Drosophila melanogaster

83 known processes

Hel25E (Dmel_CG7269)

Helicase at 25E

(Aliases: DmRH4,l(2)gdh-12,Dbp25F,uap56,sz,l(2)25Eb,l(2)jf26,WM6,hel,Wm6,Hel,UAP56,CG7269,l(2)k11511,l(2)gdh12,HEL,jf26,Dmel\CG7269)

Hel25E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pole plasm mrna localization GO:0019094 49 0.999
pole plasm oskar mrna localization GO:0045451 46 0.993
pole plasm rna localization GO:0007316 52 0.992
oocyte differentiation GO:0009994 145 0.991
oocyte development GO:0048599 124 0.989
oocyte anterior posterior axis specification GO:0007314 72 0.985
oocyte axis specification GO:0007309 108 0.985
oocyte construction GO:0007308 112 0.978
maternal determination of anterior posterior axis embryo GO:0008358 74 0.976
embryonic pattern specification GO:0009880 174 0.974
pole plasm assembly GO:0007315 61 0.971
rna localization GO:0006403 115 0.961
cytoplasm organization GO:0007028 64 0.956
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.947
blastoderm segmentation GO:0007350 159 0.945
negative regulation of rna biosynthetic process GO:1902679 240 0.943
Yeast
tripartite regional subdivision GO:0007351 103 0.917
embryonic axis specification GO:0000578 107 0.911
intracellular mrna localization GO:0008298 66 0.894
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.890
Yeast
cellular macromolecule localization GO:0070727 220 0.887
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.879
Yeast
regionalization GO:0003002 416 0.867
negative regulation of rna metabolic process GO:0051253 251 0.856
Yeast
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.852
negative regulation of transcription dna templated GO:0045892 237 0.834
Yeast
cell maturation GO:0048469 144 0.821
axis specification GO:0009798 167 0.803
regulation of gene expression epigenetic GO:0040029 128 0.728
Yeast
nucleobase containing compound catabolic process GO:0034655 165 0.725
Human Yeast
cell death GO:0008219 279 0.706
Worm
negative regulation of cellular biosynthetic process GO:0031327 277 0.679
Yeast
segmentation GO:0035282 207 0.674
protein dna complex subunit organization GO:0071824 86 0.672
single organism cellular localization GO:1902580 180 0.618
heterocycle catabolic process GO:0046700 166 0.613
Human Yeast
rna splicing GO:0008380 83 0.611
chromatin silencing GO:0006342 76 0.579
Yeast
organic substance catabolic process GO:1901575 308 0.571
Human Yeast
anterior posterior pattern specification GO:0009952 136 0.562
negative regulation of cellular metabolic process GO:0031324 382 0.552
Yeast
negative regulation of gene expression GO:0010629 387 0.542
Yeast
immune system process GO:0002376 347 0.540
heterochromatin organization GO:0070828 25 0.517
programmed cell death GO:0012501 257 0.516
Worm
mrna metabolic process GO:0016071 124 0.511
regulation of cell death GO:0010941 173 0.494
organic cyclic compound catabolic process GO:1901361 168 0.488
Human Yeast
nuclear transcribed mrna catabolic process GO:0000956 24 0.486
cellular nitrogen compound catabolic process GO:0044270 165 0.465
Human Yeast
aromatic compound catabolic process GO:0019439 166 0.460
Human Yeast
rna catabolic process GO:0006401 37 0.458
developmental maturation GO:0021700 172 0.458
anterior posterior axis specification embryo GO:0008595 103 0.419
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.414
cellular macromolecule catabolic process GO:0044265 136 0.405
regulation of response to stress GO:0080134 200 0.398
Human
death GO:0016265 284 0.396
Worm
establishment of localization in cell GO:0051649 402 0.385
mrna catabolic process GO:0006402 33 0.384
negative regulation of gene expression epigenetic GO:0045814 77 0.378
Yeast
larval development GO:0002164 104 0.371
Worm
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.366
Yeast
anterior posterior axis specification GO:0009948 109 0.364
regulation of apoptotic process GO:0042981 130 0.360
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.354
Yeast
regulation of intracellular signal transduction GO:1902531 236 0.340
macromolecule catabolic process GO:0009057 161 0.336
apoptotic process GO:0006915 159 0.334
Worm
positive regulation of gene expression GO:0010628 290 0.322
Human
muscle structure development GO:0061061 224 0.299
chromatin assembly or disassembly GO:0006333 52 0.286
positive regulation of rna metabolic process GO:0051254 271 0.282
Human
cellular catabolic process GO:0044248 372 0.281
Human Yeast
cellular response to dna damage stimulus GO:0006974 223 0.281
Human Yeast
defense response GO:0006952 300 0.279
mrna processing GO:0006397 104 0.275
positive regulation of macromolecule metabolic process GO:0010604 405 0.264
Human
chemotaxis GO:0006935 249 0.263
gene silencing GO:0016458 138 0.262
Yeast
regulation of gene silencing GO:0060968 63 0.255
negative regulation of cell cycle process GO:0010948 109 0.254
Human
regulation of cell differentiation GO:0045595 302 0.235
regulation of programmed cell death GO:0043067 152 0.232
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 8 0.230
chromatin organization GO:0006325 207 0.223
negative regulation of cell cycle phase transition GO:1901988 103 0.215
sex differentiation GO:0007548 81 0.213
Worm
stem cell differentiation GO:0048863 117 0.208
regulation of protein metabolic process GO:0051246 256 0.207
defense response to other organism GO:0098542 225 0.203
g2 dna damage checkpoint GO:0031572 69 0.203
regulation of rna splicing GO:0043484 69 0.202
multi organism reproductive behavior GO:0044705 121 0.199
histone acetylation GO:0016573 38 0.194
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.186
regulation of mrna processing GO:0050684 71 0.181
regulation of cell cycle process GO:0010564 181 0.179
Human
intracellular signal transduction GO:0035556 300 0.177
regulation of multicellular organismal development GO:2000026 414 0.176
macromolecular complex assembly GO:0065003 256 0.172
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.170
cellular macromolecular complex assembly GO:0034622 153 0.168
Human
rna splicing via transesterification reactions GO:0000375 73 0.167
catabolic process GO:0009056 409 0.158
Human Yeast
reproductive behavior GO:0019098 122 0.158
enzyme linked receptor protein signaling pathway GO:0007167 179 0.150
oxoacid metabolic process GO:0043436 103 0.148
dna conformation change GO:0071103 105 0.148
response to biotic stimulus GO:0009607 294 0.140
reproductive structure development GO:0048608 74 0.139
Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.130
Worm
negative regulation of nucleic acid templated transcription GO:1903507 240 0.129
Yeast
regulation of reproductive process GO:2000241 54 0.129
mitotic g2 dna damage checkpoint GO:0007095 69 0.122
single organism behavior GO:0044708 391 0.120
mrna splicing via spliceosome GO:0000398 73 0.120
transcription from rna polymerase ii promoter GO:0006366 368 0.118
Yeast
mitotic dna damage checkpoint GO:0044773 74 0.118
nucleoside metabolic process GO:0009116 127 0.118
Human Yeast
neuron projection guidance GO:0097485 241 0.117
meiotic cell cycle GO:0051321 171 0.114
histone methylation GO:0016571 40 0.113
mitotic dna integrity checkpoint GO:0044774 75 0.110
small molecule metabolic process GO:0044281 305 0.110
Human Yeast
positive regulation of biosynthetic process GO:0009891 316 0.110
Human
gonad development GO:0008406 50 0.109
Worm
positive regulation of transcription dna templated GO:0045893 266 0.106
Human
organophosphate metabolic process GO:0019637 195 0.106
Human Yeast
posttranscriptional gene silencing GO:0016441 46 0.105
response to other organism GO:0051707 293 0.103
regulation of mitotic cell cycle GO:0007346 190 0.102
regulation of mrna splicing via spliceosome GO:0048024 64 0.100
negative regulation of biosynthetic process GO:0009890 277 0.098
Yeast
carboxylic acid metabolic process GO:0019752 92 0.095
atp dependent chromatin remodeling GO:0043044 22 0.090
anatomical structure homeostasis GO:0060249 97 0.087
regulation of meiosis GO:0040020 3 0.081
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.081
Human
chromosome organization GO:0051276 360 0.080
camera type eye development GO:0043010 4 0.080
gene silencing by mirna GO:0035195 22 0.079
regulation of localization GO:0032879 275 0.077
dna packaging GO:0006323 91 0.076
regulation of mitotic cell cycle phase transition GO:1901990 130 0.072
positive regulation of protein metabolic process GO:0051247 128 0.071
regulation of cellular catabolic process GO:0031329 157 0.070
dendrite guidance GO:0070983 21 0.069
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.068
Human
cellular response to chemical stimulus GO:0070887 199 0.067
response to external biotic stimulus GO:0043207 293 0.066
regulation of cellular protein metabolic process GO:0032268 243 0.066
chromatin assembly GO:0031497 48 0.065
retina development in camera type eye GO:0060041 4 0.064
positive regulation of cellular protein metabolic process GO:0032270 118 0.063
nucleobase containing small molecule metabolic process GO:0055086 174 0.062
Human Yeast
peptidyl lysine acetylation GO:0018394 39 0.062
nucleosome organization GO:0034728 59 0.062
positive regulation of nucleic acid templated transcription GO:1903508 266 0.061
Human
dna integrity checkpoint GO:0031570 81 0.061
Human
mitotic cell cycle checkpoint GO:0007093 88 0.060
response to organic substance GO:0010033 284 0.059
determination of adult lifespan GO:0008340 137 0.059
negative regulation of developmental process GO:0051093 201 0.058
development of primary sexual characteristics GO:0045137 50 0.057
Worm
regulation of multi organism process GO:0043900 131 0.057
cellular ketone metabolic process GO:0042180 24 0.057
mitotic g2 m transition checkpoint GO:0044818 70 0.056
positive regulation of cell death GO:0010942 69 0.055
cell cycle phase transition GO:0044770 140 0.055
posttranscriptional regulation of gene expression GO:0010608 145 0.054
innate immune response GO:0045087 144 0.053
dna metabolic process GO:0006259 227 0.050
Yeast
positive regulation of response to stimulus GO:0048584 323 0.050
genitalia development GO:0048806 26 0.050
Worm
cell division GO:0051301 248 0.048
regulation of organelle organization GO:0033043 196 0.047
reproductive system development GO:0061458 74 0.047
Worm
chromatin remodeling GO:0006338 72 0.046
cell proliferation GO:0008283 299 0.046
rna processing GO:0006396 147 0.044
positive regulation of programmed cell death GO:0043068 62 0.044
cell motility GO:0048870 251 0.042
male gamete generation GO:0048232 201 0.041
dna damage checkpoint GO:0000077 78 0.041
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.041
positive regulation of rna biosynthetic process GO:1902680 266 0.040
Human
multicellular organismal reproductive behavior GO:0033057 110 0.040
regulation of catabolic process GO:0009894 170 0.040
regulation of transcription by chromatin organization GO:0034401 3 0.040
regulation of mrna metabolic process GO:1903311 72 0.040
regulation of proteolysis GO:0030162 87 0.039
spindle organization GO:0007051 253 0.039
dendrite morphogenesis GO:0048813 199 0.038
neurological system process GO:0050877 358 0.037
organonitrogen compound metabolic process GO:1901564 318 0.037
Human Yeast
glycosyl compound catabolic process GO:1901658 112 0.037
Human Yeast
regulation of cell proliferation GO:0042127 163 0.035
nucleoside phosphate metabolic process GO:0006753 162 0.035
Human Yeast
organic acid metabolic process GO:0006082 103 0.034
regulation of chromatin silencing GO:0031935 36 0.033
body morphogenesis GO:0010171 2 0.032
Worm
nitrogen compound transport GO:0071705 85 0.032
peptidyl lysine trimethylation GO:0018023 6 0.032
taxis GO:0042330 304 0.032
regulation of immune system process GO:0002682 176 0.032
gene silencing by rna GO:0031047 57 0.031
purine nucleoside metabolic process GO:0042278 127 0.031
Human Yeast
multi organism behavior GO:0051705 175 0.031
ribonucleoside monophosphate catabolic process GO:0009158 39 0.030
Human Yeast
meiotic nuclear division GO:0007126 151 0.030
chromatin modification GO:0016568 147 0.029
purine nucleoside monophosphate catabolic process GO:0009128 38 0.029
Human Yeast
negative regulation of mitotic cell cycle GO:0045930 109 0.028
organelle assembly GO:0070925 198 0.027
negative regulation of apoptotic process GO:0043066 63 0.027
muscle organ development GO:0007517 127 0.026
organelle fission GO:0048285 340 0.026
regulation of cell cycle GO:0051726 291 0.026
Human
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.026
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.026
cellular homeostasis GO:0019725 80 0.026
alternative mrna splicing via spliceosome GO:0000380 60 0.025
intracellular transport GO:0046907 228 0.025
ribose phosphate metabolic process GO:0019693 145 0.025
Human Yeast
positive regulation of defense response GO:0031349 59 0.025
nucleotide metabolic process GO:0009117 161 0.025
Human Yeast
response to dsrna GO:0043331 15 0.025
mitotic cell cycle phase transition GO:0044772 138 0.024
cell type specific apoptotic process GO:0097285 38 0.024
axonogenesis GO:0007409 290 0.023
nuclear division GO:0000280 332 0.023
regulation of meiotic cell cycle GO:0051445 9 0.023
negative regulation of cell cycle GO:0045786 116 0.022
Human
cytoplasmic transport GO:0016482 130 0.022
nucleoside phosphate catabolic process GO:1901292 110 0.022
Human Yeast
response to bacterium GO:0009617 198 0.022
positive regulation of molecular function GO:0044093 136 0.022
peptidyl lysine modification GO:0018205 57 0.022
positive regulation of apoptotic process GO:0043065 47 0.022
regulation of cellular ketone metabolic process GO:0010565 3 0.022
organic substance transport GO:0071702 257 0.022
negative regulation of cell death GO:0060548 81 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.021
regulation of translation GO:0006417 56 0.021
single organism catabolic process GO:0044712 228 0.021
Human Yeast
positive regulation of cellular component organization GO:0051130 156 0.020
protein localization GO:0008104 284 0.020
regulation of oocyte development GO:0060281 27 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
Human
regulation of cellular localization GO:0060341 136 0.020
multi multicellular organism process GO:0044706 123 0.020
cellular response to organic substance GO:0071310 132 0.019
prostanoid biosynthetic process GO:0046457 1 0.019
immune response GO:0006955 246 0.019
spinal cord development GO:0021510 1 0.019
cell migration GO:0016477 238 0.019
ras protein signal transduction GO:0007265 88 0.018
negative regulation of cell differentiation GO:0045596 143 0.018
oviposition GO:0018991 19 0.018
organonitrogen compound catabolic process GO:1901565 128 0.017
Human Yeast
histone h4 k20 methylation GO:0034770 4 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.017
Human Yeast
mitotic nuclear division GO:0007067 213 0.017
regulation of dna metabolic process GO:0051052 34 0.017
chromatin silencing at centromere GO:0030702 3 0.016
vesicle mediated transport GO:0016192 381 0.016
phosphorylation GO:0016310 294 0.016
response to abiotic stimulus GO:0009628 341 0.016
nucleobase containing compound transport GO:0015931 56 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
protein maturation GO:0051604 71 0.015
defense response to bacterium GO:0042742 178 0.015
axon development GO:0061564 297 0.015
negative regulation of cellular component organization GO:0051129 108 0.015
cognition GO:0050890 141 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
regulation of dna templated transcription elongation GO:0032784 17 0.015
Human
positive regulation of chromatin silencing GO:0031937 16 0.015
response to nitrogen compound GO:1901698 90 0.015
ribonucleoside monophosphate metabolic process GO:0009161 51 0.014
Human Yeast
cellular protein complex assembly GO:0043623 71 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
Human Yeast
aging GO:0007568 143 0.014
regulation of protein modification process GO:0031399 112 0.014
ribonucleoside catabolic process GO:0042454 112 0.014
Human Yeast
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
cell cycle checkpoint GO:0000075 95 0.014
Human
golgi organization GO:0007030 66 0.014
response to temperature stimulus GO:0009266 106 0.014
oocyte dorsal ventral axis specification GO:0007310 34 0.014
regulation of phosphate metabolic process GO:0019220 210 0.014
regulation of phosphatase activity GO:0010921 3 0.014
multicellular organismal aging GO:0010259 140 0.014
cell chemotaxis involved in malpighian tubule morphogenesis GO:0061352 3 0.014
endocytosis GO:0006897 310 0.014
purine nucleoside monophosphate metabolic process GO:0009126 50 0.014
Human Yeast
protein complex biogenesis GO:0070271 201 0.013
response to nutrient levels GO:0031667 114 0.013
ribonucleoprotein complex subunit organization GO:0071826 28 0.013
Human
cellular response to nitrogen compound GO:1901699 51 0.013
eye morphogenesis GO:0048592 260 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
Human Yeast
spermatogenesis GO:0007283 200 0.013
response to heat GO:0009408 63 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
mitotic spindle organization GO:0007052 220 0.013
peptidyl lysine methylation GO:0018022 16 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
Human Yeast
protein localization to organelle GO:0033365 82 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
Human Yeast
nucleoside monophosphate metabolic process GO:0009123 52 0.012
Human Yeast
purine ribonucleotide metabolic process GO:0009150 145 0.012
Human Yeast
dendrite development GO:0016358 204 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.012
Human Yeast
regulation of cellular response to stress GO:0080135 89 0.012
Human
negative regulation of organelle organization GO:0010639 56 0.012
regulation of cell maturation GO:1903429 27 0.012
regulation of cell cycle phase transition GO:1901987 130 0.012
axon guidance GO:0007411 233 0.012
response to oxygen containing compound GO:1901700 200 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
Human Yeast
regulation of cell development GO:0060284 215 0.012
chemosensory behavior GO:0007635 106 0.012
positive regulation of ribosome biogenesis GO:0090070 3 0.011
response to extracellular stimulus GO:0009991 116 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
phagocytosis GO:0006909 215 0.011
cellular response to dsrna GO:0071359 15 0.011
mapk cascade GO:0000165 107 0.011
formation of a compartment boundary GO:0060288 4 0.011
homeostatic process GO:0042592 199 0.011
regulation of transport GO:0051049 181 0.011
histone exchange GO:0043486 21 0.011
nucleoside monophosphate catabolic process GO:0009125 39 0.011
Human Yeast
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
positive regulation of cell communication GO:0010647 250 0.011
regulation of striated muscle contraction GO:0006942 2 0.010
regulation of nuclear division GO:0051783 58 0.010
tricarboxylic acid metabolic process GO:0072350 1 0.010
regulation of ras protein signal transduction GO:0046578 93 0.010
reactive oxygen species biosynthetic process GO:1903409 0 0.010

Hel25E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013