Drosophila melanogaster

156 known processes

RanGap (Dmel_CG9999)

Ran GTPase activating protein

(Aliases: Scl,Dmel\CG9999,rangap,Ran,RanGap1,Sd-RanGAP,RanGAP,CT28175,CG9999,Sd-RanGap,ranGap,dRanGAP,Sd,ranGAP,SD)

RanGap biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiotic nuclear division GO:0007126 151 0.990
meiotic cell cycle GO:0051321 171 0.978
cell cycle checkpoint GO:0000075 95 0.978
organelle fission GO:0048285 340 0.965
nuclear division GO:0000280 332 0.932
mitotic cell cycle checkpoint GO:0007093 88 0.811
embryo development ending in birth or egg hatching GO:0009792 152 0.750
establishment of localization in cell GO:0051649 402 0.728
mitotic spindle organization GO:0007052 220 0.714
protein localization GO:0008104 284 0.695
microtubule organizing center organization GO:0031023 168 0.672
organic substance transport GO:0071702 257 0.660
regulation of catabolic process GO:0009894 170 0.646
meiotic cell cycle process GO:1903046 132 0.597
negative regulation of mitotic cell cycle GO:0045930 109 0.505
regulation of cell differentiation GO:0045595 302 0.501
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.486
cellular catabolic process GO:0044248 372 0.484
spindle assembly GO:0051225 80 0.483
mitotic g2 m transition checkpoint GO:0044818 70 0.451
negative regulation of cell cycle phase transition GO:1901988 103 0.430
protein import GO:0017038 55 0.424
meiotic chromosome segregation GO:0045132 59 0.399
catabolic process GO:0009056 409 0.397
glycosyl compound catabolic process GO:1901658 112 0.394
gonad development GO:0008406 50 0.394
mitotic cell cycle phase transition GO:0044772 138 0.393
negative regulation of cell cycle process GO:0010948 109 0.384
regulation of cell cycle phase transition GO:1901987 130 0.370
dna integrity checkpoint GO:0031570 81 0.364
larval development GO:0002164 104 0.361
mitotic dna integrity checkpoint GO:0044774 75 0.360
regulation of mitotic cell cycle phase transition GO:1901990 130 0.355
regulation of cellular catabolic process GO:0031329 157 0.354
mitotic g2 dna damage checkpoint GO:0007095 69 0.343
regulation of cell cycle process GO:0010564 181 0.333
establishment of protein localization GO:0045184 163 0.312
reproductive system development GO:0061458 74 0.309
sex differentiation GO:0007548 81 0.308
regulation of cell cycle GO:0051726 291 0.292
centrosome organization GO:0051297 163 0.290
cellular macromolecule localization GO:0070727 220 0.278
determination of adult lifespan GO:0008340 137 0.277
negative regulation of cell cycle GO:0045786 116 0.269
regulation of developmental growth GO:0048638 174 0.269
reproductive structure development GO:0048608 74 0.255
negative regulation of gene expression GO:0010629 387 0.254
protein localization to organelle GO:0033365 82 0.247
growth GO:0040007 359 0.247
spindle organization GO:0007051 253 0.245
aging GO:0007568 143 0.241
regulation of cell division GO:0051302 72 0.239
mitotic dna damage checkpoint GO:0044773 74 0.235
regulation of mitotic cell cycle GO:0007346 190 0.224
centrosome cycle GO:0007098 137 0.214
g2 dna damage checkpoint GO:0031572 69 0.212
dna damage checkpoint GO:0000077 78 0.209
gene silencing GO:0016458 138 0.198
regulation of meiosis GO:0040020 3 0.192
regulation of neurogenesis GO:0050767 158 0.189
protein modification by small protein conjugation or removal GO:0070647 106 0.188
positive regulation of growth GO:0045927 75 0.185
female meiotic division GO:0007143 70 0.185
positive regulation of proteolysis GO:0045862 52 0.184
multicellular organism growth GO:0035264 46 0.184
cell cycle phase transition GO:0044770 140 0.184
nucleoside triphosphate catabolic process GO:0009143 108 0.183
multicellular organismal aging GO:0010259 140 0.181
single organism catabolic process GO:0044712 228 0.180
genitalia development GO:0048806 26 0.179
regulation of growth GO:0040008 233 0.177
gene silencing by rna GO:0031047 57 0.169
regulation of multicellular organismal development GO:2000026 414 0.161
nuclear import GO:0051170 51 0.152
response to other organism GO:0051707 293 0.151
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.138
protein targeting to nucleus GO:0044744 51 0.134
nucleoside metabolic process GO:0009116 127 0.134
protein targeting GO:0006605 64 0.134
regulation of nucleocytoplasmic transport GO:0046822 35 0.129
Human
single organism nuclear import GO:1902593 51 0.129
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.123
cell migration GO:0016477 238 0.119
neuron recognition GO:0008038 101 0.119
protein localization to nucleus GO:0034504 55 0.118
establishment of protein localization to organelle GO:0072594 62 0.117
regulation of organelle organization GO:0033043 196 0.117
nucleotide metabolic process GO:0009117 161 0.117
regulation of cell death GO:0010941 173 0.115
protein modification by small protein conjugation GO:0032446 79 0.115
spindle assembly involved in mitosis GO:0090307 50 0.114
purine ribonucleoside metabolic process GO:0046128 127 0.113
modification dependent macromolecule catabolic process GO:0043632 79 0.110
chromosome segregation GO:0007059 157 0.108
positive regulation of endopeptidase activity GO:0010950 26 0.108
negative regulation of cellular metabolic process GO:0031324 382 0.106
protein complex biogenesis GO:0070271 201 0.104
macromolecular complex assembly GO:0065003 256 0.100
intracellular transport GO:0046907 228 0.099
negative regulation of developmental process GO:0051093 201 0.096
regulation of intracellular transport GO:0032386 64 0.093
Human
protein import into nucleus GO:0006606 51 0.092
negative regulation of cellular component organization GO:0051129 108 0.092
macromolecule catabolic process GO:0009057 161 0.091
positive regulation of multicellular organism growth GO:0040018 21 0.091
organophosphate metabolic process GO:0019637 195 0.091
developmental growth GO:0048589 280 0.089
organelle assembly GO:0070925 198 0.087
nucleocytoplasmic transport GO:0006913 72 0.085
cell division GO:0051301 248 0.084
heterocycle catabolic process GO:0046700 166 0.081
purine nucleoside metabolic process GO:0042278 127 0.079
regulation of meiotic cell cycle GO:0051445 9 0.079
cellular nitrogen compound catabolic process GO:0044270 165 0.078
cytoplasmic transport GO:0016482 130 0.077
development of primary sexual characteristics GO:0045137 50 0.077
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.074
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.073
negative regulation of cellular biosynthetic process GO:0031327 277 0.071
single organism cellular localization GO:1902580 180 0.070
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.069
organic substance catabolic process GO:1901575 308 0.069
ribonucleotide catabolic process GO:0009261 109 0.067
cell death GO:0008219 279 0.067
chromosome organization GO:0051276 360 0.066
intracellular protein transport GO:0006886 104 0.065
body morphogenesis GO:0010171 2 0.065
positive regulation of hydrolase activity GO:0051345 78 0.065
oocyte maturation GO:0001556 3 0.063
dendrite development GO:0016358 204 0.063
response to external biotic stimulus GO:0043207 293 0.061
regulation of protein localization GO:0032880 76 0.061
Human
mitotic nuclear division GO:0007067 213 0.061
death GO:0016265 284 0.060
regulation of cellular localization GO:0060341 136 0.060
Human
regulation of protein metabolic process GO:0051246 256 0.059
regulation of multicellular organism growth GO:0040014 40 0.058
cellular protein localization GO:0034613 160 0.057
dendrite morphogenesis GO:0048813 199 0.056
response to biotic stimulus GO:0009607 294 0.055
positive regulation of catabolic process GO:0009896 105 0.055
positive regulation of developmental process GO:0051094 143 0.054
axon development GO:0061564 297 0.054
nucleoside phosphate metabolic process GO:0006753 162 0.053
nucleus organization GO:0006997 45 0.053
protein transport GO:0015031 155 0.052
protein complex assembly GO:0006461 200 0.052
cellular protein complex assembly GO:0043623 71 0.050
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.050
protein ubiquitination GO:0016567 70 0.049
glycosyl compound metabolic process GO:1901657 127 0.049
positive regulation of macromolecule metabolic process GO:0010604 405 0.049
negative regulation of catabolic process GO:0009895 36 0.047
ribonucleoside catabolic process GO:0042454 112 0.046
cellular macromolecule catabolic process GO:0044265 136 0.046
male gamete generation GO:0048232 201 0.046
posttranscriptional gene silencing GO:0016441 46 0.045
purine ribonucleoside catabolic process GO:0046130 112 0.044
regulation of cellular protein catabolic process GO:1903362 44 0.043
regulation of transport GO:0051049 181 0.043
Human
response to oxidative stress GO:0006979 86 0.043
organic cyclic compound catabolic process GO:1901361 168 0.043
rna interference GO:0016246 27 0.043
chromatin remodeling GO:0006338 72 0.042
guanosine containing compound metabolic process GO:1901068 74 0.042
regulation of cellular protein metabolic process GO:0032268 243 0.041
regulation of nuclear division GO:0051783 58 0.041
regulation of cell proliferation GO:0042127 163 0.040
nuclear transport GO:0051169 72 0.040
nucleoside triphosphate metabolic process GO:0009141 120 0.040
negative regulation of sister chromatid segregation GO:0033046 13 0.040
ubiquitin dependent protein catabolic process GO:0006511 78 0.039
nucleoside catabolic process GO:0009164 112 0.039
posttranscriptional regulation of gene expression GO:0010608 145 0.038
endocytosis GO:0006897 310 0.038
nucleobase containing small molecule metabolic process GO:0055086 174 0.038
regulation of protein localization to nucleus GO:1900180 29 0.038
regulation of hemocyte proliferation GO:0035206 37 0.037
positive regulation of multicellular organismal process GO:0051240 143 0.037
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.036
nucleoside phosphate catabolic process GO:1901292 110 0.036
maintenance of location GO:0051235 73 0.035
regulation of phosphate metabolic process GO:0019220 210 0.035
defense response to bacterium GO:0042742 178 0.035
purine ribonucleotide metabolic process GO:0009150 145 0.034
purine containing compound catabolic process GO:0072523 112 0.033
regulation of proteolysis GO:0030162 87 0.033
cell proliferation GO:0008283 299 0.033
homeostatic process GO:0042592 199 0.032
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.032
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.032
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.032
metaphase anaphase transition of cell cycle GO:0044784 28 0.031
camera type eye development GO:0043010 4 0.031
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.031
apoptotic process GO:0006915 159 0.031
dna replication GO:0006260 48 0.031
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 15 0.030
chromatin organization GO:0006325 207 0.030
positive regulation of molecular function GO:0044093 136 0.030
response to ketone GO:1901654 34 0.030
pronuclear migration GO:0035046 4 0.030
purine nucleotide catabolic process GO:0006195 109 0.030
regulation of protein transport GO:0051223 57 0.029
Human
positive regulation of cellular protein metabolic process GO:0032270 118 0.029
positive regulation of protein import into nucleus GO:0042307 21 0.028
regulation of molecular function GO:0065009 217 0.027
positive regulation of cellular catabolic process GO:0031331 95 0.027
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.026
aromatic compound catabolic process GO:0019439 166 0.026
response to sterol GO:0036314 34 0.026
regulation of cytoplasmic transport GO:1903649 47 0.026
Human
negative regulation of cell differentiation GO:0045596 143 0.026
dna templated transcription elongation GO:0006354 18 0.025
regulation of cdc42 protein signal transduction GO:0032489 3 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
carbohydrate derivative catabolic process GO:1901136 118 0.025
ribose phosphate metabolic process GO:0019693 145 0.025
positive regulation of transcription factor import into nucleus GO:0042993 19 0.025
proteolysis GO:0006508 192 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
epithelial cell differentiation GO:0030855 322 0.025
response to oxygen containing compound GO:1901700 200 0.023
programmed cell death GO:0012501 257 0.023
response to organic cyclic compound GO:0014070 89 0.023
muscle organ development GO:0007517 127 0.023
positive regulation of intracellular protein transport GO:0090316 30 0.022
defense response GO:0006952 300 0.022
mrna catabolic process GO:0006402 33 0.022
induction of programmed cell death by hormones GO:0035081 12 0.022
multi multicellular organism process GO:0044706 123 0.022
ribonucleoside triphosphate metabolic process GO:0009199 119 0.022
defense response to other organism GO:0098542 225 0.021
double strand break repair via homologous recombination GO:0000724 13 0.021
eggshell formation GO:0030703 105 0.021
cellular macromolecular complex assembly GO:0034622 153 0.021
negative regulation of purine nucleotide catabolic process GO:0033122 1 0.021
small gtpase mediated signal transduction GO:0007264 88 0.020
negative regulation of cellular catabolic process GO:0031330 34 0.020
proteasomal protein catabolic process GO:0010498 59 0.020
regulation of protein catabolic process GO:0042176 55 0.020
multicellular organismal reproductive behavior GO:0033057 110 0.020
purine nucleoside triphosphate metabolic process GO:0009144 119 0.020
salivary gland morphogenesis GO:0007435 145 0.020
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.020
positive regulation of mrna processing GO:0050685 4 0.019
regulation of gene expression epigenetic GO:0040029 128 0.019
regulation of intracellular protein transport GO:0033157 46 0.019
Human
cytokinesis GO:0000910 90 0.019
gland development GO:0048732 191 0.019
formation of a compartment boundary GO:0060288 4 0.019
organophosphate catabolic process GO:0046434 112 0.019
small molecule metabolic process GO:0044281 305 0.019
positive regulation of cellular component organization GO:0051130 156 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
regulation of response to stress GO:0080134 200 0.018
single organism intracellular transport GO:1902582 207 0.018
ribonucleoside triphosphate catabolic process GO:0009203 108 0.018
regulation of neuron differentiation GO:0045664 103 0.018
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.018
dna recombination GO:0006310 32 0.018
regulation of localization GO:0032879 275 0.018
Human
negative regulation of rna biosynthetic process GO:1902679 240 0.017
response to organic substance GO:0010033 284 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
purine nucleoside triphosphate catabolic process GO:0009146 108 0.017
cell cycle g1 s phase transition GO:0044843 31 0.017
nucleobase containing compound catabolic process GO:0034655 165 0.017
establishment of organelle localization GO:0051656 122 0.017
spermatogenesis GO:0007283 200 0.017
neuronal stem cell maintenance GO:0097150 4 0.016
regulation of chromosome organization GO:0033044 64 0.016
regulation of defense response GO:0031347 102 0.016
regulation of ruffle assembly GO:1900027 1 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
induction of programmed cell death by ecdysone GO:0035078 12 0.016
regulation of peptidase activity GO:0052547 39 0.016
regulation of intracellular signal transduction GO:1902531 236 0.015
phagocytosis GO:0006909 215 0.015
regulation of proteasomal protein catabolic process GO:0061136 39 0.015
regulation of apoptotic process GO:0042981 130 0.015
regulation of striated muscle contraction GO:0006942 2 0.015
posttranscriptional gene silencing by rna GO:0035194 45 0.015
gliogenesis GO:0042063 80 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.015
positive regulation of transport GO:0051050 92 0.015
mrna processing GO:0006397 104 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
negative regulation of cell proliferation GO:0008285 69 0.014
mitotic sister chromatid segregation GO:0000070 87 0.014
rna localization GO:0006403 115 0.014
oocyte axis specification GO:0007309 108 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
regulation of hydrolase activity GO:0051336 97 0.014
centrosome duplication GO:0051298 121 0.014
regulation of endopeptidase activity GO:0052548 36 0.013
meiotic cytokinesis GO:0033206 33 0.013
protein catabolic process GO:0030163 101 0.013
response to ecdysone GO:0035075 34 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336 3 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
protein modification process GO:0036211 438 0.013
regulation of multivesicular body size GO:0010796 3 0.013
progression of morphogenetic furrow involved in compound eye morphogenesis GO:0007458 8 0.013
cell recognition GO:0008037 102 0.013
regulation of phosphorus metabolic process GO:0051174 210 0.013
regulation of sister chromatid segregation GO:0033045 28 0.012
cellular protein catabolic process GO:0044257 83 0.012
negative regulation of transcription factor import into nucleus GO:0042992 4 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
histone h3 k9 modification GO:0061647 12 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
positive regulation of protein transport GO:0051222 37 0.012
localization of cell GO:0051674 257 0.012
regulation of response to external stimulus GO:0032101 115 0.012
regulation of phosphatase activity GO:0010921 3 0.011
reproductive behavior GO:0019098 122 0.011
positive regulation of protein localization to nucleus GO:1900182 21 0.011
fertilization GO:0009566 26 0.011
ecdysone mediated induction of salivary gland cell autophagic cell death GO:0035072 12 0.011
dna metabolic process GO:0006259 227 0.011
establishment of mitotic spindle localization GO:0040001 17 0.011
nucleotide catabolic process GO:0009166 109 0.011
intracellular signal transduction GO:0035556 300 0.011
cellular response to organic substance GO:0071310 132 0.010
dorsal closure leading edge cell differentiation GO:0046663 2 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
asymmetric protein localization GO:0008105 33 0.010
chorion containing eggshell formation GO:0007304 105 0.010
epithelial cell development GO:0002064 274 0.010
pole cell formation GO:0007279 19 0.010

RanGap disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
respiratory system cancer DOID:0050615 0 0.015
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015