Drosophila melanogaster

160 known processes

sima (Dmel_CG7951)

similar

(Aliases: HIF-1,Sima,DMU43090,CG7951,Dmel\CG7951,bHLHe56,SIMA,Hif-1A,HIF-1alpha,dHIF-alpha,7951,l(3)j11B7,HIF-alpha/sima)

sima biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
localization of cell GO:0051674 257 0.880
border follicle cell migration GO:0007298 113 0.815
ovarian follicle cell migration GO:0007297 121 0.782
ovarian follicle cell development GO:0030707 248 0.730
ameboidal type cell migration GO:0001667 151 0.667
Mouse
epithelial cell migration GO:0010631 148 0.588
Mouse
columnar cuboidal epithelial cell development GO:0002066 249 0.512
Mouse
tissue migration GO:0090130 155 0.509
Mouse
epithelial cell development GO:0002064 274 0.490
Mouse
negative regulation of transcription dna templated GO:0045892 237 0.470
Rat
cell motility GO:0048870 251 0.437
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.421
Mouse
epithelial cell differentiation GO:0030855 322 0.382
Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.359
positive regulation of nucleoside metabolic process GO:0045979 47 0.328
negative regulation of cellular biosynthetic process GO:0031327 277 0.323
Human Rat
cell migration GO:0016477 238 0.299
cellular response to dna damage stimulus GO:0006974 223 0.286
intracellular transport GO:0046907 228 0.273
Human
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.272
Human Rat
epithelium migration GO:0090132 148 0.257
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.255
establishment of localization in cell GO:0051649 402 0.255
Human Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.248
Human Rat
single organism intracellular transport GO:1902582 207 0.233
Human
positive regulation of transcription dna templated GO:0045893 266 0.232
regulation of organelle organization GO:0033043 196 0.224
regulation of cellular catabolic process GO:0031329 157 0.221
positive regulation of gtpase activity GO:0043547 43 0.212
nucleobase containing small molecule metabolic process GO:0055086 174 0.194
positive regulation of macromolecule metabolic process GO:0010604 405 0.191
cell projection assembly GO:0030031 94 0.188
positive regulation of ras gtpase activity GO:0032320 36 0.187
regulation of anatomical structure morphogenesis GO:0022603 242 0.187
tube morphogenesis GO:0035239 191 0.184
Mouse
response to oxygen containing compound GO:1901700 200 0.177
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.172
Human Rat
positive regulation of cellular catabolic process GO:0031331 95 0.170
respiratory system development GO:0060541 213 0.169
negative regulation of rna metabolic process GO:0051253 251 0.157
Human Rat
negative regulation of rna biosynthetic process GO:1902679 240 0.157
Human Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.154
positive regulation of molecular function GO:0044093 136 0.153
purine containing compound metabolic process GO:0072521 155 0.152
open tracheal system development GO:0007424 204 0.150
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.149
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.148
purine ribonucleoside metabolic process GO:0046128 127 0.145
vesicle mediated transport GO:0016192 381 0.139
organonitrogen compound metabolic process GO:1901564 318 0.136
Mouse
regulation of mitotic cell cycle GO:0007346 190 0.135
positive regulation of phosphorus metabolic process GO:0010562 139 0.130
acylglycerol biosynthetic process GO:0046463 2 0.128
purine ribonucleotide catabolic process GO:0009154 109 0.126
negative regulation of cellular component organization GO:0051129 108 0.125
positive regulation of catabolic process GO:0009896 105 0.125
nucleoside catabolic process GO:0009164 112 0.124
gtp catabolic process GO:0006184 72 0.123
small molecule metabolic process GO:0044281 305 0.119
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 108 0.117
carbohydrate derivative catabolic process GO:1901136 118 0.116
purine nucleoside catabolic process GO:0006152 112 0.114
positive regulation of cellular biosynthetic process GO:0031328 316 0.113
positive regulation of gtp catabolic process GO:0033126 43 0.111
nucleoside phosphate metabolic process GO:0006753 162 0.111
positive regulation of phosphate metabolic process GO:0045937 139 0.107
mitotic spindle organization GO:0007052 220 0.107
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.107
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.106
Rat
nucleotide metabolic process GO:0009117 161 0.103
regulation of localization GO:0032879 275 0.103
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.101
secretion GO:0046903 109 0.100
Mouse
ras protein signal transduction GO:0007265 88 0.100
mitotic nuclear division GO:0007067 213 0.097
organic substance catabolic process GO:1901575 308 0.096
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.095
Human Rat
purine nucleotide catabolic process GO:0006195 109 0.094
regulation of cellular component biogenesis GO:0044087 201 0.092
regulation of cellular amino acid metabolic process GO:0006521 0 0.092
positive regulation of catalytic activity GO:0043085 118 0.091
ribonucleoside catabolic process GO:0042454 112 0.091
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.091
nucleotide catabolic process GO:0009166 109 0.090
regulation of molecular function GO:0065009 217 0.088
Mouse
cellular response to chemical stimulus GO:0070887 199 0.087
organophosphate metabolic process GO:0019637 195 0.087
purine ribonucleotide metabolic process GO:0009150 145 0.087
regulation of cellular ketone metabolic process GO:0010565 3 0.087
positive regulation of rna biosynthetic process GO:1902680 266 0.086
glycosyl compound metabolic process GO:1901657 127 0.086
purine nucleoside triphosphate metabolic process GO:0009144 119 0.084
regulation of catalytic activity GO:0050790 185 0.082
Mouse
regulation of response to stress GO:0080134 200 0.082
Human Rat
regulation of gtpase activity GO:0043087 44 0.078
chemical homeostasis GO:0048878 92 0.078
Human Mouse Rat
gliogenesis GO:0042063 80 0.077
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.076
cellular nitrogen compound catabolic process GO:0044270 165 0.075
positive regulation of nucleic acid templated transcription GO:1903508 266 0.075
positive regulation of rna metabolic process GO:0051254 271 0.074
small gtpase mediated signal transduction GO:0007264 88 0.074
chromatin silencing GO:0006342 76 0.073
regulation of growth GO:0040008 233 0.072
regulation of tube architecture open tracheal system GO:0035152 68 0.072
single organism catabolic process GO:0044712 228 0.071
Mouse
regulation of phosphate metabolic process GO:0019220 210 0.071
negative regulation of developmental process GO:0051093 201 0.069
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.069
nucleoside phosphate catabolic process GO:1901292 110 0.068
endocytosis GO:0006897 310 0.068
cellular ketone metabolic process GO:0042180 24 0.067
positive regulation of hydrolase activity GO:0051345 78 0.066
response to alcohol GO:0097305 95 0.066
Rat
positive regulation of lipid metabolic process GO:0045834 4 0.065
ribonucleoside metabolic process GO:0009119 127 0.065
purine containing compound catabolic process GO:0072523 112 0.065
regulation of ras gtpase activity GO:0032318 38 0.064
positive regulation of nucleotide metabolic process GO:0045981 55 0.064
regulation of cell projection organization GO:0031344 92 0.062
purine ribonucleoside catabolic process GO:0046130 112 0.062
purine nucleoside triphosphate catabolic process GO:0009146 108 0.062
protein localization GO:0008104 284 0.062
epithelial tube morphogenesis GO:0060562 88 0.061
Mouse
cellular component assembly involved in morphogenesis GO:0010927 151 0.060
gtp metabolic process GO:0046039 72 0.060
guanosine containing compound catabolic process GO:1901069 74 0.060
negative regulation of growth GO:0045926 84 0.059
regulation of cellular amine metabolic process GO:0033238 3 0.059
regulation of tube size open tracheal system GO:0035151 43 0.059
catabolic process GO:0009056 409 0.058
nucleoside triphosphate catabolic process GO:0009143 108 0.058
regulation of proteolysis GO:0030162 87 0.058
chromosome organization GO:0051276 360 0.058
regulation of rab protein signal transduction GO:0032483 7 0.057
organic substance transport GO:0071702 257 0.057
Mouse
apoptotic process GO:0006915 159 0.056
Human Zebrafish Mouse Rat
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.056
glycosyl compound catabolic process GO:1901658 112 0.055
cell growth GO:0016049 108 0.055
cellular amine metabolic process GO:0044106 12 0.053
nuclear division GO:0000280 332 0.053
secretion by cell GO:0032940 101 0.052
Mouse
glycerolipid metabolic process GO:0046486 34 0.052
regulation of ras protein signal transduction GO:0046578 93 0.051
positive regulation of rab gtpase activity GO:0032851 7 0.051
ribonucleoside triphosphate metabolic process GO:0009199 119 0.050
regulation of cell projection assembly GO:0060491 30 0.050
negative regulation of response to stimulus GO:0048585 258 0.048
Human Mouse
neutral lipid biosynthetic process GO:0046460 2 0.048
ribonucleotide metabolic process GO:0009259 145 0.047
regulation of nucleotide catabolic process GO:0030811 48 0.047
negative regulation of cellular metabolic process GO:0031324 382 0.047
Human Rat
regulation of rab gtpase activity GO:0032313 7 0.047
negative regulation of gene expression GO:0010629 387 0.046
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.046
regulation of small gtpase mediated signal transduction GO:0051056 93 0.045
nucleobase containing compound catabolic process GO:0034655 165 0.045
response to abiotic stimulus GO:0009628 341 0.045
digestive tract development GO:0048565 149 0.045
Mouse
actomyosin structure organization GO:0031032 56 0.045
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.044
Rat
chromatin organization GO:0006325 207 0.044
phagocytosis GO:0006909 215 0.043
negative regulation of nucleic acid templated transcription GO:1903507 240 0.043
Human Rat
ribonucleotide catabolic process GO:0009261 109 0.043
response to glucose GO:0009749 2 0.043
Zebrafish Mouse Rat
positive regulation of cellular component biogenesis GO:0044089 80 0.043
sister chromatid segregation GO:0000819 92 0.042
thioester metabolic process GO:0035383 3 0.042
heterocycle catabolic process GO:0046700 166 0.042
g protein coupled receptor signaling pathway GO:0007186 136 0.041
nucleoside metabolic process GO:0009116 127 0.041
triglyceride biosynthetic process GO:0019432 2 0.041
lipid localization GO:0010876 54 0.041
renal tubule morphogenesis GO:0061333 44 0.041
response to monosaccharide GO:0034284 4 0.041
Zebrafish Mouse Rat
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.040
positive regulation of nucleotide catabolic process GO:0030813 46 0.040
regulation of embryonic development GO:0045995 68 0.040
regulation of transport GO:0051049 181 0.040
Mouse
positive regulation of cell migration GO:0030335 2 0.040
Mouse
organonitrogen compound catabolic process GO:1901565 128 0.039
regulation of cell cycle GO:0051726 291 0.039
cytoplasmic transport GO:0016482 130 0.039
regulation of gtp catabolic process GO:0033124 44 0.039
negative regulation of organelle organization GO:0010639 56 0.039
ribose phosphate metabolic process GO:0019693 145 0.039
regulation of chromosome organization GO:0033044 64 0.038
regulation of intracellular signal transduction GO:1902531 236 0.038
Human Mouse
triglyceride catabolic process GO:0019433 3 0.038
regulation of cell motility GO:2000145 23 0.038
sensory perception GO:0007600 196 0.038
Mouse
spindle organization GO:0007051 253 0.038
gastrulation GO:0007369 70 0.038
protein complex assembly GO:0006461 200 0.037
regulation of purine nucleotide catabolic process GO:0033121 48 0.037
digestive system development GO:0055123 149 0.037
Mouse
regulation of catabolic process GO:0009894 170 0.037
actin filament based process GO:0030029 220 0.036
intracellular signal transduction GO:0035556 300 0.036
Human Mouse
regulation of nucleoside metabolic process GO:0009118 50 0.036
regulation of locomotion GO:0040012 42 0.036
renal tubule development GO:0061326 64 0.035
guanosine containing compound metabolic process GO:1901068 74 0.035
aromatic compound catabolic process GO:0019439 166 0.035
regulation of cell cycle process GO:0010564 181 0.035
signal release GO:0023061 49 0.035
Mouse
homeostatic process GO:0042592 199 0.035
Human Mouse Rat
stem cell differentiation GO:0048863 117 0.035
Mouse
regulation of protein depolymerization GO:1901879 27 0.035
kidney development GO:0001822 3 0.033
branching morphogenesis of an epithelial tube GO:0048754 45 0.033
chromatin modification GO:0016568 147 0.033
organic acid metabolic process GO:0006082 103 0.033
Mouse
purine nucleoside metabolic process GO:0042278 127 0.033
regulation of nuclear division GO:0051783 58 0.033
cholesterol homeostasis GO:0042632 3 0.032
regulation of cellular component movement GO:0051270 42 0.032
oxoacid metabolic process GO:0043436 103 0.032
Mouse
pseudocleavage involved in syncytial blastoderm formation GO:0030589 9 0.031
establishment of organelle localization GO:0051656 122 0.031
regulation of purine nucleotide metabolic process GO:1900542 62 0.030
dna metabolic process GO:0006259 227 0.030
positive regulation of biosynthetic process GO:0009891 316 0.030
cellular component disassembly GO:0022411 46 0.030
mitotic spindle elongation GO:0000022 81 0.030
mitotic cell cycle phase transition GO:0044772 138 0.029
organic cyclic compound catabolic process GO:1901361 168 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.029
hemocyte migration GO:0035099 19 0.029
exocrine system development GO:0035272 162 0.029
macromolecular complex assembly GO:0065003 256 0.029
regulation of gene expression epigenetic GO:0040029 128 0.029
organelle assembly GO:0070925 198 0.029
regulation of hydrolase activity GO:0051336 97 0.028
cell cycle phase transition GO:0044770 140 0.028
adult behavior GO:0030534 137 0.028
Fly
cellular protein complex disassembly GO:0043624 35 0.028
phospholipid homeostasis GO:0055091 1 0.028
digestive tract morphogenesis GO:0048546 127 0.028
Mouse
organelle fission GO:0048285 340 0.027
tube development GO:0035295 244 0.027
Mouse
response to hexose GO:0009746 3 0.027
Zebrafish Mouse Rat
negative regulation of cell proliferation GO:0008285 69 0.027
cellular response to hormone stimulus GO:0032870 44 0.027
gene silencing GO:0016458 138 0.027
carbohydrate derivative metabolic process GO:1901135 217 0.027
Mouse
nucleoside triphosphate metabolic process GO:0009141 120 0.027
peptidyl proline hydroxylation GO:0019511 1 0.027
embryonic hemopoiesis GO:0035162 26 0.027
Mouse
negative regulation of intracellular signal transduction GO:1902532 57 0.027
Human Mouse
photoreceptor cell development GO:0042461 96 0.027
organelle localization GO:0051640 148 0.027
salivary gland morphogenesis GO:0007435 145 0.026
peptidyl tyrosine modification GO:0018212 24 0.026
heart development GO:0007507 82 0.026
Mouse
axon guidance GO:0007411 233 0.026
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.025
protein complex biogenesis GO:0070271 201 0.025
nitrogen compound transport GO:0071705 85 0.025
Mouse
regulation of protein metabolic process GO:0051246 256 0.025
response to radiation GO:0009314 155 0.025
Mouse Rat
body morphogenesis GO:0010171 2 0.025
purine nucleotide metabolic process GO:0006163 146 0.025
cardiovascular system development GO:0072358 82 0.025
Mouse
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.024
cell recognition GO:0008037 102 0.024
developmental growth GO:0048589 280 0.024
organophosphate catabolic process GO:0046434 112 0.024
hindgut development GO:0061525 58 0.024
response to organic substance GO:0010033 284 0.024
regulation of cell size GO:0008361 63 0.024
Rat
proteolysis GO:0006508 192 0.024
septate junction assembly GO:0019991 26 0.023
regulation of behavior GO:0050795 75 0.023
regulation of secretion GO:0051046 44 0.023
Mouse
glial cell differentiation GO:0010001 35 0.023
positive regulation of phosphorylation GO:0042327 87 0.023
embryonic morphogenesis GO:0048598 206 0.023
Mouse
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.023
positive regulation of cell communication GO:0010647 250 0.023
Mouse
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.023
carboxylic acid metabolic process GO:0019752 92 0.022
Mouse
malpighian tubule development GO:0072002 64 0.022
biological adhesion GO:0022610 138 0.022
chromosome separation GO:0051304 42 0.022
regulation of cell migration GO:0030334 22 0.022
retrograde transport endosome to golgi GO:0042147 3 0.022
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.022
regulation of cell differentiation GO:0045595 302 0.022
Mouse
intercellular bridge organization GO:0043063 14 0.021
regulation of chromatin modification GO:1903308 28 0.021
response to organophosphorus GO:0046683 2 0.021
sterol homeostasis GO:0055092 4 0.021
axonogenesis GO:0007409 290 0.021
Fly
cell cell junction organization GO:0045216 55 0.021
detection of stimulus involved in sensory perception GO:0050906 92 0.021
cell cell junction assembly GO:0007043 38 0.021
cell division GO:0051301 248 0.021
regulation of sequestering of triglyceride GO:0010889 3 0.021
organ growth GO:0035265 56 0.020
regulation of apoptotic process GO:0042981 130 0.020
Human Zebrafish Mouse Rat
regulation of meiosis GO:0040020 3 0.020
mesoderm development GO:0007498 78 0.020
eye photoreceptor cell development GO:0042462 81 0.020
multi multicellular organism process GO:0044706 123 0.020
Rat
negative regulation of gene expression epigenetic GO:0045814 77 0.020
cell proliferation GO:0008283 299 0.020
Mouse Rat
regulation of endopeptidase activity GO:0052548 36 0.019
cellular protein modification process GO:0006464 438 0.019
striated muscle cell differentiation GO:0051146 90 0.019
carbohydrate homeostasis GO:0033500 12 0.019
Mouse Rat
ovarian nurse cell to oocyte transport GO:0007300 27 0.019
muscle system process GO:0003012 21 0.019
lateral inhibition GO:0046331 206 0.019
forebrain development GO:0030900 2 0.019
Mouse
cellular lipid metabolic process GO:0044255 83 0.019
multicellular organismal aging GO:0010259 140 0.018
positive regulation of nervous system development GO:0051962 69 0.018
Mouse
endomembrane system organization GO:0010256 119 0.018
cellular macromolecule localization GO:0070727 220 0.018
amine metabolic process GO:0009308 12 0.018
mitotic sister chromatid segregation GO:0000070 87 0.018
chromatin remodeling GO:0006338 72 0.018
positive regulation of response to stimulus GO:0048584 323 0.018
Mouse
optokinetic behavior GO:0007634 3 0.018
macromolecular complex disassembly GO:0032984 37 0.018
regulation of microtubule depolymerization GO:0031114 24 0.017
cellular response to monosaccharide stimulus GO:0071326 2 0.017
Mouse Rat
protein localization to nucleus GO:0034504 55 0.017
somatic muscle development GO:0007525 66 0.017
rab protein signal transduction GO:0032482 6 0.017
embryonic hindgut morphogenesis GO:0048619 48 0.017
branching involved in open tracheal system development GO:0060446 45 0.017
regulation of cellular response to stress GO:0080135 89 0.017
Human Rat
multi organism reproductive behavior GO:0044705 121 0.017
nuclear import GO:0051170 51 0.017
associative learning GO:0008306 65 0.017
Mouse
regulation of protein localization GO:0032880 76 0.017
regulation of embryonic pattern specification GO:1902875 27 0.017
acyl coa metabolic process GO:0006637 3 0.017
cytokinetic process GO:0032506 27 0.017
morphogenesis of a branching structure GO:0001763 45 0.017
filopodium assembly GO:0046847 33 0.016
embryo development ending in birth or egg hatching GO:0009792 152 0.016
Mouse
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
single organism behavior GO:0044708 391 0.016
Mouse Fly
dna geometric change GO:0032392 16 0.016
sulfur compound metabolic process GO:0006790 59 0.016
regulation of cellular localization GO:0060341 136 0.016
Mouse
regulation of protein localization to nucleus GO:1900180 29 0.016
regulation of mitosis GO:0007088 56 0.016
dna repair GO:0006281 54 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
peptidyl tyrosine phosphorylation GO:0018108 24 0.016
negative regulation of cell communication GO:0010648 223 0.016
Human Mouse
wing disc morphogenesis GO:0007472 344 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.015
protein modification process GO:0036211 438 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
response to osmotic stress GO:0006970 14 0.015
Rat
negative regulation of signaling GO:0023057 219 0.015
Human Mouse
response to wounding GO:0009611 94 0.015
Mouse
determination of adult lifespan GO:0008340 137 0.015
regulation of mapk cascade GO:0043408 92 0.015
ribonucleoside monophosphate catabolic process GO:0009158 39 0.015
actin cytoskeleton organization GO:0030036 206 0.015
protein heterooligomerization GO:0051291 4 0.015
response to salt stress GO:0009651 11 0.015
Rat
purine nucleoside monophosphate metabolic process GO:0009126 50 0.015
cell fate determination GO:0001709 91 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.014
trachea development GO:0060438 29 0.014
spiracle morphogenesis open tracheal system GO:0035277 22 0.014
imaginal disc derived appendage morphogenesis GO:0035114 395 0.014
kidney epithelium development GO:0072073 3 0.014
hindbrain development GO:0030902 2 0.014
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.014
regulation of developmental growth GO:0048638 174 0.014
regulation of chromatin organization GO:1902275 32 0.014
cell junction assembly GO:0034329 42 0.014
taxis GO:0042330 304 0.014
Fly
neuron projection guidance GO:0097485 241 0.014
Fly
regulation of immune response GO:0050776 118 0.014
establishment of rna localization GO:0051236 47 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.014
stress activated mapk cascade GO:0051403 52 0.014
regulation of cell division GO:0051302 72 0.014
regulation of nucleotide metabolic process GO:0006140 62 0.014
hindgut morphogenesis GO:0007442 58 0.014
retina development in camera type eye GO:0060041 4 0.014
Mouse
adult locomotory behavior GO:0008344 76 0.013
Fly
negative regulation of mitotic cell cycle GO:0045930 109 0.013
cilium organization GO:0044782 41 0.013
response to organic cyclic compound GO:0014070 89 0.013
Rat
heart contraction GO:0060047 26 0.013
Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.013
myofibril assembly GO:0030239 36 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
phosphorylation GO:0016310 294 0.013
monocarboxylic acid transport GO:0015718 3 0.013
protein depolymerization GO:0051261 31 0.013
regulation of mitotic sister chromatid separation GO:0010965 28 0.013
nephron development GO:0072006 3 0.013
positive regulation of cell motility GO:2000147 3 0.013
Mouse
protein import GO:0017038 55 0.013
cell migration involved in gastrulation GO:0042074 9 0.013
regulation of protein complex disassembly GO:0043244 29 0.013
lipid homeostasis GO:0055088 33 0.013
positive regulation of signal transduction GO:0009967 223 0.013
Mouse
muscle tissue morphogenesis GO:0060415 2 0.013
regulation of peptidase activity GO:0052547 39 0.013
regulation of cell morphogenesis GO:0022604 163 0.013
cellular response to nitrogen compound GO:1901699 51 0.013
humoral immune response GO:0006959 117 0.013
synaptic vesicle localization GO:0097479 53 0.013
exocytosis GO:0006887 28 0.013
sensory organ morphogenesis GO:0090596 260 0.013
regulation of cysteine type endopeptidase activity GO:2000116 27 0.013
gland development GO:0048732 191 0.013
Mouse
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.013
negative regulation of protein complex disassembly GO:0043242 23 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
cell death GO:0008219 279 0.012
Human Zebrafish Mouse Rat
establishment of protein localization to organelle GO:0072594 62 0.012
larval somatic muscle development GO:0007526 19 0.012
morphogenesis of a branching epithelium GO:0061138 45 0.012
mapk cascade GO:0000165 107 0.012
dna packaging GO:0006323 91 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
regulation of response to dna damage stimulus GO:2001020 23 0.012
aging GO:0007568 143 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.012
protein complex disassembly GO:0043241 36 0.012
negative regulation of actin filament depolymerization GO:0030835 2 0.012
muscle cell development GO:0055001 50 0.012
positive regulation of defense response GO:0031349 59 0.012
synaptic transmission GO:0007268 288 0.012
single organism cell adhesion GO:0098602 47 0.012
maintenance of location GO:0051235 73 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
regulation of cell growth GO:0001558 43 0.012
cellular response to organic substance GO:0071310 132 0.012
l amino acid import GO:0043092 2 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
anatomical structure homeostasis GO:0060249 97 0.012
Mouse
establishment of synaptic vesicle localization GO:0097480 50 0.012
tube formation GO:0035148 21 0.012
Mouse
regulation of epithelial cell proliferation GO:0050678 4 0.012
regulation of protein kinase activity GO:0045859 51 0.012
programmed cell death GO:0012501 257 0.012
Human Zebrafish Mouse Rat
eye development GO:0001654 323 0.012
Mouse
oxidation reduction process GO:0055114 123 0.012
cellular homeostasis GO:0019725 80 0.012
Mouse Rat
nucleus localization GO:0051647 34 0.012
g1 s transition of mitotic cell cycle GO:0000082 31 0.012
reactive oxygen species metabolic process GO:0072593 22 0.012
protein acylation GO:0043543 42 0.012
rna localization GO:0006403 115 0.012
malpighian tubule morphogenesis GO:0007443 44 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
Human Mouse Rat
cell junction organization GO:0034330 57 0.011
neuroblast proliferation GO:0007405 74 0.011
Mouse
positive regulation of protein metabolic process GO:0051247 128 0.011
striated muscle cell development GO:0055002 50 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
Human Mouse
regulation of synapse organization GO:0050807 110 0.011
spinal cord development GO:0021510 1 0.011
cellular catabolic process GO:0044248 372 0.011
positive regulation of calcium ion transport GO:0051928 4 0.011
negative regulation of protein depolymerization GO:1901880 23 0.011
positive regulation of cell size GO:0045793 21 0.011
Rat
defense response to gram negative bacterium GO:0050829 94 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
regulation of synaptic activity GO:0060025 9 0.011
imaginal disc derived wing hair organization GO:0035317 45 0.011
response to starvation GO:0042594 97 0.011
regulation of immune system process GO:0002682 176 0.011
Mouse

sima disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.093
disease of metabolism DOID:0014667 0 0.083
acquired metabolic disease DOID:0060158 0 0.083
nervous system disease DOID:863 0 0.046
carbohydrate metabolism disease DOID:0050013 0 0.043
glucose metabolism disease DOID:4194 0 0.043
diabetes mellitus DOID:9351 0 0.023
type 2 diabetes mellitus DOID:9352 0 0.022
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
urinary system disease DOID:18 0 0.014
central nervous system disease DOID:331 0 0.013
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011