Drosophila melanogaster

130 known processes

hb (Dmel_CG9786)

hunchback

(Aliases: Hunchback,l(3)85Ah,CG9786,Rg-pbx,Dmel\CG9786,Hb,Rg-bx,hbHLH,HB,R-pbx)

hb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
segmentation GO:0035282 207 0.981
regionalization GO:0003002 416 0.969
negative regulation of cellular metabolic process GO:0031324 382 0.957
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.920
embryonic axis specification GO:0000578 107 0.907
motor neuron axon guidance GO:0008045 58 0.907
axonogenesis GO:0007409 290 0.898
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.891
negative regulation of nucleic acid templated transcription GO:1903507 240 0.863
anterior posterior axis specification embryo GO:0008595 103 0.861
negative regulation of gene expression GO:0010629 387 0.811
anterior posterior axis specification GO:0009948 109 0.795
negative regulation of cellular biosynthetic process GO:0031327 277 0.782
taxis GO:0042330 304 0.773
axon guidance GO:0007411 233 0.770
positive regulation of gene expression GO:0010628 290 0.764
negative regulation of rna metabolic process GO:0051253 251 0.725
anterior posterior pattern specification GO:0009952 136 0.705
tripartite regional subdivision GO:0007351 103 0.692
pole plasm oskar mrna localization GO:0045451 46 0.685
neuron projection guidance GO:0097485 241 0.679
oocyte development GO:0048599 124 0.671
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.670
axon development GO:0061564 297 0.666
central nervous system development GO:0007417 201 0.665
cell maturation GO:0048469 144 0.637
positive regulation of rna biosynthetic process GO:1902680 266 0.622
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.612
transcription from rna polymerase ii promoter GO:0006366 368 0.585
neuroblast fate determination GO:0007400 12 0.572
terminal region determination GO:0007362 25 0.570
positive regulation of transcription dna templated GO:0045893 266 0.568
chemotaxis GO:0006935 249 0.541
embryonic pattern specification GO:0009880 174 0.530
negative regulation of rna biosynthetic process GO:1902679 240 0.517
neuroblast fate commitment GO:0014017 19 0.509
oocyte anterior posterior axis specification GO:0007314 72 0.506
positive regulation of nucleic acid templated transcription GO:1903508 266 0.505
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.495
developmental maturation GO:0021700 172 0.443
oocyte differentiation GO:0009994 145 0.441
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.435
negative regulation of transcription dna templated GO:0045892 237 0.433
maternal determination of anterior posterior axis embryo GO:0008358 74 0.424
pole plasm mrna localization GO:0019094 49 0.395
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.386
regulation of multicellular organismal development GO:2000026 414 0.361
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.359
pole plasm assembly GO:0007315 61 0.357
axis specification GO:0009798 167 0.357
torso signaling pathway GO:0008293 21 0.346
intracellular mrna localization GO:0008298 66 0.331
negative regulation of biosynthetic process GO:0009890 277 0.325
chromatin organization GO:0006325 207 0.320
tube development GO:0035295 244 0.317
blastoderm segmentation GO:0007350 159 0.294
multi organism behavior GO:0051705 175 0.293
Worm
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.291
pole plasm rna localization GO:0007316 52 0.286
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.269
multicellular organismal reproductive behavior GO:0033057 110 0.265
Worm
circulatory system development GO:0072359 82 0.264
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.253
negative regulation of response to stimulus GO:0048585 258 0.241
germ cell migration GO:0008354 43 0.230
dendrite morphogenesis GO:0048813 199 0.220
positive regulation of biosynthetic process GO:0009891 316 0.210
antimicrobial humoral response GO:0019730 99 0.205
embryo development ending in birth or egg hatching GO:0009792 152 0.200
Worm
establishment or maintenance of cell polarity GO:0007163 167 0.198
regulation of protein metabolic process GO:0051246 256 0.196
regulation of cell proliferation GO:0042127 163 0.190
negative regulation of cell communication GO:0010648 223 0.182
immune system process GO:0002376 347 0.177
morphogenesis of an epithelium GO:0002009 276 0.173
cell death GO:0008219 279 0.172
sex determination GO:0007530 18 0.168
regulation of nervous system development GO:0051960 248 0.167
regulation of response to external stimulus GO:0032101 115 0.165
response to alcohol GO:0097305 95 0.164
oocyte construction GO:0007308 112 0.161
regulation of response to stress GO:0080134 200 0.158
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.152
positive regulation of response to stimulus GO:0048584 323 0.151
immune response GO:0006955 246 0.137
cognition GO:0050890 141 0.136
single organism behavior GO:0044708 391 0.134
embryonic morphogenesis GO:0048598 206 0.134
oocyte axis specification GO:0007309 108 0.130
response to external biotic stimulus GO:0043207 293 0.129
regulation of cellular protein metabolic process GO:0032268 243 0.128
cellular response to chemical stimulus GO:0070887 199 0.126
aggressive behavior GO:0002118 63 0.126
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.119
head development GO:0060322 135 0.117
rna localization GO:0006403 115 0.114
gene silencing GO:0016458 138 0.112
epithelial cell development GO:0002064 274 0.111
respiratory system development GO:0060541 213 0.110
response to abiotic stimulus GO:0009628 341 0.109
cell proliferation GO:0008283 299 0.108
imaginal disc derived appendage development GO:0048737 399 0.106
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.106
positive regulation of macromolecule metabolic process GO:0010604 405 0.106
tissue morphogenesis GO:0048729 297 0.105
oocyte maturation GO:0001556 3 0.104
positive regulation of cellular amine metabolic process GO:0033240 0 0.104
regulation of oocyte development GO:0060281 27 0.103
digestive system development GO:0055123 149 0.101
negative regulation of cell cycle GO:0045786 116 0.100
hindbrain development GO:0030902 2 0.098
response to oxygen containing compound GO:1901700 200 0.097
body morphogenesis GO:0010171 2 0.097
Worm
neuroblast differentiation GO:0014016 29 0.096
regulation of gene expression epigenetic GO:0040029 128 0.096
multi organism reproductive behavior GO:0044705 121 0.092
Worm
developmental growth GO:0048589 280 0.091
regulation of localization GO:0032879 275 0.090
locomotory behavior GO:0007626 176 0.090
positive regulation of rna metabolic process GO:0051254 271 0.089
gastrulation GO:0007369 70 0.089
morphogenesis of embryonic epithelium GO:0016331 94 0.087
adult locomotory behavior GO:0008344 76 0.084
cellular response to oxygen containing compound GO:1901701 79 0.084
response to organic substance GO:0010033 284 0.082
epithelial cell migration GO:0010631 148 0.081
gland development GO:0048732 191 0.081
synaptic transmission GO:0007268 288 0.079
response to other organism GO:0051707 293 0.079
positive regulation of cell communication GO:0010647 250 0.078
dorsal ventral pattern formation GO:0009953 133 0.076
protein alkylation GO:0008213 43 0.076
appendage morphogenesis GO:0035107 397 0.076
hematopoietic or lymphoid organ development GO:0048534 57 0.074
cytoplasm organization GO:0007028 64 0.071
positive regulation of signal transduction GO:0009967 223 0.070
renal system development GO:0072001 72 0.068
chromosome organization GO:0051276 360 0.067
kidney development GO:0001822 3 0.066
organic acid metabolic process GO:0006082 103 0.065
cellular ketone metabolic process GO:0042180 24 0.065
carboxylic acid metabolic process GO:0019752 92 0.065
dendrite development GO:0016358 204 0.064
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.064
regulation of immune system process GO:0002682 176 0.064
positive regulation of cell proliferation GO:0008284 47 0.061
cell migration GO:0016477 238 0.060
regulation of pole plasm oskar mrna localization GO:0007317 27 0.060
cell fate determination GO:0001709 91 0.060
negative regulation of signaling GO:0023057 219 0.059
positive regulation of signaling GO:0023056 243 0.059
regulation of humoral immune response GO:0002920 51 0.059
regulation of cell cycle GO:0051726 291 0.059
forebrain development GO:0030900 2 0.057
ventral cord development GO:0007419 16 0.056
muscle structure development GO:0061061 224 0.055
development of primary sexual characteristics GO:0045137 50 0.055
Worm
regulation of reproductive process GO:2000241 54 0.054
stem cell fate commitment GO:0048865 25 0.054
somatic stem cell division GO:0048103 37 0.053
telencephalon development GO:0021537 2 0.053
neurological system process GO:0050877 358 0.053
cellular response to endogenous stimulus GO:0071495 80 0.052
stem cell division GO:0017145 69 0.052
regulation of cellular component movement GO:0051270 42 0.052
cardiovascular system development GO:0072358 82 0.052
brain development GO:0007420 120 0.052
regulation of cell development GO:0060284 215 0.051
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.049
germarium derived female germ line cyst encapsulation GO:0030708 8 0.048
death GO:0016265 284 0.048
peptide metabolic process GO:0006518 80 0.048
camera type eye development GO:0043010 4 0.048
learning or memory GO:0007611 141 0.048
cell motility GO:0048870 251 0.048
amide biosynthetic process GO:0043604 42 0.048
oviposition GO:0018991 19 0.047
Worm
tissue migration GO:0090130 155 0.045
regulation of cellular amino acid metabolic process GO:0006521 0 0.045
cellular component assembly involved in morphogenesis GO:0010927 151 0.044
response to nitrogen compound GO:1901698 90 0.044
covalent chromatin modification GO:0016569 106 0.044
imaginal disc derived wing morphogenesis GO:0007476 337 0.044
embryonic development via the syncytial blastoderm GO:0001700 148 0.043
reproductive behavior GO:0019098 122 0.043
Worm
spinal cord development GO:0021510 1 0.043
digestive tract development GO:0048565 149 0.043
small molecule metabolic process GO:0044281 305 0.043
adult behavior GO:0030534 137 0.042
central nervous system neuron differentiation GO:0021953 8 0.042
regulation of immune response GO:0050776 118 0.042
learning GO:0007612 75 0.042
response to wounding GO:0009611 94 0.041
cellular protein modification process GO:0006464 438 0.041
digestive tract morphogenesis GO:0048546 127 0.040
apoptotic process GO:0006915 159 0.039
neuron fate commitment GO:0048663 50 0.038
response to endogenous stimulus GO:0009719 119 0.038
imaginal disc derived appendage morphogenesis GO:0035114 395 0.037
regulation of organelle organization GO:0033043 196 0.037
antimicrobial peptide production GO:0002775 46 0.037
humoral immune response GO:0006959 117 0.037
negative regulation of developmental process GO:0051093 201 0.036
response to radiation GO:0009314 155 0.036
appendage development GO:0048736 401 0.036
establishment of localization in cell GO:0051649 402 0.035
trunk segmentation GO:0035290 8 0.035
organic hydroxy compound metabolic process GO:1901615 83 0.034
regulation of molecular function GO:0065009 217 0.034
cellular amide metabolic process GO:0043603 80 0.034
negative regulation of signal transduction GO:0009968 206 0.034
positive regulation of cellular protein metabolic process GO:0032270 118 0.034
regulation of cellular amide metabolic process GO:0034248 39 0.033
regulation of chitin based cuticle tanning GO:0007564 14 0.032
regulation of gene silencing GO:0060968 63 0.032
immune system development GO:0002520 57 0.032
rhythmic process GO:0048511 106 0.031
head involution GO:0008258 35 0.031
localization of cell GO:0051674 257 0.031
dendrite guidance GO:0070983 21 0.031
spermatogenesis GO:0007283 200 0.031
muscle organ development GO:0007517 127 0.031
immune effector process GO:0002252 98 0.031
sensory perception of chemical stimulus GO:0007606 116 0.030
regulation of multi organism process GO:0043900 131 0.030
oocyte microtubule cytoskeleton organization GO:0016325 35 0.030
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
cell division GO:0051301 248 0.030
specification of segmental identity trunk GO:0035292 7 0.030
defense response to other organism GO:0098542 225 0.030
organonitrogen compound biosynthetic process GO:1901566 117 0.030
regulation of antimicrobial humoral response GO:0002759 50 0.029
response to biotic stimulus GO:0009607 294 0.029
programmed cell death GO:0012501 257 0.028
macromolecular complex assembly GO:0065003 256 0.028
response to decreased oxygen levels GO:0036293 58 0.028
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.027
amine metabolic process GO:0009308 12 0.027
phagocytosis GO:0006909 215 0.027
pole plasm protein localization GO:0007318 10 0.027
chromatin assembly or disassembly GO:0006333 52 0.027
post embryonic appendage morphogenesis GO:0035120 385 0.027
imaginal disc pattern formation GO:0007447 91 0.027
inter male aggressive behavior GO:0002121 60 0.027
regulation of production of molecular mediator of immune response GO:0002700 44 0.026
neuron remodeling GO:0016322 29 0.026
meiotic nuclear division GO:0007126 151 0.026
long term memory GO:0007616 62 0.026
response to organic cyclic compound GO:0014070 89 0.026
connective tissue development GO:0061448 3 0.026
epithelial tube morphogenesis GO:0060562 88 0.026
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.025
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.025
circadian rhythm GO:0007623 105 0.025
regulation of cell death GO:0010941 173 0.024
compound eye photoreceptor fate commitment GO:0001752 36 0.024
antimicrobial peptide biosynthetic process GO:0002777 38 0.024
nuclear division GO:0000280 332 0.024
cellular response to organic substance GO:0071310 132 0.024
organonitrogen compound metabolic process GO:1901564 318 0.023
single organism biosynthetic process GO:0044711 206 0.023
regulation of phosphatase activity GO:0010921 3 0.023
stem cell differentiation GO:0048863 117 0.023
exocrine system development GO:0035272 162 0.023
neuron recognition GO:0008038 101 0.023
regulation of cell adhesion GO:0030155 27 0.023
segment specification GO:0007379 33 0.023
regulation of cellular response to stress GO:0080135 89 0.022
cellular response to decreased oxygen levels GO:0036294 30 0.022
hemopoiesis GO:0030097 46 0.022
male meiosis GO:0007140 52 0.022
negative regulation of cell cycle phase transition GO:1901988 103 0.022
sensitization GO:0046960 1 0.021
pigment metabolic process GO:0042440 84 0.021
regulation of epithelial cell proliferation GO:0050678 4 0.021
response to temperature stimulus GO:0009266 106 0.020
neuroblast development GO:0014019 13 0.020
negative regulation of cellular protein metabolic process GO:0032269 85 0.020
cell activation GO:0001775 9 0.020
extracellular structure organization GO:0043062 46 0.020
kidney epithelium development GO:0072073 3 0.020
growth GO:0040007 359 0.020
regulation of tube size GO:0035150 46 0.020
chemosensory behavior GO:0007635 106 0.019
wnt signaling pathway GO:0016055 98 0.019
negative regulation of cell differentiation GO:0045596 143 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.019
methylation GO:0032259 47 0.019
regulation of programmed cell death GO:0043067 152 0.019
ameboidal type cell migration GO:0001667 151 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.019
regulation of response to biotic stimulus GO:0002831 63 0.019
regulation of wnt signaling pathway GO:0030111 68 0.019
regulation of antimicrobial peptide production GO:0002784 44 0.019
defense response GO:0006952 300 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.018
proteolysis GO:0006508 192 0.018
defense response to gram negative bacterium GO:0050829 94 0.018
regulation of apoptotic process GO:0042981 130 0.018
lateral inhibition GO:0046331 206 0.018
phosphorylation GO:0016310 294 0.018
regulation of cell size GO:0008361 63 0.018
embryonic organ development GO:0048568 50 0.018
cellular macromolecule localization GO:0070727 220 0.018
feeding behavior GO:0007631 50 0.018
protein complex biogenesis GO:0070271 201 0.018
protein complex assembly GO:0006461 200 0.018
positive regulation of intracellular signal transduction GO:1902533 116 0.017
notch signaling pathway GO:0007219 120 0.017
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.017
dna integrity checkpoint GO:0031570 81 0.017
epithelial cell differentiation GO:0030855 322 0.017
response to fungus GO:0009620 50 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
positive regulation of cell differentiation GO:0045597 64 0.017
branching morphogenesis of an epithelial tube GO:0048754 45 0.016
nephron development GO:0072006 3 0.016
open tracheal system development GO:0007424 204 0.016
epithelial cell migration open tracheal system GO:0007427 32 0.016
neural precursor cell proliferation GO:0061351 75 0.016
response to extracellular stimulus GO:0009991 116 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
single organism intracellular transport GO:1902582 207 0.016
imaginal disc derived female genitalia development GO:0007486 6 0.016
aging GO:0007568 143 0.016
germarium derived egg chamber formation GO:0007293 101 0.016
protein modification process GO:0036211 438 0.016
cellular amine metabolic process GO:0044106 12 0.016
response to organonitrogen compound GO:0010243 75 0.016
olfactory behavior GO:0042048 97 0.016
protein methylation GO:0006479 43 0.015
posterior head segmentation GO:0035289 6 0.015
establishment of ommatidial planar polarity GO:0042067 49 0.015
positive regulation of cell migration GO:0030335 2 0.015
instar larval development GO:0002168 55 0.015
synaptic target recognition GO:0008039 45 0.015
blood circulation GO:0008015 26 0.015
negative regulation of growth GO:0045926 84 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
male gamete generation GO:0048232 201 0.015
larval development GO:0002164 104 0.015
Worm
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.015
regulation of epithelial cell migration GO:0010632 12 0.014
mitotic nuclear division GO:0007067 213 0.014
response to acid chemical GO:0001101 25 0.014
regulation of cell motility GO:2000145 23 0.014
cellular lipid metabolic process GO:0044255 83 0.014
intracellular signal transduction GO:0035556 300 0.014
oocyte dorsal ventral axis specification GO:0007310 34 0.014
cell fate specification GO:0001708 71 0.014
female germ line cyst encapsulation GO:0048139 8 0.014
immune response regulating signaling pathway GO:0002764 2 0.014
peptide biosynthetic process GO:0043043 42 0.014
germ line cyst encapsulation GO:0048138 8 0.014
establishment of tissue polarity GO:0007164 87 0.014
dorsal closure GO:0007391 79 0.014
positive regulation of immune system process GO:0002684 68 0.014
response to hormone GO:0009725 45 0.013
histone methylation GO:0016571 40 0.013
regulation of membrane depolarization GO:0003254 1 0.013
positive regulation of molecular function GO:0044093 136 0.013
response to hypoxia GO:0001666 53 0.013
morphogenesis of a branching epithelium GO:0061138 45 0.013
axon choice point recognition GO:0016198 26 0.013
regulation of neurogenesis GO:0050767 158 0.013
regulation of locomotion GO:0040012 42 0.013
molting cycle GO:0042303 56 0.013
urogenital system development GO:0001655 72 0.013
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.013
heart development GO:0007507 82 0.013
membrane depolarization GO:0051899 4 0.013
wound healing GO:0042060 75 0.012
catabolic process GO:0009056 409 0.012
nitrogen compound transport GO:0071705 85 0.012
sex differentiation GO:0007548 81 0.012
Worm
spiracle morphogenesis open tracheal system GO:0035277 22 0.012
positive regulation of antimicrobial peptide production GO:0002225 28 0.012
multicellular organismal aging GO:0010259 140 0.012
single organism cellular localization GO:1902580 180 0.012
maintenance of protein location in cell GO:0032507 26 0.012
regulation of protein modification process GO:0031399 112 0.012
developmental cell growth GO:0048588 52 0.012
mesenchymal cell development GO:0014031 1 0.012
regulation of defense response GO:0031347 102 0.012
negative regulation of defense response GO:0031348 35 0.012
regulation of growth GO:0040008 233 0.012
nephron epithelium development GO:0072009 3 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
positive regulation of cell death GO:0010942 69 0.012
chromatin modification GO:0016568 147 0.012
positive regulation of apoptotic process GO:0043065 47 0.012
negative regulation of cell cell adhesion GO:0022408 8 0.012
positive regulation of cell motility GO:2000147 3 0.011
wing disc morphogenesis GO:0007472 344 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
kidney morphogenesis GO:0060993 3 0.011
cell aging GO:0007569 2 0.011
response to oxygen levels GO:0070482 59 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
nephron tubule development GO:0072080 3 0.011
neuroblast fate specification GO:0014018 2 0.011
neuron maturation GO:0042551 31 0.011
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.011
neuroblast division GO:0055057 35 0.011
intracellular transport GO:0046907 228 0.011
multi multicellular organism process GO:0044706 123 0.011
Worm
response to bacterium GO:0009617 198 0.011
regulation of dna templated transcription in response to stress GO:0043620 4 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
developmental programmed cell death GO:0010623 138 0.011
determination of adult lifespan GO:0008340 137 0.011
border follicle cell migration GO:0007298 113 0.010
innate immune response GO:0045087 144 0.010
cellular response to lipopolysaccharide GO:0071222 3 0.010
negative regulation of mitotic cell cycle GO:0045930 109 0.010
response to reactive oxygen species GO:0000302 24 0.010
skin development GO:0043588 65 0.010
cardioblast cell fate commitment GO:0042684 14 0.010
asymmetric cell division GO:0008356 37 0.010
positive regulation of multi organism process GO:0043902 40 0.010
regulation of chromatin organization GO:1902275 32 0.010
cellular response to lipid GO:0071396 20 0.010

hb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011