Drosophila melanogaster

268 known processes

Mtor (Dmel_CG8274)

Megator

(Aliases: CG8274,Bx34,l(2)k03905,TPR,Dmel\CG8274,Tpr)

Mtor biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear pore organization GO:0006999 1 0.981
Human
smad protein import into nucleus GO:0007184 11 0.517
microtubule organizing center organization GO:0031023 168 0.439
negative regulation of gene expression GO:0010629 387 0.422
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.390
Human
nucleus organization GO:0006997 45 0.385
Human
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.336
cell migration GO:0016477 238 0.325
chromosome organization GO:0051276 360 0.322
epithelial cell differentiation GO:0030855 322 0.315
germ line stem cell maintenance GO:0030718 50 0.314
brain development GO:0007420 120 0.309
central nervous system development GO:0007417 201 0.297
negative regulation of transcription dna templated GO:0045892 237 0.270
Human
ovarian follicle cell development GO:0030707 248 0.268
macromolecular complex assembly GO:0065003 256 0.267
negative regulation of nucleic acid templated transcription GO:1903507 240 0.246
Human
centrosome organization GO:0051297 163 0.243
negative regulation of biosynthetic process GO:0009890 277 0.223
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.191
localization of cell GO:0051674 257 0.182
imaginal disc derived appendage development GO:0048737 399 0.181
appendage morphogenesis GO:0035107 397 0.178
embryo development ending in birth or egg hatching GO:0009792 152 0.167
Worm
regulation of developmental growth GO:0048638 174 0.166
regulation of protein metabolic process GO:0051246 256 0.163
cell motility GO:0048870 251 0.153
epithelial cell development GO:0002064 274 0.152
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.149
dna metabolic process GO:0006259 227 0.147
Human
multicellular organismal aging GO:0010259 140 0.143
regulation of cellular protein metabolic process GO:0032268 243 0.143
developmental growth GO:0048589 280 0.142
stem cell maintenance GO:0019827 67 0.136
protein complex biogenesis GO:0070271 201 0.134
stem cell development GO:0048864 79 0.132
eggshell formation GO:0030703 105 0.131
endocytosis GO:0006897 310 0.127
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.122
neurological system process GO:0050877 358 0.120
tissue morphogenesis GO:0048729 297 0.117
enzyme linked receptor protein signaling pathway GO:0007167 179 0.117
regulation of cell differentiation GO:0045595 302 0.116
cellular protein modification process GO:0006464 438 0.116
protein complex assembly GO:0006461 200 0.111
tube morphogenesis GO:0035239 191 0.111
appendage development GO:0048736 401 0.107
regulation of response to external stimulus GO:0032101 115 0.104
negative regulation of response to stimulus GO:0048585 258 0.101
post embryonic appendage morphogenesis GO:0035120 385 0.100
cell cell signaling involved in cell fate commitment GO:0045168 210 0.099
chromatin organization GO:0006325 207 0.099
chromatin modification GO:0016568 147 0.099
columnar cuboidal epithelial cell development GO:0002066 249 0.096
phosphorylation GO:0016310 294 0.095
Human
growth GO:0040007 359 0.093
head development GO:0060322 135 0.085
centrosome cycle GO:0007098 137 0.085
compound eye morphogenesis GO:0001745 249 0.084
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.084
Human
regulation of cell cycle GO:0051726 291 0.083
cellular macromolecular complex assembly GO:0034622 153 0.083
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.083
Human
regulation of antimicrobial peptide production GO:0002784 44 0.081
tube development GO:0035295 244 0.080
adult behavior GO:0030534 137 0.080
signal transduction by phosphorylation GO:0023014 107 0.080
Human
multicellular organism growth GO:0035264 46 0.078
positive regulation of apoptotic signaling pathway GO:2001235 4 0.076
cell death GO:0008219 279 0.073
regulation of apoptotic process GO:0042981 130 0.073
nuclear import GO:0051170 51 0.073
Human
imaginal disc derived wing morphogenesis GO:0007476 337 0.071
negative regulation of rna metabolic process GO:0051253 251 0.069
Human
rna splicing GO:0008380 83 0.069
imaginal disc derived appendage morphogenesis GO:0035114 395 0.068
protein localization to nucleus GO:0034504 55 0.067
Human
protein import GO:0017038 55 0.066
Human
vesicle mediated transport GO:0016192 381 0.066
positive regulation of signaling GO:0023056 243 0.065
posttranscriptional gene silencing GO:0016441 46 0.062
mrna metabolic process GO:0016071 124 0.062
negative regulation of cell cycle process GO:0010948 109 0.062
determination of adult lifespan GO:0008340 137 0.061
axon development GO:0061564 297 0.060
chorion containing eggshell formation GO:0007304 105 0.060
positive regulation of gene expression GO:0010628 290 0.060
programmed cell death GO:0012501 257 0.058
mitotic spindle organization GO:0007052 220 0.058
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.058
Human
positive regulation of rna metabolic process GO:0051254 271 0.058
intracellular transport GO:0046907 228 0.058
regulation of response to stress GO:0080134 200 0.057
rna processing GO:0006396 147 0.057
posttranscriptional regulation of gene expression GO:0010608 145 0.057
Human
intracellular signal transduction GO:0035556 300 0.055
Human
body morphogenesis GO:0010171 2 0.054
protein localization GO:0008104 284 0.054
regulation of rna splicing GO:0043484 69 0.053
cellular macromolecule localization GO:0070727 220 0.053
tissue migration GO:0090130 155 0.052
rna localization GO:0006403 115 0.052
Human
sensory organ morphogenesis GO:0090596 260 0.052
morphogenesis of an epithelium GO:0002009 276 0.052
positive regulation of cell communication GO:0010647 250 0.051
negative regulation of cellular metabolic process GO:0031324 382 0.050
wing disc morphogenesis GO:0007472 344 0.050
positive regulation of response to stimulus GO:0048584 323 0.050
reproductive system development GO:0061458 74 0.050
cell proliferation GO:0008283 299 0.049
organelle localization GO:0051640 148 0.049
defense response GO:0006952 300 0.046
forebrain development GO:0030900 2 0.046
apoptotic process GO:0006915 159 0.046
aging GO:0007568 143 0.045
autophagy GO:0006914 108 0.045
regulation of intracellular signal transduction GO:1902531 236 0.044
single organism behavior GO:0044708 391 0.044
regulation of localization GO:0032879 275 0.044
nls bearing protein import into nucleus GO:0006607 5 0.044
immune system process GO:0002376 347 0.043
cytokinesis GO:0000910 90 0.043
regulation of mrna splicing via spliceosome GO:0048024 64 0.043
cell division GO:0051301 248 0.042
regulation of growth GO:0040008 233 0.042
stem cell differentiation GO:0048863 117 0.042
negative regulation of cellular biosynthetic process GO:0031327 277 0.041
Human
regulation of molecular function GO:0065009 217 0.041
cellular protein complex assembly GO:0043623 71 0.040
rna splicing via transesterification reactions GO:0000375 73 0.040
locomotory behavior GO:0007626 176 0.040
response to abiotic stimulus GO:0009628 341 0.038
establishment or maintenance of cell polarity GO:0007163 167 0.037
negative regulation of cell communication GO:0010648 223 0.037
regulation of mrna processing GO:0050684 71 0.037
single organism nuclear import GO:1902593 51 0.037
Human
ameboidal type cell migration GO:0001667 151 0.036
protein targeting to nucleus GO:0044744 51 0.035
Human
eye development GO:0001654 323 0.035
digestive system development GO:0055123 149 0.035
cellular protein localization GO:0034613 160 0.034
organonitrogen compound metabolic process GO:1901564 318 0.034
digestive tract morphogenesis GO:0048546 127 0.034
gland development GO:0048732 191 0.033
compound eye development GO:0048749 307 0.033
spindle organization GO:0007051 253 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.033
sister chromatid segregation GO:0000819 92 0.031
mrna splicing via spliceosome GO:0000398 73 0.031
mitotic nuclear division GO:0007067 213 0.031
negative regulation of rna biosynthetic process GO:1902679 240 0.030
Human
negative regulation of developmental process GO:0051093 201 0.030
positive regulation of signal transduction GO:0009967 223 0.030
protein modification process GO:0036211 438 0.030
organelle fission GO:0048285 340 0.030
positive regulation of protein metabolic process GO:0051247 128 0.029
negative regulation of multicellular organismal process GO:0051241 142 0.028
positive regulation of intracellular signal transduction GO:1902533 116 0.028
gonad development GO:0008406 50 0.028
oviposition GO:0018991 19 0.027
positive regulation of macromolecule metabolic process GO:0010604 405 0.027
embryonic pattern specification GO:0009880 174 0.027
macromolecule catabolic process GO:0009057 161 0.027
cell cycle arrest GO:0007050 4 0.027
regulation of mrna metabolic process GO:1903311 72 0.027
regulation of cellular response to stress GO:0080135 89 0.027
small molecule metabolic process GO:0044281 305 0.027
eye morphogenesis GO:0048592 260 0.027
protein import into nucleus GO:0006606 51 0.027
Human
epithelium migration GO:0090132 148 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.026
regulation of multicellular organismal development GO:2000026 414 0.026
regulation of nucleobase containing compound transport GO:0032239 4 0.026
Human
regulation of multicellular organism growth GO:0040014 40 0.026
dna templated transcription elongation GO:0006354 18 0.025
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.025
regulation of anatomical structure morphogenesis GO:0022603 242 0.025
catabolic process GO:0009056 409 0.024
response to radiation GO:0009314 155 0.024
organic acid metabolic process GO:0006082 103 0.024
negative regulation of protein export from nucleus GO:0046826 2 0.024
regulation of phosphorylation GO:0042325 147 0.024
regulation of hydrolase activity GO:0051336 97 0.024
cellular catabolic process GO:0044248 372 0.024
regulation of cellular component biogenesis GO:0044087 201 0.024
regulation of antimicrobial humoral response GO:0002759 50 0.023
mitotic cell cycle checkpoint GO:0007093 88 0.023
epidermal cell differentiation GO:0009913 51 0.023
regulation of organelle organization GO:0033043 196 0.023
digestive tract development GO:0048565 149 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
regulation of programmed cell death GO:0043067 152 0.023
nucleocytoplasmic transport GO:0006913 72 0.023
Human
protein dna complex assembly GO:0065004 63 0.023
cell cycle checkpoint GO:0000075 95 0.023
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.022
innate immune response GO:0045087 144 0.022
positive regulation of transcription dna templated GO:0045893 266 0.022
response to external biotic stimulus GO:0043207 293 0.022
terminal region determination GO:0007362 25 0.022
cellular response to dna damage stimulus GO:0006974 223 0.021
regulation of establishment of protein localization GO:0070201 61 0.021
positive regulation of apoptotic process GO:0043065 47 0.021
regulation of immune response GO:0050776 118 0.021
axonogenesis GO:0007409 290 0.021
response to organic substance GO:0010033 284 0.021
Human
regulation of production of molecular mediator of immune response GO:0002700 44 0.021
negative regulation of signaling GO:0023057 219 0.021
regulation of phosphate metabolic process GO:0019220 210 0.021
establishment of planar polarity GO:0001736 87 0.020
embryonic morphogenesis GO:0048598 206 0.020
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 15 0.020
morphogenesis of a polarized epithelium GO:0001738 93 0.020
negative regulation of cell cycle GO:0045786 116 0.020
negative regulation of signal transduction GO:0009968 206 0.020
regulation of dna templated transcription elongation GO:0032784 17 0.020
response to oxidative stress GO:0006979 86 0.020
ras protein signal transduction GO:0007265 88 0.020
reproductive behavior GO:0019098 122 0.020
regulation of circadian rhythm GO:0042752 49 0.020
jak stat cascade GO:0007259 49 0.020
regulation of intracellular transport GO:0032386 64 0.020
positive regulation of programmed cell death GO:0043068 62 0.020
cellular macromolecule catabolic process GO:0044265 136 0.019
regulation of cellular localization GO:0060341 136 0.019
multi organism reproductive behavior GO:0044705 121 0.019
nuclear envelope organization GO:0006998 7 0.019
regulation of protein localization GO:0032880 76 0.019
synaptic transmission GO:0007268 288 0.019
cytoplasmic transport GO:0016482 130 0.019
Human
death GO:0016265 284 0.019
nuclear transport GO:0051169 72 0.018
Human
gene silencing by rna GO:0031047 57 0.018
reproductive structure development GO:0048608 74 0.018
single organism cellular localization GO:1902580 180 0.018
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.018
negative regulation of immune system process GO:0002683 50 0.018
protein transport GO:0015031 155 0.018
positive regulation of cellular component organization GO:0051130 156 0.018
regulation of protein export from nucleus GO:0046825 3 0.017
centrosome duplication GO:0051298 121 0.017
regulation of mitotic cell cycle phase transition GO:1901990 130 0.017
regulation of mapk cascade GO:0043408 92 0.017
protein targeting GO:0006605 64 0.017
Human
mitotic cell cycle phase transition GO:0044772 138 0.017
phagocytosis GO:0006909 215 0.017
positive regulation of developmental growth GO:0048639 62 0.017
spermatogenesis GO:0007283 200 0.017
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
skin development GO:0043588 65 0.017
exocrine system development GO:0035272 162 0.016
chromatin remodeling GO:0006338 72 0.016
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
compound eye photoreceptor cell differentiation GO:0001751 140 0.016
establishment of organelle localization GO:0051656 122 0.016
positive regulation of cell death GO:0010942 69 0.016
single organism membrane organization GO:0044802 93 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
peptidyl lysine modification GO:0018205 57 0.016
atp metabolic process GO:0046034 49 0.016
dna repair GO:0006281 54 0.016
rna 3 end processing GO:0031123 45 0.015
negative regulation of cell cycle phase transition GO:1901988 103 0.015
protein localization to organelle GO:0033365 82 0.015
Human
regulation of gene expression epigenetic GO:0040029 128 0.015
histone modification GO:0016570 106 0.015
sex differentiation GO:0007548 81 0.015
nucleobase containing small molecule metabolic process GO:0055086 174 0.015
blood circulation GO:0008015 26 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
positive regulation of developmental process GO:0051094 143 0.015
epithelial cell migration open tracheal system GO:0007427 32 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
epithelial tube morphogenesis GO:0060562 88 0.015
covalent chromatin modification GO:0016569 106 0.015
positive regulation of cellular protein metabolic process GO:0032270 118 0.015
protein catabolic process GO:0030163 101 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.015
single organism catabolic process GO:0044712 228 0.015
negative regulation of cell proliferation GO:0008285 69 0.014
salivary gland development GO:0007431 162 0.014
regulation of transport GO:0051049 181 0.014
regulation of catalytic activity GO:0050790 185 0.014
oocyte differentiation GO:0009994 145 0.014
dsrna fragmentation GO:0031050 15 0.014
immune effector process GO:0002252 98 0.014
organic substance catabolic process GO:1901575 308 0.014
establishment of protein localization GO:0045184 163 0.014
mrna processing GO:0006397 104 0.014
regulation of catabolic process GO:0009894 170 0.014
positive regulation of growth GO:0045927 75 0.014
oocyte dorsal ventral axis specification GO:0007310 34 0.014
regulation of autophagy GO:0010506 62 0.014
developmental programmed cell death GO:0010623 138 0.014
response to other organism GO:0051707 293 0.014
cellular response to organic substance GO:0071310 132 0.013
gastrulation GO:0007369 70 0.013
epithelial cell migration GO:0010631 148 0.013
mrna 3 end processing GO:0031124 28 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
mitotic dna integrity checkpoint GO:0044774 75 0.013
macromolecule methylation GO:0043414 45 0.013
defense response to other organism GO:0098542 225 0.013
nucleotide metabolic process GO:0009117 161 0.013
nucleus localization GO:0051647 34 0.012
regulation of protein modification process GO:0031399 112 0.012
apoptotic signaling pathway GO:0097190 27 0.012
nitrogen compound transport GO:0071705 85 0.012
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
organelle assembly GO:0070925 198 0.012
protein phosphorylation GO:0006468 169 0.012
regulation of multi organism process GO:0043900 131 0.012
positive regulation of multicellular organismal process GO:0051240 143 0.012
salivary gland morphogenesis GO:0007435 145 0.012
blastoderm segmentation GO:0007350 159 0.012
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.012
gene silencing GO:0016458 138 0.012
organophosphate metabolic process GO:0019637 195 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
regulation of humoral immune response GO:0002920 51 0.012
positive regulation of multicellular organism growth GO:0040018 21 0.011
ribonucleoside monophosphate metabolic process GO:0009161 51 0.011
immune response GO:0006955 246 0.011
dorsal ventral axis specification GO:0009950 66 0.011
regulation of cell development GO:0060284 215 0.011
gene silencing by mirna GO:0035195 22 0.011
larval development GO:0002164 104 0.011
Worm
regulation of chromosome organization GO:0033044 64 0.011
kidney development GO:0001822 3 0.011
endomembrane system organization GO:0010256 119 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
methylation GO:0032259 47 0.011
production of molecular mediator of immune response GO:0002440 46 0.011
peptidyl amino acid modification GO:0018193 105 0.011
open tracheal system development GO:0007424 204 0.011
response to organic cyclic compound GO:0014070 89 0.011
regulation of cell proliferation GO:0042127 163 0.011
organic substance transport GO:0071702 257 0.011
dendrite morphogenesis GO:0048813 199 0.011
single organism intracellular transport GO:1902582 207 0.011
Human
regulation of cell cycle phase transition GO:1901987 130 0.011
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.011
segmentation GO:0035282 207 0.011
cell cycle phase transition GO:0044770 140 0.010
oocyte axis specification GO:0007309 108 0.010
regulation of intracellular protein transport GO:0033157 46 0.010
ncrna 3 end processing GO:0043628 17 0.010

Mtor disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.102
central nervous system disease DOID:331 0 0.025
nervous system disease DOID:863 0 0.025
cancer DOID:162 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
organ system cancer DOID:0050686 0 0.022
sensory system disease DOID:0050155 0 0.010