Drosophila melanogaster

49 known processes

PGRP-LE (Dmel_CG8995)

Peptidoglycan recognition protein LE

(Aliases: PGRP,anon-WO0153538.66,Dmel\CG8995,CG8995)

PGRP-LE biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune response GO:0006955 246 0.528
chitin based cuticle sclerotization GO:0007593 19 0.402
response to other organism GO:0051707 293 0.257
regulation of chitin based cuticle tanning GO:0007564 14 0.225
adult chitin containing cuticle pigmentation GO:0048085 16 0.210
muscle structure development GO:0061061 224 0.190
regulation of endopeptidase activity GO:0052548 36 0.173
defense response GO:0006952 300 0.165
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.150
Fly
catabolic process GO:0009056 409 0.147
Fly
developmental pigmentation GO:0048066 68 0.133
response to inorganic substance GO:0010035 44 0.130
regulation of cuticle pigmentation GO:0048079 16 0.129
response to external biotic stimulus GO:0043207 293 0.128
humoral immune response GO:0006959 117 0.122
Fly
antibacterial humoral response GO:0019731 44 0.113
Fly
regulation of response to stress GO:0080134 200 0.110
regulation of immune response GO:0050776 118 0.109
regulation of multi organism process GO:0043900 131 0.104
Fly
neurological system process GO:0050877 358 0.103
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.102
cellular response to dna damage stimulus GO:0006974 223 0.102
response to oxygen containing compound GO:1901700 200 0.100
Fly
response to biotic stimulus GO:0009607 294 0.099
peptide metabolic process GO:0006518 80 0.096
Fly
cuticle pigmentation GO:0048067 22 0.094
innate immune response GO:0045087 144 0.093
response to bacterium GO:0009617 198 0.093
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.092
metal ion transport GO:0030001 74 0.091
positive regulation of macromolecule metabolic process GO:0010604 405 0.091
molting cycle chitin based cuticle GO:0007591 56 0.090
regulation of cellular localization GO:0060341 136 0.090
regulation of defense response to virus by host GO:0050691 10 0.090
transmembrane transport GO:0055085 139 0.088
positive regulation of response to stimulus GO:0048584 323 0.088
spermatogenesis GO:0007283 200 0.085
organic substance catabolic process GO:1901575 308 0.084
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.083
regulation of response to external stimulus GO:0032101 115 0.083
Fly
vesicle mediated transport GO:0016192 381 0.082
response to abiotic stimulus GO:0009628 341 0.081
regulation of transport GO:0051049 181 0.080
response to organonitrogen compound GO:0010243 75 0.080
Fly
defense response to bacterium GO:0042742 178 0.080
defense response to gram negative bacterium GO:0050829 94 0.079
Fly
cell proliferation GO:0008283 299 0.075
positive regulation of signal transduction GO:0009967 223 0.075
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.075
Fly
negative regulation of gene expression GO:0010629 387 0.074
positive regulation of cellular biosynthetic process GO:0031328 316 0.073
Fly
positive regulation of biosynthetic process GO:0009891 316 0.072
Fly
developmental maturation GO:0021700 172 0.071
oocyte axis specification GO:0007309 108 0.070
intracellular signal transduction GO:0035556 300 0.070
Fly
positive regulation of gene expression GO:0010628 290 0.069
cellular component assembly involved in morphogenesis GO:0010927 151 0.068
molting cycle process GO:0022404 29 0.067
chromosome organization GO:0051276 360 0.067
regionalization GO:0003002 416 0.066
ion transport GO:0006811 145 0.065
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.064
organonitrogen compound biosynthetic process GO:1901566 117 0.064
Fly
positive regulation of transcription dna templated GO:0045893 266 0.063
endocytosis GO:0006897 310 0.063
pigmentation GO:0043473 75 0.061
response to starvation GO:0042594 97 0.060
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.060
regulation of protein metabolic process GO:0051246 256 0.059
programmed cell death GO:0012501 257 0.056
positive regulation of cell communication GO:0010647 250 0.055
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.055
Fly
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.054
Fly
single organism biosynthetic process GO:0044711 206 0.054
protein localization to nucleus GO:0034504 55 0.054
intracellular transport GO:0046907 228 0.054
regulation of cysteine type endopeptidase activity GO:2000116 27 0.054
cation transport GO:0006812 110 0.054
dna integrity checkpoint GO:0031570 81 0.053
positive regulation of rna metabolic process GO:0051254 271 0.053
regulation of immune effector process GO:0002697 52 0.053
Fly
wing disc morphogenesis GO:0007472 344 0.053
regulation of proteolysis GO:0030162 87 0.053
cation transmembrane transport GO:0098655 88 0.052
negative regulation of cellular metabolic process GO:0031324 382 0.051
Fly
spermatid differentiation GO:0048515 114 0.051
cell death GO:0008219 279 0.051
phagocytosis GO:0006909 215 0.049
regulation of humoral immune response GO:0002920 51 0.049
Fly
positive regulation of defense response to virus by host GO:0002230 10 0.048
nuclear import GO:0051170 51 0.048
regulation of catalytic activity GO:0050790 185 0.048
cell division GO:0051301 248 0.047
apoptotic process GO:0006915 159 0.047
response to organic substance GO:0010033 284 0.047
Fly
regulation of localization GO:0032879 275 0.047
establishment of localization in cell GO:0051649 402 0.047
positive regulation of signaling GO:0023056 243 0.046
small molecule metabolic process GO:0044281 305 0.046
male gamete generation GO:0048232 201 0.045
regulation of peptidase activity GO:0052547 39 0.045
regulation of innate immune response GO:0045088 71 0.045
death GO:0016265 284 0.043
proteolysis GO:0006508 192 0.043
response to extracellular stimulus GO:0009991 116 0.042
regulation of intracellular protein transport GO:0033157 46 0.042
nuclear division GO:0000280 332 0.042
antimicrobial humoral response GO:0019730 99 0.042
Fly
single organism nuclear import GO:1902593 51 0.042
regulation of response to biotic stimulus GO:0002831 63 0.041
Fly
regulation of programmed cell death GO:0043067 152 0.041
positive regulation of programmed cell death GO:0043068 62 0.041
regulation of multicellular organismal development GO:2000026 414 0.041
single organism behavior GO:0044708 391 0.040
regulation of cytoplasmic transport GO:1903649 47 0.040
regulation of cellular protein metabolic process GO:0032268 243 0.040
immune system process GO:0002376 347 0.040
molting cycle GO:0042303 56 0.039
response to nutrient levels GO:0031667 114 0.039
regulation of production of molecular mediator of immune response GO:0002700 44 0.039
Fly
oocyte construction GO:0007308 112 0.038
regulation of apoptotic process GO:0042981 130 0.038
positive regulation of nucleic acid templated transcription GO:1903508 266 0.038
translation GO:0006412 69 0.037
sensory organ morphogenesis GO:0090596 260 0.037
protein localization GO:0008104 284 0.037
regulation of cell cycle GO:0051726 291 0.037
regulation of immune system process GO:0002682 176 0.036
open tracheal system development GO:0007424 204 0.036
regulation of defense response to bacterium GO:1900424 30 0.036
Fly
regulation of protein import into nucleus GO:0042306 28 0.036
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.036
post embryonic appendage morphogenesis GO:0035120 385 0.036
positive regulation of phosphate metabolic process GO:0045937 139 0.035
positive regulation of endopeptidase activity GO:0010950 26 0.035
imaginal disc derived appendage development GO:0048737 399 0.035
cell migration GO:0016477 238 0.035
regulation of antimicrobial humoral response GO:0002759 50 0.035
Fly
positive regulation of peptidase activity GO:0010952 29 0.034
spermatid development GO:0007286 98 0.034
regulation of cell death GO:0010941 173 0.034
organelle fission GO:0048285 340 0.034
muscle cell differentiation GO:0042692 103 0.033
ion transmembrane transport GO:0034220 122 0.033
negative regulation of cell cycle GO:0045786 116 0.033
regulation of cell cycle process GO:0010564 181 0.033
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.033
positive regulation of protein metabolic process GO:0051247 128 0.032
cell cycle checkpoint GO:0000075 95 0.032
regulation of defense response to virus GO:0050688 14 0.032
regulation of cellular response to stress GO:0080135 89 0.032
Fly
single organism cellular localization GO:1902580 180 0.032
negative regulation of cellular protein metabolic process GO:0032269 85 0.032
negative regulation of response to stimulus GO:0048585 258 0.031
Fly
protein processing GO:0016485 68 0.031
phosphorylation GO:0016310 294 0.031
Fly
appendage morphogenesis GO:0035107 397 0.031
response to hydrogen peroxide GO:0042542 11 0.031
positive regulation of protein import into nucleus GO:0042307 21 0.031
defense response to other organism GO:0098542 225 0.031
dna metabolic process GO:0006259 227 0.031
single organism intracellular transport GO:1902582 207 0.031
appendage development GO:0048736 401 0.030
eye morphogenesis GO:0048592 260 0.030
cytoplasmic transport GO:0016482 130 0.030
negative regulation of protein metabolic process GO:0051248 85 0.030
protein modification process GO:0036211 438 0.030
positive regulation of response to external stimulus GO:0032103 44 0.030
Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.030
cell maturation GO:0048469 144 0.030
regulation of phosphorus metabolic process GO:0051174 210 0.029
Fly
positive regulation of humoral immune response GO:0002922 28 0.029
Fly
response to temperature stimulus GO:0009266 106 0.029
regulation of nucleocytoplasmic transport GO:0046822 35 0.029
response to metal ion GO:0010038 23 0.029
regulation of system process GO:0044057 36 0.029
antimicrobial peptide biosynthetic process GO:0002777 38 0.029
Fly
muscle organ development GO:0007517 127 0.029
negative regulation of developmental process GO:0051093 201 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
Fly
response to oxygen radical GO:0000305 3 0.029
organic substance transport GO:0071702 257 0.029
Fly
forebrain development GO:0030900 2 0.028
actin cytoskeleton organization GO:0030036 206 0.028
positive regulation of antibacterial peptide production GO:0002803 20 0.027
Fly
cellular response to chemical stimulus GO:0070887 199 0.027
Fly
eggshell formation GO:0030703 105 0.027
imaginal disc derived wing morphogenesis GO:0007476 337 0.027
imaginal disc derived appendage morphogenesis GO:0035114 395 0.027
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.027
chromatin remodeling GO:0006338 72 0.026
positive regulation of protein transport GO:0051222 37 0.026
regulation of developmental pigmentation GO:0048070 24 0.026
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.026
positive regulation of antimicrobial humoral response GO:0002760 28 0.026
Fly
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.026
response to glucose GO:0009749 2 0.025
regulation of intracellular transport GO:0032386 64 0.024
negative regulation of cellular biosynthetic process GO:0031327 277 0.024
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
cellular catabolic process GO:0044248 372 0.024
striated muscle cell differentiation GO:0051146 90 0.024
nitrogen compound transport GO:0071705 85 0.024
Fly
digestive tract morphogenesis GO:0048546 127 0.024
positive regulation of cell death GO:0010942 69 0.023
genital disc development GO:0035215 44 0.023
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.023
necrotic cell death GO:0070265 1 0.023
connective tissue development GO:0061448 3 0.023
response to organophosphorus GO:0046683 2 0.023
response to radiation GO:0009314 155 0.023
eye development GO:0001654 323 0.023
positive regulation of apoptotic process GO:0043065 47 0.023
cuticle development GO:0042335 86 0.022
positive regulation of immune response GO:0050778 63 0.022
regulation of anatomical structure size GO:0090066 163 0.022
myotube cell development GO:0014904 3 0.022
antimicrobial peptide production GO:0002775 46 0.022
Fly
regulation of antibacterial peptide production GO:0002786 22 0.022
Fly
immune effector process GO:0002252 98 0.022
Fly
central nervous system development GO:0007417 201 0.022
positive regulation of protein localization to nucleus GO:1900182 21 0.022
negative regulation of biosynthetic process GO:0009890 277 0.021
organophosphate catabolic process GO:0046434 112 0.021
regulation of protein transport GO:0051223 57 0.021
telencephalon development GO:0021537 2 0.021
chromatin organization GO:0006325 207 0.021
actin filament based process GO:0030029 220 0.021
respiratory system development GO:0060541 213 0.021
negative regulation of mitotic cell cycle GO:0045930 109 0.021
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.021
Fly
positive regulation of response to biotic stimulus GO:0002833 31 0.021
Fly
protein targeting to nucleus GO:0044744 51 0.021
response to monosaccharide GO:0034284 4 0.021
protein import GO:0017038 55 0.021
negative regulation of cell differentiation GO:0045596 143 0.021
organonitrogen compound catabolic process GO:1901565 128 0.021
Fly
single organism catabolic process GO:0044712 228 0.021
positive regulation of antimicrobial peptide production GO:0002225 28 0.021
Fly
secondary metabolic process GO:0019748 75 0.021
Fly
response to light stimulus GO:0009416 124 0.020
muscle cell development GO:0055001 50 0.020
positive regulation of intracellular transport GO:0032388 42 0.020
regulation of defense response GO:0031347 102 0.020
regulation of cellular component size GO:0032535 98 0.020
positive regulation of multi organism process GO:0043902 40 0.020
Fly
cellular response to extracellular stimulus GO:0031668 64 0.020
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
epithelial cell differentiation GO:0030855 322 0.020
lipid biosynthetic process GO:0008610 46 0.020
carboxylic acid metabolic process GO:0019752 92 0.020
stem cell differentiation GO:0048863 117 0.020
mitotic spindle organization GO:0007052 220 0.019
protein catabolic process GO:0030163 101 0.019
oocyte development GO:0048599 124 0.019
regulation of antimicrobial peptide production GO:0002784 44 0.019
Fly
segmentation GO:0035282 207 0.019
mitotic nuclear division GO:0007067 213 0.019
regulation of protein localization GO:0032880 76 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
membrane organization GO:0061024 112 0.019
compound eye development GO:0048749 307 0.019
regulation of protein localization to nucleus GO:1900180 29 0.019
organophosphate metabolic process GO:0019637 195 0.019
germ line stem cell maintenance GO:0030718 50 0.019
regulation of establishment of protein localization GO:0070201 61 0.019
embryonic morphogenesis GO:0048598 206 0.019
cellular response to oxidative stress GO:0034599 28 0.018
cellular amino acid metabolic process GO:0006520 61 0.018
cellular protein modification process GO:0006464 438 0.018
g2 dna damage checkpoint GO:0031572 69 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
extrinsic apoptotic signaling pathway GO:0097191 1 0.018
cellular response to molecule of bacterial origin GO:0071219 3 0.018
Fly
synaptic transmission GO:0007268 288 0.018
protein transport GO:0015031 155 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
Fly
striated muscle cell development GO:0055002 50 0.018
protein maturation GO:0051604 71 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
response to nitrogen compound GO:1901698 90 0.018
Fly
protein import into nucleus GO:0006606 51 0.018
eggshell chorion assembly GO:0007306 66 0.017
protein modification by small protein conjugation or removal GO:0070647 106 0.017
response to copper ion GO:0046688 4 0.017
response to oxidative stress GO:0006979 86 0.017
blastoderm segmentation GO:0007350 159 0.017
cellular response to oxygen containing compound GO:1901701 79 0.017
Fly
stress activated protein kinase signaling cascade GO:0031098 55 0.017
Fly
negative regulation of apoptotic process GO:0043066 63 0.017
positive regulation of intracellular protein transport GO:0090316 30 0.017
dendrite morphogenesis GO:0048813 199 0.017
negative regulation of transcription dna templated GO:0045892 237 0.017
maternal determination of anterior posterior axis embryo GO:0008358 74 0.017
head development GO:0060322 135 0.017
intracellular protein transport GO:0006886 104 0.017
regulation of autophagy GO:0010506 62 0.017
columnar cuboidal epithelial cell development GO:0002066 249 0.017
response to lipopolysaccharide GO:0032496 4 0.016
Fly
amide biosynthetic process GO:0043604 42 0.016
Fly
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
dorsal appendage formation GO:0046843 47 0.016
nucleoside triphosphate catabolic process GO:0009143 108 0.016
nuclear transport GO:0051169 72 0.016
response to lipid GO:0033993 38 0.016
Fly
compound eye morphogenesis GO:0001745 249 0.016
protein complex assembly GO:0006461 200 0.016
cognition GO:0050890 141 0.016
peptide biosynthetic process GO:0043043 42 0.016
Fly
response to hexose GO:0009746 3 0.016
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.016
organic acid metabolic process GO:0006082 103 0.016
wound healing GO:0042060 75 0.016
homeostatic process GO:0042592 199 0.015
protein phosphorylation GO:0006468 169 0.015
regulation of hydrolase activity GO:0051336 97 0.015
chromatin modification GO:0016568 147 0.015
heterocycle catabolic process GO:0046700 166 0.015
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.015
negative regulation of cell death GO:0060548 81 0.015
stem cell maintenance GO:0019827 67 0.015
regulation of mapk cascade GO:0043408 92 0.015
Fly
lateral inhibition GO:0046331 206 0.015
digestive tract development GO:0048565 149 0.015
cell type specific apoptotic process GO:0097285 38 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
response to peptide GO:1901652 29 0.015
gene silencing GO:0016458 138 0.015
negative regulation of signaling GO:0023057 219 0.014
Fly
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.014
Fly
carbohydrate metabolic process GO:0005975 82 0.014
positive regulation of proteolysis GO:0045862 52 0.014
response to superoxide GO:0000303 3 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
establishment of protein localization GO:0045184 163 0.014
spindle organization GO:0007051 253 0.014
regulation of protein processing GO:0070613 32 0.014
negative regulation of immune system process GO:0002683 50 0.014
Fly
cellular amide metabolic process GO:0043603 80 0.014
Fly
response to organic cyclic compound GO:0014070 89 0.014
negative regulation of immune response GO:0050777 39 0.014
Fly
signal transduction in response to dna damage GO:0042770 3 0.014
response to reactive oxygen species GO:0000302 24 0.014
response to wounding GO:0009611 94 0.014
negative regulation of innate immune response GO:0045824 30 0.014
Fly
regulation of protein targeting GO:1903533 29 0.014
cell aging GO:0007569 2 0.014
organ or tissue specific immune response GO:0002251 10 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
embryonic pattern specification GO:0009880 174 0.014
apoptotic signaling pathway GO:0097190 27 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
positive regulation of transport GO:0051050 92 0.013
epiboly involved in wound healing GO:0090505 2 0.013
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.013
Fly
negative regulation of growth GO:0045926 84 0.013
cellular response to arsenic containing substance GO:0071243 6 0.013
protein modification by small protein conjugation GO:0032446 79 0.013
positive regulation of cell motility GO:2000147 3 0.013
gonad development GO:0008406 50 0.013
cellular response to organic substance GO:0071310 132 0.013
Fly
regulation of mrna splicing via spliceosome GO:0048024 64 0.013
modification dependent protein catabolic process GO:0019941 78 0.013
antibacterial peptide production GO:0002778 22 0.013
Fly
regulation of cell differentiation GO:0045595 302 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
endoderm formation GO:0001706 3 0.013
establishment or maintenance of cell polarity GO:0007163 167 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
digestive system development GO:0055123 149 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
Fly
response to endogenous stimulus GO:0009719 119 0.013
Fly
cellular response to peptide hormone stimulus GO:0071375 28 0.013
macromolecule catabolic process GO:0009057 161 0.013
Fly
negative regulation of rna metabolic process GO:0051253 251 0.013
cellular response to nutrient levels GO:0031669 62 0.013
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.013
Fly
regulation of cell size GO:0008361 63 0.013
pole plasm assembly GO:0007315 61 0.013
glycosyl compound catabolic process GO:1901658 112 0.013
salivary gland cell autophagic cell death GO:0035071 83 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
stress activated mapk cascade GO:0051403 52 0.013
Fly
negative regulation of programmed cell death GO:0043069 72 0.013
ovarian follicle cell development GO:0030707 248 0.012
organic hydroxy compound metabolic process GO:1901615 83 0.012
Fly
cellular macromolecule localization GO:0070727 220 0.012
negative regulation of proteolysis GO:0045861 31 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
Fly
female gonad development GO:0008585 12 0.012
regulation of vesicle mediated transport GO:0060627 59 0.012
tube morphogenesis GO:0035239 191 0.012
regulation of behavior GO:0050795 75 0.012
anterior posterior axis specification GO:0009948 109 0.012
positive regulation of cell migration GO:0030335 2 0.012
dna damage checkpoint GO:0000077 78 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
epithelial cell development GO:0002064 274 0.012
collateral sprouting of injured axon GO:0048674 3 0.012
cellular homeostasis GO:0019725 80 0.012
protein targeting GO:0006605 64 0.012
inorganic ion transmembrane transport GO:0098660 73 0.012
lipid metabolic process GO:0006629 121 0.012
salivary gland development GO:0007431 162 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
pigment metabolic process GO:0042440 84 0.012
Fly
peptidyl amino acid modification GO:0018193 105 0.012
camera type eye development GO:0043010 4 0.012
ion homeostasis GO:0050801 55 0.011
hormone catabolic process GO:0042447 3 0.011
regulation of rna splicing GO:0043484 69 0.011
reactive oxygen species metabolic process GO:0072593 22 0.011
skeletal muscle fiber development GO:0048741 3 0.011
regulation of translation GO:0006417 56 0.011
mapk cascade GO:0000165 107 0.011
Fly
atp metabolic process GO:0046034 49 0.011
dna dependent dna replication GO:0006261 17 0.011
tissue morphogenesis GO:0048729 297 0.011
localization of cell GO:0051674 257 0.011
cellular chemical homeostasis GO:0055082 40 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
regulation of catabolic process GO:0009894 170 0.011
dendrite development GO:0016358 204 0.011
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.011
pattern recognition receptor signaling pathway GO:0002221 2 0.011
Fly
androgen metabolic process GO:0008209 1 0.011
protein ubiquitination GO:0016567 70 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.011
transition metal ion transport GO:0000041 16 0.011
establishment of protein localization to organelle GO:0072594 62 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
regulation of molecular function GO:0065009 217 0.011
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.011
organelle assembly GO:0070925 198 0.011
positive regulation of cellular amide metabolic process GO:0034250 26 0.011
Fly
regulation of mitotic cell cycle GO:0007346 190 0.011
reproductive structure development GO:0048608 74 0.011
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.011
i kappab phosphorylation GO:0007252 3 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
negative regulation of protein processing GO:0010955 31 0.011
cellular ketone metabolic process GO:0042180 24 0.011
negative regulation of rna biosynthetic process GO:1902679 240 0.011
positive regulation of defense response GO:0031349 59 0.010
morphogenesis of an epithelium GO:0002009 276 0.010
positive regulation of phosphorylation GO:0042327 87 0.010
purine containing compound metabolic process GO:0072521 155 0.010
chromosome segregation GO:0007059 157 0.010
cell cycle arrest GO:0007050 4 0.010
positive regulation of apoptotic signaling pathway GO:2001235 4 0.010
adult behavior GO:0030534 137 0.010
negative regulation of catalytic activity GO:0043086 42 0.010
single organism carbohydrate metabolic process GO:0044723 72 0.010
regulation of phosphorylation GO:0042325 147 0.010
Fly
cellular lipid metabolic process GO:0044255 83 0.010
protein heterooligomerization GO:0051291 4 0.010
asymmetric cell division GO:0008356 37 0.010

PGRP-LE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.045
disease of cellular proliferation DOID:14566 0 0.019
cancer DOID:162 0 0.019
central nervous system disease DOID:331 0 0.010
nervous system disease DOID:863 0 0.010