Drosophila melanogaster

117 known processes

spn-A (Dmel_CG7948)

spindle A

(Aliases: Dm Rad51,Dmrad51,CG7948,RA51,DMR1,Dmel\CG7948,RA51_DROME,dmRAD51,rad51,DMR,RAD51,D37788,Spn-A,Rad51,spnA,DmRad51,DMR/DroRAD51,Rad51dm,DmRAD51)

spn-A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
reciprocal meiotic recombination GO:0007131 19 1.000
Yeast
meiotic nuclear division GO:0007126 151 0.999
dna recombination GO:0006310 32 0.991
reciprocal dna recombination GO:0035825 19 0.990
Yeast
meiotic cell cycle process GO:1903046 132 0.986
Yeast Worm
organelle fission GO:0048285 340 0.965
dna metabolic process GO:0006259 227 0.959
female meiotic division GO:0007143 70 0.955
chorion containing eggshell formation GO:0007304 105 0.948
meiotic cell cycle GO:0051321 171 0.948
meiosis i GO:0007127 59 0.946
Yeast
double strand break repair GO:0006302 26 0.938
germarium derived oocyte fate determination GO:0007294 26 0.921
transcription from rna polymerase ii promoter GO:0006366 368 0.913
germarium derived egg chamber formation GO:0007293 101 0.908
nuclear division GO:0000280 332 0.901
double strand break repair via nonhomologous end joining GO:0006303 5 0.895
chromosome segregation GO:0007059 157 0.886
Worm
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.873
karyosome formation GO:0030717 22 0.811
nucleotide excision repair GO:0006289 8 0.799
oocyte differentiation GO:0009994 145 0.791
meiotic chromosome segregation GO:0045132 59 0.762
Worm
nucleobase containing compound catabolic process GO:0034655 165 0.709
Human Yeast Worm
negative regulation of cellular biosynthetic process GO:0031327 277 0.682
non recombinational repair GO:0000726 7 0.651
double strand break repair via homologous recombination GO:0000724 13 0.632
oocyte development GO:0048599 124 0.617
columnar cuboidal epithelial cell development GO:0002066 249 0.612
chromosome organization GO:0051276 360 0.495
negative regulation of rna metabolic process GO:0051253 251 0.492
recombinational repair GO:0000725 13 0.473
cellular nitrogen compound catabolic process GO:0044270 165 0.432
Human Yeast Worm
mitotic dna damage checkpoint GO:0044773 74 0.429
embryo development ending in birth or egg hatching GO:0009792 152 0.419
Worm
ovarian follicle cell development GO:0030707 248 0.407
regulation of phosphorylation GO:0042325 147 0.399
oocyte anterior posterior axis specification GO:0007314 72 0.382
negative regulation of biosynthetic process GO:0009890 277 0.366
aromatic compound catabolic process GO:0019439 166 0.361
Human Yeast Worm
response to uv GO:0009411 24 0.360
dna synthesis involved in dna repair GO:0000731 5 0.359
anterior posterior axis specification GO:0009948 109 0.353
organelle fusion GO:0048284 46 0.343
oocyte fate determination GO:0030716 27 0.332
negative regulation of rna biosynthetic process GO:1902679 240 0.307
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.291
axis specification GO:0009798 167 0.291
negative regulation of nucleic acid templated transcription GO:1903507 240 0.280
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.278
embryonic pattern specification GO:0009880 174 0.274
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.272
negative regulation of cellular metabolic process GO:0031324 382 0.269
rna localization GO:0006403 115 0.266
cellular response to dna damage stimulus GO:0006974 223 0.264
germarium derived oocyte differentiation GO:0030706 29 0.260
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.256
macromolecule catabolic process GO:0009057 161 0.254
dna geometric change GO:0032392 16 0.241
Human
organic substance catabolic process GO:1901575 308 0.229
Human Yeast Worm
developmental maturation GO:0021700 172 0.226
response to ionizing radiation GO:0010212 32 0.225
Human
polarity specification of dorsal ventral axis GO:0009951 6 0.222
segmentation GO:0035282 207 0.218
oocyte axis specification GO:0007309 108 0.218
protein modification process GO:0036211 438 0.216
chromatin organization GO:0006325 207 0.213
anterior posterior pattern specification GO:0009952 136 0.211
phosphorylation GO:0016310 294 0.209
cell death GO:0008219 279 0.206
Worm
response to organonitrogen compound GO:0010243 75 0.199
intracellular mrna localization GO:0008298 66 0.197
dna double strand break processing GO:0000729 3 0.195
cellular macromolecule localization GO:0070727 220 0.181
negative regulation of gene expression GO:0010629 387 0.180
purine ribonucleoside metabolic process GO:0046128 127 0.176
Human Yeast Worm
specification of axis polarity GO:0065001 6 0.170
glycosyl compound catabolic process GO:1901658 112 0.167
Human Yeast Worm
regionalization GO:0003002 416 0.164
positive regulation of intracellular signal transduction GO:1902533 116 0.162
epithelial cell differentiation GO:0030855 322 0.159
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.156
eggshell chorion assembly GO:0007306 66 0.155
negative regulation of transcription dna templated GO:0045892 237 0.154
cell division GO:0051301 248 0.153
regulation of cell cycle process GO:0010564 181 0.153
organic cyclic compound catabolic process GO:1901361 168 0.153
Human Yeast Worm
positive regulation of gene expression GO:0010628 290 0.149
eggshell formation GO:0030703 105 0.149
positive regulation of cell communication GO:0010647 250 0.148
carbohydrate derivative catabolic process GO:1901136 118 0.148
Human Yeast Worm
dna replication GO:0006260 48 0.148
Human
oocyte dorsal ventral axis specification GO:0007310 34 0.146
embryonic axis specification GO:0000578 107 0.145
pole plasm rna localization GO:0007316 52 0.144
cell cycle checkpoint GO:0000075 95 0.141
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.141
Human Yeast Worm
cellular protein modification process GO:0006464 438 0.136
regulation of cell cycle GO:0051726 291 0.136
oocyte construction GO:0007308 112 0.135
response to light stimulus GO:0009416 124 0.134
mrna metabolic process GO:0016071 124 0.130
regulation of mrna splicing via spliceosome GO:0048024 64 0.129
tripartite regional subdivision GO:0007351 103 0.127
negative regulation of cell cycle GO:0045786 116 0.125
cellular catabolic process GO:0044248 372 0.125
Human Yeast Worm
dna repair GO:0006281 54 0.123
regulation of mitotic cell cycle GO:0007346 190 0.120
regulation of cellular response to stress GO:0080135 89 0.114
purine containing compound metabolic process GO:0072521 155 0.113
Human Yeast Worm
regulation of cell cycle phase transition GO:1901987 130 0.111
regulation of phosphate metabolic process GO:0019220 210 0.110
cellular component assembly involved in morphogenesis GO:0010927 151 0.104
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.102
pole plasm assembly GO:0007315 61 0.099
positive regulation of response to stimulus GO:0048584 323 0.098
aging GO:0007568 143 0.097
regulation of intracellular signal transduction GO:1902531 236 0.097
growth GO:0040007 359 0.096
apoptotic signaling pathway GO:0097190 27 0.095
Worm
catabolic process GO:0009056 409 0.095
Human Yeast Worm
single organism membrane organization GO:0044802 93 0.093
single organism cellular localization GO:1902580 180 0.092
regulation of developmental growth GO:0048638 174 0.091
positive regulation of signaling GO:0023056 243 0.089
organophosphate metabolic process GO:0019637 195 0.088
Human Yeast Worm
mitotic dna integrity checkpoint GO:0044774 75 0.086
regulation of mapk cascade GO:0043408 92 0.086
alternative mrna splicing via spliceosome GO:0000380 60 0.082
negative regulation of developmental process GO:0051093 201 0.082
ribose phosphate metabolic process GO:0019693 145 0.081
Human Yeast Worm
reproductive system development GO:0061458 74 0.079
development of primary sexual characteristics GO:0045137 50 0.079
positive regulation of programmed cell death GO:0043068 62 0.079
pole plasm oskar mrna localization GO:0045451 46 0.078
regulation of cell proliferation GO:0042127 163 0.077
regulation of catalytic activity GO:0050790 185 0.076
body morphogenesis GO:0010171 2 0.075
regulation of cellular protein metabolic process GO:0032268 243 0.075
intracellular signal transduction GO:0035556 300 0.075
Worm
regulation of organelle organization GO:0033043 196 0.075
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.075
Human Yeast Worm
regulation of protein metabolic process GO:0051246 256 0.074
dna damage checkpoint GO:0000077 78 0.074
pole plasm mrna localization GO:0019094 49 0.073
regulation of phosphorus metabolic process GO:0051174 210 0.073
ribonucleoside catabolic process GO:0042454 112 0.071
Human Yeast Worm
purine ribonucleotide metabolic process GO:0009150 145 0.071
Human Yeast Worm
g2 m transition of mitotic cell cycle GO:0000086 19 0.070
cellular macromolecule catabolic process GO:0044265 136 0.068
translesion synthesis GO:0019985 2 0.068
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.065
multicellular organismal aging GO:0010259 140 0.064
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.063
purine nucleoside metabolic process GO:0042278 127 0.062
Human Yeast Worm
female meiosis chromosome segregation GO:0016321 33 0.062
regulation of mrna metabolic process GO:1903311 72 0.061
response to abiotic stimulus GO:0009628 341 0.059
Human
epithelial cell development GO:0002064 274 0.059
death GO:0016265 284 0.059
Worm
nucleoside catabolic process GO:0009164 112 0.059
Human Yeast Worm
positive regulation of cellular protein metabolic process GO:0032270 118 0.058
response to radiation GO:0009314 155 0.057
Human
immune system development GO:0002520 57 0.056
dorsal appendage formation GO:0046843 47 0.055
mrna processing GO:0006397 104 0.054
anterior posterior axis specification embryo GO:0008595 103 0.054
dna conformation change GO:0071103 105 0.054
Human Worm
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.053
positive regulation of cellular component organization GO:0051130 156 0.052
purine ribonucleoside catabolic process GO:0046130 112 0.051
Human Yeast Worm
gene silencing GO:0016458 138 0.049
vesicle mediated transport GO:0016192 381 0.049
positive regulation of phosphorylation GO:0042327 87 0.048
regulation of response to stress GO:0080134 200 0.047
gene silencing by rna GO:0031047 57 0.047
maternal determination of anterior posterior axis embryo GO:0008358 74 0.047
regulation of nervous system development GO:0051960 248 0.046
blastoderm segmentation GO:0007350 159 0.046
establishment or maintenance of cell polarity GO:0007163 167 0.045
larval development GO:0002164 104 0.044
nucleotide metabolic process GO:0009117 161 0.043
Human Yeast Worm
protein phosphorylation GO:0006468 169 0.043
negative regulation of protein metabolic process GO:0051248 85 0.042
purine nucleoside catabolic process GO:0006152 112 0.042
Human Yeast Worm
positive regulation of macromolecule metabolic process GO:0010604 405 0.041
Human
positive regulation of signal transduction GO:0009967 223 0.041
eggshell chorion gene amplification GO:0007307 9 0.041
sex differentiation GO:0007548 81 0.041
mitotic cell cycle phase transition GO:0044772 138 0.041
male gamete generation GO:0048232 201 0.040
single organism behavior GO:0044708 391 0.040
response to nitrogen compound GO:1901698 90 0.040
establishment of localization in cell GO:0051649 402 0.039
purine nucleoside triphosphate catabolic process GO:0009146 108 0.038
Human Yeast Worm
telomere maintenance via recombination GO:0000722 1 0.038
Yeast
regulation of gene expression epigenetic GO:0040029 128 0.038
positive regulation of phosphorus metabolic process GO:0010562 139 0.038
cellular protein localization GO:0034613 160 0.038
ribonucleoside triphosphate metabolic process GO:0009199 119 0.038
Human Yeast Worm
positive regulation of cellular biosynthetic process GO:0031328 316 0.037
ribonucleoside triphosphate catabolic process GO:0009203 108 0.037
Human Yeast Worm
negative regulation of cellular component organization GO:0051129 108 0.037
regulation of meiosis GO:0040020 3 0.037
rna processing GO:0006396 147 0.036
meiotic chromosome separation GO:0051307 8 0.036
oocyte microtubule cytoskeleton organization GO:0016325 35 0.036
cognition GO:0050890 141 0.035
apoptotic process GO:0006915 159 0.035
Worm
dna biosynthetic process GO:0071897 24 0.035
regulation of cell cycle g1 s phase transition GO:1902806 23 0.034
chromatin modification GO:0016568 147 0.033
positive regulation of phosphate metabolic process GO:0045937 139 0.033
nuclear dna replication GO:0033260 1 0.033
regulation of meiotic cell cycle GO:0051445 9 0.032
telomere maintenance GO:0000723 21 0.032
Yeast
spindle assembly involved in female meiosis GO:0007056 14 0.031
negative regulation of mitotic cell cycle GO:0045930 109 0.031
positive regulation of cellular catabolic process GO:0031331 95 0.031
ribonucleotide metabolic process GO:0009259 145 0.031
Human Yeast Worm
endocytosis GO:0006897 310 0.031
purine nucleotide catabolic process GO:0006195 109 0.030
Human Yeast Worm
heterocycle catabolic process GO:0046700 166 0.030
Human Yeast Worm
positive regulation of protein metabolic process GO:0051247 128 0.030
polarity specification of anterior posterior axis GO:0009949 5 0.030
purine nucleotide metabolic process GO:0006163 146 0.030
Human Yeast Worm
negative regulation of cell communication GO:0010648 223 0.030
protein complex biogenesis GO:0070271 201 0.030
Human
nucleotide catabolic process GO:0009166 109 0.030
Human Yeast Worm
small molecule metabolic process GO:0044281 305 0.030
Human Yeast Worm
dna integrity checkpoint GO:0031570 81 0.029
regulation of rna splicing GO:0043484 69 0.029
cell cycle arrest GO:0007050 4 0.029
negative regulation of gene expression epigenetic GO:0045814 77 0.029
imaginal disc derived appendage development GO:0048737 399 0.028
nucleoside metabolic process GO:0009116 127 0.028
Human Yeast Worm
positive regulation of organelle organization GO:0010638 65 0.027
regulation of cell death GO:0010941 173 0.027
Worm
morphogenesis of follicular epithelium GO:0016333 36 0.027
negative regulation of signal transduction GO:0009968 206 0.027
mapk cascade GO:0000165 107 0.027
cell proliferation GO:0008283 299 0.026
mitotic g2 dna damage checkpoint GO:0007095 69 0.026
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.026
positive regulation of apoptotic process GO:0043065 47 0.025
positive regulation of mapk cascade GO:0043410 63 0.025
negative regulation of cell proliferation GO:0008285 69 0.025
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.025
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.025
negative regulation of programmed cell death GO:0043069 72 0.025
Worm
response to endogenous stimulus GO:0009719 119 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
regulation of mitotic cell cycle phase transition GO:1901990 130 0.024
rna interference GO:0016246 27 0.024
locomotory behavior GO:0007626 176 0.024
response to organic substance GO:0010033 284 0.024
positive regulation of biosynthetic process GO:0009891 316 0.024
regulation of programmed cell death GO:0043067 152 0.024
Worm
regulation of catabolic process GO:0009894 170 0.023
protein complex assembly GO:0006461 200 0.023
Human
ovarian fusome organization GO:0030723 11 0.023
organonitrogen compound catabolic process GO:1901565 128 0.023
Human Yeast Worm
dna packaging GO:0006323 91 0.023
Worm
spindle organization GO:0007051 253 0.023
signal transduction by phosphorylation GO:0023014 107 0.022
negative regulation of signaling GO:0023057 219 0.022
regulation of cellular component biogenesis GO:0044087 201 0.022
organonitrogen compound metabolic process GO:1901564 318 0.022
Human Yeast Worm
mitotic g2 m transition checkpoint GO:0044818 70 0.022
dna dependent dna replication GO:0006261 17 0.022
Human
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.021
Worm
glycosyl compound metabolic process GO:1901657 127 0.021
Human Yeast Worm
postreplication repair GO:0006301 2 0.021
dna catabolic process GO:0006308 16 0.021
jak stat cascade GO:0007259 49 0.021
purine containing compound catabolic process GO:0072523 112 0.020
Human Yeast Worm
mitotic cell cycle checkpoint GO:0007093 88 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
Human
protein localization GO:0008104 284 0.020
establishment of organelle localization GO:0051656 122 0.020
enzyme linked receptor protein signaling pathway GO:0007167 179 0.020
positive regulation of cell death GO:0010942 69 0.019
organelle assembly GO:0070925 198 0.019
chromatin silencing GO:0006342 76 0.019
response to alkaloid GO:0043279 26 0.019
nucleobase containing small molecule metabolic process GO:0055086 174 0.019
Human Yeast Worm
purine ribonucleotide catabolic process GO:0009154 109 0.019
Human Yeast Worm
nucleoside phosphate metabolic process GO:0006753 162 0.018
Human Yeast Worm
positive regulation of catalytic activity GO:0043085 118 0.018
negative regulation of cell differentiation GO:0045596 143 0.018
regulation of mrna processing GO:0050684 71 0.017
negative regulation of cell cycle process GO:0010948 109 0.017
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.017
wing disc morphogenesis GO:0007472 344 0.017
learning or memory GO:0007611 141 0.017
positive regulation of protein modification process GO:0031401 58 0.016
intrinsic apoptotic signaling pathway GO:0097193 16 0.016
Worm
reproductive structure development GO:0048608 74 0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.016
rna splicing GO:0008380 83 0.016
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
regulation of growth GO:0040008 233 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.015
Human Yeast Worm
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
Human Yeast Worm
regulation of phosphatase activity GO:0010921 3 0.015
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.015
cellular response to growth factor stimulus GO:0071363 30 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.015
Human
mitotic recombination GO:0006312 2 0.015
Yeast
dorsal ventral pattern formation GO:0009953 133 0.015
nucleoside phosphate catabolic process GO:1901292 110 0.015
Human Yeast Worm
genitalia development GO:0048806 26 0.014
meiotic spindle organization GO:0000212 36 0.014
immune system process GO:0002376 347 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.014
Human Yeast Worm
mrna splicing via spliceosome GO:0000398 73 0.014
ubiquitin dependent protein catabolic process GO:0006511 78 0.014
spindle assembly involved in meiosis GO:0090306 20 0.014
forebrain development GO:0030900 2 0.014
cell maturation GO:0048469 144 0.014
ribonucleoside metabolic process GO:0009119 127 0.013
Human Yeast Worm
atp metabolic process GO:0046034 49 0.013
Human Yeast Worm
glandular epithelial cell differentiation GO:0002067 1 0.013
protein maturation GO:0051604 71 0.013
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.013
telomere organization GO:0032200 21 0.013
Yeast
g2 dna damage checkpoint GO:0031572 69 0.013
proteolysis GO:0006508 192 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
negative regulation of phosphate metabolic process GO:0045936 45 0.012
regulation of pole plasm oskar mrna localization GO:0007317 27 0.012
mrna catabolic process GO:0006402 33 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.012
organophosphate catabolic process GO:0046434 112 0.012
Human Yeast Worm
regulation of double strand break repair GO:2000779 3 0.012
appendage morphogenesis GO:0035107 397 0.012
gonad development GO:0008406 50 0.012
nuclear transcribed mrna catabolic process GO:0000956 24 0.011
regulation of anatomical structure size GO:0090066 163 0.011
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.011
defense response to bacterium GO:0042742 178 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
cell cycle dna replication GO:0044786 23 0.011
connective tissue development GO:0061448 3 0.011
cell cycle phase transition GO:0044770 140 0.011
positive regulation of cell proliferation GO:0008284 47 0.011
sister chromatid cohesion GO:0007062 18 0.011
jnk cascade GO:0007254 50 0.011
dna replication initiation GO:0006270 6 0.011
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 8 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
Human Yeast Worm
hematopoietic or lymphoid organ development GO:0048534 57 0.011
posttranscriptional gene silencing by rna GO:0035194 45 0.011
glycerolipid catabolic process GO:0046503 3 0.010
peptidyl amino acid modification GO:0018193 105 0.010
positive regulation of developmental process GO:0051094 143 0.010
membrane fusion GO:0061025 42 0.010
positive regulation of transcription dna templated GO:0045893 266 0.010
cellular response to radiation GO:0071478 52 0.010
Human
defense response to gram negative bacterium GO:0050829 94 0.010
regulation of protein modification process GO:0031399 112 0.010
macromolecular complex assembly GO:0065003 256 0.010
Human
modification dependent protein catabolic process GO:0019941 78 0.010
negative regulation of dna metabolic process GO:0051053 12 0.010
regulation of multi organism process GO:0043900 131 0.010
spermatogenesis GO:0007283 200 0.010

spn-A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.077
Human
disease of cellular proliferation DOID:14566 0 0.077
Human
organ system cancer DOID:0050686 0 0.032
Human
thoracic cancer DOID:5093 0 0.013
Human
disease of metabolism DOID:0014667 0 0.011