Homo sapiens

0 known processes

SMEK1

SMEK homolog 1, suppressor of mek1 (Dictyostelium)

(Aliases: smk1,PP4R3A,FLFL1,smk-1,KIAA2010)

SMEK1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via homologous recombination GO:0000724 50 0.731
cellular response to dna damage stimulus GO:0006974 379 0.714
regulation of double strand break repair via homologous recombination GO:0010569 11 0.702
recombinational repair GO:0000725 50 0.670
regulation of dna repair GO:0006282 47 0.606
regulation of response to dna damage stimulus GO:2001020 94 0.596
regulation of dna metabolic process GO:0051052 153 0.553
dna repair GO:0006281 198 0.543
double strand break repair GO:0006302 101 0.460
regulation of cellular response to stress GO:0080135 244 0.439
regulation of double strand break repair GO:2000779 22 0.428
regulation of dna recombination GO:0000018 23 0.382
carbohydrate metabolic process GO:0005975 207 0.289
Mouse
protein glycosylation GO:0006486 62 0.206
cardiovascular system development GO:0072358 262 0.192
peptidyl serine phosphorylation GO:0018105 101 0.113
cell cycle checkpoint GO:0000075 117 0.110
positive regulation of dna metabolic process GO:0051054 73 0.094
chromatin modification GO:0016568 298 0.094
peptidyl lysine acetylation GO:0018394 101 0.090
dna recombination GO:0006310 77 0.080
female gamete generation GO:0007292 2 0.079
cellular amine metabolic process GO:0044106 41 0.077
protein modification by small protein conjugation GO:0032446 342 0.075
microtubule based process GO:0007017 210 0.073
anatomical structure formation involved in morphogenesis GO:0048646 284 0.073
response to cytokine GO:0034097 232 0.070
ras protein signal transduction GO:0007265 73 0.069
peptidyl lysine modification GO:0018205 144 0.064
negative regulation of cell death GO:0060548 345 0.063
oxidation reduction process GO:0055114 396 0.063
post embryonic development GO:0009791 2 0.061
regulation of cellular amino acid metabolic process GO:0006521 6 0.060
negative regulation of proteolysis GO:0045861 132 0.060
regulation of meiotic cell cycle GO:0051445 4 0.059
histone modification GO:0016570 251 0.059
neural tube formation GO:0001841 3 0.059
peptidyl serine modification GO:0018209 106 0.057
central nervous system neuron axonogenesis GO:0021955 3 0.056
protein autophosphorylation GO:0046777 123 0.055
posttranscriptional regulation of gene expression GO:0010608 213 0.054
cellular ketone metabolic process GO:0042180 80 0.054
Mouse
positive regulation of programmed cell death GO:0043068 249 0.053
protein acetylation GO:0006473 116 0.053
positive regulation of response to dna damage stimulus GO:2001022 43 0.053
internal protein amino acid acetylation GO:0006475 101 0.052
regulation of cellular amine metabolic process GO:0033238 11 0.050
dna integrity checkpoint GO:0031570 71 0.050
regulation of cellular ketone metabolic process GO:0010565 50 0.050
Mouse
microtubule cytoskeleton organization GO:0000226 176 0.048
oogenesis GO:0048477 2 0.047
embryonic viscerocranium morphogenesis GO:0048703 1 0.044
amine metabolic process GO:0009308 44 0.044
internal peptidyl lysine acetylation GO:0018393 97 0.043
positive regulation of apoptotic process GO:0043065 246 0.041
regulation of meiosis GO:0040020 3 0.040
negative regulation of phosphorus metabolic process GO:0010563 267 0.040
cellular amino acid metabolic process GO:0006520 116 0.039
cellular response to interleukin 1 GO:0071347 35 0.038
cellular glucan metabolic process GO:0006073 22 0.038
negative regulation of protein metabolic process GO:0051248 391 0.038
protein processing GO:0016485 226 0.037
response to oxygen containing compound GO:1901700 369 0.037
regulation of mapk cascade GO:0043408 262 0.037
nervous system development GO:0007399 293 0.036
glycosylation GO:0070085 71 0.036
negative regulation of catalytic activity GO:0043086 335 0.036
macromolecule glycosylation GO:0043413 63 0.036
signal transduction by phosphorylation GO:0023014 297 0.035
neuroblast proliferation GO:0007405 4 0.034
negative regulation of protein processing GO:0010955 142 0.032
regulation of stress activated mapk cascade GO:0032872 84 0.032
endomembrane system organization GO:0010256 196 0.032
cellular component morphogenesis GO:0032989 314 0.031
immune response GO:0006955 307 0.031
regulation of proteolysis GO:0030162 293 0.031
stress activated mapk cascade GO:0051403 93 0.030
rna interference GO:0016246 4 0.030
regulation of protein complex assembly GO:0043254 147 0.029
heart development GO:0007507 95 0.029
defense response GO:0006952 315 0.029
covalent chromatin modification GO:0016569 254 0.029
regulation of homeostatic process GO:0032844 121 0.029
determination of adult lifespan GO:0008340 2 0.029
histone acetylation GO:0016573 93 0.029
cellular response to arsenic containing substance GO:0071243 4 0.029
chromatin organization GO:0006325 351 0.028
carbohydrate derivative biosynthetic process GO:1901137 207 0.028
rho protein signal transduction GO:0007266 26 0.028
protein acylation GO:0043543 138 0.027
negative regulation of catabolic process GO:0009895 104 0.027
glycoprotein metabolic process GO:0009100 110 0.027
head development GO:0060322 108 0.027
hemopoiesis GO:0030097 180 0.027
anterior posterior axis specification GO:0009948 2 0.027
cell development GO:0048468 328 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
morphogenesis of embryonic epithelium GO:0016331 4 0.027
negative regulation of apoptotic process GO:0043066 316 0.026
positive regulation of immune system process GO:0002684 283 0.026
protein stabilization GO:0050821 64 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
glycoprotein biosynthetic process GO:0009101 91 0.026
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.026
negative regulation of protein maturation GO:1903318 142 0.026
circulatory system development GO:0072359 262 0.026
behavioral response to ethanol GO:0048149 2 0.025
regulation of kinase activity GO:0043549 314 0.025
cellular polysaccharide metabolic process GO:0044264 27 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
mapk cascade GO:0000165 288 0.025
blood vessel morphogenesis GO:0048514 162 0.025
embryonic epithelial tube formation GO:0001838 4 0.025
reproductive process GO:0022414 106 0.024
behavior GO:0007610 112 0.024
regulation of cell cycle GO:0051726 393 0.024
response to carbohydrate GO:0009743 21 0.024
positive regulation of cellular amine metabolic process GO:0033240 7 0.024
erk1 and erk2 cascade GO:0070371 104 0.023
regulation of cell cycle process GO:0010564 266 0.023
response to salt stress GO:0009651 3 0.023
regulation of translation GO:0006417 89 0.023
cell morphogenesis GO:0000902 296 0.022
glucose homeostasis GO:0042593 31 0.022
stress activated protein kinase signaling cascade GO:0031098 94 0.022
negative regulation of cell cycle GO:0045786 193 0.022
positive regulation of mapk cascade GO:0043410 190 0.022
oocyte development GO:0048599 1 0.022
protein deubiquitination GO:0016579 79 0.022
regulation of protein processing GO:0070613 150 0.022
hematopoietic or lymphoid organ development GO:0048534 186 0.022
multicellular organismal aging GO:0010259 3 0.021
cellular chemical homeostasis GO:0055082 180 0.021
positive regulation of cellular component organization GO:0051130 376 0.021
positive regulation of transferase activity GO:0051347 227 0.021
spermatid differentiation GO:0048515 4 0.021
dna dependent dna replication GO:0006261 44 0.021
regulation of chromosome organization GO:0033044 103 0.021
regulation of response to external stimulus GO:0032101 222 0.020
vasculature development GO:0001944 181 0.020
canonical wnt signaling pathway GO:0060070 116 0.020
response to abiotic stimulus GO:0009628 336 0.020
regulation of transferase activity GO:0051338 355 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
response to tumor necrosis factor GO:0034612 76 0.020
segmentation GO:0035282 4 0.020
meiotic chromosome segregation GO:0045132 4 0.020
regulation of protein maturation GO:1903317 150 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.020
positive regulation of protein phosphorylation GO:0001934 313 0.020
locomotory behavior GO:0007626 1 0.019
dna replication GO:0006260 116 0.019
immune system development GO:0002520 195 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
regulation of small gtpase mediated signal transduction GO:0051056 156 0.019
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.019
positive regulation of cell death GO:0010942 263 0.019
positive regulation of dna replication GO:0045740 35 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
response to biotic stimulus GO:0009607 276 0.019
regulation of peptidase activity GO:0052547 180 0.018
innate immune response GO:0045087 178 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
regulation of protein kinase activity GO:0045859 289 0.018
cellular carbohydrate metabolic process GO:0044262 84 0.018
Mouse
cartilage condensation GO:0001502 1 0.018
myeloid cell differentiation GO:0030099 117 0.018
translation GO:0006412 132 0.018
protein ubiquitination GO:0016567 314 0.018
positive regulation of immune response GO:0050778 159 0.018
nuclear transport GO:0051169 179 0.017
regulation of immune response GO:0050776 201 0.017
glycogen metabolic process GO:0005977 22 0.017
positive regulation of transport GO:0051050 336 0.017
activation of protein kinase activity GO:0032147 90 0.017
chemical homeostasis GO:0048878 306 0.017
blood vessel development GO:0001568 172 0.017
regulation of anatomical structure size GO:0090066 101 0.017
organ morphogenesis GO:0009887 147 0.017
extrinsic apoptotic signaling pathway GO:0097191 119 0.017
brain development GO:0007420 97 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
response to fungus GO:0009620 4 0.017
mrna metabolic process GO:0016071 175 0.017
cellular protein catabolic process GO:0044257 261 0.017
embryo development GO:0009790 123 0.017
regulation of mrna metabolic process GO:1903311 53 0.017
regulation of histone acetylation GO:0035065 19 0.016
negative regulation of protein modification process GO:0031400 200 0.016
regulation of canonical wnt signaling pathway GO:0060828 88 0.016
regulation of cytokine production GO:0001817 232 0.016
generation of precursor metabolites and energy GO:0006091 68 0.016
protein oligomerization GO:0051259 173 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.016
central nervous system development GO:0007417 123 0.016
single organism carbohydrate metabolic process GO:0044723 193 0.016
Mouse
spermatid development GO:0007286 4 0.016
positive regulation of organelle organization GO:0010638 195 0.016
negative regulation of endopeptidase activity GO:0010951 84 0.016
blastoderm segmentation GO:0007350 2 0.016
apoptotic signaling pathway GO:0097190 268 0.016
i kappab kinase nf kappab signaling GO:0007249 166 0.015
protein dephosphorylation GO:0006470 81 0.015
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.015
forelimb morphogenesis GO:0035136 4 0.015
secretion GO:0046903 254 0.015
protein modification by small protein removal GO:0070646 92 0.015
protein maturation GO:0051604 233 0.015
cellular homeostasis GO:0019725 196 0.015
negative regulation of organelle organization GO:0010639 126 0.015
regulation of apoptotic signaling pathway GO:2001233 175 0.015
morphogenesis of an epithelium GO:0002009 60 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
epithelium development GO:0060429 227 0.014
regulation of response to wounding GO:1903034 101 0.014
embryonic placenta development GO:0001892 1 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
memory GO:0007613 3 0.014
protein catabolic process GO:0030163 325 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
regulation of cysteine type endopeptidase activity GO:2000116 127 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
maintenance of location GO:0051235 112 0.014
positive regulation of cell size GO:0045793 3 0.014
regulation of erk1 and erk2 cascade GO:0070372 99 0.014
cell activation GO:0001775 213 0.013
regulation of jnk cascade GO:0046328 73 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
neural tube closure GO:0001843 3 0.013
regulation of microtubule based process GO:0032886 74 0.013
dosage compensation GO:0007549 3 0.013
cell projection organization GO:0030030 252 0.013
cellular protein complex assembly GO:0043623 188 0.013
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
glycerolipid metabolic process GO:0046486 107 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
protein homooligomerization GO:0051260 100 0.013
negative regulation of oxidative stress induced cell death GO:1903202 17 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
system process GO:0003008 349 0.012
histone lysine methylation GO:0034968 50 0.012
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.012
dna conformation change GO:0071103 113 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
lipid localization GO:0010876 106 0.012
neurotransmitter secretion GO:0007269 4 0.012
anatomical structure homeostasis GO:0060249 100 0.012
energy derivation by oxidation of organic compounds GO:0015980 43 0.012
regulation of chromatin modification GO:1903308 51 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
macromolecule methylation GO:0043414 97 0.012
negative regulation of cell cycle phase transition GO:1901988 89 0.012
regulation of growth GO:0040008 165 0.012
neuron projection development GO:0031175 106 0.012
neuron development GO:0048666 113 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
neurological system process GO:0050877 163 0.012
angiogenesis GO:0001525 147 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
cellular response to external stimulus GO:0071496 111 0.012
nucleotide catabolic process GO:0009166 408 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
defense response to bacterium GO:0042742 63 0.012
negative regulation of chromatin silencing GO:0031936 4 0.012
rna processing GO:0006396 255 0.011
regulation of peptidyl lysine acetylation GO:2000756 22 0.011
regulation of rho gtpase activity GO:0032319 66 0.011
protein heterotrimerization GO:0070208 4 0.011
negative regulation of binding GO:0051100 57 0.011
jnk cascade GO:0007254 80 0.011
regulation of map kinase activity GO:0043405 108 0.011
cytokine production GO:0001816 247 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
skeletal system development GO:0001501 79 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
reproductive system development GO:0061458 56 0.011
heart morphogenesis GO:0003007 48 0.011
neurogenesis GO:0022008 169 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
negative regulation of phosphatase activity GO:0010923 61 0.011
response to external biotic stimulus GO:0043207 261 0.011
regulation of dna replication GO:0006275 68 0.011
regulation of proteasomal protein catabolic process GO:0061136 87 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
peptidyl threonine phosphorylation GO:0018107 41 0.011
regulation of myeloid cell differentiation GO:0045637 81 0.011
adult locomotory behavior GO:0008344 1 0.011
regulation of gene expression epigenetic GO:0040029 73 0.011
negative regulation of response to external stimulus GO:0032102 83 0.010
cellular macromolecule catabolic process GO:0044265 380 0.010
cell growth GO:0016049 160 0.010
central nervous system neuron development GO:0021954 7 0.010
tor signaling GO:0031929 39 0.010
defense response to fungus GO:0050832 4 0.010
regulation of intracellular transport GO:0032386 195 0.010
cell part morphogenesis GO:0032990 137 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.010
negative regulation of mapk cascade GO:0043409 56 0.010
activation of mapk activity GO:0000187 45 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010
gene silencing GO:0016458 49 0.010
negative regulation of cell differentiation GO:0045596 171 0.010

SMEK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.042
eye and adnexa disease DOID:1492 150 0.042
nervous system disease DOID:863 431 0.042
eye disease DOID:5614 149 0.039