Drosophila melanogaster

61 known processes

wupA (Dmel_CG7178)

wings up A

(Aliases: wup-A,WupA,Dmel\CG7178,HDP,TnI,hdp,DROTROPONI,Tn I,CG7178,TpnI,HLI,DmTpnI,HL08042,HL-I)

wupA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
myofibril assembly GO:0030239 36 0.994
muscle cell development GO:0055001 50 0.984
skeletal muscle adaptation GO:0043501 1 0.980
Mouse
sarcomere organization GO:0045214 26 0.969
cellular component assembly involved in morphogenesis GO:0010927 151 0.955
muscle structure development GO:0061061 224 0.942
striated muscle cell differentiation GO:0051146 90 0.939
actin filament based process GO:0030029 220 0.938
actin cytoskeleton organization GO:0030036 206 0.929
heart process GO:0003015 37 0.923
organelle assembly GO:0070925 198 0.919
muscle cell differentiation GO:0042692 103 0.902
striated muscle cell development GO:0055002 50 0.855
striated muscle myosin thick filament assembly GO:0071688 3 0.845
heart morphogenesis GO:0003007 32 0.845
Mouse
actomyosin structure organization GO:0031032 56 0.816
mesoderm development GO:0007498 78 0.794
protein complex biogenesis GO:0070271 201 0.776
head development GO:0060322 135 0.685
lipid storage GO:0019915 38 0.674
actin filament based movement GO:0030048 26 0.673
somatic muscle development GO:0007525 66 0.656
heart contraction GO:0060047 26 0.646
muscle organ morphogenesis GO:0048644 7 0.615
Mouse
circulatory system development GO:0072359 82 0.613
circulatory system process GO:0003013 37 0.596
actin filament capping GO:0051693 2 0.588
heart development GO:0007507 82 0.576
catabolic process GO:0009056 409 0.563
muscle thin filament assembly GO:0071689 5 0.551
cell motility GO:0048870 251 0.546
muscle organ development GO:0007517 127 0.543
macromolecular complex assembly GO:0065003 256 0.534
muscle system process GO:0003012 21 0.524
Mouse
striated muscle adaptation GO:0014888 1 0.520
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.512
regulation of blood circulation GO:1903522 21 0.509
regulation of organelle organization GO:0033043 196 0.491
skeletal myofibril assembly GO:0014866 6 0.487
actin filament organization GO:0007015 126 0.463
protein catabolic process GO:0030163 101 0.445
myotube cell development GO:0014904 3 0.435
regulation of protein complex disassembly GO:0043244 29 0.435
muscle contraction GO:0006936 13 0.424
Mouse
central nervous system development GO:0007417 201 0.410
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.408
larval development GO:0002164 104 0.407
reproductive behavior GO:0019098 122 0.399
muscle tissue morphogenesis GO:0060415 2 0.399
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.397
glycosyl compound metabolic process GO:1901657 127 0.377
small molecule metabolic process GO:0044281 305 0.376
purine containing compound metabolic process GO:0072521 155 0.376
organic substance catabolic process GO:1901575 308 0.351
regulation of actin filament depolymerization GO:0030834 3 0.349
cellular macromolecular complex assembly GO:0034622 153 0.342
tube development GO:0035295 244 0.335
protein complex assembly GO:0006461 200 0.334
nucleoside monophosphate metabolic process GO:0009123 52 0.322
atp metabolic process GO:0046034 49 0.309
transmembrane transport GO:0055085 139 0.306
immune system process GO:0002376 347 0.293
response to abiotic stimulus GO:0009628 341 0.289
regulation of cell motility GO:2000145 23 0.278
regulation of heart contraction GO:0008016 21 0.275
cardiovascular system development GO:0072358 82 0.269
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.268
locomotory behavior GO:0007626 176 0.266
cellular response to reactive oxygen species GO:0034614 14 0.258
multicellular organismal reproductive behavior GO:0033057 110 0.256
cell division GO:0051301 248 0.252
nucleoside monophosphate catabolic process GO:0009125 39 0.252
regulation of phosphate metabolic process GO:0019220 210 0.251
phosphorylation GO:0016310 294 0.249
anatomical structure homeostasis GO:0060249 97 0.248
purine nucleoside metabolic process GO:0042278 127 0.243
regulation of localization GO:0032879 275 0.234
vesicle mediated transport GO:0016192 381 0.230
ribonucleoside triphosphate catabolic process GO:0009203 108 0.230
actin mediated cell contraction GO:0070252 21 0.230
maintenance of location GO:0051235 73 0.229
purine ribonucleotide catabolic process GO:0009154 109 0.229
nucleotide catabolic process GO:0009166 109 0.228
multi organism reproductive behavior GO:0044705 121 0.218
purine nucleotide catabolic process GO:0006195 109 0.218
adult somatic muscle development GO:0007527 14 0.218
regulation of cellular component biogenesis GO:0044087 201 0.217
nucleobase containing compound catabolic process GO:0034655 165 0.215
ribonucleoside metabolic process GO:0009119 127 0.215
ribonucleoside monophosphate catabolic process GO:0009158 39 0.213
ribonucleoside triphosphate metabolic process GO:0009199 119 0.213
purine ribonucleotide metabolic process GO:0009150 145 0.212
ribonucleoside monophosphate metabolic process GO:0009161 51 0.210
cellular protein complex assembly GO:0043623 71 0.208
purine nucleoside catabolic process GO:0006152 112 0.208
ribose phosphate metabolic process GO:0019693 145 0.208
positive regulation of cellular component organization GO:0051130 156 0.205
striated muscle contraction GO:0006941 5 0.204
Mouse
intracellular signal transduction GO:0035556 300 0.200
cell recognition GO:0008037 102 0.199
multi multicellular organism process GO:0044706 123 0.196
organelle fission GO:0048285 340 0.196
purine nucleoside triphosphate catabolic process GO:0009146 108 0.193
skeletal muscle myosin thick filament assembly GO:0030241 3 0.191
regulation of purine nucleotide catabolic process GO:0033121 48 0.189
negative regulation of actin filament depolymerization GO:0030835 2 0.188
positive regulation of atp catabolic process GO:1903291 3 0.188
purine nucleoside monophosphate catabolic process GO:0009128 38 0.186
cellular protein modification process GO:0006464 438 0.184
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.182
organophosphate metabolic process GO:0019637 195 0.180
purine containing compound catabolic process GO:0072523 112 0.179
purine ribonucleoside metabolic process GO:0046128 127 0.179
response to inorganic substance GO:0010035 44 0.177
localization of cell GO:0051674 257 0.171
macromolecule catabolic process GO:0009057 161 0.166
regulation of phosphorus metabolic process GO:0051174 210 0.165
nucleoside triphosphate catabolic process GO:0009143 108 0.164
regulation of catalytic activity GO:0050790 185 0.164
cytokinesis GO:0000910 90 0.156
single organism behavior GO:0044708 391 0.154
positive regulation of catalytic activity GO:0043085 118 0.154
nucleoside phosphate metabolic process GO:0006753 162 0.154
nucleoside metabolic process GO:0009116 127 0.153
cellular catabolic process GO:0044248 372 0.151
body morphogenesis GO:0010171 2 0.149
protein modification process GO:0036211 438 0.149
negative regulation of actin filament polymerization GO:0030837 7 0.147
positive regulation of molecular function GO:0044093 136 0.146
purine ribonucleoside catabolic process GO:0046130 112 0.145
embryo development ending in birth or egg hatching GO:0009792 152 0.143
Worm
regulation of locomotion GO:0040012 42 0.143
positive regulation of nucleotide metabolic process GO:0045981 55 0.141
oviposition GO:0018991 19 0.140
metal ion homeostasis GO:0055065 44 0.139
Mouse
axonal fasciculation GO:0007413 12 0.139
regulation of cellular catabolic process GO:0031329 157 0.136
organic cyclic compound catabolic process GO:1901361 168 0.136
carbohydrate derivative metabolic process GO:1901135 217 0.134
carbohydrate derivative catabolic process GO:1901136 118 0.132
regulation of transport GO:0051049 181 0.131
regulation of catabolic process GO:0009894 170 0.130
embryonic morphogenesis GO:0048598 206 0.129
cardiac muscle tissue development GO:0048738 9 0.129
morphogenesis of an epithelium GO:0002009 276 0.128
striated muscle tissue development GO:0014706 27 0.127
macromolecular complex disassembly GO:0032984 37 0.127
regulation of cellular component movement GO:0051270 42 0.125
purine nucleoside triphosphate metabolic process GO:0009144 119 0.122
adult behavior GO:0030534 137 0.122
myosin filament organization GO:0031033 5 0.118
negative regulation of protein complex disassembly GO:0043242 23 0.116
stem cell differentiation GO:0048863 117 0.115
kidney development GO:0001822 3 0.113
organonitrogen compound catabolic process GO:1901565 128 0.109
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.105
regulation of nucleoside metabolic process GO:0009118 50 0.105
regulation of system process GO:0044057 36 0.104
Mouse
cell adhesion GO:0007155 136 0.103
myosin filament assembly GO:0031034 5 0.103
ribonucleoside catabolic process GO:0042454 112 0.102
tissue migration GO:0090130 155 0.102
regulation of hydrolase activity GO:0051336 97 0.100
stem cell proliferation GO:0072089 88 0.099
actin filament bundle assembly GO:0051017 26 0.099
heterocycle catabolic process GO:0046700 166 0.097
ribonucleotide catabolic process GO:0009261 109 0.097
brain development GO:0007420 120 0.095
nucleobase containing small molecule metabolic process GO:0055086 174 0.095
regulation of heart rate GO:0002027 11 0.093
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.093
lipid localization GO:0010876 54 0.090
nucleotide metabolic process GO:0009117 161 0.090
negative regulation of cytoskeleton organization GO:0051494 30 0.088
aromatic compound catabolic process GO:0019439 166 0.087
negative regulation of cellular component organization GO:0051129 108 0.087
nucleoside catabolic process GO:0009164 112 0.087
endocytosis GO:0006897 310 0.084
cardiocyte differentiation GO:0035051 29 0.081
regulation of cytoskeleton organization GO:0051493 89 0.081
columnar cuboidal epithelial cell development GO:0002066 249 0.081
atp catabolic process GO:0006200 38 0.079
establishment of localization in cell GO:0051649 402 0.079
regulation of muscle contraction GO:0006937 5 0.078
Mouse
regulation of nucleotide metabolic process GO:0006140 62 0.078
larval somatic muscle development GO:0007526 19 0.077
positive regulation of nucleoside metabolic process GO:0045979 47 0.076
nucleoside triphosphate metabolic process GO:0009141 120 0.075
single organism catabolic process GO:0044712 228 0.074
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.074
response to oxygen containing compound GO:1901700 200 0.073
organophosphate catabolic process GO:0046434 112 0.073
positive regulation of phosphorus metabolic process GO:0010562 139 0.072
axon development GO:0061564 297 0.069
positive regulation of phosphate metabolic process GO:0045937 139 0.068
purine nucleoside monophosphate metabolic process GO:0009126 50 0.067
protein depolymerization GO:0051261 31 0.067
cellular protein complex disassembly GO:0043624 35 0.064
neuron recognition GO:0008038 101 0.063
ameboidal type cell migration GO:0001667 151 0.062
mating behavior GO:0007617 106 0.061
organonitrogen compound metabolic process GO:1901564 318 0.061
regulation of cell migration GO:0030334 22 0.061
epithelium migration GO:0090132 148 0.061
regulation of molecular function GO:0065009 217 0.060
ribonucleotide metabolic process GO:0009259 145 0.059
negative regulation of cellular metabolic process GO:0031324 382 0.058
regulation of actin filament bundle assembly GO:0032231 8 0.058
regulation of growth GO:0040008 233 0.057
mitochondrion organization GO:0007005 65 0.056
cell proliferation GO:0008283 299 0.056
apoptotic process GO:0006915 159 0.055
biological adhesion GO:0022610 138 0.054
ovulation GO:0030728 4 0.054
cellular response to chemical stimulus GO:0070887 199 0.053
regulation of intracellular signal transduction GO:1902531 236 0.053
regulation of nucleotide catabolic process GO:0030811 48 0.052
growth GO:0040007 359 0.052
protein localization GO:0008104 284 0.050
muscle fiber development GO:0048747 12 0.050
regulation of purine nucleotide metabolic process GO:1900542 62 0.049
regulation of actin filament length GO:0030832 27 0.046
mitotic nuclear division GO:0007067 213 0.045
regulation of cellular component size GO:0032535 98 0.044
regulation of apoptotic process GO:0042981 130 0.044
chromosome organization GO:0051276 360 0.042
positive regulation of hydrolase activity GO:0051345 78 0.042
regulation of multicellular organismal development GO:2000026 414 0.042
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.041
regulation of actin filament based process GO:0032970 42 0.041
determination of adult lifespan GO:0008340 137 0.041
centrosome organization GO:0051297 163 0.041
muscle tissue development GO:0060537 30 0.041
negative regulation of gene expression GO:0010629 387 0.041
epithelial cell migration open tracheal system GO:0007427 32 0.040
microtubule organizing center organization GO:0031023 168 0.040
regulation of cellular localization GO:0060341 136 0.040
epithelial cell migration GO:0010631 148 0.040
regulation of reproductive process GO:2000241 54 0.040
multi organism behavior GO:0051705 175 0.039
cellular nitrogen compound catabolic process GO:0044270 165 0.039
negative regulation of response to stimulus GO:0048585 258 0.038
positive regulation of nucleotide catabolic process GO:0030813 46 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.037
negative regulation of organelle organization GO:0010639 56 0.036
death GO:0016265 284 0.035
regulation of cell death GO:0010941 173 0.035
immune system development GO:0002520 57 0.035
response to hypoxia GO:0001666 53 0.035
hematopoietic or lymphoid organ development GO:0048534 57 0.035
programmed cell death GO:0012501 257 0.034
neurotransmitter transport GO:0006836 37 0.034
stem cell development GO:0048864 79 0.034
male mating behavior GO:0060179 70 0.032
calcium ion homeostasis GO:0055074 23 0.032
Mouse
negative regulation of signal transduction GO:0009968 206 0.031
mitotic cytokinesis GO:0000281 50 0.031
appendage development GO:0048736 401 0.031
purine nucleotide metabolic process GO:0006163 146 0.031
regulation of response to stress GO:0080134 200 0.030
positive regulation of organelle organization GO:0010638 65 0.029
cellular chemical homeostasis GO:0055082 40 0.029
Mouse
organic substance transport GO:0071702 257 0.029
imaginal disc derived appendage development GO:0048737 399 0.029
camera type eye development GO:0043010 4 0.028
mating GO:0007618 120 0.028
tyrosine metabolic process GO:0006570 1 0.027
positive regulation of cell proliferation GO:0008284 47 0.027
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.027
establishment of organelle localization GO:0051656 122 0.027
tissue morphogenesis GO:0048729 297 0.027
Mouse
regulation of sarcomere organization GO:0060297 2 0.027
adult locomotory behavior GO:0008344 76 0.026
synaptic vesicle localization GO:0097479 53 0.026
transcription from rna polymerase ii promoter GO:0006366 368 0.025
negative regulation of phosphate metabolic process GO:0045936 45 0.025
cell death GO:0008219 279 0.025
epithelial cell development GO:0002064 274 0.025
regulation of vesicle mediated transport GO:0060627 59 0.025
response to oxygen levels GO:0070482 59 0.024
muscle adaptation GO:0043500 1 0.024
Mouse
skeletal muscle fiber development GO:0048741 3 0.024
negative regulation of protein depolymerization GO:1901880 23 0.024
response to decreased oxygen levels GO:0036293 58 0.024
negative regulation of cell migration GO:0030336 5 0.024
hemopoiesis GO:0030097 46 0.024
regulation of protein depolymerization GO:1901879 27 0.023
renal system development GO:0072001 72 0.023
positive regulation of catabolic process GO:0009896 105 0.023
phagocytosis GO:0006909 215 0.023
response to metal ion GO:0010038 23 0.023
signal transduction by phosphorylation GO:0023014 107 0.022
actin filament depolymerization GO:0030042 5 0.022
imaginal disc derived appendage morphogenesis GO:0035114 395 0.022
blood circulation GO:0008015 26 0.022
actin filament bundle organization GO:0061572 28 0.021
negative regulation of catabolic process GO:0009895 36 0.021
regulation of cell adhesion GO:0030155 27 0.021
protein phosphorylation GO:0006468 169 0.021
negative regulation of phosphorus metabolic process GO:0010563 45 0.021
positive regulation of cellular component biogenesis GO:0044089 80 0.020
regulation of actin cytoskeleton organization GO:0032956 42 0.020
protein targeting to nucleus GO:0044744 51 0.020
respiratory system development GO:0060541 213 0.020
negative regulation of molecular function GO:0044092 51 0.019
positive regulation of cellular catabolic process GO:0031331 95 0.019
regulation of cell cycle GO:0051726 291 0.019
cytoskeleton dependent cytokinesis GO:0061640 81 0.019
receptor mediated endocytosis GO:0006898 21 0.019
epidermis development GO:0008544 65 0.019
glycosyl compound catabolic process GO:1901658 112 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.018
response to oxidative stress GO:0006979 86 0.018
reproductive structure development GO:0048608 74 0.018
epithelial cell differentiation GO:0030855 322 0.018
multicellular organismal aging GO:0010259 140 0.018
mapk cascade GO:0000165 107 0.018
cellular response to organic substance GO:0071310 132 0.018
sex differentiation GO:0007548 81 0.017
cellular response to oxygen containing compound GO:1901701 79 0.017
ovarian follicle cell development GO:0030707 248 0.017
positive regulation of cytoskeleton organization GO:0051495 21 0.017
negative regulation of apoptotic process GO:0043066 63 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.016
response to heat GO:0009408 63 0.016
cardiac muscle cell differentiation GO:0055007 4 0.016
negative regulation of cellular catabolic process GO:0031330 34 0.016
regulation of establishment of protein localization GO:0070201 61 0.016
regulation of dna templated transcription elongation GO:0032784 17 0.016
skeletal muscle tissue development GO:0007519 13 0.015
oocyte differentiation GO:0009994 145 0.015
dopamine biosynthetic process GO:0042416 3 0.015
regulation of multi organism process GO:0043900 131 0.015
hematopoietic progenitor cell differentiation GO:0002244 1 0.015
regulation of protein complex assembly GO:0043254 42 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
regulation of binding GO:0051098 16 0.015
cation homeostasis GO:0055080 51 0.015
Mouse
posttranscriptional regulation of gene expression GO:0010608 145 0.015
aging GO:0007568 143 0.015
myotube differentiation GO:0014902 46 0.015
positive regulation of transport GO:0051050 92 0.015
cation transport GO:0006812 110 0.015
molting cycle GO:0042303 56 0.015
regulation of protein modification process GO:0031399 112 0.014
flight GO:0060361 10 0.014
negative regulation of protein polymerization GO:0032272 7 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
cellular component disassembly GO:0022411 46 0.014
regulation of cellular protein metabolic process GO:0032268 243 0.014
response to light stimulus GO:0009416 124 0.014
cellular macromolecule localization GO:0070727 220 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.013
actin polymerization or depolymerization GO:0008154 31 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.013
cellular metal ion homeostasis GO:0006875 31 0.013
Mouse
positive regulation of biosynthetic process GO:0009891 316 0.013
cellular divalent inorganic cation homeostasis GO:0072503 23 0.013
Mouse
homeostatic process GO:0042592 199 0.012
morphogenesis of a branching epithelium GO:0061138 45 0.012
regulation of immune system process GO:0002682 176 0.012
tube morphogenesis GO:0035239 191 0.012
synaptic transmission GO:0007268 288 0.012
organelle localization GO:0051640 148 0.012
response to reactive oxygen species GO:0000302 24 0.012
germarium derived egg chamber formation GO:0007293 101 0.012
nuclear division GO:0000280 332 0.012
ion homeostasis GO:0050801 55 0.011
Mouse
cell cycle arrest GO:0007050 4 0.011
forebrain development GO:0030900 2 0.011
mesenchymal cell development GO:0014031 1 0.011
regulation of endocytosis GO:0030100 37 0.011
regulation of protein localization GO:0032880 76 0.011
response to calcium ion GO:0051592 1 0.011
developmental maturation GO:0021700 172 0.011
protein polymerization GO:0051258 42 0.011
actin filament polymerization GO:0030041 27 0.011
positive regulation of stem cell differentiation GO:2000738 3 0.011
cellular response to abiotic stimulus GO:0071214 58 0.010
cardiac cell development GO:0055006 3 0.010
regulation of secretion by cell GO:1903530 39 0.010
positive regulation of cell adhesion GO:0045785 10 0.010
secretion by cell GO:0032940 101 0.010
nucleoside phosphate catabolic process GO:1901292 110 0.010
regulation of actin polymerization or depolymerization GO:0008064 27 0.010
regulation of protein polymerization GO:0032271 28 0.010
organic acid metabolic process GO:0006082 103 0.010
positive regulation of nucleic acid templated transcription GO:1903508 266 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
wing disc morphogenesis GO:0007472 344 0.010

wupA disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.760
muscular disease DOID:0080000 0 0.760
heart disease DOID:114 0 0.760
cardiomyopathy DOID:0050700 0 0.760
dilated cardiomyopathy DOID:12930 0 0.760
disease of anatomical entity DOID:7 0 0.760
intrinsic cardiomyopathy DOID:0060036 0 0.760
cardiovascular system disease DOID:1287 0 0.760
musculoskeletal system disease DOID:17 0 0.760
muscle tissue disease DOID:66 0 0.760
nervous system disease DOID:863 0 0.033
bone disease DOID:0080001 0 0.023
connective tissue disease DOID:65 0 0.023
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017