Drosophila melanogaster

77 known processes

Scm (Dmel_CG9495)

Sex comb on midleg

(Aliases: SCM,scm,Dmel\CG9495,CG9495,Su(z)302,l(3)85Ef)

Scm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of rna metabolic process GO:0051253 251 0.998
chromosome organization GO:0051276 360 0.994
Mouse
chromatin silencing GO:0006342 76 0.986
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.977
chromatin organization GO:0006325 207 0.976
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.976
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.968
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.962
negative regulation of cellular biosynthetic process GO:0031327 277 0.962
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.961
negative regulation of gene expression epigenetic GO:0045814 77 0.961
negative regulation of transcription dna templated GO:0045892 237 0.957
negative regulation of nucleic acid templated transcription GO:1903507 240 0.945
regulation of gene expression epigenetic GO:0040029 128 0.938
negative regulation of rna biosynthetic process GO:1902679 240 0.915
negative regulation of cellular metabolic process GO:0031324 382 0.799
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.795
positive regulation of biosynthetic process GO:0009891 316 0.794
covalent chromatin modification GO:0016569 106 0.790
chromatin modification GO:0016568 147 0.732
Mouse
gene silencing GO:0016458 138 0.705
histone modification GO:0016570 106 0.704
dna metabolic process GO:0006259 227 0.684
chemotaxis GO:0006935 249 0.663
imaginal disc derived wing morphogenesis GO:0007476 337 0.655
positive regulation of rna metabolic process GO:0051254 271 0.648
negative regulation of gene expression GO:0010629 387 0.617
regulation of cell differentiation GO:0045595 302 0.582
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.578
taxis GO:0042330 304 0.577
death GO:0016265 284 0.545
imaginal disc derived appendage development GO:0048737 399 0.479
neurological system process GO:0050877 358 0.479
neuron projection guidance GO:0097485 241 0.477
transcription from rna polymerase ii promoter GO:0006366 368 0.457
ovarian follicle cell development GO:0030707 248 0.382
germ line cyst encapsulation GO:0048138 8 0.367
ovarian follicle cell stalk formation GO:0030713 17 0.351
regulation of cell death GO:0010941 173 0.347
mitotic cell cycle embryonic GO:0045448 38 0.320
imaginal disc derived appendage morphogenesis GO:0035114 395 0.313
peptidyl lysine modification GO:0018205 57 0.310
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.306
internal peptidyl lysine acetylation GO:0018393 38 0.304
protein modification by small protein conjugation or removal GO:0070647 106 0.303
internal protein amino acid acetylation GO:0006475 38 0.300
protein modification process GO:0036211 438 0.279
wing disc morphogenesis GO:0007472 344 0.279
positive regulation of cellular biosynthetic process GO:0031328 316 0.268
negative regulation of response to stimulus GO:0048585 258 0.257
regulation of response to gamma radiation GO:2001228 4 0.253
blastoderm segmentation GO:0007350 159 0.252
histone h3 k27 methylation GO:0070734 6 0.242
positive regulation of transcription dna templated GO:0045893 266 0.235
anterior posterior pattern specification GO:0009952 136 0.226
Mouse
positive regulation of gene expression GO:0010628 290 0.225
sensory organ morphogenesis GO:0090596 260 0.225
programmed cell death GO:0012501 257 0.223
histone acetylation GO:0016573 38 0.222
protein acetylation GO:0006473 39 0.203
dendrite development GO:0016358 204 0.197
axon guidance GO:0007411 233 0.197
axonogenesis GO:0007409 290 0.194
chromatin mediated maintenance of transcription GO:0048096 7 0.193
negative regulation of response to gamma radiation GO:2001229 4 0.192
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.190
appendage development GO:0048736 401 0.189
regulation of cell morphogenesis GO:0022604 163 0.186
segmentation GO:0035282 207 0.184
stem cell differentiation GO:0048863 117 0.177
positive regulation of cellular component organization GO:0051130 156 0.173
dendrite morphogenesis GO:0048813 199 0.167
positive regulation of macromolecule metabolic process GO:0010604 405 0.166
eggshell chorion assembly GO:0007306 66 0.163
response to abiotic stimulus GO:0009628 341 0.163
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.152
chromatin remodeling GO:0006338 72 0.151
Mouse
tripartite regional subdivision GO:0007351 103 0.151
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.143
negative regulation of cell differentiation GO:0045596 143 0.139
appendage morphogenesis GO:0035107 397 0.133
apoptotic process GO:0006915 159 0.133
male gamete generation GO:0048232 201 0.130
Mouse
meiotic nuclear division GO:0007126 151 0.129
positive regulation of rna biosynthetic process GO:1902680 266 0.124
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.123
negative regulation of developmental process GO:0051093 201 0.122
regulation of response to biotic stimulus GO:0002831 63 0.121
regulation of nervous system development GO:0051960 248 0.108
peptidyl lysine acetylation GO:0018394 39 0.107
response to oxygen containing compound GO:1901700 200 0.107
post embryonic appendage morphogenesis GO:0035120 385 0.105
trunk segmentation GO:0035290 8 0.102
regulation of neurogenesis GO:0050767 158 0.102
histone ubiquitination GO:0016574 4 0.097
germarium derived female germ line cyst encapsulation GO:0030708 8 0.097
cell motility GO:0048870 251 0.096
regulation of protein metabolic process GO:0051246 256 0.091
peptidyl amino acid modification GO:0018193 105 0.088
regulation of cell development GO:0060284 215 0.088
regulation of anatomical structure morphogenesis GO:0022603 242 0.086
specification of segmental identity trunk GO:0035292 7 0.085
regulation of chromatin silencing GO:0031935 36 0.084
periodic partitioning GO:0007365 29 0.084
germ line stem cell division GO:0042078 25 0.082
immune system process GO:0002376 347 0.082
dendrite guidance GO:0070983 21 0.080
regulation of response to external stimulus GO:0032101 115 0.078
embryonic pattern specification GO:0009880 174 0.078
renal tubule development GO:0061326 64 0.078
leg disc morphogenesis GO:0007478 80 0.076
cell migration GO:0016477 238 0.076
negative regulation of chromatin silencing GO:0031936 9 0.072
torso signaling pathway GO:0008293 21 0.070
regulation of apoptotic process GO:0042981 130 0.070
dna methylation GO:0006306 4 0.069
embryonic hemopoiesis GO:0035162 26 0.068
regulation of tube diameter GO:0035296 14 0.067
regulation of multicellular organismal development GO:2000026 414 0.067
cuticle development GO:0042335 86 0.066
regulation of developmental growth GO:0048638 174 0.066
muscle organ development GO:0007517 127 0.065
single organism biosynthetic process GO:0044711 206 0.065
courtship behavior GO:0007619 68 0.064
chitin based cuticle development GO:0040003 49 0.064
protein acylation GO:0043543 42 0.064
regulation of cuticle pigmentation GO:0048079 16 0.063
localization of cell GO:0051674 257 0.062
eggshell formation GO:0030703 105 0.062
chromatin assembly GO:0031497 48 0.061
eye development GO:0001654 323 0.061
response to lipid GO:0033993 38 0.060
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.059
establishment of localization in cell GO:0051649 402 0.059
positive regulation of cellular protein metabolic process GO:0032270 118 0.058
cell maturation GO:0048469 144 0.057
negative regulation of signal transduction GO:0009968 206 0.057
regulation of dendrite morphogenesis GO:0048814 28 0.056
positive regulation of response to external stimulus GO:0032103 44 0.055
mushroom body development GO:0016319 70 0.055
posttranscriptional regulation of gene expression GO:0010608 145 0.055
small molecule metabolic process GO:0044281 305 0.053
positive regulation of developmental process GO:0051094 143 0.053
regulation of gene silencing GO:0060968 63 0.052
eye photoreceptor cell differentiation GO:0001754 145 0.052
macromolecular complex assembly GO:0065003 256 0.051
cell death GO:0008219 279 0.051
protein ubiquitination GO:0016567 70 0.051
cellular protein modification process GO:0006464 438 0.051
negative regulation of nervous system development GO:0051961 92 0.050
organic substance catabolic process GO:1901575 308 0.050
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.050
heart development GO:0007507 82 0.050
negative regulation of developmental growth GO:0048640 64 0.049
endocytosis GO:0006897 310 0.048
larval development GO:0002164 104 0.047
positive regulation of gene expression epigenetic GO:0045815 16 0.047
regulation of cellular component biogenesis GO:0044087 201 0.047
cellular response to dna damage stimulus GO:0006974 223 0.046
protein modification by small protein conjugation GO:0032446 79 0.046
cellular response to abiotic stimulus GO:0071214 58 0.046
cellular response to oxygen containing compound GO:1901701 79 0.045
hematopoietic or lymphoid organ development GO:0048534 57 0.045
regulation of cellular protein metabolic process GO:0032268 243 0.045
regionalization GO:0003002 416 0.045
Mouse
tube development GO:0035295 244 0.044
histone h4 k16 acetylation GO:0043984 4 0.044
negative regulation of neural precursor cell proliferation GO:2000178 27 0.044
digestive tract morphogenesis GO:0048546 127 0.044
epithelial cell development GO:0002064 274 0.044
stem cell development GO:0048864 79 0.043
protein localization GO:0008104 284 0.043
axon development GO:0061564 297 0.043
negative regulation of growth GO:0045926 84 0.042
multi organism behavior GO:0051705 175 0.042
dna conformation change GO:0071103 105 0.041
regulation of cytoskeleton organization GO:0051493 89 0.040
terminal region determination GO:0007362 25 0.040
spermatid development GO:0007286 98 0.039
response to sterol GO:0036314 34 0.039
methylation GO:0032259 47 0.039
camera type eye morphogenesis GO:0048593 2 0.038
digestive tract development GO:0048565 149 0.037
immune system development GO:0002520 57 0.037
single organism behavior GO:0044708 391 0.037
response to ecdysone GO:0035075 34 0.036
embryonic organ development GO:0048568 50 0.036
regulation of chromosome organization GO:0033044 64 0.036
regulation of programmed cell death GO:0043067 152 0.036
stem cell division GO:0017145 69 0.035
limb morphogenesis GO:0035108 1 0.035
development of primary sexual characteristics GO:0045137 50 0.035
positive regulation of nucleic acid templated transcription GO:1903508 266 0.035
cellular macromolecular complex assembly GO:0034622 153 0.035
neuroblast differentiation GO:0014016 29 0.034
regulation of cell cycle GO:0051726 291 0.034
chromatin assembly or disassembly GO:0006333 52 0.034
negative regulation of multicellular organismal process GO:0051241 142 0.034
segment polarity determination GO:0007367 25 0.034
posttranscriptional gene silencing GO:0016441 46 0.034
eye antennal disc morphogenesis GO:0007455 34 0.033
regulation of growth GO:0040008 233 0.033
eye morphogenesis GO:0048592 260 0.033
embryonic axis specification GO:0000578 107 0.032
protein complex biogenesis GO:0070271 201 0.032
locomotory behavior GO:0007626 176 0.032
posttranscriptional gene silencing by rna GO:0035194 45 0.032
morphogenesis of an epithelium GO:0002009 276 0.032
muscle cell differentiation GO:0042692 103 0.031
phosphorylation GO:0016310 294 0.031
intracellular receptor signaling pathway GO:0030522 19 0.030
epithelial cell migration GO:0010631 148 0.030
protein transport GO:0015031 155 0.030
compound eye photoreceptor cell differentiation GO:0001751 140 0.030
anterior posterior axis specification GO:0009948 109 0.029
limb development GO:0060173 1 0.029
chorion containing eggshell formation GO:0007304 105 0.029
determination of dorsal ventral asymmetry GO:0048262 3 0.029
cellular response to extracellular stimulus GO:0031668 64 0.028
compound eye development GO:0048749 307 0.028
ribonucleotide metabolic process GO:0009259 145 0.028
cellular macromolecule localization GO:0070727 220 0.028
regulation of mapk cascade GO:0043408 92 0.028
negative regulation of organelle organization GO:0010639 56 0.028
establishment of organelle localization GO:0051656 122 0.027
germ cell migration GO:0008354 43 0.027
salivary gland development GO:0007431 162 0.027
mating GO:0007618 120 0.026
defense response to other organism GO:0098542 225 0.026
positive regulation of dendrite morphogenesis GO:0050775 9 0.026
dna packaging GO:0006323 91 0.026
neuroblast fate commitment GO:0014017 19 0.026
cell division GO:0051301 248 0.025
protein localization to organelle GO:0033365 82 0.025
cellular response to chemical stimulus GO:0070887 199 0.025
body morphogenesis GO:0010171 2 0.025
gene silencing by rna GO:0031047 57 0.025
regulation of response to stress GO:0080134 200 0.025
mapk cascade GO:0000165 107 0.024
regulation of organelle organization GO:0033043 196 0.024
glycosyl compound catabolic process GO:1901658 112 0.024
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.024
regulation of synapse assembly GO:0051963 94 0.024
sterol homeostasis GO:0055092 4 0.023
camera type eye development GO:0043010 4 0.023
regulation of establishment of protein localization GO:0070201 61 0.023
columnar cuboidal epithelial cell development GO:0002066 249 0.023
regulation of cell cycle process GO:0010564 181 0.023
histone h4 acetylation GO:0043967 13 0.023
negative regulation of cell communication GO:0010648 223 0.023
regulation of histone h3 k27 methylation GO:0061085 3 0.023
positive regulation of protein metabolic process GO:0051247 128 0.023
nephron tubule development GO:0072080 3 0.022
imaginal disc derived female genitalia development GO:0007486 6 0.022
dna methylation or demethylation GO:0044728 4 0.022
positive regulation of response to stimulus GO:0048584 323 0.022
signal transduction by phosphorylation GO:0023014 107 0.022
salivary gland morphogenesis GO:0007435 145 0.022
apposition of dorsal and ventral imaginal disc derived wing surfaces GO:0007475 15 0.021
cellular component assembly involved in morphogenesis GO:0010927 151 0.021
axon midline choice point recognition GO:0016199 26 0.021
response to other organism GO:0051707 293 0.021
ovarian follicle cell migration GO:0007297 121 0.021
response to organic substance GO:0010033 284 0.021
regulation of phosphorylation GO:0042325 147 0.020
molting cycle chitin based cuticle GO:0007591 56 0.020
multicellular organismal aging GO:0010259 140 0.020
cell cycle phase transition GO:0044770 140 0.020
phagocytosis GO:0006909 215 0.020
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.020
dosage compensation GO:0007549 16 0.020
regulation of intracellular signal transduction GO:1902531 236 0.020
g1 s transition of mitotic cell cycle GO:0000082 31 0.020
axon choice point recognition GO:0016198 26 0.020
macromolecule methylation GO:0043414 45 0.019
gliogenesis GO:0042063 80 0.019
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.019
positive regulation of behavior GO:0048520 19 0.019
regulation of protein modification process GO:0031399 112 0.019
dna alkylation GO:0006305 4 0.019
negative regulation of hormone biosynthetic process GO:0032353 1 0.019
negative regulation of apoptotic process GO:0043066 63 0.019
oocyte axis specification GO:0007309 108 0.019
spermatogenesis GO:0007283 200 0.019
Mouse
eye photoreceptor cell development GO:0042462 81 0.019
regulation of molecular function GO:0065009 217 0.018
developmental maturation GO:0021700 172 0.018
cellular response to organic substance GO:0071310 132 0.018
male mating behavior GO:0060179 70 0.018
wound healing GO:0042060 75 0.018
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.018
molting cycle GO:0042303 56 0.018
regulation of cellular catabolic process GO:0031329 157 0.018
stem cell proliferation GO:0072089 88 0.017
ribonucleoside monophosphate catabolic process GO:0009158 39 0.017
response to ketone GO:1901654 34 0.017
protein phosphorylation GO:0006468 169 0.017
regulation of muscle cell differentiation GO:0051147 8 0.017
protein dna complex subunit organization GO:0071824 86 0.016
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.016
response to alcohol GO:0097305 95 0.016
protein targeting GO:0006605 64 0.016
regulation of cell shape GO:0008360 113 0.016
segment specification GO:0007379 33 0.016
anterior posterior axis specification embryo GO:0008595 103 0.016
sensory perception GO:0007600 196 0.016
multi organism reproductive behavior GO:0044705 121 0.016
negative regulation of cell cycle process GO:0010948 109 0.016
gene silencing by mirna GO:0035195 22 0.016
neuroblast development GO:0014019 13 0.016
regulation of phosphatase activity GO:0010921 3 0.015
leg disc development GO:0035218 92 0.015
organic substance transport GO:0071702 257 0.015
imaginal disc derived leg morphogenesis GO:0007480 80 0.015
positive regulation of multicellular organismal process GO:0051240 143 0.015
interspecies interaction between organisms GO:0044419 16 0.015
positive regulation of multi organism process GO:0043902 40 0.015
regulation of synapse organization GO:0050807 110 0.015
immune effector process GO:0002252 98 0.015
epithelial cell differentiation GO:0030855 322 0.015
oocyte development GO:0048599 124 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
retina development in camera type eye GO:0060041 4 0.015
lipid biosynthetic process GO:0008610 46 0.015
response to external biotic stimulus GO:0043207 293 0.015
regulation of behavior GO:0050795 75 0.015
reproductive behavior GO:0019098 122 0.014
response to biotic stimulus GO:0009607 294 0.014
intracellular signal transduction GO:0035556 300 0.014
reproductive system development GO:0061458 74 0.014
regulation of neuron projection development GO:0010975 69 0.014
regulation of protein localization to nucleus GO:1900180 29 0.014
skin development GO:0043588 65 0.014
positive regulation of protein modification process GO:0031401 58 0.014
positive regulation of neurogenesis GO:0050769 41 0.014
axis specification GO:0009798 167 0.014
regulation of immune system process GO:0002682 176 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.014
kidney epithelium development GO:0072073 3 0.013
outflow tract morphogenesis GO:0003151 4 0.013
photoreceptor cell development GO:0042461 96 0.013
regulation of malpighian tubule diameter GO:0035297 3 0.013
heart morphogenesis GO:0003007 32 0.013
stem cell maintenance GO:0019827 67 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
mesenchymal cell differentiation GO:0048762 1 0.013
regulation of dendrite development GO:0050773 37 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 15 0.013
male courtship behavior veined wing extension GO:0048065 22 0.013
sarcomere organization GO:0045214 26 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
somatic stem cell division GO:0048103 37 0.013
histone methylation GO:0016571 40 0.013
protein alkylation GO:0008213 43 0.013
aggressive behavior GO:0002118 63 0.013
oocyte differentiation GO:0009994 145 0.013
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
developmental growth GO:0048589 280 0.012
positive regulation of molecular function GO:0044093 136 0.012
gastrulation GO:0007369 70 0.012
organonitrogen compound metabolic process GO:1901564 318 0.012
regulation of neuron differentiation GO:0045664 103 0.012
dorsal trunk growth open tracheal system GO:0035001 7 0.012
positive regulation of cell proliferation GO:0008284 47 0.012
positive regulation of translation GO:0045727 12 0.012
neuron remodeling GO:0016322 29 0.012
dna integrity checkpoint GO:0031570 81 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.012
regulation of histone acetylation GO:0035065 7 0.012
embryonic hindgut morphogenesis GO:0048619 48 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.012
wnt signaling pathway GO:0016055 98 0.012
brain development GO:0007420 120 0.011
bmp signaling pathway GO:0030509 27 0.011
reproductive structure development GO:0048608 74 0.011
pigmentation GO:0043473 75 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
atp metabolic process GO:0046034 49 0.011
positive regulation of cell development GO:0010720 61 0.011
compound eye photoreceptor development GO:0042051 78 0.011
skeletal muscle organ development GO:0060538 48 0.011
chemosensory behavior GO:0007635 106 0.011
female sex differentiation GO:0046660 20 0.011
purine nucleoside monophosphate catabolic process GO:0009128 38 0.011
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.011
regulation of cell proliferation GO:0042127 163 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
histone h2a ubiquitination GO:0033522 2 0.011
synaptic transmission GO:0007268 288 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
male genitalia development GO:0030539 19 0.011
neuron recognition GO:0008038 101 0.010
peptidyl lysine methylation GO:0018022 16 0.010
cellular component disassembly GO:0022411 46 0.010
tube morphogenesis GO:0035239 191 0.010
nucleoside phosphate metabolic process GO:0006753 162 0.010
positive regulation of cell differentiation GO:0045597 64 0.010
nucleoside phosphate catabolic process GO:1901292 110 0.010
rna splicing GO:0008380 83 0.010
gonad morphogenesis GO:0035262 7 0.010
female gonad development GO:0008585 12 0.010
positive regulation of phosphorylation GO:0042327 87 0.010
meiotic cell cycle GO:0051321 171 0.010

Scm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.036
disease of cellular proliferation DOID:14566 0 0.036
organ system cancer DOID:0050686 0 0.036
disease of anatomical entity DOID:7 0 0.013