Drosophila melanogaster

297 known processes

rok (Dmel_CG9774)

Rho-kinase

(Aliases: DRok,Dmel\CG9774,ROK,Drok,CG9774,RhoK,drok,dRok,ROCK-1,ROKalpha/beta,ROCK1,Rock,DROK,Rhk,Rok,ROCK,DRhk,dROK)

rok biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin filament organization GO:0007015 126 0.997
morphogenesis of a polarized epithelium GO:0001738 93 0.996
regulation of cell morphogenesis GO:0022604 163 0.996
tissue morphogenesis GO:0048729 297 0.995
establishment or maintenance of cell polarity GO:0007163 167 0.994
morphogenesis of an epithelium GO:0002009 276 0.993
cell projection assembly GO:0030031 94 0.993
Mouse
establishment of tissue polarity GO:0007164 87 0.991
actin filament based process GO:0030029 220 0.988
pole plasm mrna localization GO:0019094 49 0.987
regulation of dendrite morphogenesis GO:0048814 28 0.987
establishment of planar polarity GO:0001736 87 0.983
cortical actin cytoskeleton organization GO:0030866 24 0.976
regulation of anatomical structure morphogenesis GO:0022603 242 0.976
sensory organ morphogenesis GO:0090596 260 0.973
ovarian follicle cell development GO:0030707 248 0.965
actin cytoskeleton organization GO:0030036 206 0.964
epithelial cell differentiation GO:0030855 322 0.963
imaginal disc derived wing hair organization GO:0035317 45 0.958
oocyte axis specification GO:0007309 108 0.957
oocyte anterior posterior axis specification GO:0007314 72 0.931
digestive tract morphogenesis GO:0048546 127 0.931
embryonic development via the syncytial blastoderm GO:0001700 148 0.923
axonogenesis GO:0007409 290 0.922
establishment of monopolar cell polarity GO:0061162 15 0.917
epithelial cell development GO:0002064 274 0.913
pole plasm assembly GO:0007315 61 0.906
phosphorylation GO:0016310 294 0.897
pole plasm oskar mrna localization GO:0045451 46 0.895
compound eye morphogenesis GO:0001745 249 0.888
pole plasm rna localization GO:0007316 52 0.888
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.887
wing disc morphogenesis GO:0007472 344 0.886
axon development GO:0061564 297 0.885
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.880
protein modification process GO:0036211 438 0.878
appendage development GO:0048736 401 0.877
ommatidial rotation GO:0016318 20 0.865
oocyte microtubule cytoskeleton organization GO:0016325 35 0.860
regulation of neuron projection development GO:0010975 69 0.854
oocyte development GO:0048599 124 0.853
regulation of cell projection organization GO:0031344 92 0.852
dorsal appendage formation GO:0046843 47 0.849
nucleobase containing small molecule metabolic process GO:0055086 174 0.818
eye morphogenesis GO:0048592 260 0.816
blastoderm segmentation GO:0007350 159 0.808
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.806
biological adhesion GO:0022610 138 0.805
chorion containing eggshell formation GO:0007304 105 0.804
compound eye development GO:0048749 307 0.798
positive regulation of gtp catabolic process GO:0033126 43 0.798
regulation of rho protein signal transduction GO:0035023 20 0.793
axis specification GO:0009798 167 0.791
neuron projection guidance GO:0097485 241 0.778
anterior posterior pattern specification GO:0009952 136 0.773
single organism cell adhesion GO:0098602 47 0.759
Human
cytokinesis GO:0000910 90 0.757
maternal determination of anterior posterior axis embryo GO:0008358 74 0.753
embryonic pattern specification GO:0009880 174 0.752
germarium derived egg chamber formation GO:0007293 101 0.751
positive regulation of gtpase activity GO:0043547 43 0.749
establishment or maintenance of monopolar cell polarity GO:0061339 15 0.748
photoreceptor cell differentiation GO:0046530 170 0.745
mapk cascade GO:0000165 107 0.742
regulation of actin cytoskeleton organization GO:0032956 42 0.741
growth GO:0040007 359 0.741
ovarian follicle cell migration GO:0007297 121 0.729
non sensory hair organization GO:0035316 47 0.729
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.726
embryonic morphogenesis GO:0048598 206 0.715
central nervous system development GO:0007417 201 0.712
cellular nitrogen compound catabolic process GO:0044270 165 0.712
initiation of dorsal closure GO:0007392 12 0.711
regulation of cell development GO:0060284 215 0.704
regulation of molecular function GO:0065009 217 0.704
nucleotide catabolic process GO:0009166 109 0.703
tube development GO:0035295 244 0.702
eggshell chorion assembly GO:0007306 66 0.699
dorsal closure GO:0007391 79 0.699
single organism cellular localization GO:1902580 180 0.696
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.684
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.683
columnar cuboidal epithelial cell development GO:0002066 249 0.680
actin polymerization or depolymerization GO:0008154 31 0.672
Fly
regulation of cell differentiation GO:0045595 302 0.663
ras protein signal transduction GO:0007265 88 0.651
unidimensional cell growth GO:0009826 15 0.649
appendage morphogenesis GO:0035107 397 0.641
imaginal disc derived appendage morphogenesis GO:0035114 395 0.639
wnt signaling pathway GO:0016055 98 0.629
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.627
segmentation GO:0035282 207 0.627
organophosphate metabolic process GO:0019637 195 0.626
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.626
digestive system development GO:0055123 149 0.624
actin filament bundle organization GO:0061572 28 0.622
defense response GO:0006952 300 0.619
hair cell differentiation GO:0035315 47 0.613
body morphogenesis GO:0010171 2 0.611
Worm
regulation of axonogenesis GO:0050770 32 0.608
eggshell formation GO:0030703 105 0.607
establishment of cell polarity GO:0030010 40 0.606
eye development GO:0001654 323 0.602
regulation of cytoskeleton organization GO:0051493 89 0.599
positive regulation of rho gtpase activity GO:0032321 19 0.598
cellular protein modification process GO:0006464 438 0.596
imaginal disc derived wing hair site selection GO:0035320 4 0.590
neuron recognition GO:0008038 101 0.584
Fly
regionalization GO:0003002 416 0.583
cellularization GO:0007349 90 0.580
establishment of epithelial cell apical basal polarity GO:0045198 10 0.570
cellular macromolecule localization GO:0070727 220 0.569
regulation of intracellular signal transduction GO:1902531 236 0.568
cell motility GO:0048870 251 0.565
Human Zebrafish Mouse Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.559
regulation of phosphate metabolic process GO:0019220 210 0.558
regulation of cell cell adhesion GO:0022407 21 0.552
nucleus localization GO:0051647 34 0.551
regulation of phosphorus metabolic process GO:0051174 210 0.550
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.550
cell cell junction assembly GO:0007043 38 0.546
nucleobase containing compound catabolic process GO:0034655 165 0.543
negative regulation of response to stimulus GO:0048585 258 0.532
regulation of dendrite development GO:0050773 37 0.531
developmental growth GO:0048589 280 0.530
nucleotide metabolic process GO:0009117 161 0.528
cell junction organization GO:0034330 57 0.527
regulation of catalytic activity GO:0050790 185 0.526
oocyte differentiation GO:0009994 145 0.519
male gamete generation GO:0048232 201 0.518
regulation of multicellular organismal development GO:2000026 414 0.515
purine nucleoside metabolic process GO:0042278 127 0.514
purine ribonucleotide catabolic process GO:0009154 109 0.513
gtp metabolic process GO:0046039 72 0.508
post embryonic appendage morphogenesis GO:0035120 385 0.507
positive regulation of phosphate metabolic process GO:0045937 139 0.504
regulation of protein metabolic process GO:0051246 256 0.501
guanosine containing compound metabolic process GO:1901068 74 0.491
maintenance of protein location GO:0045185 28 0.483
rho protein signal transduction GO:0007266 14 0.476
positive regulation of nucleotide metabolic process GO:0045981 55 0.473
ribose phosphate metabolic process GO:0019693 145 0.472
regulation of rho gtpase activity GO:0032319 20 0.470
zonula adherens assembly GO:0045186 6 0.470
epidermis development GO:0008544 65 0.468
dendrite morphogenesis GO:0048813 199 0.466
Mouse
chaeta development GO:0022416 97 0.456
regulation of organelle organization GO:0033043 196 0.454
establishment of proximal distal cell polarity GO:0022606 4 0.453
dendrite self avoidance GO:0070593 8 0.449
regulation of phosphorylation GO:0042325 147 0.447
positive regulation of ras gtpase activity GO:0032320 36 0.447
oocyte construction GO:0007308 112 0.444
regulation of protein polymerization GO:0032271 28 0.443
Fly
adherens junction assembly GO:0034333 11 0.442
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.438
glycosyl compound metabolic process GO:1901657 127 0.437
cell cell junction organization GO:0045216 55 0.436
Mouse
establishment of ommatidial planar polarity GO:0042067 49 0.435
single organismal cell cell adhesion GO:0016337 45 0.433
Human
small gtpase mediated signal transduction GO:0007264 88 0.433
wound healing GO:0042060 75 0.427
border follicle cell migration GO:0007298 113 0.423
developmental maturation GO:0021700 172 0.412
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.409
intracellular signal transduction GO:0035556 300 0.407
regulation of neuron differentiation GO:0045664 103 0.402
tube morphogenesis GO:0035239 191 0.399
protein polymerization GO:0051258 42 0.397
Fly
spermatid differentiation GO:0048515 114 0.391
purine nucleoside triphosphate metabolic process GO:0009144 119 0.390
immune response GO:0006955 246 0.388
guanosine containing compound catabolic process GO:1901069 74 0.387
positive regulation of catalytic activity GO:0043085 118 0.385
purine ribonucleotide metabolic process GO:0009150 145 0.381
chemotaxis GO:0006935 249 0.379
regulation of actin filament polymerization GO:0030833 25 0.378
Fly
establishment of apical basal cell polarity GO:0035089 12 0.368
nucleoside triphosphate catabolic process GO:0009143 108 0.364
regulation of anatomical structure size GO:0090066 163 0.364
Fly
aromatic compound catabolic process GO:0019439 166 0.362
apical constriction GO:0003383 18 0.362
cell junction assembly GO:0034329 42 0.361
positive regulation of protein modification process GO:0031401 58 0.360
macromolecule catabolic process GO:0009057 161 0.358
Zebrafish
embryonic axis specification GO:0000578 107 0.358
establishment of localization in cell GO:0051649 402 0.350
response to other organism GO:0051707 293 0.348
compound eye photoreceptor development GO:0042051 78 0.348
cuticle development GO:0042335 86 0.346
Worm
adherens junction organization GO:0034332 27 0.345
Mouse
vesicle mediated transport GO:0016192 381 0.344
asymmetric protein localization GO:0008105 33 0.341
endocytosis GO:0006897 310 0.340
cell division GO:0051301 248 0.340
regulation of protein phosphorylation GO:0001932 64 0.338
regulation of gtpase activity GO:0043087 44 0.336
regulation of cellular component biogenesis GO:0044087 201 0.336
negative regulation of cellular component organization GO:0051129 108 0.334
germ line cyst formation GO:0048134 44 0.333
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.333
gtp catabolic process GO:0006184 72 0.333
positive regulation of molecular function GO:0044093 136 0.332
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.325
maintenance of protein location in cell GO:0032507 26 0.325
regulation of actin filament based process GO:0032970 42 0.320
glycosyl compound catabolic process GO:1901658 112 0.318
signal transduction by phosphorylation GO:0023014 107 0.315
organic cyclic compound catabolic process GO:1901361 168 0.313
protein localization GO:0008104 284 0.312
immune system process GO:0002376 347 0.312
Human
delamination GO:0060232 8 0.307
lamellipodium organization GO:0097581 21 0.307
germarium derived oocyte fate determination GO:0007294 26 0.306
regulation of notch signaling pathway GO:0008593 100 0.305
ribonucleoside metabolic process GO:0009119 127 0.298
regulation of actin polymerization or depolymerization GO:0008064 27 0.297
Fly
regulation of neurogenesis GO:0050767 158 0.296
anterior posterior axis specification embryo GO:0008595 103 0.294
actin filament polymerization GO:0030041 27 0.288
Fly
positive regulation of filopodium assembly GO:0051491 15 0.287
tripartite regional subdivision GO:0007351 103 0.286
maintenance of cell polarity GO:0030011 18 0.286
anterior posterior axis specification GO:0009948 109 0.286
regulation of ras protein signal transduction GO:0046578 93 0.282
developmental growth involved in morphogenesis GO:0060560 65 0.281
epithelial cell cell adhesion GO:0090136 6 0.281
regulation of body fluid levels GO:0050878 14 0.280
regulation of ras gtpase activity GO:0032318 38 0.278
polarized epithelial cell differentiation GO:0030859 10 0.278
heterocycle catabolic process GO:0046700 166 0.277
dorsal closure elongation of leading edge cells GO:0007394 10 0.273
actomyosin structure organization GO:0031032 56 0.272
regulation of cell shape GO:0008360 113 0.271
cell recognition GO:0008037 102 0.270
Fly
cell growth GO:0016049 108 0.270
cellular protein localization GO:0034613 160 0.269
positive regulation of phosphorus metabolic process GO:0010562 139 0.269
cell cell adhesion mediated by cadherin GO:0044331 6 0.269
regulation of mapk cascade GO:0043408 92 0.267
establishment of mitotic spindle orientation GO:0000132 13 0.263
nucleoside triphosphate metabolic process GO:0009141 120 0.262
regulation of microtubule based process GO:0032886 49 0.261
Mouse
negative regulation of neurogenesis GO:0050768 53 0.258
regulation of actin filament length GO:0030832 27 0.258
Fly
eye photoreceptor cell development GO:0042462 81 0.256
respiratory system development GO:0060541 213 0.255
aggressive behavior GO:0002118 63 0.254
nucleoside metabolic process GO:0009116 127 0.251
apical constriction involved in gastrulation GO:0003384 7 0.251
protein phosphorylation GO:0006468 169 0.251
protein ubiquitination GO:0016567 70 0.250
nucleoside catabolic process GO:0009164 112 0.246
cellular component assembly involved in morphogenesis GO:0010927 151 0.246
response to organic substance GO:0010033 284 0.245
regulation of growth GO:0040008 233 0.244
morphogenesis of embryonic epithelium GO:0016331 94 0.242
maintenance of location GO:0051235 73 0.239
protein modification by small protein conjugation GO:0032446 79 0.238
cognition GO:0050890 141 0.237
positive regulation of cell communication GO:0010647 250 0.237
localization of cell GO:0051674 257 0.236
Human Zebrafish Mouse Worm
regulation of embryonic cell shape GO:0016476 30 0.233
positive regulation of nucleotide catabolic process GO:0030813 46 0.233
protein complex assembly GO:0006461 200 0.233
Fly
ribonucleotide catabolic process GO:0009261 109 0.232
establishment of organelle localization GO:0051656 122 0.231
negative regulation of nervous system development GO:0051961 92 0.229
jnk cascade GO:0007254 50 0.228
ribonucleoside catabolic process GO:0042454 112 0.227
negative regulation of cytoskeleton organization GO:0051494 30 0.227
response to organonitrogen compound GO:0010243 75 0.226
head involution GO:0008258 35 0.226
small molecule metabolic process GO:0044281 305 0.226
positive regulation of cell death GO:0010942 69 0.225
purine containing compound metabolic process GO:0072521 155 0.223
negative regulation of signaling GO:0023057 219 0.223
positive regulation of cellular component organization GO:0051130 156 0.220
establishment of epithelial cell polarity GO:0090162 13 0.220
organophosphate catabolic process GO:0046434 112 0.218
cell adhesion GO:0007155 136 0.216
Human Mouse
regulation of response to wounding GO:1903034 19 0.215
ribonucleotide metabolic process GO:0009259 145 0.215
reproductive system development GO:0061458 74 0.214
positive regulation of catabolic process GO:0009896 105 0.212
filopodium assembly GO:0046847 33 0.210
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.209
dendrite development GO:0016358 204 0.209
Mouse
regulation of actin filament bundle assembly GO:0032231 8 0.208
planar cell polarity pathway involved in axis elongation GO:0003402 3 0.208
organelle assembly GO:0070925 198 0.205
positive regulation of macromolecule metabolic process GO:0010604 405 0.205
negative regulation of cell development GO:0010721 62 0.204
purine nucleoside triphosphate catabolic process GO:0009146 108 0.203
regulation of wnt signaling pathway GO:0030111 68 0.200
larval development GO:0002164 104 0.195
Worm
regulation of localization GO:0032879 275 0.194
nuclear division GO:0000280 332 0.193
axon guidance GO:0007411 233 0.192
chromosome segregation GO:0007059 157 0.189
protein modification by small protein conjugation or removal GO:0070647 106 0.189
purine ribonucleoside catabolic process GO:0046130 112 0.188
protein complex biogenesis GO:0070271 201 0.186
Fly
regulation of kinase activity GO:0043549 53 0.185
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.182
purine containing compound catabolic process GO:0072523 112 0.182
nucleoside phosphate catabolic process GO:1901292 110 0.181
ribonucleoside triphosphate metabolic process GO:0009199 119 0.180
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.180
mating behavior GO:0007617 106 0.177
negative regulation of cell differentiation GO:0045596 143 0.177
positive regulation of cell projection organization GO:0031346 29 0.176
response to wounding GO:0009611 94 0.176
regulation of cell projection assembly GO:0060491 30 0.175
axon choice point recognition GO:0016198 26 0.173
protein transport GO:0015031 155 0.172
epithelial tube morphogenesis GO:0060562 88 0.171
Mouse
memory GO:0007613 94 0.169
pseudocleavage involved in syncytial blastoderm formation GO:0030589 9 0.168
establishment of spindle orientation GO:0051294 18 0.167
developmental programmed cell death GO:0010623 138 0.167
spermatogenesis GO:0007283 200 0.167
taxis GO:0042330 304 0.167
positive regulation of hydrolase activity GO:0051345 78 0.167
long term memory GO:0007616 62 0.167
positive regulation of nucleoside metabolic process GO:0045979 47 0.166
regulation of purine nucleotide catabolic process GO:0033121 48 0.164
notch signaling pathway GO:0007219 120 0.163
purine nucleotide catabolic process GO:0006195 109 0.163
forebrain development GO:0030900 2 0.162
axon midline choice point recognition GO:0016199 26 0.161
regulation of cell adhesion GO:0030155 27 0.159
Mouse
g protein coupled receptor signaling pathway GO:0007186 136 0.158
digestive tract development GO:0048565 149 0.155
spindle organization GO:0007051 253 0.151
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 3 0.151
salivary gland morphogenesis GO:0007435 145 0.151
ribonucleoside triphosphate catabolic process GO:0009203 108 0.150
detection of stimulus GO:0051606 156 0.150
carbohydrate derivative catabolic process GO:1901136 118 0.149
regulation of embryonic development GO:0045995 68 0.148
positive regulation of wnt signaling pathway GO:0030177 25 0.148
apical junction assembly GO:0043297 32 0.148
negative regulation of signal transduction GO:0009968 206 0.147
purine nucleoside catabolic process GO:0006152 112 0.147
regulation of protein modification process GO:0031399 112 0.146
carbohydrate derivative metabolic process GO:1901135 217 0.146
regulation of small gtpase mediated signal transduction GO:0051056 93 0.146
apoptotic process GO:0006915 159 0.144
Mouse Worm
cytoplasm organization GO:0007028 64 0.143
cortical cytoskeleton organization GO:0030865 29 0.142
morphogenesis of follicular epithelium GO:0016333 36 0.142
spermatid development GO:0007286 98 0.141
negative regulation of notch signaling pathway GO:0045746 41 0.141
positive regulation of rac gtpase activity GO:0032855 8 0.140
histolysis GO:0007559 102 0.138
cellular response to chemical stimulus GO:0070887 199 0.138
regulation of lamellipodium organization GO:1902743 15 0.138
defense response to other organism GO:0098542 225 0.134
branching involved in open tracheal system development GO:0060446 45 0.134
positive regulation of signaling GO:0023056 243 0.134
hemocyte migration GO:0035099 19 0.132
regulation of jnk cascade GO:0046328 40 0.131
gastrulation GO:0007369 70 0.131
regulation of cellular component size GO:0032535 98 0.131
Fly
axon extension GO:0048675 32 0.130
regulation of sister chromatid cohesion GO:0007063 2 0.130
tissue death GO:0016271 102 0.130
imaginal disc derived appendage development GO:0048737 399 0.130
branching morphogenesis of an epithelial tube GO:0048754 45 0.129
mitotic nuclear division GO:0007067 213 0.129
regulation of cellular amino acid metabolic process GO:0006521 0 0.129
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.128
eye photoreceptor cell differentiation GO:0001754 145 0.128
response to abiotic stimulus GO:0009628 341 0.127
epithelium migration GO:0090132 148 0.126
amine metabolic process GO:0009308 12 0.126
histone modification GO:0016570 106 0.125
positive regulation of cellular catabolic process GO:0031331 95 0.125
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.125
programmed cell death GO:0012501 257 0.125
Mouse Worm
regulation of purine nucleotide metabolic process GO:1900542 62 0.124
asymmetric cell division GO:0008356 37 0.124
purine nucleotide metabolic process GO:0006163 146 0.124
calcium ion homeostasis GO:0055074 23 0.124
establishment or maintenance of neuroblast polarity GO:0045196 8 0.123
negative regulation of gene expression GO:0010629 387 0.122
stress activated mapk cascade GO:0051403 52 0.122
regulation of tube size open tracheal system GO:0035151 43 0.121
cell cell signaling involved in cell fate commitment GO:0045168 210 0.120
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.119
mitotic cytokinesis GO:0000281 50 0.119
epidermal cell differentiation GO:0009913 51 0.119
regulation of microtubule cytoskeleton organization GO:0070507 41 0.119
Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.117
cell migration GO:0016477 238 0.116
Human Zebrafish Mouse Worm
positive regulation of signal transduction GO:0009967 223 0.116
response to endogenous stimulus GO:0009719 119 0.115
modification dependent macromolecule catabolic process GO:0043632 79 0.114
regulation of nucleotide metabolic process GO:0006140 62 0.113
regulation of transport GO:0051049 181 0.113
epithelial cell migration GO:0010631 148 0.112
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.110
cellular protein complex assembly GO:0043623 71 0.110
Fly
substrate dependent cell migration cell extension GO:0006930 3 0.110
regulation of hydrolase activity GO:0051336 97 0.109
actin nucleation GO:0045010 8 0.108
cytokinetic cell separation GO:0000920 1 0.108
stress activated protein kinase signaling cascade GO:0031098 55 0.108
regulation of gtp catabolic process GO:0033124 44 0.106
membrane organization GO:0061024 112 0.106
maintenance of location in cell GO:0051651 28 0.106
regulation of cellular protein metabolic process GO:0032268 243 0.105
cell death GO:0008219 279 0.105
Mouse Worm
cellular ketone metabolic process GO:0042180 24 0.104
cuticle pattern formation GO:0035017 27 0.104
nucleoside phosphate metabolic process GO:0006753 162 0.103
molting cycle GO:0042303 56 0.103
cytoskeleton dependent cytokinesis GO:0061640 81 0.102
regulation of axon extension involved in axon guidance GO:0048841 4 0.102
regulation of nervous system development GO:0051960 248 0.101
posttranscriptional regulation of gene expression GO:0010608 145 0.101
intercellular bridge organization GO:0043063 14 0.101
retinal ganglion cell axon guidance GO:0031290 12 0.099
regulation of filopodium assembly GO:0051489 24 0.099
regulation of nucleotide catabolic process GO:0030811 48 0.098
response to external biotic stimulus GO:0043207 293 0.097
dorsal ventral axon guidance GO:0033563 2 0.097
synapse organization GO:0050808 196 0.097
reproductive structure development GO:0048608 74 0.097
sex differentiation GO:0007548 81 0.097
head development GO:0060322 135 0.096
endomembrane system organization GO:0010256 119 0.096
chromosome organization GO:0051276 360 0.096
organic substance catabolic process GO:1901575 308 0.096
Zebrafish
regulation of nucleoside metabolic process GO:0009118 50 0.095
asymmetric neuroblast division GO:0055059 33 0.094
photoreceptor cell development GO:0042461 96 0.093
developmental cell growth GO:0048588 52 0.092
mitotic spindle organization GO:0007052 220 0.092
protein catabolic process GO:0030163 101 0.092
Zebrafish
gonad morphogenesis GO:0035262 7 0.092
morphogenesis of a branching epithelium GO:0061138 45 0.090
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.090
positive regulation of response to stimulus GO:0048584 323 0.090
organic substance transport GO:0071702 257 0.090
immune effector process GO:0002252 98 0.089
cell proliferation GO:0008283 299 0.089
regulation of establishment of planar polarity GO:0090175 22 0.089
negative regulation of dendrite development GO:2000171 2 0.088
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.088
dna metabolic process GO:0006259 227 0.087
positive regulation of jun kinase activity GO:0043507 4 0.087
neuron projection extension GO:1990138 32 0.087
germarium derived female germ line cyst encapsulation GO:0030708 8 0.087
positive regulation of protein phosphorylation GO:0001934 34 0.086
gonad development GO:0008406 50 0.086
regulation of catabolic process GO:0009894 170 0.085
catabolic process GO:0009056 409 0.084
Zebrafish
imaginal disc fusion GO:0046528 19 0.083
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.083
cell maturation GO:0048469 144 0.083
negative regulation of heart induction GO:1901320 3 0.082
regulation of protein kinase activity GO:0045859 51 0.082
single organism catabolic process GO:0044712 228 0.082
skin development GO:0043588 65 0.082
glial cell migration GO:0008347 31 0.081
negative regulation of developmental process GO:0051093 201 0.080
Human
negative regulation of organelle organization GO:0010639 56 0.080
regulation of stress activated mapk cascade GO:0032872 41 0.080
filtration diaphragm assembly GO:0036058 4 0.079
compound eye retinal cell programmed cell death GO:0046667 23 0.079
salivary gland development GO:0007431 162 0.079
innate immune response GO:0045087 144 0.078
negative regulation of cellular metabolic process GO:0031324 382 0.078
intracellular mrna localization GO:0008298 66 0.078
hindbrain development GO:0030902 2 0.078
tube fusion GO:0035146 17 0.077
convergent extension GO:0060026 2 0.076
Zebrafish
parallel actin filament bundle assembly GO:0030046 2 0.076
response to biotic stimulus GO:0009607 294 0.075
germarium derived female germ line cyst formation GO:0030727 42 0.075
macromolecular complex assembly GO:0065003 256 0.074
Fly
open tracheal system development GO:0007424 204 0.074
ion homeostasis GO:0050801 55 0.074
female germ line cyst formation GO:0048135 42 0.073
microtubule bundle formation GO:0001578 27 0.073
muscle structure development GO:0061061 224 0.072
phagocytosis GO:0006909 215 0.072
regulation of sequestering of calcium ion GO:0051282 3 0.071
substrate dependent cell migration GO:0006929 3 0.071
neuroblast proliferation GO:0007405 74 0.069
positive regulation of actin filament polymerization GO:0030838 11 0.069
positive regulation of transport GO:0051050 92 0.068
homeostatic process GO:0042592 199 0.068
establishment of spindle localization GO:0051293 22 0.068
actin filament bundle assembly GO:0051017 26 0.068
neuroblast division GO:0055057 35 0.067
intracellular transport GO:0046907 228 0.067
regulation of cell death GO:0010941 173 0.067
Mouse

rok disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org