Drosophila melanogaster

117 known processes

E(spl) (Dmel_CG8365)

Enhancer of split

(Aliases: clone 1.71,l(3)96Fd,e(spl),Hes,E(spl)M8,Su(H)[[m8]],E(spl)-m8,m8,E(spl)bHLH,E(spl)m8,E(spl)-C,En(spl),HLHm8,En(spl)-C,E(spl) m8,CG8365,bHLHb36,anon-EST:Liang-1.71,M8,Dmel\CG8365)

E(spl) biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ precursor cell fate determination GO:0016360 19 1.000
neuron fate determination GO:0048664 1 1.000
Mouse
cell fate determination involved in pattern specification GO:0060582 19 1.000
formation of organ boundary GO:0010160 30 1.000
cell fate determination GO:0001709 91 1.000
sensory organ boundary specification GO:0008052 22 1.000
cell fate commitment involved in pattern specification GO:0060581 31 1.000
eye photoreceptor cell differentiation GO:0001754 145 0.999
Fly
eye morphogenesis GO:0048592 260 0.998
Fly
stem cell maintenance GO:0019827 67 0.998
Human Mouse Rat
r7 cell differentiation GO:0045466 43 0.998
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.998
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.998
Mouse
compound eye morphogenesis GO:0001745 249 0.998
Fly
compound eye development GO:0048749 307 0.998
negative regulation of nucleic acid templated transcription GO:1903507 240 0.998
head development GO:0060322 135 0.997
Zebrafish Mouse Rat Fly
morphogenesis of an epithelium GO:0002009 276 0.997
Mouse
r1 r6 cell differentiation GO:0048052 4 0.996
Fly
organ formation GO:0048645 39 0.996
forebrain development GO:0030900 2 0.996
Mouse Rat
brain development GO:0007420 120 0.995
Zebrafish Mouse Rat Fly
positive regulation of bmp signaling pathway GO:0030513 5 0.995
Mouse
nephron epithelium morphogenesis GO:0072088 3 0.995
Mouse
tube morphogenesis GO:0035239 191 0.994
Mouse Fly
sensory organ morphogenesis GO:0090596 260 0.994
Fly
positive regulation of transcription dna templated GO:0045893 266 0.994
Mouse
notch signaling pathway GO:0007219 120 0.993
Human Zebrafish Mouse Fly
regulation of cell differentiation GO:0045595 302 0.993
Human Zebrafish Mouse Rat Fly
glial cell fate commitment GO:0021781 3 0.993
Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.992
Fly
regulation of cell development GO:0060284 215 0.991
Zebrafish Mouse Rat Fly
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.991
negative regulation of cell development GO:0010721 62 0.991
Zebrafish Mouse Rat
tissue morphogenesis GO:0048729 297 0.990
Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.990
axon development GO:0061564 297 0.989
Zebrafish
positive regulation of rna metabolic process GO:0051254 271 0.989
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.989
regulation of neural precursor cell proliferation GO:2000177 35 0.989
Fly
formation of anatomical boundary GO:0048859 37 0.989
mesoderm development GO:0007498 78 0.988
regulation of nervous system development GO:0051960 248 0.988
Zebrafish Mouse Rat Fly
eye development GO:0001654 323 0.986
negative regulation of gene expression GO:0010629 387 0.986
cranial nerve development GO:0021545 1 0.986
Mouse
regionalization GO:0003002 416 0.985
renal tubule morphogenesis GO:0061333 44 0.984
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.984
nerve development GO:0021675 6 0.984
Mouse
regulation of mitosis GO:0007088 56 0.984
Fly
regulation of notch signaling pathway GO:0008593 100 0.984
Mouse
gliogenesis GO:0042063 80 0.983
Zebrafish Mouse Rat
renal system development GO:0072001 72 0.982
Mouse
regulation of glial cell differentiation GO:0045685 1 0.982
Mouse
glial cell differentiation GO:0010001 35 0.981
Mouse Rat
negative regulation of transcription dna templated GO:0045892 237 0.978
negative regulation of rna metabolic process GO:0051253 251 0.975
renal tubule development GO:0061326 64 0.975
Mouse
neuroblast proliferation GO:0007405 74 0.974
Fly
dosage compensation GO:0007549 16 0.974
Fly
chaeta morphogenesis GO:0008407 42 0.971
kidney epithelium development GO:0072073 3 0.970
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.970
axonogenesis GO:0007409 290 0.970
Zebrafish
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.970
regulation of timing of cell differentiation GO:0048505 1 0.968
Mouse
regulation of gliogenesis GO:0014013 11 0.966
Mouse
glial cell development GO:0021782 27 0.966
Mouse
primary sex determination soma GO:0007539 2 0.965
Fly
positive regulation of developmental process GO:0051094 143 0.964
Fly
negative regulation of stem cell differentiation GO:2000737 8 0.964
Human
rhythmic process GO:0048511 106 0.964
Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.962
Mouse
telencephalon development GO:0021537 2 0.961
Mouse
nephron development GO:0072006 3 0.960
Mouse
stem cell fate commitment GO:0048865 25 0.959
epidermal cell differentiation GO:0009913 51 0.958
Mouse Worm
malpighian tubule morphogenesis GO:0007443 44 0.956
regulation of neuroblast proliferation GO:1902692 34 0.955
Fly
cell fate specification GO:0001708 71 0.952
Worm
tube development GO:0035295 244 0.952
Zebrafish Mouse Fly
negative regulation of cellular metabolic process GO:0031324 382 0.952
central nervous system development GO:0007417 201 0.951
Zebrafish Mouse Rat Fly
stem cell proliferation GO:0072089 88 0.951
Fly
positive regulation of nucleic acid templated transcription GO:1903508 266 0.950
Mouse
negative regulation of multicellular organismal process GO:0051241 142 0.950
Zebrafish Mouse Rat
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.949
cell division GO:0051301 248 0.947
Fly
negative regulation of biosynthetic process GO:0009890 277 0.947
locomotory behavior GO:0007626 176 0.946
Fly
embryonic hindgut morphogenesis GO:0048619 48 0.943
dendrite morphogenesis GO:0048813 199 0.942
regulation of neuron differentiation GO:0045664 103 0.942
Mouse Rat
hair cell differentiation GO:0035315 47 0.939
Mouse
regulation of neurogenesis GO:0050767 158 0.939
Zebrafish Mouse Rat Fly
positive regulation of macromolecule metabolic process GO:0010604 405 0.937
Zebrafish Mouse
sex determination GO:0007530 18 0.936
Fly
dendrite development GO:0016358 204 0.935
epidermis development GO:0008544 65 0.933
Mouse Worm
regulation of cell morphogenesis GO:0022604 163 0.932
photoreceptor cell differentiation GO:0046530 170 0.932
Fly
bolwig s organ development GO:0055034 8 0.931
kidney morphogenesis GO:0060993 3 0.931
Mouse
regulation of stem cell differentiation GO:2000736 14 0.929
Human
eye photoreceptor cell fate commitment GO:0042706 37 0.924
negative regulation of nervous system development GO:0051961 92 0.922
Zebrafish Mouse Rat
kidney development GO:0001822 3 0.921
Mouse
gland morphogenesis GO:0022612 145 0.918
Fly
negative regulation of cell differentiation GO:0045596 143 0.917
Human Zebrafish Mouse Rat
exocrine system development GO:0035272 162 0.916
Fly
camera type eye development GO:0043010 4 0.915
Mouse
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.913
Rat
regulation of gene expression epigenetic GO:0040029 128 0.908
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.908
Mouse
negative regulation of gliogenesis GO:0014014 6 0.906
Mouse
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.904
Mouse
epithelial tube morphogenesis GO:0060562 88 0.901
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.899
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.899
Mouse
gland development GO:0048732 191 0.893
Fly
mitotic nuclear division GO:0007067 213 0.886
Fly
positive regulation of cell proliferation GO:0008284 47 0.885
Human Fly
hindbrain development GO:0030902 2 0.884
Mouse
neuroepithelial cell differentiation GO:0060563 6 0.884
neuron fate commitment GO:0048663 50 0.882
Mouse
positive regulation of neurogenesis GO:0050769 41 0.879
Fly
neuronal stem cell maintenance GO:0097150 4 0.878
Human Mouse Rat
organelle fission GO:0048285 340 0.874
Fly
regulation of multicellular organismal development GO:2000026 414 0.874
Zebrafish Mouse Rat Fly
neuroblast fate specification GO:0014018 2 0.873
nephron tubule morphogenesis GO:0072078 3 0.870
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.868
Mouse
cell maturation GO:0048469 144 0.867
Mouse
neuron projection guidance GO:0097485 241 0.867
nephron epithelium development GO:0072009 3 0.864
Mouse
neuron fate specification GO:0048665 12 0.862
protein complex assembly GO:0006461 200 0.860
Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.860
biological adhesion GO:0022610 138 0.856
Mouse
regulation of mitotic cell cycle GO:0007346 190 0.853
Fly
stem cell fate specification GO:0048866 2 0.845
hindgut morphogenesis GO:0007442 58 0.844
regulation of glial cell proliferation GO:0060251 11 0.841
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.838
negative regulation of developmental process GO:0051093 201 0.836
Human Zebrafish Mouse Rat
positive regulation of neural precursor cell proliferation GO:2000179 8 0.836
Fly
nuclear division GO:0000280 332 0.836
Fly
cellular response to dna damage stimulus GO:0006974 223 0.831
Fly
immune system process GO:0002376 347 0.830
Rat
respiratory system development GO:0060541 213 0.829
Fly
regulation of stem cell proliferation GO:0072091 40 0.826
Fly
positive regulation of biosynthetic process GO:0009891 316 0.823
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.822
salivary gland development GO:0007431 162 0.819
Fly
epithelial cell differentiation GO:0030855 322 0.818
Mouse Worm
regulation of bmp signaling pathway GO:0030510 23 0.796
Mouse
positive regulation of nervous system development GO:0051962 69 0.793
Fly
neuroblast fate determination GO:0007400 12 0.793
compound eye photoreceptor fate commitment GO:0001752 36 0.790
axon ensheathment in central nervous system GO:0032291 3 0.788
Mouse
neural precursor cell proliferation GO:0061351 75 0.785
Fly
nephron tubule formation GO:0072079 3 0.779
Mouse
nephron morphogenesis GO:0072028 3 0.777
Mouse
nephron tubule development GO:0072080 3 0.774
Mouse
chaeta development GO:0022416 97 0.770
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.766
Mouse
cellular protein modification process GO:0006464 438 0.764
Zebrafish Mouse
sex determination establishment of x a ratio GO:0007540 1 0.757
Fly
somatic sex determination GO:0018993 2 0.747
Fly
bolwig s organ morphogenesis GO:0001746 8 0.730
negative regulation of notch signaling pathway GO:0045746 41 0.730
positive regulation of cell development GO:0010720 61 0.713
Fly
urogenital system development GO:0001655 72 0.709
Mouse
digestive tract morphogenesis GO:0048546 127 0.707
embryonic organ development GO:0048568 50 0.705
Zebrafish
regulation of axonogenesis GO:0050770 32 0.692
morphogenesis of embryonic epithelium GO:0016331 94 0.691
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.691
neuroblast fate commitment GO:0014017 19 0.689
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.687
skin development GO:0043588 65 0.677
Mouse Worm
segment specification GO:0007379 33 0.674
Zebrafish Mouse
positive regulation of gene expression GO:0010628 290 0.673
Mouse
regulation of cell proliferation GO:0042127 163 0.672
Human Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.669
brain morphogenesis GO:0048854 16 0.668
Fly
lateral inhibition GO:0046331 206 0.662
startle response GO:0001964 16 0.659
Fly
protein phosphorylation GO:0006468 169 0.656
Zebrafish Mouse
regulation of cellular protein metabolic process GO:0032268 243 0.653
Zebrafish Mouse
protein modification process GO:0036211 438 0.650
Zebrafish Mouse
stem cell development GO:0048864 79 0.646
Human Mouse Rat
connective tissue development GO:0061448 3 0.644
Human Mouse
imaginal disc pattern formation GO:0007447 91 0.642
Fly
positive regulation of neuroblast proliferation GO:0002052 7 0.638
Fly
protein complex biogenesis GO:0070271 201 0.636
Mouse
central nervous system neuron differentiation GO:0021953 8 0.629
Rat
bmp signaling pathway GO:0030509 27 0.622
Mouse
regulation of axon guidance GO:1902667 10 0.620
peripheral nervous system neuron differentiation GO:0048934 8 0.619
Zebrafish
positive regulation of cellular protein metabolic process GO:0032270 118 0.616
Zebrafish Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.613
Mouse
positive regulation of notch signaling pathway GO:0045747 34 0.594
Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.590
Fly
negative regulation of glial cell proliferation GO:0060253 6 0.587
tyrosine phosphorylation of stat protein GO:0007260 1 0.573
Mouse
regulation of axon extension involved in axon guidance GO:0048841 4 0.571
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 9 0.569
Mouse
regulation of organelle organization GO:0033043 196 0.568
Fly
segmentation GO:0035282 207 0.561
Zebrafish Mouse
dorsal ventral pattern formation GO:0009953 133 0.561
Fly
positive regulation of neuron differentiation GO:0045666 26 0.557
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.555
Mouse
localization of cell GO:0051674 257 0.555
regulation of cell division GO:0051302 72 0.553
Fly
regulation of cellular amine metabolic process GO:0033238 3 0.551
salivary gland morphogenesis GO:0007435 145 0.550
Fly
hematopoietic progenitor cell differentiation GO:0002244 1 0.549
Rat
regulation of response to dna damage stimulus GO:2001020 23 0.543
Fly
compound eye cone cell fate commitment GO:0042676 5 0.538
response to organic substance GO:0010033 284 0.537
negative regulation of neurogenesis GO:0050768 53 0.536
Zebrafish Mouse Rat
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.531
Zebrafish
stem cell fate determination GO:0048867 15 0.530
enzyme linked receptor protein signaling pathway GO:0007167 179 0.529
Mouse
cellular amine metabolic process GO:0044106 12 0.525
negative regulation of immune system process GO:0002683 50 0.517
Rat
positive regulation of cell differentiation GO:0045597 64 0.512
Fly
cellular amino acid metabolic process GO:0006520 61 0.507
regulation of neuron projection development GO:0010975 69 0.504
regulation of epithelial cell differentiation GO:0030856 4 0.501
regulation of protein metabolic process GO:0051246 256 0.499
Zebrafish Mouse
positive regulation of response to stimulus GO:0048584 323 0.485
Mouse
circadian rhythm GO:0007623 105 0.485
regulation of phosphate metabolic process GO:0019220 210 0.484
Zebrafish Mouse
cell proliferation GO:0008283 299 0.481
Human Fly
regulation of cell cycle GO:0051726 291 0.476
Zebrafish Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.476
Mouse
macromolecular complex assembly GO:0065003 256 0.475
Mouse
positive regulation of cell cycle GO:0045787 43 0.470
Zebrafish Fly
organonitrogen compound metabolic process GO:1901564 318 0.470
courtship behavior GO:0007619 68 0.468
regulation of cellular amino acid metabolic process GO:0006521 0 0.467
hematopoietic or lymphoid organ development GO:0048534 57 0.463
Rat
oenocyte development GO:0007438 8 0.463
regulation of nuclear division GO:0051783 58 0.454
Fly
stem cell differentiation GO:0048863 117 0.448
Human Mouse Rat
proximal distal pattern formation GO:0009954 15 0.439
Mouse
cell death GO:0008219 279 0.434
axon guidance GO:0007411 233 0.422
cellular ketone metabolic process GO:0042180 24 0.422
response to abiotic stimulus GO:0009628 341 0.421
Fly
cell fate commitment involved in formation of primary germ layer GO:0060795 10 0.419
humoral immune response GO:0006959 117 0.417
r8 cell fate commitment GO:0007460 6 0.414
anterior posterior pattern specification GO:0009952 136 0.412
Zebrafish Mouse Worm
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.407
Mouse
adult behavior GO:0030534 137 0.406
Fly
neuroblast differentiation GO:0014016 29 0.406
regulation of cell cycle process GO:0010564 181 0.405
Fly
peripheral nervous system neuron development GO:0048935 8 0.400
Zebrafish
glial cell proliferation GO:0014009 13 0.399
regulation of protein modification process GO:0031399 112 0.392
Zebrafish Mouse
embryonic morphogenesis GO:0048598 206 0.379
Zebrafish Mouse
digestive system development GO:0055123 149 0.378
cell cell signaling involved in cell fate commitment GO:0045168 210 0.370
axon extension involved in axon guidance GO:0048846 10 0.366
positive regulation of cellular component organization GO:0051130 156 0.360
Fly
peptidyl tyrosine phosphorylation GO:0018108 24 0.356
Mouse
epithelial cell development GO:0002064 274 0.355
regulation of axon extension GO:0030516 8 0.355
locomotor rhythm GO:0045475 56 0.352
response to external biotic stimulus GO:0043207 293 0.352
smoothened signaling pathway GO:0007224 49 0.351
Mouse
response to hypoxia GO:0001666 53 0.347
Fly
positive regulation of stem cell proliferation GO:2000648 8 0.347
Fly
immune response GO:0006955 246 0.346
positive regulation of protein metabolic process GO:0051247 128 0.341
Zebrafish Mouse
neuron projection extension GO:1990138 32 0.337
epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013 11 0.333
regulation of anatomical structure morphogenesis GO:0022603 242 0.333
Mouse
positive regulation of signal transduction GO:0009967 223 0.332
Mouse
cell adhesion GO:0007155 136 0.327
Mouse
larval behavior GO:0030537 42 0.325
Fly
wing disc pattern formation GO:0035222 66 0.323
Fly
epithelial tube formation GO:0072175 7 0.318
Mouse
immune system development GO:0002520 57 0.317
Rat
positive regulation of molecular function GO:0044093 136 0.317
Zebrafish
regulation of phosphorylation GO:0042325 147 0.317
Zebrafish Mouse
mesodermal cell differentiation GO:0048333 7 0.316
chromosome organization GO:0051276 360 0.310
amine metabolic process GO:0009308 12 0.306
embryonic epithelial tube formation GO:0001838 6 0.306
Mouse
developmental maturation GO:0021700 172 0.300
Mouse
somatic stem cell maintenance GO:0035019 14 0.299
hemopoiesis GO:0030097 46 0.296
Rat
regulation of immune system process GO:0002682 176 0.293
Rat
regulation of localization GO:0032879 275 0.292
single organism behavior GO:0044708 391 0.289
Fly
peripheral nervous system development GO:0007422 52 0.287
Zebrafish
transmission of nerve impulse GO:0019226 12 0.287
Mouse
formation of primary germ layer GO:0001704 24 0.285
small molecule metabolic process GO:0044281 305 0.281
compound eye cone cell differentiation GO:0042675 13 0.278
central nervous system neuron development GO:0021954 8 0.277
mesodermal cell fate commitment GO:0001710 7 0.276
negative regulation of cell cycle process GO:0010948 109 0.268
intracellular signal transduction GO:0035556 300 0.268
Mouse
photoreceptor cell fate commitment GO:0046552 41 0.263
glandular epithelial cell differentiation GO:0002067 1 0.262
wing disc dorsal ventral pattern formation GO:0048190 47 0.255
Fly
neuromuscular process GO:0050905 21 0.255
Fly
actin cytoskeleton organization GO:0030036 206 0.251
negative regulation of neuron differentiation GO:0045665 16 0.248
Mouse Rat
morphogenesis of a polarized epithelium GO:0001738 93 0.246
medulla oblongata development GO:0021550 2 0.244
chromatin organization GO:0006325 207 0.244
spinal cord patterning GO:0021511 1 0.241
response to growth factor GO:0070848 31 0.239
taxis GO:0042330 304 0.238
gastrulation involving germ band extension GO:0010004 36 0.234
oxoacid metabolic process GO:0043436 103 0.232
regulation of protein phosphorylation GO:0001932 64 0.231
Zebrafish Mouse
larval development GO:0002164 104 0.228
regulation of phosphorus metabolic process GO:0051174 210 0.228
Zebrafish Mouse
appendage development GO:0048736 401 0.224
carboxylic acid metabolic process GO:0019752 92 0.223
regulation of molecular function GO:0065009 217 0.221
Zebrafish
embryonic organ morphogenesis GO:0048562 5 0.220
Zebrafish
spinal cord development GO:0021510 1 0.219
open tracheal system development GO:0007424 204 0.219
Fly
cell migration GO:0016477 238 0.217
negative regulation of cell proliferation GO:0008285 69 0.217
regulation of cell projection organization GO:0031344 92 0.216
regulation of intracellular signal transduction GO:1902531 236 0.216
Mouse
negative regulation of signaling GO:0023057 219 0.207
cellular response to chemical stimulus GO:0070887 199 0.205
camera type eye photoreceptor cell differentiation GO:0060219 2 0.204
organic acid metabolic process GO:0006082 103 0.204
regulation of epidermal cell differentiation GO:0045604 3 0.203
camera type eye morphogenesis GO:0048593 2 0.203
tube formation GO:0035148 21 0.203
Mouse
negative regulation of signal transduction GO:0009968 206 0.200
jak stat cascade GO:0007259 49 0.200
Mouse
cellular response to organic substance GO:0071310 132 0.197
actin filament based process GO:0030029 220 0.196
negative regulation of programmed cell death GO:0043069 72 0.195
peptidyl amino acid modification GO:0018193 105 0.191
Mouse
positive regulation of signaling GO:0023056 243 0.186
Mouse
developmental cell growth GO:0048588 52 0.185
neuron migration GO:0001764 5 0.183
regulation of cell size GO:0008361 63 0.182
apoptotic process GO:0006915 159 0.182
positive regulation of mitotic cell cycle GO:0045931 34 0.181
Fly
neural retina development GO:0003407 4 0.180
multi organism behavior GO:0051705 175 0.177
adult locomotory behavior GO:0008344 76 0.176
Fly
death GO:0016265 284 0.175
regulation of compound eye cone cell fate specification GO:0042682 4 0.174
regulation of dendrite morphogenesis GO:0048814 28 0.163
regulation of catalytic activity GO:0050790 185 0.162
Zebrafish
appendage morphogenesis GO:0035107 397 0.161
peptidyl tyrosine modification GO:0018212 24 0.160
Mouse
mesenchymal cell differentiation GO:0048762 1 0.158
retinal cone cell differentiation GO:0042670 2 0.158
mesoderm morphogenesis GO:0048332 22 0.157
immune effector process GO:0002252 98 0.155
retina morphogenesis in camera type eye GO:0060042 2 0.154
regulation of response to external stimulus GO:0032101 115 0.153
regulation of cellular response to stress GO:0080135 89 0.152
Fly
malpighian tubule tip cell differentiation GO:0061382 9 0.152
muscle cell differentiation GO:0042692 103 0.147
neurological system process GO:0050877 358 0.145
Mouse Fly
spinal cord dorsal ventral patterning GO:0021513 1 0.145
response to biotic stimulus GO:0009607 294 0.143
larval locomotory behavior GO:0008345 27 0.143
Fly
developmental growth GO:0048589 280 0.142
sensory perception of sound GO:0007605 56 0.141
regulation of cellular component movement GO:0051270 42 0.141
antennal development GO:0007469 25 0.141
negative regulation of cellular component organization GO:0051129 108 0.140
epithelial cell proliferation GO:0050673 15 0.140
regulation of muscle organ development GO:0048634 13 0.139
growth GO:0040007 359 0.138
gastrulation with mouth forming first GO:0001703 36 0.138
defense response GO:0006952 300 0.136
regulation of growth GO:0040008 233 0.135
gastrulation GO:0007369 70 0.135
programmed cell death GO:0012501 257 0.133
positive regulation of organelle organization GO:0010638 65 0.131
Fly
positive regulation of protein modification process GO:0031401 58 0.130
Zebrafish Mouse
positive regulation of cell division GO:0051781 16 0.129
Fly
eye antennal disc development GO:0035214 60 0.128
muscle organ development GO:0007517 127 0.127
male courtship behavior veined wing generated song production GO:0045433 20 0.124
negative regulation of cell communication GO:0010648 223 0.121
positive regulation of intracellular signal transduction GO:1902533 116 0.120
Mouse
phosphorylation GO:0016310 294 0.120
Zebrafish Mouse
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.119
Fly
digestive tract development GO:0048565 149 0.119
imaginal disc derived appendage morphogenesis GO:0035114 395 0.117
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.117
Zebrafish
regulation of oviposition GO:0046662 14 0.116
aggressive behavior GO:0002118 63 0.116
negative regulation of mitotic cell cycle GO:0045930 109 0.115
regulation of protein kinase activity GO:0045859 51 0.115
Zebrafish
antennal joint development GO:0048098 5 0.114
regulation of developmental growth GO:0048638 174 0.112
response to other organism GO:0051707 293 0.110
positive regulation of cell communication GO:0010647 250 0.109
Mouse
regulation of cell fate specification GO:0042659 27 0.108
neuronal action potential GO:0019228 10 0.106
Mouse
cell growth GO:0016049 108 0.105
negative regulation of cell death GO:0060548 81 0.105
body morphogenesis GO:0010171 2 0.103
regulation of kinase activity GO:0043549 53 0.103
Zebrafish
muscle structure development GO:0061061 224 0.103
multi organism reproductive behavior GO:0044705 121 0.103
regulation of transferase activity GO:0051338 58 0.102
Zebrafish
male courtship behavior veined wing extension GO:0048065 22 0.101
establishment of tissue polarity GO:0007164 87 0.100
apoptotic process involved in morphogenesis GO:0060561 3 0.100
imaginal disc derived appendage development GO:0048737 399 0.099
establishment of planar polarity GO:0001736 87 0.098
mesoderm formation GO:0001707 21 0.097
response to decreased oxygen levels GO:0036293 58 0.096
Fly
neuron apoptotic process GO:0051402 17 0.095
cellular response to endogenous stimulus GO:0071495 80 0.094
ensheathment of neurons GO:0007272 10 0.094
Mouse
muscle cell development GO:0055001 50 0.093
circadian behavior GO:0048512 76 0.092
negative regulation of cell cycle GO:0045786 116 0.091
regulation of behavior GO:0050795 75 0.090
positive regulation of phosphate metabolic process GO:0045937 139 0.089
Zebrafish Mouse
oenocyte differentiation GO:0001742 8 0.089
response to endogenous stimulus GO:0009719 119 0.089
regulation of programmed cell death GO:0043067 152 0.088
regulation of response to stress GO:0080134 200 0.086
Fly
regulation of organ morphogenesis GO:2000027 78 0.086
limb development GO:0060173 1 0.085
response to wounding GO:0009611 94 0.085
rhythmic behavior GO:0007622 76 0.084
axon extension GO:0048675 32 0.084
mesodermal cell fate specification GO:0007501 2 0.084
regulation of r7 cell differentiation GO:0045676 15 0.083
regulation of extent of cell growth GO:0061387 8 0.082
retina development in camera type eye GO:0060041 4 0.079
positive regulation of kinase activity GO:0033674 25 0.079
Zebrafish
regulation of immune effector process GO:0002697 52 0.078
cell motility GO:0048870 251 0.077
positive regulation of epithelial cell differentiation GO:0030858 1 0.076
positive regulation of phosphorylation GO:0042327 87 0.075
Zebrafish Mouse
positive regulation of catalytic activity GO:0043085 118 0.075
Zebrafish
response to oxygen levels GO:0070482 59 0.073
Fly
positive regulation of gliogenesis GO:0014015 5 0.073
cell type specific apoptotic process GO:0097285 38 0.071
negative regulation of cell division GO:0051782 17 0.070
antimicrobial humoral response GO:0019730 99 0.069
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.069
regulation of cell death GO:0010941 173 0.068
adult chitin based cuticle pattern formation GO:0035018 1 0.068
establishment of ommatidial planar polarity GO:0042067 49 0.068
positive regulation of protein phosphorylation GO:0001934 34 0.067
Zebrafish Mouse
regulation of immune response GO:0050776 118 0.067
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.067
malpighian tubule development GO:0072002 64 0.067
renal filtration cell differentiation GO:0061318 12 0.065
positive regulation of transferase activity GO:0051347 26 0.063
Zebrafish
developmental growth involved in morphogenesis GO:0060560 65 0.063
imaginal disc derived wing vein specification GO:0007474 48 0.063
negative regulation of organelle organization GO:0010639 56 0.062
regeneration GO:0031099 16 0.062
cell recognition GO:0008037 102 0.060
striated muscle cell differentiation GO:0051146 90 0.059
r8 cell differentiation GO:0045465 13 0.059
multicellular organismal reproductive behavior GO:0033057 110 0.058
positive regulation of cell cycle process GO:0090068 28 0.057
Fly
male courtship behavior veined wing vibration GO:0016545 21 0.056
peptide metabolic process GO:0006518 80 0.054
regulation of reproductive process GO:2000241 54 0.053
mesenchymal cell development GO:0014031 1 0.053
striated muscle tissue development GO:0014706 27 0.052
cellular response to growth factor stimulus GO:0071363 30 0.051
regulation of chemotaxis GO:0050920 12 0.051
ommatidial rotation GO:0016318 20 0.051
regulation of cellular amide metabolic process GO:0034248 39 0.051
regulation of cellular component size GO:0032535 98 0.050
adult chitin based cuticle development GO:0008365 2 0.049
wing disc morphogenesis GO:0007472 344 0.049
positive regulation of protein kinase activity GO:0045860 25 0.049
Zebrafish
chemotaxis GO:0006935 249 0.048

E(spl) disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
spondylocostal dysostosis DOID:0050568 0 0.974
Human
bone development disease DOID:0080006 0 0.974
Human
bone disease DOID:0080001 0 0.974
Human
disease of anatomical entity DOID:7 0 0.974
Human
dysostosis DOID:1934 0 0.974
Human
musculoskeletal system disease DOID:17 0 0.974
Human
connective tissue disease DOID:65 0 0.974
Human