Drosophila melanogaster

123 known processes

Hrb98DE (Dmel_CG9983)

Heterogeneous nuclear ribonucleoprotein at 98DE

(Aliases: E7Delta6,Hrb1,hrp38,HRB98DE/hrp38,HDP(P9),p9,Pen9,anon-E7Delta6,Dmel\CG9983,hrb98DE,CG9983)

Hrb98DE biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription dna templated GO:0045892 237 0.687
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.636
Mouse
negative regulation of gene expression GO:0010629 387 0.591
negative regulation of rna biosynthetic process GO:1902679 240 0.571
Mouse
apoptotic process GO:0006915 159 0.498
chromosome organization GO:0051276 360 0.491
regulation of programmed cell death GO:0043067 152 0.485
response to external biotic stimulus GO:0043207 293 0.467
meiotic cell cycle process GO:1903046 132 0.450
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.445
Mouse
mrna metabolic process GO:0016071 124 0.440
translation GO:0006412 69 0.434
multicellular organismal aging GO:0010259 140 0.434
Worm
negative regulation of cellular biosynthetic process GO:0031327 277 0.415
Mouse
immune system process GO:0002376 347 0.410
muscle structure development GO:0061061 224 0.378
death GO:0016265 284 0.357
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.338
regulation of cell death GO:0010941 173 0.334
response to other organism GO:0051707 293 0.332
cellular macromolecule localization GO:0070727 220 0.330
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.285
Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.277
Mouse
regulation of apoptotic process GO:0042981 130 0.269
negative regulation of nucleic acid templated transcription GO:1903507 240 0.253
Mouse
regulation of rna splicing GO:0043484 69 0.243
rna processing GO:0006396 147 0.238
lateral inhibition GO:0046331 206 0.229
protein localization GO:0008104 284 0.227
nuclear division GO:0000280 332 0.223
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.222
stem cell maintenance GO:0019827 67 0.222
stem cell development GO:0048864 79 0.221
negative regulation of cellular metabolic process GO:0031324 382 0.219
mrna processing GO:0006397 104 0.218
positive regulation of cellular component organization GO:0051130 156 0.214
determination of adult lifespan GO:0008340 137 0.213
Worm
positive regulation of cell death GO:0010942 69 0.197
asymmetric stem cell division GO:0098722 49 0.196
nucleosome organization GO:0034728 59 0.196
cell death GO:0008219 279 0.194
mrna catabolic process GO:0006402 33 0.187
posttranscriptional regulation of gene expression GO:0010608 145 0.181
positive regulation of macromolecule metabolic process GO:0010604 405 0.175
macromolecular complex assembly GO:0065003 256 0.165
negative regulation of rna metabolic process GO:0051253 251 0.159
imaginal disc derived appendage development GO:0048737 399 0.158
mitotic spindle organization GO:0007052 220 0.150
posttranscriptional gene silencing GO:0016441 46 0.150
cellular nitrogen compound catabolic process GO:0044270 165 0.148
spindle organization GO:0007051 253 0.148
regulation of mitotic cell cycle GO:0007346 190 0.148
regulation of mrna metabolic process GO:1903311 72 0.147
positive regulation of programmed cell death GO:0043068 62 0.146
muscle organ development GO:0007517 127 0.145
dendrite development GO:0016358 204 0.143
growth GO:0040007 359 0.142
Worm
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.141
Mouse
response to biotic stimulus GO:0009607 294 0.140
regulation of meiosis GO:0040020 3 0.140
intercellular bridge organization GO:0043063 14 0.132
nucleobase containing compound catabolic process GO:0034655 165 0.130
regionalization GO:0003002 416 0.118
response to abiotic stimulus GO:0009628 341 0.109
Fly
regulation of developmental growth GO:0048638 174 0.109
response to bacterium GO:0009617 198 0.107
organelle fission GO:0048285 340 0.107
Fly
modification dependent macromolecule catabolic process GO:0043632 79 0.107
rna catabolic process GO:0006401 37 0.104
cellular macromolecular complex assembly GO:0034622 153 0.102
regulation of mrna splicing via spliceosome GO:0048024 64 0.101
oocyte differentiation GO:0009994 145 0.101
aging GO:0007568 143 0.101
Worm
negative regulation of translation GO:0017148 28 0.101
spindle elongation GO:0051231 83 0.100
stem cell differentiation GO:0048863 117 0.099
negative regulation of cell cycle process GO:0010948 109 0.098
programmed cell death GO:0012501 257 0.098
cell fate determination GO:0001709 91 0.098
organonitrogen compound metabolic process GO:1901564 318 0.097
regulation of growth GO:0040008 233 0.097
morphogenesis of a polarized epithelium GO:0001738 93 0.094
regulation of organelle organization GO:0033043 196 0.093
negative regulation of developmental process GO:0051093 201 0.090
regulation of translation GO:0006417 56 0.090
cell cell signaling involved in cell fate commitment GO:0045168 210 0.088
imaginal disc derived appendage morphogenesis GO:0035114 395 0.087
positive regulation of transcription dna templated GO:0045893 266 0.085
aromatic compound catabolic process GO:0019439 166 0.084
mitotic spindle elongation GO:0000022 81 0.081
negative regulation of gene expression epigenetic GO:0045814 77 0.081
cellular protein modification process GO:0006464 438 0.080
regulation of gene expression epigenetic GO:0040029 128 0.080
negative regulation of cell death GO:0060548 81 0.078
response to dsrna GO:0043331 15 0.078
meiotic nuclear division GO:0007126 151 0.076
defense response to other organism GO:0098542 225 0.076
body morphogenesis GO:0010171 2 0.076
regulation of cellular protein metabolic process GO:0032268 243 0.076
single organism cellular localization GO:1902580 180 0.074
positive regulation of apoptotic process GO:0043065 47 0.073
histone exchange GO:0043486 21 0.073
developmental growth GO:0048589 280 0.073
antimicrobial peptide production GO:0002775 46 0.072
meiotic cell cycle GO:0051321 171 0.072
negative regulation of cell cycle phase transition GO:1901988 103 0.071
dna metabolic process GO:0006259 227 0.070
protein dna complex subunit organization GO:0071824 86 0.069
regulation of localization GO:0032879 275 0.068
gene silencing by rna GO:0031047 57 0.067
microtubule organizing center organization GO:0031023 168 0.065
gene silencing GO:0016458 138 0.064
chromatin organization GO:0006325 207 0.063
morphogenesis of embryonic epithelium GO:0016331 94 0.061
embryo development ending in birth or egg hatching GO:0009792 152 0.061
Worm
alternative mrna splicing via spliceosome GO:0000380 60 0.060
embryonic morphogenesis GO:0048598 206 0.060
cellular protein localization GO:0034613 160 0.059
endocytosis GO:0006897 310 0.059
negative regulation of cell communication GO:0010648 223 0.058
central nervous system development GO:0007417 201 0.058
positive regulation of multi organism process GO:0043902 40 0.057
positive regulation of signal transduction GO:0009967 223 0.057
cell division GO:0051301 248 0.056
dendrite morphogenesis GO:0048813 199 0.056
axon guidance GO:0007411 233 0.054
synapse organization GO:0050808 196 0.053
organic substance transport GO:0071702 257 0.053
Human
positive regulation of signaling GO:0023056 243 0.052
dorsal ventral pattern formation GO:0009953 133 0.052
regulation of multi organism process GO:0043900 131 0.052
regulation of response to stress GO:0080134 200 0.052
male gamete generation GO:0048232 201 0.052
Fly
positive regulation of transport GO:0051050 92 0.052
regulation of cell cycle GO:0051726 291 0.051
rna splicing GO:0008380 83 0.051
small molecule metabolic process GO:0044281 305 0.051
positive regulation of rna biosynthetic process GO:1902680 266 0.050
protein transport GO:0015031 155 0.049
sensory organ morphogenesis GO:0090596 260 0.049
chromosome localization GO:0050000 20 0.049
regulation of immune response GO:0050776 118 0.048
regulation of immune system process GO:0002682 176 0.048
regulation of canonical wnt signaling pathway GO:0060828 15 0.047
negative regulation of cellular component organization GO:0051129 108 0.047
peptide metabolic process GO:0006518 80 0.047
positive regulation of nucleic acid templated transcription GO:1903508 266 0.046
organic substance catabolic process GO:1901575 308 0.046
regulation of mrna processing GO:0050684 71 0.046
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.046
nucleus organization GO:0006997 45 0.046
establishment of planar polarity GO:0001736 87 0.045
chromatin remodeling GO:0006338 72 0.045
nuclear body organization GO:0030575 6 0.045
apoptotic signaling pathway GO:0097190 27 0.045
homeostatic process GO:0042592 199 0.045
cellular macromolecule catabolic process GO:0044265 136 0.045
regulation of cell differentiation GO:0045595 302 0.044
purine nucleotide catabolic process GO:0006195 109 0.044
vesicle mediated transport GO:0016192 381 0.043
eye development GO:0001654 323 0.043
positive regulation of response to stimulus GO:0048584 323 0.042
response to starvation GO:0042594 97 0.042
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.041
regulation of anatomical structure morphogenesis GO:0022603 242 0.041
dna damage checkpoint GO:0000077 78 0.040
immune response GO:0006955 246 0.039
single organism behavior GO:0044708 391 0.039
amide biosynthetic process GO:0043604 42 0.039
mitotic nuclear division GO:0007067 213 0.039
Fly
imaginal disc derived leg morphogenesis GO:0007480 80 0.038
nuclear transcribed mrna catabolic process GO:0000956 24 0.038
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.037
Mouse
gene silencing by mirna GO:0035195 22 0.037
oocyte development GO:0048599 124 0.037
maintenance of protein location in cell GO:0032507 26 0.037
chromosome segregation GO:0007059 157 0.036
synapse assembly GO:0007416 143 0.035
secretion GO:0046903 109 0.035
organic cyclic compound catabolic process GO:1901361 168 0.035
meiotic spindle organization GO:0000212 36 0.035
signal transduction by phosphorylation GO:0023014 107 0.035
intracellular receptor signaling pathway GO:0030522 19 0.035
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.035
proteolysis GO:0006508 192 0.035
post embryonic appendage morphogenesis GO:0035120 385 0.034
establishment or maintenance of cell polarity GO:0007163 167 0.034
germline stem cell asymmetric division GO:0098728 15 0.034
endomembrane system organization GO:0010256 119 0.033
regulation of cell proliferation GO:0042127 163 0.032
cellular response to organic cyclic compound GO:0071407 32 0.032
response to alcohol GO:0097305 95 0.032
cytoplasm organization GO:0007028 64 0.032
regulation of reproductive process GO:2000241 54 0.032
negative regulation of cell differentiation GO:0045596 143 0.032
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.032
response to organic substance GO:0010033 284 0.032
dorsal ventral axis specification GO:0009950 66 0.031
mrna splicing via spliceosome GO:0000398 73 0.031
cell proliferation GO:0008283 299 0.030
regulation of secretion GO:0051046 44 0.030
rrna processing GO:0006364 3 0.030
regulation of transport GO:0051049 181 0.030
regulation of nuclear division GO:0051783 58 0.030
negative regulation of apoptotic process GO:0043066 63 0.030
establishment of ommatidial planar polarity GO:0042067 49 0.030
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.029
ribonucleoside triphosphate metabolic process GO:0009199 119 0.029
negative regulation of programmed cell death GO:0043069 72 0.029
protein complex biogenesis GO:0070271 201 0.029
response to nutrient levels GO:0031667 114 0.028
Fly
regulation of synapse structure and activity GO:0050803 128 0.028
dna conformation change GO:0071103 105 0.028
circulatory system development GO:0072359 82 0.028
detection of stimulus involved in sensory perception GO:0050906 92 0.028
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.028
protein modification by small protein conjugation or removal GO:0070647 106 0.028
spermatid development GO:0007286 98 0.027
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.027
establishment of protein localization to organelle GO:0072594 62 0.027
purine nucleoside metabolic process GO:0042278 127 0.027
developmental maturation GO:0021700 172 0.027
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.027
salivary gland development GO:0007431 162 0.026
germ line stem cell division GO:0042078 25 0.026
positive regulation of intracellular signal transduction GO:1902533 116 0.026
multi organism reproductive behavior GO:0044705 121 0.026
tube morphogenesis GO:0035239 191 0.026
protein dna complex assembly GO:0065004 63 0.025
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.025
embryonic development via the syncytial blastoderm GO:0001700 148 0.025
heterocycle catabolic process GO:0046700 166 0.025
defense response to bacterium GO:0042742 178 0.025
purine nucleotide metabolic process GO:0006163 146 0.025
nuclear pore organization GO:0006999 1 0.025
catabolic process GO:0009056 409 0.024
neural retina development GO:0003407 4 0.024
pole plasm mrna localization GO:0019094 49 0.024
neuroblast proliferation GO:0007405 74 0.024
purine containing compound metabolic process GO:0072521 155 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.024
camera type eye development GO:0043010 4 0.024
protein modification process GO:0036211 438 0.024
phosphorylation GO:0016310 294 0.024
organelle assembly GO:0070925 198 0.024
appendage development GO:0048736 401 0.024
locomotory behavior GO:0007626 176 0.023
regulation of mitotic cell cycle phase transition GO:1901990 130 0.023
cell growth GO:0016049 108 0.023
maintenance of location GO:0051235 73 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
neuron projection guidance GO:0097485 241 0.022
macromolecule catabolic process GO:0009057 161 0.022
mitotic cell cycle checkpoint GO:0007093 88 0.022
positive regulation of cellular protein metabolic process GO:0032270 118 0.022
segmentation GO:0035282 207 0.022
head development GO:0060322 135 0.021
axis specification GO:0009798 167 0.021
microtubule polymerization or depolymerization GO:0031109 39 0.021
regulation of cell cycle process GO:0010564 181 0.021
alcohol biosynthetic process GO:0046165 14 0.021
rna splicing via transesterification reactions GO:0000375 73 0.021
response to oxygen containing compound GO:1901700 200 0.020
purine nucleoside triphosphate catabolic process GO:0009146 108 0.020
purine ribonucleotide metabolic process GO:0009150 145 0.020
covalent chromatin modification GO:0016569 106 0.020
production of molecular mediator of immune response GO:0002440 46 0.020
antimicrobial humoral response GO:0019730 99 0.020
mitotic g2 m transition checkpoint GO:0044818 70 0.020
protein complex assembly GO:0006461 200 0.020
regulation of cell shape GO:0008360 113 0.020
mrna splice site selection GO:0006376 1 0.020
neurological system process GO:0050877 358 0.019
regulation of mitosis GO:0007088 56 0.019
intracellular signal transduction GO:0035556 300 0.019
positive regulation of apoptotic signaling pathway GO:2001235 4 0.019
regulation of dendrite morphogenesis GO:0048814 28 0.019
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.019
regulation of anatomical structure size GO:0090066 163 0.019
wing disc morphogenesis GO:0007472 344 0.019
ribonucleoprotein complex assembly GO:0022618 23 0.018
organophosphate catabolic process GO:0046434 112 0.018
positive regulation of multicellular organism growth GO:0040018 21 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.018
rna 3 end processing GO:0031123 45 0.018
cellular response to dna damage stimulus GO:0006974 223 0.018
regulation of cell division GO:0051302 72 0.018
regulation of oskar mrna translation GO:0046011 8 0.018
negative regulation of multicellular organismal process GO:0051241 142 0.018
ribonucleoside metabolic process GO:0009119 127 0.018
stem cell division GO:0017145 69 0.018
regulation of molecular function GO:0065009 217 0.017
regulation of protein localization GO:0032880 76 0.017
neuronal stem cell maintenance GO:0097150 4 0.017
regulation of synapse assembly GO:0051963 94 0.017
rna localization GO:0006403 115 0.017
Human
germline ring canal formation GO:0030725 13 0.017
defense response GO:0006952 300 0.017
regulation of cellular localization GO:0060341 136 0.017
female germ line cyst formation GO:0048135 42 0.017
retina development in camera type eye GO:0060041 4 0.016
aggressive behavior GO:0002118 63 0.016
chromatin modification GO:0016568 147 0.016
imaginal disc derived wing morphogenesis GO:0007476 337 0.016
retina morphogenesis in camera type eye GO:0060042 2 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
maintenance of location in cell GO:0051651 28 0.016
positive regulation of cell communication GO:0010647 250 0.016
posttranscriptional gene silencing by rna GO:0035194 45 0.016
chemotaxis GO:0006935 249 0.015
single organism catabolic process GO:0044712 228 0.015
brain development GO:0007420 120 0.015
convergent extension GO:0060026 2 0.015
nucleosome mobilization GO:0042766 9 0.015
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.015
nuclear envelope organization GO:0006998 7 0.015
negative regulation of organelle organization GO:0010639 56 0.015
multi organism behavior GO:0051705 175 0.015
nucleotide catabolic process GO:0009166 109 0.015
kidney development GO:0001822 3 0.015
gland morphogenesis GO:0022612 145 0.015
innate immune response GO:0045087 144 0.015
ncrna metabolic process GO:0034660 43 0.015
cytokinesis GO:0000910 90 0.015
regulation of chromosome organization GO:0033044 64 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
oocyte axis specification GO:0007309 108 0.014
regulation of behavior GO:0050795 75 0.014
rna phosphodiester bond hydrolysis GO:0090501 17 0.014
stem cell proliferation GO:0072089 88 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.014
establishment of tissue polarity GO:0007164 87 0.014
appendage morphogenesis GO:0035107 397 0.014
cellular homeostasis GO:0019725 80 0.014
establishment of localization in cell GO:0051649 402 0.013
Human
regulation of circadian rhythm GO:0042752 49 0.013
tissue morphogenesis GO:0048729 297 0.013
establishment of chromosome localization GO:0051303 20 0.013
positive regulation of growth GO:0045927 75 0.013
hemopoiesis GO:0030097 46 0.013
spermatogenesis GO:0007283 200 0.013
Fly
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
regulation of wnt signaling pathway GO:0030111 68 0.013
regulation of cytoskeleton organization GO:0051493 89 0.013
dna recombination GO:0006310 32 0.013
metaphase plate congression GO:0051310 19 0.013
meiosis i GO:0007127 59 0.013
dna integrity checkpoint GO:0031570 81 0.013
ribose phosphate metabolic process GO:0019693 145 0.012
cell maturation GO:0048469 144 0.012
cell cycle phase transition GO:0044770 140 0.012
renal system process GO:0003014 12 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
negative regulation of developmental growth GO:0048640 64 0.012
transmembrane transport GO:0055085 139 0.012
mapk cascade GO:0000165 107 0.012
regulation of intracellular signal transduction GO:1902531 236 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
nephron development GO:0072006 3 0.012
leg disc morphogenesis GO:0007478 80 0.012
regulation of multicellular organismal development GO:2000026 414 0.012
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.012
cellular protein catabolic process GO:0044257 83 0.012
regulation of cell cycle phase transition GO:1901987 130 0.012
glycosyl compound catabolic process GO:1901658 112 0.012
intracellular transport GO:0046907 228 0.012
Human
negative regulation of protein modification process GO:0031400 29 0.012
synaptic transmission GO:0007268 288 0.012
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.011
regulation of oocyte development GO:0060281 27 0.011
maintenance of protein location GO:0045185 28 0.011
protein ubiquitination GO:0016567 70 0.011
cytoplasmic mrna processing body assembly GO:0033962 10 0.011
negative regulation of cell division GO:0051782 17 0.011
meiotic chromosome segregation GO:0045132 59 0.011
forebrain development GO:0030900 2 0.011
wing disc pattern formation GO:0035222 66 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
establishment of protein localization GO:0045184 163 0.011
regulation of multicellular organism growth GO:0040014 40 0.011
dsrna fragmentation GO:0031050 15 0.011
mrna 3 end processing GO:0031124 28 0.011
g2 dna damage checkpoint GO:0031572 69 0.011
compound eye development GO:0048749 307 0.011
maternal determination of anterior posterior axis embryo GO:0008358 74 0.011
regulation of production of molecular mediator of immune response GO:0002700 44 0.011
oocyte microtubule cytoskeleton organization GO:0016325 35 0.011
proteasomal protein catabolic process GO:0010498 59 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
positive regulation of secretion by cell GO:1903532 20 0.011
extracellular structure organization GO:0043062 46 0.011
renal system development GO:0072001 72 0.011
cellular component assembly involved in morphogenesis GO:0010927 151 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
chromatin silencing GO:0006342 76 0.011
digestive tract development GO:0048565 149 0.011
sister chromatid segregation GO:0000819 92 0.011
response to ecdysone GO:0035075 34 0.010
regulation of neuron death GO:1901214 26 0.010
positive regulation of lipid metabolic process GO:0045834 4 0.010
ecdysone receptor mediated signaling pathway GO:0035076 11 0.010
regulation of gene silencing GO:0060968 63 0.010
regulation of antimicrobial humoral response GO:0002759 50 0.010
single organism intracellular transport GO:1902582 207 0.010
regulation of cell growth GO:0001558 43 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
synaptic growth at neuromuscular junction GO:0051124 119 0.010
regulation of mrna 3 end processing GO:0031440 7 0.010
ribonucleoside catabolic process GO:0042454 112 0.010
embryonic hemopoiesis GO:0035162 26 0.010
response to nitrogen compound GO:1901698 90 0.010
positive regulation of rna metabolic process GO:0051254 271 0.010
blastoderm segmentation GO:0007350 159 0.010
heart development GO:0007507 82 0.010
mitotic sister chromatid segregation GO:0000070 87 0.010
purine containing compound catabolic process GO:0072523 112 0.010

Hrb98DE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.117
Human
nervous system disease DOID:863 0 0.110
Human
central nervous system disease DOID:331 0 0.015
Human
neurodegenerative disease DOID:1289 0 0.015
Human
sensory system disease DOID:0050155 0 0.012