Drosophila melanogaster

37 known processes

eIF-2alpha (Dmel_CG9946)

eukaryotic translation Initiation Factor 2alpha

(Aliases: eIF2alpha,eIF-2,M(1)8e3-10,M(1)19-153,eIF2 alpha,CG9946,l(1)14Cf,eIF-2 alpha,Eif2alpha,elF2alpha,IF2A_DROME,eIF2-alpha,eIF2a,M(1)14C,eIF-2 a,l(1)19-153,Dmel\CG9946)

eIF-2alpha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic spindle organization GO:0007052 220 0.672
spindle organization GO:0007051 253 0.328
spindle elongation GO:0051231 83 0.233
mitotic spindle elongation GO:0000022 81 0.131
embryo development ending in birth or egg hatching GO:0009792 152 0.102
body morphogenesis GO:0010171 2 0.092
purine ribonucleoside metabolic process GO:0046128 127 0.087
carbohydrate derivative metabolic process GO:1901135 217 0.073
purine containing compound metabolic process GO:0072521 155 0.070
positive regulation of macromolecule metabolic process GO:0010604 405 0.066
establishment of localization in cell GO:0051649 402 0.065
translational initiation GO:0006413 11 0.061
organonitrogen compound metabolic process GO:1901564 318 0.061
sex differentiation GO:0007548 81 0.053
cellular response to chemical stimulus GO:0070887 199 0.053
organelle localization GO:0051640 148 0.052
oocyte construction GO:0007308 112 0.051
positive regulation of protein metabolic process GO:0051247 128 0.051
positive regulation of cellular biosynthetic process GO:0031328 316 0.049
nucleobase containing small molecule metabolic process GO:0055086 174 0.046
nucleoside metabolic process GO:0009116 127 0.042
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.041
regulation of protein metabolic process GO:0051246 256 0.040
centrosome organization GO:0051297 163 0.040
small molecule metabolic process GO:0044281 305 0.040
negative regulation of response to stimulus GO:0048585 258 0.040
single organism cellular localization GO:1902580 180 0.037
regulation of translation GO:0006417 56 0.036
rrna processing GO:0006364 3 0.036
single organism intracellular transport GO:1902582 207 0.035
nucleoside triphosphate metabolic process GO:0009141 120 0.033
nucleotide metabolic process GO:0009117 161 0.030
larval development GO:0002164 104 0.030
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.030
cellular response to organic substance GO:0071310 132 0.029
vesicle mediated transport GO:0016192 381 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.028
organic substance transport GO:0071702 257 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.026
cell maturation GO:0048469 144 0.026
response to abiotic stimulus GO:0009628 341 0.026
reproductive system development GO:0061458 74 0.025
purine nucleoside triphosphate metabolic process GO:0009144 119 0.025
positive regulation of biosynthetic process GO:0009891 316 0.024
cytoplasmic transport GO:0016482 130 0.024
positive regulation of gene expression GO:0010628 290 0.024
developmental maturation GO:0021700 172 0.024
translational elongation GO:0006414 4 0.023
protein modification process GO:0036211 438 0.023
cellular macromolecule localization GO:0070727 220 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.023
negative regulation of cellular biosynthetic process GO:0031327 277 0.022
centrosome cycle GO:0007098 137 0.022
jak stat cascade GO:0007259 49 0.021
chromosome organization GO:0051276 360 0.021
endocytosis GO:0006897 310 0.021
negative regulation of gene expression GO:0010629 387 0.021
cell death GO:0008219 279 0.021
growth GO:0040007 359 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
nucleoside phosphate metabolic process GO:0006753 162 0.020
oocyte axis specification GO:0007309 108 0.020
phagocytosis GO:0006909 215 0.020
endomembrane system organization GO:0010256 119 0.020
ribonucleoside catabolic process GO:0042454 112 0.019
oocyte development GO:0048599 124 0.019
establishment of protein localization GO:0045184 163 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
regulation of cell proliferation GO:0042127 163 0.019
positive regulation of rna metabolic process GO:0051254 271 0.019
protein transport GO:0015031 155 0.018
translation GO:0006412 69 0.018
cellular nitrogen compound catabolic process GO:0044270 165 0.018
cellular catabolic process GO:0044248 372 0.018
regulation of apoptotic process GO:0042981 130 0.018
catabolic process GO:0009056 409 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.017
regulation of intracellular signal transduction GO:1902531 236 0.017
single organism membrane organization GO:0044802 93 0.017
regulation of multi organism process GO:0043900 131 0.017
macromolecule catabolic process GO:0009057 161 0.017
cytoplasmic translation GO:0002181 0 0.016
intracellular transport GO:0046907 228 0.016
regulation of peptidase activity GO:0052547 39 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
microtubule organizing center organization GO:0031023 168 0.016
positive regulation of signal transduction GO:0009967 223 0.016
ribose phosphate metabolic process GO:0019693 145 0.016
intracellular protein transport GO:0006886 104 0.015
regulation of catalytic activity GO:0050790 185 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
negative regulation of signal transduction GO:0009968 206 0.015
positive regulation of hydrolase activity GO:0051345 78 0.015
immune system process GO:0002376 347 0.015
meiotic cell cycle GO:0051321 171 0.015
positive regulation of cell communication GO:0010647 250 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
aromatic compound catabolic process GO:0019439 166 0.015
regulation of gene expression epigenetic GO:0040029 128 0.014
response to oxidative stress GO:0006979 86 0.014
eye development GO:0001654 323 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.014
pigment metabolic process GO:0042440 84 0.014
protein processing GO:0016485 68 0.014
negative regulation of cellular protein metabolic process GO:0032269 85 0.014
regulation of cellular protein metabolic process GO:0032268 243 0.014
oocyte differentiation GO:0009994 145 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
stem cell differentiation GO:0048863 117 0.014
dna metabolic process GO:0006259 227 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.014
death GO:0016265 284 0.013
mesenchymal cell differentiation GO:0048762 1 0.013
heterocycle catabolic process GO:0046700 166 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
regulation of endopeptidase activity GO:0052548 36 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
protein catabolic process GO:0030163 101 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
organophosphate metabolic process GO:0019637 195 0.013
cellular response to oxygen containing compound GO:1901701 79 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
rna splicing GO:0008380 83 0.012
mrna processing GO:0006397 104 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
response to oxygen containing compound GO:1901700 200 0.012
chemical homeostasis GO:0048878 92 0.012
development of primary sexual characteristics GO:0045137 50 0.012
segmentation GO:0035282 207 0.012
cellular protein localization GO:0034613 160 0.012
nucleoside monophosphate metabolic process GO:0009123 52 0.012
response to oxygen levels GO:0070482 59 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
regionalization GO:0003002 416 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
cellular protein modification process GO:0006464 438 0.011
positive regulation of molecular function GO:0044093 136 0.011
response to external biotic stimulus GO:0043207 293 0.011
response to decreased oxygen levels GO:0036293 58 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
single organism biosynthetic process GO:0044711 206 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
reproductive structure development GO:0048608 74 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
negative regulation of signaling GO:0023057 219 0.011
regulation of neuron apoptotic process GO:0043523 16 0.011
neuron apoptotic process GO:0051402 17 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
spermatogenesis GO:0007283 200 0.011
cellular amine metabolic process GO:0044106 12 0.011
negative regulation of cell cycle phase transition GO:1901988 103 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
regulation of neuron death GO:1901214 26 0.011
rna localization GO:0006403 115 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
determination of adult lifespan GO:0008340 137 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.010
axis specification GO:0009798 167 0.010
macromolecular complex assembly GO:0065003 256 0.010
transcription from rna polymerase ii promoter GO:0006366 368 0.010
immune effector process GO:0002252 98 0.010
positive regulation of signaling GO:0023056 243 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.010
cell proliferation GO:0008283 299 0.010
intracellular signal transduction GO:0035556 300 0.010
negative regulation of neuron death GO:1901215 18 0.010

eIF-2alpha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023