0.023
central nervous system development GO:0007417 201 0.023
centrosome duplication GO:0051298 121 0.023
regulation of programmed cell death GO:0043067 152 0.022
carbohydrate derivative metabolic process GO:1901135 217 0.022
cell death GO:0008219 279 0.022
regulation of cellular localization GO:0060341 136 0.021
heart development GO:0007507 82 0.021
cellular hormone metabolic process GO:0034754 23 0.021
metal ion homeostasis GO:0055065 44 0.021
apoptotic process GO:0006915 159 0.021
transcription from rna polymerase ii promoter GO:0006366 368 0.021
response to extracellular stimulus GO:0009991 116 0.020
cellular amino acid biosynthetic process GO:0008652 9 0.020
Yeast
amine catabolic process GO:0009310 1 0.020
anion transport GO:0006820 41 0.020
glycerolipid metabolic process GO:0046486 34 0.020
death GO:0016265 284 0.020
mitotic spindle organization GO:0007052 220 0.020
glucan biosynthetic process GO:0009250 2 0.020
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
pentose metabolic process GO:0019321 1 0.019
membrane organization GO:0061024 112 0.019
organonitrogen compound biosynthetic process GO:1901566 117 0.019
Yeast
regulation of cell death GO:0010941 173 0.019
cation homeostasis GO:0055080 51 0.019
response to metal ion GO:0010038 23 0.019
positive regulation of transport GO:0051050 92 0.018
regulation of growth GO:0040008 233 0.018
nitrogen compound transport GO:0071705 85 0.018
sex differentiation GO:0007548 81 0.018
Rat
nucleoside phosphate metabolic process GO:0006753 162 0.018
response to hexose GO:0009746 3 0.018
small molecule biosynthetic process GO:0044283 37 0.018
Yeast
glucose metabolic process GO:0006006 5 0.018
striated muscle myosin thick filament assembly GO:0071688 3 0.017
glutamine family amino acid metabolic process GO:0009064 12 0.017
Yeast
tube development GO:0035295 244 0.017
organic hydroxy compound metabolic process GO:1901615 83 0.017
tricarboxylic acid metabolic process GO:0072350 1 0.017
cell aging GO:0007569 2 0.017
cellular homeostasis GO:0019725 80 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
appendage morphogenesis GO:0035107 397 0.017
protein complex assembly GO:0006461 200 0.016
intracellular signal transduction GO:0035556 300 0.016
cellular response to organic substance GO:0071310 132 0.016
proteolysis GO:0006508 192 0.016
cellular metal ion homeostasis GO:0006875 31 0.016
visual learning GO:0008542 4 0.016
lipid localization GO:0010876 54 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
determination of adult lifespan GO:0008340 137 0.015
carboxylic acid biosynthetic process GO:0046394 15 0.015
Yeast
cellular response to hormone stimulus GO:0032870 44 0.015
protein modification process GO:0036211 438 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
macromolecular complex assembly GO:0065003 256 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
organophosphate biosynthetic process GO:0090407 46 0.014
kidney development GO:0001822 3 0.014
ph reduction GO:0045851 7 0.014
epithelial cell development GO:0002064 274 0.014
embryo development ending in birth or egg hatching GO:0009792 152 0.014
aromatic amino acid family metabolic process GO:0009072 3 0.014
imaginal disc derived appendage development GO:0048737 399 0.013
regulation of rac protein signal transduction GO:0035020 3 0.013
water homeostasis GO:0030104 3 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.013
cell maturation GO:0048469 144 0.013
wing disc morphogenesis GO:0007472 344 0.013
heterocycle catabolic process GO:0046700 166 0.013
single organism carbohydrate catabolic process GO:0044724 7 0.013
cell proliferation GO:0008283 299 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.013
neutral lipid biosynthetic process GO:0046460 2 0.013
response to oxygen levels GO:0070482 59 0.013
regulation of cell proliferation GO:0042127 163 0.013
cardiovascular system development GO:0072358 82 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
response to monosaccharide GO:0034284 4 0.012
cellular aldehyde metabolic process GO:0006081 10 0.012
male gamete generation GO:0048232 201 0.012
spindle organization GO:0007051 253 0.012
cellular polysaccharide metabolic process GO:0044264 11 0.012
appendage development GO:0048736 401 0.012
histolysis GO:0007559 102 0.012
acyl coa biosynthetic process GO:0071616 2 0.012
telencephalon development GO:0021537 2 0.012
response to decreased oxygen levels GO:0036293 58 0.012
generation of precursor metabolites and energy GO:0006091 42 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
brain development GO:0007420 120 0.011
amine metabolic process GO:0009308 12 0.011
regulation of catalytic activity GO:0050790 185 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
alcohol metabolic process GO:0006066 25 0.011
taxis GO:0042330 304 0.011
negative regulation of rna metabolic process GO:0051253 251 0.011
regulation of proteolysis GO:0030162 87 0.011
development of primary sexual characteristics GO:0045137 50 0.011
Rat
exocrine system development GO:0035272 162 0.011
open tracheal system development GO:0007424 204 0.011
positive regulation of programmed cell death GO:0043068 62 0.011
positive regulation of signal transduction GO:0009967 223 0.011
regulation of cell cycle GO:0051726 291 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
glutamine family amino acid catabolic process GO:0009065 3 0.011
connective tissue development GO:0061448 3 0.011
renal system development GO:0072001 72 0.010
organic acid biosynthetic process GO:0016053 15 0.010
Yeast
circulatory system development GO:0072359 82 0.010
carbohydrate biosynthetic process GO:0016051 17 0.010
negative regulation of homeostatic process GO:0032845 2 0.010
developmental growth GO:0048589 280 0.010
alpha amino acid metabolic process GO:1901605 20 0.010
Yeast

Idh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.298
inherited metabolic disorder DOID:655 0 0.298
carbohydrate metabolism disease DOID:0050013 0 0.046
glucose metabolism disease DOID:4194 0 0.046
acquired metabolic disease DOID:0060158 0 0.046
disease of anatomical entity DOID:7 0 0.019
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
nervous system disease DOID:863 0 0.012