Drosophila melanogaster

232 known processes

BubR1 (Dmel_CG7838)

Bub1-related kinase

(Aliases: bubr1,bub1,Bub1,BcDNA:LD23835,dBUB1,31/13,Dmbub1,l(2)k06109,bubR1,CG 7838,l(2)k03113,Mad3,DmBUB1,BUB1,Dmel\CG7838,BUBR1,CG7838)

BubR1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear division GO:0000280 332 0.999
organelle fission GO:0048285 340 0.999
meiotic cell cycle GO:0051321 171 0.998
male meiosis GO:0007140 52 0.998
meiotic nuclear division GO:0007126 151 0.996
centrosome cycle GO:0007098 137 0.995
spindle organization GO:0007051 253 0.993
mitotic spindle organization GO:0007052 220 0.992
chromosome organization GO:0051276 360 0.992
mitotic sister chromatid separation GO:0051306 30 0.991
chromosome segregation GO:0007059 157 0.984
sister chromatid segregation GO:0000819 92 0.978
centrosome duplication GO:0051298 121 0.974
spindle assembly involved in meiosis GO:0090306 20 0.973
chromosome condensation GO:0030261 41 0.967
spindle assembly involved in mitosis GO:0090307 50 0.919
microtubule organizing center organization GO:0031023 168 0.904
regulation of mitotic sister chromatid segregation GO:0033047 28 0.896
meiotic spindle organization GO:0000212 36 0.894
dna conformation change GO:0071103 105 0.882
dna metabolic process GO:0006259 227 0.875
meiotic cell cycle process GO:1903046 132 0.874
meiotic chromosome segregation GO:0045132 59 0.834
mitotic sister chromatid segregation GO:0000070 87 0.824
spindle assembly involved in female meiosis GO:0007056 14 0.775
spindle assembly GO:0051225 80 0.759
negative regulation of chromosome segregation GO:0051985 14 0.737
regulation of mitotic spindle organization GO:0060236 9 0.718
dna packaging GO:0006323 91 0.708
regulation of mitotic cell cycle phase transition GO:1901990 130 0.680
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.666
regulation of cell cycle phase transition GO:1901987 130 0.651
microtubule polymerization or depolymerization GO:0031109 39 0.635
cell cycle phase transition GO:0044770 140 0.635
mitotic cell cycle phase transition GO:0044772 138 0.634
spindle assembly involved in female meiosis i GO:0007057 5 0.605
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.601
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.579
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.570
mitotic spindle stabilization GO:0043148 6 0.543
protein complex assembly GO:0006461 200 0.543
regulation of mitosis GO:0007088 56 0.534
cellular protein complex assembly GO:0043623 71 0.521
metaphase anaphase transition of cell cycle GO:0044784 28 0.520
female meiotic division GO:0007143 70 0.486
male meiosis cytokinesis GO:0007112 26 0.483
mitotic chromosome condensation GO:0007076 22 0.475
pronuclear migration GO:0035046 4 0.474
protein polymerization GO:0051258 42 0.471
centrosome organization GO:0051297 163 0.447
female meiosis i GO:0007144 8 0.423
macromolecular complex assembly GO:0065003 256 0.422
mitotic centrosome separation GO:0007100 8 0.404
centrosome separation GO:0051299 20 0.371
negative regulation of cell cycle GO:0045786 116 0.362
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.356
regulation of cell division GO:0051302 72 0.348
meiosis i GO:0007127 59 0.339
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.337
organelle assembly GO:0070925 198 0.324
mitotic nuclear division GO:0007067 213 0.320
regulation of sister chromatid segregation GO:0033045 28 0.319
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.298
establishment or maintenance of cell polarity GO:0007163 167 0.285
mitotic spindle elongation GO:0000022 81 0.285
chromosome separation GO:0051304 42 0.267
gonad development GO:0008406 50 0.253
cystoblast division GO:0007282 10 0.247
regulation of mitotic sister chromatid separation GO:0010965 28 0.243
histone modification GO:0016570 106 0.242
regulation of mitotic cell cycle GO:0007346 190 0.241
regulation of chromosome segregation GO:0051983 32 0.233
negative regulation of mitotic cell cycle GO:0045930 109 0.229
regulation of chromosome organization GO:0033044 64 0.201
negative regulation of biosynthetic process GO:0009890 277 0.185
meiosis ii GO:0007135 23 0.181
positive regulation of mitotic metaphase anaphase transition GO:0045842 10 0.177
cell division GO:0051301 248 0.174
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.173
regulation of proteasomal protein catabolic process GO:0061136 39 0.173
dna integrity checkpoint GO:0031570 81 0.165
mitotic spindle checkpoint GO:0071174 11 0.158
regulation of nuclear division GO:0051783 58 0.157
spindle midzone assembly GO:0051255 4 0.156
regulation of mitotic spindle elongation GO:0032888 1 0.155
cellular response to dna damage stimulus GO:0006974 223 0.154
dna dependent dna replication GO:0006261 17 0.140
mitotic g2 m transition checkpoint GO:0044818 70 0.136
mitotic cytokinesis GO:0000281 50 0.133
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.130
microtubule polymerization GO:0046785 15 0.130
cellular macromolecular complex assembly GO:0034622 153 0.124
synaptonemal complex organization GO:0070193 5 0.123
nuclear dna replication GO:0033260 1 0.122
chromatin organization GO:0006325 207 0.121
embryo development ending in birth or egg hatching GO:0009792 152 0.115
regulation of microtubule cytoskeleton organization GO:0070507 41 0.111
positive regulation of catalytic activity GO:0043085 118 0.110
kinetochore organization GO:0051383 9 0.105
development of primary sexual characteristics GO:0045137 50 0.104
larval development GO:0002164 104 0.103
dna recombination GO:0006310 32 0.102
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.102
negative regulation of cell division GO:0051782 17 0.098
regulation of spindle elongation GO:0032887 1 0.096
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 13 0.096
nucleus localization GO:0051647 34 0.094
asymmetric stem cell division GO:0098722 49 0.091
centriole replication GO:0007099 24 0.088
positive regulation of macromolecule metabolic process GO:0010604 405 0.085
chromatin modification GO:0016568 147 0.085
regulation of cell cycle process GO:0010564 181 0.084
cellular protein modification process GO:0006464 438 0.080
negative regulation of cell cycle process GO:0010948 109 0.079
mitotic cell cycle checkpoint GO:0007093 88 0.077
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.077
sister chromatid cohesion GO:0007062 18 0.077
regulation of microtubule based process GO:0032886 49 0.076
negative regulation of cellular metabolic process GO:0031324 382 0.074
lateral inhibition GO:0046331 206 0.074
neuronal stem cell division GO:0036445 35 0.072
chromosome movement towards spindle pole GO:0051305 4 0.072
pronuclear fusion GO:0007344 4 0.066
dna damage checkpoint GO:0000077 78 0.065
protein modification process GO:0036211 438 0.064
oocyte maturation GO:0001556 3 0.064
spindle checkpoint GO:0031577 11 0.063
mitotic spindle assembly checkpoint GO:0007094 11 0.061
cell cell signaling involved in cell fate commitment GO:0045168 210 0.060
purine nucleoside triphosphate metabolic process GO:0009144 119 0.060
regulation of dna metabolic process GO:0051052 34 0.060
negative regulation of cell cycle phase transition GO:1901988 103 0.058
brain development GO:0007420 120 0.058
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.057
regulation of cellular protein catabolic process GO:1903362 44 0.055
vesicle mediated transport GO:0016192 381 0.055
regulation of dna replication GO:0006275 13 0.054
regulation of cellular catabolic process GO:0031329 157 0.053
cytokinesis GO:0000910 90 0.052
positive regulation of phosphate metabolic process GO:0045937 139 0.052
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.051
meiotic dna double strand break processing GO:0000706 3 0.051
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.050
meiotic sister chromatid segregation GO:0045144 6 0.049
dna geometric change GO:0032392 16 0.049
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.049
cellular catabolic process GO:0044248 372 0.048
sperm axoneme assembly GO:0007288 13 0.048
single organism catabolic process GO:0044712 228 0.047
ras protein signal transduction GO:0007265 88 0.045
germ line cyst formation GO:0048134 44 0.045
negative regulation of mitotic metaphase anaphase transition GO:0045841 13 0.044
organic substance transport GO:0071702 257 0.044
modification dependent protein catabolic process GO:0019941 78 0.044
germarium derived female germ line cyst formation GO:0030727 42 0.042
negative regulation of sister chromatid segregation GO:0033046 13 0.041
somatic stem cell division GO:0048103 37 0.041
cell proliferation GO:0008283 299 0.041
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.038
regulation of catalytic activity GO:0050790 185 0.038
meiotic chromosome condensation GO:0010032 3 0.038
nucleobase containing compound catabolic process GO:0034655 165 0.037
negative regulation of chromosome organization GO:2001251 19 0.036
asymmetric neuroblast division GO:0055059 33 0.036
positive regulation of cellular protein metabolic process GO:0032270 118 0.035
g2 dna damage checkpoint GO:0031572 69 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.034
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.034
dna replication GO:0006260 48 0.033
positive regulation of chromosome segregation GO:0051984 10 0.033
centriole assembly GO:0098534 24 0.033
meiotic cytokinesis GO:0033206 33 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.031
sex differentiation GO:0007548 81 0.031
negative regulation of cellular component organization GO:0051129 108 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
female meiosis chromosome segregation GO:0016321 33 0.030
mitotic g2 dna damage checkpoint GO:0007095 69 0.030
microtubule anchoring GO:0034453 11 0.030
g2 m transition of mitotic cell cycle GO:0000086 19 0.030
reproductive system development GO:0061458 74 0.030
negative regulation of proteolysis GO:0045861 31 0.030
nucleoside phosphate metabolic process GO:0006753 162 0.029
dna replication initiation GO:0006270 6 0.028
regulation of intracellular signal transduction GO:1902531 236 0.027
reproductive structure development GO:0048608 74 0.027
cytoskeleton dependent cytokinesis GO:0061640 81 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.026
nucleoside phosphate catabolic process GO:1901292 110 0.026
protein complex biogenesis GO:0070271 201 0.026
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.025
nuclear envelope organization GO:0006998 7 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
purine nucleoside catabolic process GO:0006152 112 0.024
regulation of molecular function GO:0065009 217 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
response to abiotic stimulus GO:0009628 341 0.023
negative regulation of cellular biosynthetic process GO:0031327 277 0.023
response to organic substance GO:0010033 284 0.022
nuclear migration GO:0007097 20 0.022
regulation of catabolic process GO:0009894 170 0.022
positive regulation of cell cycle process GO:0090068 28 0.022
spindle elongation GO:0051231 83 0.022
neuroblast proliferation GO:0007405 74 0.021
head development GO:0060322 135 0.021
gene silencing GO:0016458 138 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.021
positive regulation of nucleic acid templated transcription GO:1903508 266 0.021
microtubule bundle formation GO:0001578 27 0.021
endomembrane system organization GO:0010256 119 0.021
positive regulation of mitotic cell cycle GO:0045931 34 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.021
purine ribonucleoside metabolic process GO:0046128 127 0.020
ribonucleoside triphosphate catabolic process GO:0009203 108 0.020
establishment of spindle orientation GO:0051294 18 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.020
negative regulation of rna metabolic process GO:0051253 251 0.020
forebrain development GO:0030900 2 0.019
positive regulation of protein transport GO:0051222 37 0.019
microtubule nucleation GO:0007020 8 0.019
karyogamy GO:0000741 4 0.018
metaphase plate congression GO:0051310 19 0.018
cell cycle checkpoint GO:0000075 95 0.018
protein phosphorylation GO:0006468 169 0.018
macromolecule catabolic process GO:0009057 161 0.018
positive regulation of cellular component biogenesis GO:0044089 80 0.018
mitotic sister chromatid cohesion GO:0007064 6 0.017
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.017
embryonic cleavage GO:0040016 5 0.017
aromatic compound catabolic process GO:0019439 166 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.017
positive regulation of signaling GO:0023056 243 0.017
maintenance of location GO:0051235 73 0.017
establishment of meiotic spindle orientation GO:0051296 2 0.017
chitin based larval cuticle pattern formation GO:0035293 11 0.017
neuronal stem cell maintenance GO:0097150 4 0.016
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.016
organophosphate metabolic process GO:0019637 195 0.016
proteolysis GO:0006508 192 0.016
covalent chromatin modification GO:0016569 106 0.016
attachment of spindle microtubules to kinetochore GO:0008608 5 0.016
distributive segregation GO:0032837 6 0.016
purine ribonucleotide catabolic process GO:0009154 109 0.016
heterocycle catabolic process GO:0046700 166 0.016
regulation of hemocyte proliferation GO:0035206 37 0.016
regulation of organelle organization GO:0033043 196 0.016
reciprocal meiotic recombination GO:0007131 19 0.015
dna duplex unwinding GO:0032508 16 0.015
positive regulation of protein modification process GO:0031401 58 0.015
regulation of chromatin binding GO:0035561 3 0.015
protein import GO:0017038 55 0.015
dna endoreduplication GO:0042023 22 0.014
regulation of cytoskeleton organization GO:0051493 89 0.014
protein localization to organelle GO:0033365 82 0.014
Human Mouse
mitotic spindle midzone assembly GO:0051256 1 0.014
cell cycle g2 m phase transition GO:0044839 22 0.014
membrane organization GO:0061024 112 0.014
regulation of neuron differentiation GO:0045664 103 0.014
regulation of meiosis GO:0040020 3 0.014
icosanoid biosynthetic process GO:0046456 1 0.014
positive regulation of developmental process GO:0051094 143 0.014
endocytosis GO:0006897 310 0.014
peptidyl threonine modification GO:0018210 3 0.014
regulation of spindle organization GO:0090224 17 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
maintenance of protein location GO:0045185 28 0.013
reciprocal dna recombination GO:0035825 19 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
pole cell migration GO:0007280 13 0.013
regulation of cell cycle GO:0051726 291 0.013
nucleoside catabolic process GO:0009164 112 0.013
positive regulation of gene expression GO:0010628 290 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
cytoplasmic transport GO:0016482 130 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
ribonucleoside catabolic process GO:0042454 112 0.013
regulation of nervous system development GO:0051960 248 0.013
spindle assembly involved in male meiosis GO:0007053 5 0.013
peptidyl threonine phosphorylation GO:0018107 2 0.013
positive regulation of signal transduction GO:0009967 223 0.013
nucleolus organization GO:0007000 4 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
genitalia development GO:0048806 26 0.013
single organism biosynthetic process GO:0044711 206 0.012
negative regulation of neurogenesis GO:0050768 53 0.012
neural precursor cell proliferation GO:0061351 75 0.012
body morphogenesis GO:0010171 2 0.012
apoptotic process GO:0006915 159 0.012
neuroblast division GO:0055057 35 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
telomere capping GO:0016233 11 0.012
meiotic spindle midzone assembly GO:0051257 3 0.012
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.012
digestive tract development GO:0048565 149 0.012
organonitrogen compound catabolic process GO:1901565 128 0.012
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
establishment of protein localization GO:0045184 163 0.011
actomyosin structure organization GO:0031032 56 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
organophosphate biosynthetic process GO:0090407 46 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
fatty acid derivative biosynthetic process GO:1901570 1 0.011
regulation of transcription by chromatin organization GO:0034401 3 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
regulation of growth GO:0040008 233 0.011
cellular protein localization GO:0034613 160 0.011
Human Mouse
negative regulation of transcription dna templated GO:0045892 237 0.011
nucleoside monophosphate catabolic process GO:0009125 39 0.011
histone mrna metabolic process GO:0008334 8 0.011
actin cytoskeleton organization GO:0030036 206 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
response to external biotic stimulus GO:0043207 293 0.011
positive regulation of molecular function GO:0044093 136 0.011
protein processing GO:0016485 68 0.011
female germ line cyst formation GO:0048135 42 0.011
glycosyl compound metabolic process GO:1901657 127 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.010
regulation of neurogenesis GO:0050767 158 0.010
protein maturation GO:0051604 71 0.010
establishment of nucleus localization GO:0040023 26 0.010
single fertilization GO:0007338 24 0.010
meiotic g2 mi transition GO:0008315 3 0.010

BubR1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org