Drosophila melanogaster

88 known processes

topi (Dmel_CG8484)

matotopetli

(Aliases: CG8484,Topi,Dmel\CG8484)

topi biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spermatid differentiation GO:0048515 114 0.529
spermatogenesis GO:0007283 200 0.188
male gamete generation GO:0048232 201 0.172
small molecule metabolic process GO:0044281 305 0.143
positive regulation of nucleic acid templated transcription GO:1903508 266 0.115
positive regulation of macromolecule metabolic process GO:0010604 405 0.106
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.105
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.105
death GO:0016265 284 0.105
nuclear division GO:0000280 332 0.088
spermatid development GO:0007286 98 0.086
positive regulation of biosynthetic process GO:0009891 316 0.086
cell division GO:0051301 248 0.082
positive regulation of cellular biosynthetic process GO:0031328 316 0.077
positive regulation of rna metabolic process GO:0051254 271 0.065
regulation of endopeptidase activity GO:0052548 36 0.065
programmed cell death GO:0012501 257 0.064
positive regulation of hydrolase activity GO:0051345 78 0.061
positive regulation of rna biosynthetic process GO:1902680 266 0.061
cell death GO:0008219 279 0.061
organophosphate metabolic process GO:0019637 195 0.058
carbohydrate derivative metabolic process GO:1901135 217 0.054
transcription from rna polymerase ii promoter GO:0006366 368 0.052
apoptotic process GO:0006915 159 0.052
ion transmembrane transport GO:0034220 122 0.051
positive regulation of gene expression GO:0010628 290 0.051
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.051
meiotic nuclear division GO:0007126 151 0.049
organonitrogen compound metabolic process GO:1901564 318 0.046
cytokinesis GO:0000910 90 0.046
nucleoside metabolic process GO:0009116 127 0.045
sister chromatid segregation GO:0000819 92 0.045
regulation of hydrolase activity GO:0051336 97 0.045
chromosome organization GO:0051276 360 0.044
cilium assembly GO:0042384 38 0.044
regulation of proteolysis GO:0030162 87 0.042
negative regulation of gene expression GO:0010629 387 0.040
regulation of programmed cell death GO:0043067 152 0.040
transmembrane transport GO:0055085 139 0.038
single organism catabolic process GO:0044712 228 0.038
positive regulation of endopeptidase activity GO:0010950 26 0.038
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.038
organic substance catabolic process GO:1901575 308 0.037
negative regulation of signal transduction GO:0009968 206 0.037
organelle fusion GO:0048284 46 0.037
positive regulation of transcription dna templated GO:0045893 266 0.036
cation transmembrane transport GO:0098655 88 0.036
carboxylic acid metabolic process GO:0019752 92 0.035
regulation of cell cycle process GO:0010564 181 0.035
negative regulation of cell communication GO:0010648 223 0.035
sperm individualization GO:0007291 48 0.034
single organism membrane fusion GO:0044801 42 0.034
organelle fission GO:0048285 340 0.034
negative regulation of cellular metabolic process GO:0031324 382 0.034
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.034
positive regulation of cell communication GO:0010647 250 0.034
regulation of catalytic activity GO:0050790 185 0.033
positive regulation of molecular function GO:0044093 136 0.033
regulation of cell death GO:0010941 173 0.033
purine nucleoside metabolic process GO:0042278 127 0.032
cellularization GO:0007349 90 0.032
regulation of apoptotic process GO:0042981 130 0.032
protein modification process GO:0036211 438 0.032
positive regulation of catalytic activity GO:0043085 118 0.031
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.031
cell proliferation GO:0008283 299 0.031
cation transport GO:0006812 110 0.031
appendage development GO:0048736 401 0.031
proteolysis GO:0006508 192 0.030
ribonucleoside metabolic process GO:0009119 127 0.030
cellular protein modification process GO:0006464 438 0.030
regulation of cysteine type endopeptidase activity GO:2000116 27 0.029
purine containing compound metabolic process GO:0072521 155 0.029
organic acid metabolic process GO:0006082 103 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.029
regulation of organelle organization GO:0033043 196 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.028
regulation of anatomical structure morphogenesis GO:0022603 242 0.028
cytoskeleton dependent cytokinesis GO:0061640 81 0.028
activation of cysteine type endopeptidase activity GO:0097202 17 0.028
positive regulation of signal transduction GO:0009967 223 0.028
regulation of cell cycle phase transition GO:1901987 130 0.028
oxoacid metabolic process GO:0043436 103 0.028
regulation of intracellular signal transduction GO:1902531 236 0.027
vesicle mediated transport GO:0016192 381 0.027
organelle assembly GO:0070925 198 0.027
regulation of cellular protein metabolic process GO:0032268 243 0.027
spindle organization GO:0007051 253 0.027
glycosyl compound metabolic process GO:1901657 127 0.027
meiotic cell cycle GO:0051321 171 0.027
phagocytosis GO:0006909 215 0.027
positive regulation of proteolysis GO:0045862 52 0.026
atp metabolic process GO:0046034 49 0.026
purine ribonucleoside metabolic process GO:0046128 127 0.025
nucleobase containing compound catabolic process GO:0034655 165 0.025
single organism biosynthetic process GO:0044711 206 0.025
regulation of localization GO:0032879 275 0.025
nucleobase containing small molecule metabolic process GO:0055086 174 0.025
protein maturation GO:0051604 71 0.025
protein modification by small protein conjugation GO:0032446 79 0.024
negative regulation of wnt signaling pathway GO:0030178 28 0.024
negative regulation of mitotic cell cycle GO:0045930 109 0.024
ribonucleotide metabolic process GO:0009259 145 0.024
negative regulation of signaling GO:0023057 219 0.024
protein localization GO:0008104 284 0.024
cellular catabolic process GO:0044248 372 0.024
protein processing GO:0016485 68 0.024
regulation of molecular function GO:0065009 217 0.023
regulation of protein metabolic process GO:0051246 256 0.023
cellular response to dna damage stimulus GO:0006974 223 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.023
organic substance transport GO:0071702 257 0.023
regulation of catabolic process GO:0009894 170 0.023
positive regulation of programmed cell death GO:0043068 62 0.022
catabolic process GO:0009056 409 0.022
body morphogenesis GO:0010171 2 0.022
purine containing compound catabolic process GO:0072523 112 0.022
regulation of response to stress GO:0080134 200 0.021
nucleoside phosphate metabolic process GO:0006753 162 0.021
purine nucleotide metabolic process GO:0006163 146 0.021
developmental programmed cell death GO:0010623 138 0.021
proteasomal protein catabolic process GO:0010498 59 0.021
regulation of cellular catabolic process GO:0031329 157 0.020
purine nucleoside triphosphate metabolic process GO:0009144 119 0.020
somatic muscle development GO:0007525 66 0.020
positive regulation of cellular catabolic process GO:0031331 95 0.020
eye development GO:0001654 323 0.020
amine metabolic process GO:0009308 12 0.020
multi multicellular organism process GO:0044706 123 0.019
inorganic cation transmembrane transport GO:0098662 61 0.019
cellular amine metabolic process GO:0044106 12 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
heterocycle catabolic process GO:0046700 166 0.019
negative regulation of cellular component organization GO:0051129 108 0.019
ubiquitin dependent protein catabolic process GO:0006511 78 0.019
ribonucleoside triphosphate metabolic process GO:0009199 119 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
cell cycle checkpoint GO:0000075 95 0.019
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
regulation of cell cycle GO:0051726 291 0.019
ribose phosphate metabolic process GO:0019693 145 0.018
negative regulation of rna metabolic process GO:0051253 251 0.018
nucleotide metabolic process GO:0009117 161 0.018
compound eye development GO:0048749 307 0.018
carbohydrate derivative catabolic process GO:1901136 118 0.018
intracellular signal transduction GO:0035556 300 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
modification dependent protein catabolic process GO:0019941 78 0.018
cellular macromolecule catabolic process GO:0044265 136 0.018
cellular protein localization GO:0034613 160 0.018
aromatic compound catabolic process GO:0019439 166 0.018
macromolecule catabolic process GO:0009057 161 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.018
protein modification by small protein conjugation or removal GO:0070647 106 0.018
meiosis ii GO:0007135 23 0.017
purine nucleoside catabolic process GO:0006152 112 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
response to organic substance GO:0010033 284 0.017
organic cyclic compound catabolic process GO:1901361 168 0.017
membrane organization GO:0061024 112 0.017
glycosyl compound catabolic process GO:1901658 112 0.017
organic acid transport GO:0015849 18 0.017
modification dependent macromolecule catabolic process GO:0043632 79 0.017
microtubule organizing center organization GO:0031023 168 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.016
mitotic cell cycle checkpoint GO:0007093 88 0.016
positive regulation of response to stimulus GO:0048584 323 0.016
negative regulation of cellular catabolic process GO:0031330 34 0.016
negative regulation of cellular biosynthetic process GO:0031327 277 0.016
regulation of protein catabolic process GO:0042176 55 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.016
response to external biotic stimulus GO:0043207 293 0.016
regulation of cell division GO:0051302 72 0.016
segment polarity determination GO:0007367 25 0.016
positive regulation of intracellular signal transduction GO:1902533 116 0.016
intracellular transport GO:0046907 228 0.016
eye morphogenesis GO:0048592 260 0.016
response to biotic stimulus GO:0009607 294 0.016
histolysis GO:0007559 102 0.016
homeostatic process GO:0042592 199 0.016
ribonucleoside monophosphate metabolic process GO:0009161 51 0.016
purine nucleoside triphosphate catabolic process GO:0009146 108 0.016
regulation of mitosis GO:0007088 56 0.016
positive regulation of signaling GO:0023056 243 0.016
ribonucleoside catabolic process GO:0042454 112 0.016
meiotic cell cycle process GO:1903046 132 0.016
regulation of cellular response to stress GO:0080135 89 0.015
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.015
chromosome separation GO:0051304 42 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.015
male meiosis GO:0007140 52 0.015
carbohydrate metabolic process GO:0005975 82 0.015
ion transport GO:0006811 145 0.015
growth GO:0040007 359 0.015
response to abiotic stimulus GO:0009628 341 0.015
negative regulation of biosynthetic process GO:0009890 277 0.015
regionalization GO:0003002 416 0.015
salivary gland cell autophagic cell death GO:0035071 83 0.015
blastoderm segmentation GO:0007350 159 0.015
mitotic sister chromatid segregation GO:0000070 87 0.015
regulation of transport GO:0051049 181 0.015
embryonic pattern specification GO:0009880 174 0.015
single organism intracellular transport GO:1902582 207 0.015
cellular component assembly involved in morphogenesis GO:0010927 151 0.015
gland development GO:0048732 191 0.015
ethanolamine containing compound metabolic process GO:0042439 4 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
camera type eye development GO:0043010 4 0.014
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
response to bacterium GO:0009617 198 0.014
protein ubiquitination GO:0016567 70 0.014
compound eye morphogenesis GO:0001745 249 0.014
regulation of phosphate metabolic process GO:0019220 210 0.014
nucleoside monophosphate metabolic process GO:0009123 52 0.014
response to lipopolysaccharide GO:0032496 4 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
mitotic cell cycle phase transition GO:0044772 138 0.014
positive regulation of peptidase activity GO:0010952 29 0.014
response to alcohol GO:0097305 95 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.014
regulation of peptidase activity GO:0052547 39 0.014
nucleoside catabolic process GO:0009164 112 0.014
monocarboxylic acid transport GO:0015718 3 0.014
imaginal disc derived wing morphogenesis GO:0007476 337 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.014
embryo development ending in birth or egg hatching GO:0009792 152 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
spindle assembly GO:0051225 80 0.014
l amino acid import GO:0043092 2 0.014
wing disc morphogenesis GO:0007472 344 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
defense response to bacterium GO:0042742 178 0.014
antimicrobial humoral response GO:0019730 99 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
cellular protein catabolic process GO:0044257 83 0.014
regulation of cell differentiation GO:0045595 302 0.013
protein catabolic process GO:0030163 101 0.013
negative regulation of rna biosynthetic process GO:1902679 240 0.013
chromatin remodeling GO:0006338 72 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
regulation of phosphorus metabolic process GO:0051174 210 0.013
regulation of microtubule based process GO:0032886 49 0.013
synapse organization GO:0050808 196 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.013
negative regulation of organelle organization GO:0010639 56 0.013
cell cycle phase transition GO:0044770 140 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
cytoplasmic transport GO:0016482 130 0.013
endocytosis GO:0006897 310 0.013
nucleotide catabolic process GO:0009166 109 0.013
positive regulation of cell death GO:0010942 69 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
regulation of epithelial cell differentiation GO:0030856 4 0.012
positive regulation of apoptotic signaling pathway GO:2001235 4 0.012
negative regulation of cell cycle process GO:0010948 109 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
establishment of localization in cell GO:0051649 402 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
negative regulation of cell cycle phase transition GO:1901988 103 0.012
maintenance of location GO:0051235 73 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
gland morphogenesis GO:0022612 145 0.012
single organism membrane organization GO:0044802 93 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
exocrine system development GO:0035272 162 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
mitotic spindle organization GO:0007052 220 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
regulation of cell projection organization GO:0031344 92 0.011
metal ion transport GO:0030001 74 0.011
positive regulation of transport GO:0051050 92 0.011
cellular lipid metabolic process GO:0044255 83 0.011
purine nucleotide catabolic process GO:0006195 109 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
cellular homeostasis GO:0019725 80 0.011
regulation of synapse organization GO:0050807 110 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
positive regulation of nucleoside metabolic process GO:0045979 47 0.011
forebrain development GO:0030900 2 0.011
response to other organism GO:0051707 293 0.011
purine nucleoside monophosphate metabolic process GO:0009126 50 0.011
negative regulation of proteolysis GO:0045861 31 0.011
inorganic ion transmembrane transport GO:0098660 73 0.011
salivary gland development GO:0007431 162 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
positive regulation of apoptotic process GO:0043065 47 0.011
response to nutrient levels GO:0031667 114 0.011
imaginal disc derived appendage morphogenesis GO:0035114 395 0.011
cell migration GO:0016477 238 0.011
salivary gland morphogenesis GO:0007435 145 0.011
regulation of cell development GO:0060284 215 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
segmentation GO:0035282 207 0.011
appendage morphogenesis GO:0035107 397 0.011
axonogenesis GO:0007409 290 0.011
response to oxygen containing compound GO:1901700 200 0.011
larval development GO:0002164 104 0.010
positive regulation of cell motility GO:2000147 3 0.010
telencephalon development GO:0021537 2 0.010
positive regulation of catabolic process GO:0009896 105 0.010
phosphorylation GO:0016310 294 0.010
immune response GO:0006955 246 0.010
post embryonic appendage morphogenesis GO:0035120 385 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.010
intrinsic apoptotic signaling pathway GO:0097193 16 0.010
nitrogen compound transport GO:0071705 85 0.010
single organism carbohydrate metabolic process GO:0044723 72 0.010
kidney development GO:0001822 3 0.010
negative regulation of apoptotic process GO:0043066 63 0.010

topi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.019
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.010