Drosophila melanogaster

5 known processes

Dhod (Dmel_CG9741)

Dihydroorotate dehydrogenase

(Aliases: l(3)s3512,DHOD,DHODH,CG9741,Dmel\CG9741,dhod)

Dhod biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.389
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.282
intracellular transport GO:0046907 228 0.235
single organism intracellular transport GO:1902582 207 0.229
protein localization GO:0008104 284 0.226
regulation of cellular protein metabolic process GO:0032268 243 0.214
cellular macromolecule localization GO:0070727 220 0.214
negative regulation of cellular metabolic process GO:0031324 382 0.204
imaginal disc derived appendage morphogenesis GO:0035114 395 0.184
cellular catabolic process GO:0044248 372 0.182
posttranscriptional regulation of gene expression GO:0010608 145 0.170
establishment of localization in cell GO:0051649 402 0.168
localization of cell GO:0051674 257 0.166
regulation of cell cycle phase transition GO:1901987 130 0.150
regulation of mitotic cell cycle GO:0007346 190 0.147
positive regulation of response to stimulus GO:0048584 323 0.142
cellular protein catabolic process GO:0044257 83 0.141
mitotic cell cycle checkpoint GO:0007093 88 0.131
cellular response to dna damage stimulus GO:0006974 223 0.126
endocytosis GO:0006897 310 0.125
regulation of translation GO:0006417 56 0.124
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.119
cellular protein modification process GO:0006464 438 0.111
intracellular protein transport GO:0006886 104 0.111
cell motility GO:0048870 251 0.109
enzyme linked receptor protein signaling pathway GO:0007167 179 0.109
protein modification by small protein conjugation or removal GO:0070647 106 0.105
cell migration GO:0016477 238 0.102
negative regulation of cell cycle GO:0045786 116 0.101
regulation of protein metabolic process GO:0051246 256 0.101
cellular macromolecule catabolic process GO:0044265 136 0.100
vesicle mediated transport GO:0016192 381 0.098
protein ubiquitination GO:0016567 70 0.096
organic substance transport GO:0071702 257 0.096
macromolecule catabolic process GO:0009057 161 0.092
protein modification process GO:0036211 438 0.089
cellular protein localization GO:0034613 160 0.087
cell cycle checkpoint GO:0000075 95 0.084
negative regulation of cell cycle process GO:0010948 109 0.082
apoptotic signaling pathway GO:0097190 27 0.082
protein transport GO:0015031 155 0.081
regulation of phosphate metabolic process GO:0019220 210 0.080
embryonic development via the syncytial blastoderm GO:0001700 148 0.080
regulation of localization GO:0032879 275 0.078
mitotic cell cycle phase transition GO:0044772 138 0.076
cell division GO:0051301 248 0.076
intracellular signal transduction GO:0035556 300 0.076
negative regulation of cell cycle phase transition GO:1901988 103 0.074
phagocytosis GO:0006909 215 0.071
positive regulation of macromolecule metabolic process GO:0010604 405 0.071
imaginal disc derived appendage development GO:0048737 399 0.069
negative regulation of mitotic cell cycle GO:0045930 109 0.068
regulation of intracellular signal transduction GO:1902531 236 0.068
regulation of phosphorylation GO:0042325 147 0.067
establishment of protein localization GO:0045184 163 0.067
macromolecular complex assembly GO:0065003 256 0.067
cellular amide metabolic process GO:0043603 80 0.066
positive regulation of endopeptidase activity GO:0010950 26 0.065
regulation of cell cycle process GO:0010564 181 0.065
ubiquitin dependent protein catabolic process GO:0006511 78 0.063
cellular response to chemical stimulus GO:0070887 199 0.063
proteasomal protein catabolic process GO:0010498 59 0.063
regulation of mitotic cell cycle phase transition GO:1901990 130 0.062
epidermal growth factor receptor signaling pathway GO:0007173 58 0.061
spermatid development GO:0007286 98 0.059
protein localization to organelle GO:0033365 82 0.059
regulation of phosphorus metabolic process GO:0051174 210 0.059
cell proliferation GO:0008283 299 0.058
regulation of cell cycle GO:0051726 291 0.058
protein targeting GO:0006605 64 0.058
regulation of cell death GO:0010941 173 0.057
regulation of cellular catabolic process GO:0031329 157 0.057
spermatogenesis GO:0007283 200 0.056
response to temperature stimulus GO:0009266 106 0.055
response to organic substance GO:0010033 284 0.055
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.054
organelle assembly GO:0070925 198 0.054
cell growth GO:0016049 108 0.053
death GO:0016265 284 0.053
appendage morphogenesis GO:0035107 397 0.053
transmembrane transport GO:0055085 139 0.052
negative regulation of signaling GO:0023057 219 0.052
regulation of catalytic activity GO:0050790 185 0.051
modification dependent macromolecule catabolic process GO:0043632 79 0.050
catabolic process GO:0009056 409 0.049
male gamete generation GO:0048232 201 0.049
positive regulation of cell communication GO:0010647 250 0.049
cytoplasmic transport GO:0016482 130 0.047
mitotic g2 m transition checkpoint GO:0044818 70 0.046
wing disc morphogenesis GO:0007472 344 0.046
mitochondrion organization GO:0007005 65 0.045
negative regulation of cell communication GO:0010648 223 0.045
mapk cascade GO:0000165 107 0.045
organic substance catabolic process GO:1901575 308 0.045
positive regulation of signaling GO:0023056 243 0.044
mitotic dna integrity checkpoint GO:0044774 75 0.044
positive regulation of proteolysis GO:0045862 52 0.044
cell cycle phase transition GO:0044770 140 0.044
establishment of protein localization to organelle GO:0072594 62 0.043
positive regulation of signal transduction GO:0009967 223 0.042
protein maturation GO:0051604 71 0.042
regulation of mapk cascade GO:0043408 92 0.042
chromosome organization GO:0051276 360 0.041
segmentation GO:0035282 207 0.041
post embryonic appendage morphogenesis GO:0035120 385 0.041
growth GO:0040007 359 0.041
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.041
negative regulation of response to stimulus GO:0048585 258 0.040
response to oxidative stress GO:0006979 86 0.040
modification dependent protein catabolic process GO:0019941 78 0.039
dendrite development GO:0016358 204 0.039
single organism cellular localization GO:1902580 180 0.039
phosphorylation GO:0016310 294 0.038
programmed cell death GO:0012501 257 0.038
oxoacid metabolic process GO:0043436 103 0.036
mitotic dna damage checkpoint GO:0044773 74 0.036
sex differentiation GO:0007548 81 0.036
signal transduction by phosphorylation GO:0023014 107 0.036
activation of cysteine type endopeptidase activity GO:0097202 17 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.034
apoptotic process GO:0006915 159 0.034
cell death GO:0008219 279 0.034
regulation of molecular function GO:0065009 217 0.034
mitochondrial transport GO:0006839 8 0.034
cellular response to starvation GO:0009267 61 0.033
positive regulation of molecular function GO:0044093 136 0.033
single organism biosynthetic process GO:0044711 206 0.032
dna damage checkpoint GO:0000077 78 0.032
protein catabolic process GO:0030163 101 0.031
positive regulation of cellular catabolic process GO:0031331 95 0.031
translation GO:0006412 69 0.031
peptide metabolic process GO:0006518 80 0.030
epithelial cell differentiation GO:0030855 322 0.030
endosomal transport GO:0016197 44 0.030
sperm individualization GO:0007291 48 0.030
embryonic morphogenesis GO:0048598 206 0.030
regulation of gene expression epigenetic GO:0040029 128 0.030
regulation of dna metabolic process GO:0051052 34 0.029
protein complex assembly GO:0006461 200 0.029
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.029
erbb signaling pathway GO:0038127 58 0.028
regulation of erbb signaling pathway GO:1901184 42 0.028
regionalization GO:0003002 416 0.028
positive regulation of catabolic process GO:0009896 105 0.028
protein complex biogenesis GO:0070271 201 0.028
appendage development GO:0048736 401 0.027
regulation of proteolysis GO:0030162 87 0.027
cellular response to extracellular stimulus GO:0031668 64 0.026
imaginal disc derived wing morphogenesis GO:0007476 337 0.025
ion transport GO:0006811 145 0.025
response to starvation GO:0042594 97 0.025
oocyte differentiation GO:0009994 145 0.024
mitotic g2 dna damage checkpoint GO:0007095 69 0.024
immune system process GO:0002376 347 0.024
positive regulation of cell death GO:0010942 69 0.024
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
somatic muscle development GO:0007525 66 0.023
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.023
heterocycle catabolic process GO:0046700 166 0.023
g2 dna damage checkpoint GO:0031572 69 0.023
regulation of hydrolase activity GO:0051336 97 0.023
regulation of organelle organization GO:0033043 196 0.023
response to abiotic stimulus GO:0009628 341 0.023
cilium assembly GO:0042384 38 0.023
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
organonitrogen compound metabolic process GO:1901564 318 0.022
cell aging GO:0007569 2 0.022
dorsal closure GO:0007391 79 0.022
sperm axoneme assembly GO:0007288 13 0.022
positive regulation of lipid metabolic process GO:0045834 4 0.021
dna metabolic process GO:0006259 227 0.021
negative regulation of cell death GO:0060548 81 0.021
positive regulation of catalytic activity GO:0043085 118 0.021
developmental maturation GO:0021700 172 0.021
regulation of programmed cell death GO:0043067 152 0.021
regulation of peptidase activity GO:0052547 39 0.021
pigmentation GO:0043473 75 0.021
regulation of multicellular organismal development GO:2000026 414 0.021
response to endogenous stimulus GO:0009719 119 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
positive regulation of phosphate metabolic process GO:0045937 139 0.020
cation transport GO:0006812 110 0.020
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.020
regulation of response to stress GO:0080134 200 0.020
posttranscriptional gene silencing GO:0016441 46 0.020
cilium morphogenesis GO:0060271 39 0.020
organelle fission GO:0048285 340 0.020
negative regulation of erbb signaling pathway GO:1901185 29 0.020
negative regulation of phosphorus metabolic process GO:0010563 45 0.020
protein phosphorylation GO:0006468 169 0.020
nucleoside triphosphate metabolic process GO:0009141 120 0.020
exocrine system development GO:0035272 162 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.019
response to other organism GO:0051707 293 0.019
protein k48 linked ubiquitination GO:0070936 3 0.019
regulation of cellular component biogenesis GO:0044087 201 0.019
dendrite morphogenesis GO:0048813 199 0.019
negative regulation of catalytic activity GO:0043086 42 0.019
regulation of catabolic process GO:0009894 170 0.019
hematopoietic or lymphoid organ development GO:0048534 57 0.018
intrinsic apoptotic signaling pathway GO:0097193 16 0.018
dna integrity checkpoint GO:0031570 81 0.018
mitotic spindle organization GO:0007052 220 0.018
nucleoside phosphate metabolic process GO:0006753 162 0.018
protein transmembrane transport GO:0071806 4 0.018
protein processing GO:0016485 68 0.018
nucleoside phosphate catabolic process GO:1901292 110 0.018
regulation of protein localization GO:0032880 76 0.018
purine nucleotide metabolic process GO:0006163 146 0.018
embryonic axis specification GO:0000578 107 0.018
small molecule metabolic process GO:0044281 305 0.018
response to oxygen containing compound GO:1901700 200 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
morphogenesis of an epithelium GO:0002009 276 0.017
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
reproductive system development GO:0061458 74 0.017
regulation of proteasomal protein catabolic process GO:0061136 39 0.017
positive regulation of hydrolase activity GO:0051345 78 0.017
mitotic nuclear division GO:0007067 213 0.017
negative regulation of programmed cell death GO:0043069 72 0.017
cellular homeostasis GO:0019725 80 0.017
meiotic cell cycle GO:0051321 171 0.016
embryonic pattern specification GO:0009880 174 0.016
embryo development ending in birth or egg hatching GO:0009792 152 0.016
negative regulation of signal transduction GO:0009968 206 0.016
cellular response to nutrient levels GO:0031669 62 0.016
regulation of cell division GO:0051302 72 0.016
aromatic compound catabolic process GO:0019439 166 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
negative regulation of phosphorylation GO:0042326 35 0.016
negative regulation of protein modification process GO:0031400 29 0.016
defense response GO:0006952 300 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
regulation of autophagy GO:0010506 62 0.015
rna processing GO:0006396 147 0.015
ribosomal large subunit biogenesis GO:0042273 1 0.015
positive regulation of phosphorylation GO:0042327 87 0.015
spindle organization GO:0007051 253 0.015
negative regulation of cellular component organization GO:0051129 108 0.015
ribonucleoside triphosphate catabolic process GO:0009203 108 0.015
positive regulation of cell motility GO:2000147 3 0.015
homeostatic process GO:0042592 199 0.015
negative regulation of molecular function GO:0044092 51 0.015
regulation of cellular response to stress GO:0080135 89 0.015
negative regulation of phosphate metabolic process GO:0045936 45 0.015
negative regulation of protein phosphorylation GO:0001933 17 0.015
secretion by cell GO:0032940 101 0.015
ribonucleotide catabolic process GO:0009261 109 0.015
response to nutrient levels GO:0031667 114 0.015
protein modification by small protein conjugation GO:0032446 79 0.014
peptidyl amino acid modification GO:0018193 105 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.014
anterior posterior pattern specification GO:0009952 136 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.014
chemical homeostasis GO:0048878 92 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
taxis GO:0042330 304 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
regulation of cell proliferation GO:0042127 163 0.014
organophosphate metabolic process GO:0019637 195 0.014
response to external biotic stimulus GO:0043207 293 0.014
negative regulation of transcription dna templated GO:0045892 237 0.014
response to biotic stimulus GO:0009607 294 0.014
cellular response to external stimulus GO:0071496 66 0.014
sister chromatid segregation GO:0000819 92 0.014
membrane organization GO:0061024 112 0.014
positive regulation of gene expression GO:0010628 290 0.014
axon midline choice point recognition GO:0016199 26 0.014
oocyte construction GO:0007308 112 0.014
atp metabolic process GO:0046034 49 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.013
positive regulation of transport GO:0051050 92 0.013
organophosphate catabolic process GO:0046434 112 0.013
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
cellular macromolecular complex assembly GO:0034622 153 0.013
tissue migration GO:0090130 155 0.013
nephrocyte filtration GO:0097206 7 0.013
protein localization to mitochondrion GO:0070585 1 0.013
negative regulation of cellular catabolic process GO:0031330 34 0.013
transcription from rna polymerase ii promoter GO:0006366 368 0.013
regulation of sister chromatid segregation GO:0033045 28 0.013
regulation of cellular protein catabolic process GO:1903362 44 0.013
rna localization GO:0006403 115 0.013
regulation of synapse structure and activity GO:0050803 128 0.013
negative regulation of biosynthetic process GO:0009890 277 0.012
purine containing compound metabolic process GO:0072521 155 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
regulation of epithelial cell proliferation GO:0050678 4 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
spindle assembly GO:0051225 80 0.012
regulation of apoptotic process GO:0042981 130 0.012
negative regulation of nucleic acid templated transcription GO:1903507 240 0.012
defense response to other organism GO:0098542 225 0.012
chaeta morphogenesis GO:0008407 42 0.012
regulation of immune system process GO:0002682 176 0.012
gene silencing by rna GO:0031047 57 0.012
zymogen activation GO:0031638 20 0.012
gene silencing GO:0016458 138 0.012
muscle structure development GO:0061061 224 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
stress activated protein kinase signaling cascade GO:0031098 55 0.012
posttranscriptional gene silencing by rna GO:0035194 45 0.012
gonad development GO:0008406 50 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
eye antennal disc development GO:0035214 60 0.012
nuclear division GO:0000280 332 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
induction of programmed cell death by ecdysone GO:0035078 12 0.012
actin filament based process GO:0030029 220 0.012
positive regulation of rna metabolic process GO:0051254 271 0.012
cell maturation GO:0048469 144 0.012
cellular response to organic substance GO:0071310 132 0.012
sulfur compound metabolic process GO:0006790 59 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
retrograde transport endosome to golgi GO:0042147 3 0.012
molting cycle chitin based cuticle GO:0007591 56 0.011
intracellular protein transmembrane transport GO:0065002 4 0.011
leg disc development GO:0035218 92 0.011
tripartite regional subdivision GO:0007351 103 0.011
cell projection assembly GO:0030031 94 0.011
epithelial cell development GO:0002064 274 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.011
regulation of protein phosphorylation GO:0001932 64 0.011
axis specification GO:0009798 167 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.011
gland morphogenesis GO:0022612 145 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.011
endomitotic cell cycle GO:0007113 7 0.011
regulation of protein catabolic process GO:0042176 55 0.011
dna repair GO:0006281 54 0.011
ion transmembrane transport GO:0034220 122 0.011
autophagy GO:0006914 108 0.011
developmental pigmentation GO:0048066 68 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
response to dsrna GO:0043331 15 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
body morphogenesis GO:0010171 2 0.011
oocyte development GO:0048599 124 0.011
wnt signaling pathway GO:0016055 98 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
rrna processing GO:0006364 3 0.011
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
ras protein signal transduction GO:0007265 88 0.010
purine ribonucleotide catabolic process GO:0009154 109 0.010
positive regulation of apoptotic process GO:0043065 47 0.010
nucleotide catabolic process GO:0009166 109 0.010
positive regulation of apoptotic signaling pathway GO:2001235 4 0.010
inorganic ion transmembrane transport GO:0098660 73 0.010
immune response GO:0006955 246 0.010
development of primary sexual characteristics GO:0045137 50 0.010
single organism catabolic process GO:0044712 228 0.010
camera type eye development GO:0043010 4 0.010
epithelium migration GO:0090132 148 0.010
humoral immune response GO:0006959 117 0.010
regulation of protein kinase activity GO:0045859 51 0.010
cellularization GO:0007349 90 0.010
carbohydrate derivative metabolic process GO:1901135 217 0.010

Dhod disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.017
central nervous system disease DOID:331 0 0.013
neurodegenerative disease DOID:1289 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
sensory system disease DOID:0050155 0 0.011