Drosophila melanogaster

55 known processes

SRPK (Dmel_CG8174)

CG8174 gene product from transcript CG8174-RA

(Aliases: BcDNA:SD03158,dSRPK1,CG8174,dSRPK,srpk,Dmel\CG8174)

SRPK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oocyte development GO:0048599 124 0.991
oocyte differentiation GO:0009994 145 0.985
oocyte axis specification GO:0007309 108 0.977
pole plasm assembly GO:0007315 61 0.964
oocyte construction GO:0007308 112 0.931
pole plasm mrna localization GO:0019094 49 0.882
germarium derived egg chamber formation GO:0007293 101 0.856
cytoplasm organization GO:0007028 64 0.811
negative regulation of biosynthetic process GO:0009890 277 0.797
pole plasm rna localization GO:0007316 52 0.779
germarium derived oocyte differentiation GO:0030706 29 0.635
oocyte anterior posterior axis specification GO:0007314 72 0.633
oocyte microtubule cytoskeleton organization GO:0016325 35 0.620
organelle assembly GO:0070925 198 0.607
negative regulation of cellular biosynthetic process GO:0031327 277 0.551
pole plasm oskar mrna localization GO:0045451 46 0.548
axis specification GO:0009798 167 0.516
establishment of localization in cell GO:0051649 402 0.498
organelle localization GO:0051640 148 0.477
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.454
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.446
germarium derived oocyte fate determination GO:0007294 26 0.432
karyosome formation GO:0030717 22 0.399
regulation of rna splicing GO:0043484 69 0.399
regulation of pole plasm oskar mrna localization GO:0007317 27 0.388
negative regulation of cellular metabolic process GO:0031324 382 0.386
organelle fission GO:0048285 340 0.383
rna splicing GO:0008380 83 0.377
Human Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.371
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.354
mitotic nuclear division GO:0007067 213 0.317
negative regulation of gene expression GO:0010629 387 0.317
dorsal ventral axis specification GO:0009950 66 0.298
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.288
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.277
columnar cuboidal epithelial cell development GO:0002066 249 0.262
oocyte dorsal ventral axis specification GO:0007310 34 0.244
regulation of growth GO:0040008 233 0.227
cell division GO:0051301 248 0.222
Zebrafish Worm
developmental maturation GO:0021700 172 0.205
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.205
intracellular mrna localization GO:0008298 66 0.200
establishment of organelle localization GO:0051656 122 0.197
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.196
anterior posterior axis specification embryo GO:0008595 103 0.191
mitotic spindle organization GO:0007052 220 0.189
ovarian follicle cell development GO:0030707 248 0.188
spindle organization GO:0007051 253 0.187
defense response GO:0006952 300 0.172
regulation of reproductive process GO:2000241 54 0.168
rna localization GO:0006403 115 0.166
single organism cellular localization GO:1902580 180 0.164
chromosome organization GO:0051276 360 0.158
negative regulation of rna biosynthetic process GO:1902679 240 0.154
growth GO:0040007 359 0.148
death GO:0016265 284 0.144
Mouse Worm
macromolecular complex assembly GO:0065003 256 0.137
mrna processing GO:0006397 104 0.133
Human Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.132
intracellular transport GO:0046907 228 0.129
transcription from rna polymerase ii promoter GO:0006366 368 0.129
mrna metabolic process GO:0016071 124 0.129
Human Mouse
dorsal ventral pattern formation GO:0009953 133 0.124
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.123
Human Mouse
mrna splicing via spliceosome GO:0000398 73 0.120
Human Mouse
maternal determination of anterior posterior axis embryo GO:0008358 74 0.119
regulation of oocyte development GO:0060281 27 0.117
anterior posterior pattern specification GO:0009952 136 0.115
Zebrafish
anterior posterior axis specification GO:0009948 109 0.114
regulation of mrna splicing via spliceosome GO:0048024 64 0.113
meiotic cell cycle process GO:1903046 132 0.113
cell maturation GO:0048469 144 0.105
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.105
negative regulation of transcription dna templated GO:0045892 237 0.105
developmental growth GO:0048589 280 0.104
oocyte fate determination GO:0030716 27 0.101
tripartite regional subdivision GO:0007351 103 0.100
rna processing GO:0006396 147 0.100
Human Mouse
defense response to other organism GO:0098542 225 0.098
regulation of protein metabolic process GO:0051246 256 0.096
cellular macromolecule localization GO:0070727 220 0.092
alternative mrna splicing via spliceosome GO:0000380 60 0.090
single organism intracellular transport GO:1902582 207 0.088
single organism biosynthetic process GO:0044711 206 0.087
positive regulation of cellular biosynthetic process GO:0031328 316 0.085
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.084
positive regulation of rna metabolic process GO:0051254 271 0.082
gene silencing by rna GO:0031047 57 0.082
segmentation GO:0035282 207 0.077
Zebrafish
embryonic pattern specification GO:0009880 174 0.077
neurological system process GO:0050877 358 0.073
regulation of cell differentiation GO:0045595 302 0.073
rna splicing via transesterification reactions GO:0000375 73 0.072
Human Mouse
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.072
epithelial cell differentiation GO:0030855 322 0.069
cell death GO:0008219 279 0.067
Mouse Worm
response to biotic stimulus GO:0009607 294 0.066
protein localization GO:0008104 284 0.066
enzyme linked receptor protein signaling pathway GO:0007167 179 0.064
regulation of cell development GO:0060284 215 0.063
meiotic spindle organization GO:0000212 36 0.063
regionalization GO:0003002 416 0.060
Zebrafish
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.057
cell proliferation GO:0008283 299 0.057
Human Mouse
rna catabolic process GO:0006401 37 0.056
organic substance catabolic process GO:1901575 308 0.054
embryonic axis specification GO:0000578 107 0.054
regulation of response to stress GO:0080134 200 0.054
neuron projection guidance GO:0097485 241 0.054
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.053
dna metabolic process GO:0006259 227 0.052
cellular response to dna damage stimulus GO:0006974 223 0.051
endocytosis GO:0006897 310 0.051
cytoskeleton dependent cytokinesis GO:0061640 81 0.051
positive regulation of nucleic acid templated transcription GO:1903508 266 0.051
ribonucleoprotein complex subunit organization GO:0071826 28 0.050
Human Mouse
regulation of multicellular organismal development GO:2000026 414 0.050
establishment of spindle localization GO:0051293 22 0.050
rrna processing GO:0006364 3 0.048
cellular response to chemical stimulus GO:0070887 199 0.048
negative regulation of cellular protein metabolic process GO:0032269 85 0.048
translation GO:0006412 69 0.048
posttranscriptional regulation of gene expression GO:0010608 145 0.046
Zebrafish
cellular macromolecule catabolic process GO:0044265 136 0.046
regulation of cellular amine metabolic process GO:0033238 3 0.045
regulation of nervous system development GO:0051960 248 0.044
protein ubiquitination GO:0016567 70 0.044
establishment or maintenance of cell polarity GO:0007163 167 0.044
regulation of localization GO:0032879 275 0.044
cellular macromolecular complex assembly GO:0034622 153 0.043
Human Mouse
chromosome segregation GO:0007059 157 0.043
Human
regulation of translation GO:0006417 56 0.042
mrna catabolic process GO:0006402 33 0.041
negative regulation of response to stimulus GO:0048585 258 0.040
axon development GO:0061564 297 0.040
spermatogenesis GO:0007283 200 0.040
protein complex biogenesis GO:0070271 201 0.040
regulation of transport GO:0051049 181 0.040
regulation of nurse cell apoptotic process GO:0045477 9 0.039
organic substance transport GO:0071702 257 0.039
regulation of cell cycle phase transition GO:1901987 130 0.039
body morphogenesis GO:0010171 2 0.038
nucleus localization GO:0051647 34 0.037
spindle assembly involved in mitosis GO:0090307 50 0.037
homeostatic process GO:0042592 199 0.037
response to bacterium GO:0009617 198 0.037
cellular protein modification process GO:0006464 438 0.036
Human Zebrafish Mouse Worm
regulation of embryonic pattern specification GO:1902875 27 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.035
chorion containing eggshell formation GO:0007304 105 0.034
cell growth GO:0016049 108 0.034
blastoderm segmentation GO:0007350 159 0.034
dephosphorylation GO:0016311 51 0.033
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.033
immune response GO:0006955 246 0.033
head development GO:0060322 135 0.033
negative regulation of rna metabolic process GO:0051253 251 0.033
extracellular structure organization GO:0043062 46 0.033
regulation of cell maturation GO:1903429 27 0.033
spindle localization GO:0051653 22 0.032
reproductive structure development GO:0048608 74 0.032
Worm
regulation of microtubule based process GO:0032886 49 0.032
negative regulation of translation GO:0017148 28 0.032
cellular protein complex assembly GO:0043623 71 0.032
negative regulation of protein metabolic process GO:0051248 85 0.032
regulation of cell cycle process GO:0010564 181 0.031
morphogenesis of follicular epithelium GO:0016333 36 0.030
mitotic cell cycle phase transition GO:0044772 138 0.030
regulation of mrna metabolic process GO:1903311 72 0.029
Human Mouse
negative regulation of cell cycle process GO:0010948 109 0.029
nuclear division GO:0000280 332 0.029
regulation of cellular ketone metabolic process GO:0010565 3 0.029
regulation of mrna processing GO:0050684 71 0.029
Human Mouse
nitrogen compound transport GO:0071705 85 0.028
response to abiotic stimulus GO:0009628 341 0.028
actin cytoskeleton organization GO:0030036 206 0.028
appendage development GO:0048736 401 0.028
stem cell differentiation GO:0048863 117 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.028
negative regulation of nervous system development GO:0051961 92 0.027
regulation of cellular protein metabolic process GO:0032268 243 0.027
positive regulation of cellular component organization GO:0051130 156 0.027
negative regulation of phosphorus metabolic process GO:0010563 45 0.027
ovarian fusome organization GO:0030723 11 0.027
positive regulation of macromolecule metabolic process GO:0010604 405 0.027
Mouse
response to external biotic stimulus GO:0043207 293 0.027
mesenchymal cell differentiation GO:0048762 1 0.027
negative regulation of signal transduction GO:0009968 206 0.027
epithelial cell development GO:0002064 274 0.027
regulation of cellular component biogenesis GO:0044087 201 0.026
eggshell formation GO:0030703 105 0.026
mesenchymal cell development GO:0014031 1 0.026
central nervous system development GO:0007417 201 0.025
positive regulation of multicellular organismal process GO:0051240 143 0.024
stem cell maintenance GO:0019827 67 0.024
establishment of cell polarity GO:0030010 40 0.024
negative regulation of cell cycle GO:0045786 116 0.023
Worm
eye morphogenesis GO:0048592 260 0.023
eggshell chorion assembly GO:0007306 66 0.023
cellular component assembly involved in morphogenesis GO:0010927 151 0.023
response to other organism GO:0051707 293 0.023
vesicle mediated transport GO:0016192 381 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
mrna transport GO:0051028 15 0.023
negative regulation of developmental process GO:0051093 201 0.023
regulation of cell cycle GO:0051726 291 0.023
Mouse Worm
protein complex assembly GO:0006461 200 0.023
carboxylic acid metabolic process GO:0019752 92 0.022
endomembrane system organization GO:0010256 119 0.022
negative regulation of cell communication GO:0010648 223 0.022
macromolecule catabolic process GO:0009057 161 0.022
epidermal growth factor receptor signaling pathway GO:0007173 58 0.021
microtubule polymerization or depolymerization GO:0031109 39 0.021
ion transport GO:0006811 145 0.021
positive regulation of response to stimulus GO:0048584 323 0.021
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.021
cellular response to organic substance GO:0071310 132 0.021
meiosis i GO:0007127 59 0.021
embryo development ending in birth or egg hatching GO:0009792 152 0.021
Zebrafish Worm
cytokinesis GO:0000910 90 0.021
Worm
localization of cell GO:0051674 257 0.020
cellular component disassembly GO:0022411 46 0.020
imaginal disc derived appendage development GO:0048737 399 0.020
cellularization GO:0007349 90 0.020
organic cyclic compound catabolic process GO:1901361 168 0.019
establishment of nucleus localization GO:0040023 26 0.019
synaptic vesicle localization GO:0097479 53 0.019
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.019
posttranscriptional gene silencing by rna GO:0035194 45 0.019
negative regulation of smoothened signaling pathway GO:0045879 16 0.019
spinal cord development GO:0021510 1 0.019
pronuclear migration GO:0035046 4 0.018
protein dna complex assembly GO:0065004 63 0.018
regulation of developmental growth GO:0048638 174 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.018
vesicle organization GO:0016050 44 0.018
amine metabolic process GO:0009308 12 0.017
negative regulation of protein complex disassembly GO:0043242 23 0.017
axon guidance GO:0007411 233 0.017
regulation of mitotic cell cycle GO:0007346 190 0.017
Worm
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.016
genitalia development GO:0048806 26 0.016
Worm
positive regulation of gene expression GO:0010628 290 0.016
Mouse
innate immune response GO:0045087 144 0.016
nuclear migration GO:0007097 20 0.016
positive regulation of rna biosynthetic process GO:1902680 266 0.016
mitotic g2 dna damage checkpoint GO:0007095 69 0.016
negative regulation of cell differentiation GO:0045596 143 0.016
response to nutrient levels GO:0031667 114 0.016
male gamete generation GO:0048232 201 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
protein modification by small protein conjugation GO:0032446 79 0.016
meiotic cell cycle GO:0051321 171 0.016
negative regulation of cellular component organization GO:0051129 108 0.016
mitotic dna integrity checkpoint GO:0044774 75 0.016
defense response to bacterium GO:0042742 178 0.015
smoothened signaling pathway GO:0007224 49 0.015
proteolysis GO:0006508 192 0.015
nucleocytoplasmic transport GO:0006913 72 0.015
regulation of protein complex assembly GO:0043254 42 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
compound eye morphogenesis GO:0001745 249 0.015
lipid metabolic process GO:0006629 121 0.014
stem cell development GO:0048864 79 0.014
macromolecular complex disassembly GO:0032984 37 0.014
mitotic cytokinesis GO:0000281 50 0.014
protein modification process GO:0036211 438 0.014
Human Zebrafish Mouse Worm
cell fate determination GO:0001709 91 0.014
single organism behavior GO:0044708 391 0.014
rna transport GO:0050658 46 0.014
oxoacid metabolic process GO:0043436 103 0.014
negative regulation of cell death GO:0060548 81 0.014
oxidation reduction process GO:0055114 123 0.014
reproductive system development GO:0061458 74 0.014
Worm
mapk cascade GO:0000165 107 0.014
Zebrafish
microtubule organizing center organization GO:0031023 168 0.014
germ line cyst formation GO:0048134 44 0.014
cell migration GO:0016477 238 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.013
negative regulation of signaling GO:0023057 219 0.013
ncrna metabolic process GO:0034660 43 0.013
nuclear transport GO:0051169 72 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
eye development GO:0001654 323 0.013
modification dependent macromolecule catabolic process GO:0043632 79 0.013
cell motility GO:0048870 251 0.013
cellular catabolic process GO:0044248 372 0.013
cellular ketone metabolic process GO:0042180 24 0.013
synaptic vesicle transport GO:0048489 50 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
protein transport GO:0015031 155 0.012
negative regulation of microtubule depolymerization GO:0007026 21 0.012
intercellular bridge organization GO:0043063 14 0.012
establishment of mitotic spindle localization GO:0040001 17 0.012
regulation of multi organism process GO:0043900 131 0.012
Human
cellular amino acid metabolic process GO:0006520 61 0.012
regulation of cell death GO:0010941 173 0.012
Mouse
negative regulation of protein modification process GO:0031400 29 0.012
axonogenesis GO:0007409 290 0.012
dsrna fragmentation GO:0031050 15 0.012
synaptic vesicle recycling GO:0036465 28 0.012
organic acid metabolic process GO:0006082 103 0.012
immune system process GO:0002376 347 0.012
response to organonitrogen compound GO:0010243 75 0.011
negative regulation of organelle organization GO:0010639 56 0.011
defense response to gram negative bacterium GO:0050829 94 0.011
developmental cell growth GO:0048588 52 0.011
regulation of cellular response to stress GO:0080135 89 0.011
cellular lipid metabolic process GO:0044255 83 0.011
negative regulation of apoptotic process GO:0043066 63 0.011
establishment of protein localization GO:0045184 163 0.011
erbb signaling pathway GO:0038127 58 0.011
cell cycle phase transition GO:0044770 140 0.011
nucleobase containing compound transport GO:0015931 56 0.011
response to organic cyclic compound GO:0014070 89 0.011
mitotic dna damage checkpoint GO:0044773 74 0.011
cytoplasmic transport GO:0016482 130 0.011
rhythmic process GO:0048511 106 0.011
sensory organ morphogenesis GO:0090596 260 0.011
positive regulation of signal transduction GO:0009967 223 0.011
nuclear transcribed mrna catabolic process GO:0000956 24 0.010
regulation of system process GO:0044057 36 0.010
immune response regulating signaling pathway GO:0002764 2 0.010
carbohydrate biosynthetic process GO:0016051 17 0.010
regulation of organelle organization GO:0033043 196 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.010
neural precursor cell proliferation GO:0061351 75 0.010
meiotic nuclear division GO:0007126 151 0.010
fusome organization GO:0045478 13 0.010
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.010
negative regulation of cell cycle phase transition GO:1901988 103 0.010

SRPK disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.118
musculoskeletal system disease DOID:17 0 0.035
muscular disease DOID:0080000 0 0.032
muscle tissue disease DOID:66 0 0.032
cancer DOID:162 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
nervous system disease DOID:863 0 0.021
central nervous system disease DOID:331 0 0.017
neurodegenerative disease DOID:1289 0 0.017
cardiovascular system disease DOID:1287 0 0.014
organ system cancer DOID:0050686 0 0.013