Homo sapiens

47 known processes

PDK2

pyruvate dehydrogenase kinase, isozyme 2

(Aliases: PDHK2)

PDK2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 116 0.300
cellular ketone metabolic process GO:0042180 80 0.124
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.112
regulation of cellular ketone metabolic process GO:0010565 50 0.111
Human
regulation of cellular amine metabolic process GO:0033238 11 0.103
amine metabolic process GO:0009308 44 0.100
cellular lipid metabolic process GO:0044255 303 0.080
Human
cellular amine metabolic process GO:0044106 41 0.077
positive regulation of cellular amine metabolic process GO:0033240 7 0.075
post embryonic development GO:0009791 2 0.074
lipid metabolic process GO:0006629 381 0.064
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.059
organonitrogen compound biosynthetic process GO:1901566 200 0.056
regulation of cellular component biogenesis GO:0044087 281 0.055
posttranscriptional regulation of gene expression GO:0010608 213 0.054
cation transport GO:0006812 331 0.051
regulation of cell cycle GO:0051726 393 0.045
nervous system development GO:0007399 293 0.045
cellular homeostasis GO:0019725 196 0.042
negative regulation of cellular protein metabolic process GO:0032269 353 0.041
small molecule biosynthetic process GO:0044283 157 0.041
Human
oogenesis GO:0048477 2 0.039
determination of adult lifespan GO:0008340 2 0.038
positive regulation of transport GO:0051050 336 0.038
cation homeostasis GO:0055080 189 0.037
protein ubiquitination GO:0016567 314 0.036
oxidation reduction process GO:0055114 396 0.036
negative regulation of protein metabolic process GO:0051248 391 0.035
multicellular organismal aging GO:0010259 3 0.035
chromatin organization GO:0006325 351 0.034
negative regulation of phosphate metabolic process GO:0045936 267 0.034
mitotic cell cycle process GO:1903047 286 0.034
neuromuscular junction development GO:0007528 3 0.034
positive regulation of ion transport GO:0043270 87 0.033
response to abiotic stimulus GO:0009628 336 0.033
Human
regulation of ion transport GO:0043269 189 0.032
organelle fission GO:0048285 149 0.032
single organism cellular localization GO:1902580 332 0.032
negative regulation of cellular amine metabolic process GO:0033239 3 0.031
ribonucleoside triphosphate catabolic process GO:0009203 391 0.031
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
chemical homeostasis GO:0048878 306 0.030
protein modification by small protein conjugation GO:0032446 342 0.030
positive regulation of phosphorylation GO:0042327 394 0.030
positive regulation of synaptic transmission GO:0050806 4 0.029
protein catabolic process GO:0030163 325 0.029
regulation of cell cycle process GO:0010564 266 0.029
apoptotic signaling pathway GO:0097190 268 0.028
purine ribonucleoside metabolic process GO:0046128 437 0.028
organophosphate biosynthetic process GO:0090407 163 0.028
system process GO:0003008 349 0.028
negative regulation of catalytic activity GO:0043086 335 0.028
regulation of transferase activity GO:0051338 355 0.028
response to organic cyclic compound GO:0014070 204 0.027
cytoplasmic transport GO:0016482 379 0.027
membrane organization GO:0061024 292 0.027
regulation of proteolysis GO:0030162 293 0.027
negative regulation of phosphorus metabolic process GO:0010563 267 0.027
covalent chromatin modification GO:0016569 254 0.027
mitotic cell cycle GO:0000278 326 0.026
regulation of protein complex assembly GO:0043254 147 0.026
positive regulation of cellular component organization GO:0051130 376 0.026
purine containing compound catabolic process GO:0072523 411 0.026
response to oxygen containing compound GO:1901700 369 0.025
metal ion homeostasis GO:0055065 169 0.025
carboxylic acid biosynthetic process GO:0046394 97 0.025
Human
nucleoside triphosphate metabolic process GO:0009141 422 0.025
positive regulation of protein phosphorylation GO:0001934 313 0.025
nucleoside phosphate catabolic process GO:1901292 412 0.024
positive regulation of developmental process GO:0051094 314 0.024
regulation of intracellular transport GO:0032386 195 0.024
vesicle mediated transport GO:0016192 371 0.024
compound eye development GO:0048749 1 0.024
cellular response to nitrogen compound GO:1901699 144 0.024
Human
lipid biosynthetic process GO:0008610 177 0.024
Human
peptidyl serine phosphorylation GO:0018105 101 0.024
Human Rat
cellular response to endogenous stimulus GO:0071495 336 0.024
Human
calcium ion homeostasis GO:0055074 122 0.024
memory GO:0007613 3 0.024
negative regulation of phosphorylation GO:0042326 174 0.023
monocarboxylic acid metabolic process GO:0032787 185 0.023
Human
cellular chemical homeostasis GO:0055082 180 0.023
regulation of protein localization GO:0032880 296 0.023
nucleotide catabolic process GO:0009166 408 0.023
single organism membrane organization GO:0044802 268 0.023
cellular response to oxygen containing compound GO:1901701 276 0.023
dephosphorylation GO:0016311 209 0.023
positive regulation of organelle organization GO:0010638 195 0.022
neurotransmitter secretion GO:0007269 4 0.022
carboxylic acid catabolic process GO:0046395 71 0.022
fatty acid metabolic process GO:0006631 115 0.022
Human
sequestering of calcium ion GO:0051208 17 0.022
negative regulation of developmental process GO:0051093 247 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
reactive oxygen species metabolic process GO:0072593 75 0.022
Human
regulation of lipid metabolic process GO:0019216 96 0.022
Human
secretion by cell GO:0032940 226 0.022
response to nitrogen compound GO:1901698 184 0.022
Human
regulation of dephosphorylation GO:0035303 96 0.021
regulation of neurotransmitter secretion GO:0046928 3 0.021
ribonucleoside catabolic process GO:0042454 406 0.021
ras protein signal transduction GO:0007265 73 0.021
peripheral nervous system development GO:0007422 2 0.021
cellular protein catabolic process GO:0044257 261 0.021
female gamete generation GO:0007292 2 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
maintenance of location GO:0051235 112 0.020
organic acid catabolic process GO:0016054 71 0.020
locomotory behavior GO:0007626 1 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.020
cellular ion homeostasis GO:0006873 168 0.020
divalent metal ion transport GO:0070838 152 0.020
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.020
protein localization to organelle GO:0033365 280 0.019
organ formation GO:0048645 3 0.019
glycosyl compound catabolic process GO:1901658 413 0.019
metal ion transport GO:0030001 272 0.019
nitrogen compound transport GO:0071705 191 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
regulation of protein kinase activity GO:0045859 289 0.019
regulation of kinase activity GO:0043549 314 0.019
cellular calcium ion homeostasis GO:0006874 117 0.019
transmembrane transport GO:0055085 399 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
sequestering of metal ion GO:0051238 24 0.019
regulation of dna metabolic process GO:0051052 153 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
response to hormone GO:0009725 175 0.018
Human
regulation of reactive oxygen species metabolic process GO:2000377 41 0.018
Human
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
cellular response to dna damage stimulus GO:0006974 379 0.018
cell projection organization GO:0030030 252 0.018
ion homeostasis GO:0050801 230 0.018
protein maturation GO:0051604 233 0.018
cell division GO:0051301 168 0.018
histone modification GO:0016570 251 0.018
regulation of protein transport GO:0051223 213 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
nucleoside catabolic process GO:0009164 408 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
inorganic cation transmembrane transport GO:0098662 194 0.018
chromatin modification GO:0016568 298 0.018
neurological system process GO:0050877 163 0.018
segmentation GO:0035282 4 0.018
cellular component morphogenesis GO:0032989 314 0.018
endomembrane system organization GO:0010256 196 0.018
signal transduction by phosphorylation GO:0023014 297 0.017
modification dependent protein catabolic process GO:0019941 209 0.017
generation of precursor metabolites and energy GO:0006091 68 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
ion transmembrane transport GO:0034220 338 0.017
developmental programmed cell death GO:0010623 3 0.017
phospholipid metabolic process GO:0006644 99 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
divalent inorganic cation transport GO:0072511 158 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
cellular macromolecular complex assembly GO:0034622 324 0.017
regulation of mapk cascade GO:0043408 262 0.017
alcohol metabolic process GO:0006066 114 0.017
negative regulation of protein modification process GO:0031400 200 0.017
response to cytokine GO:0034097 232 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
Human
purine nucleotide catabolic process GO:0006195 405 0.017
peptidyl lysine modification GO:0018205 144 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
atp metabolic process GO:0046034 176 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.016
response to lipid GO:0033993 206 0.016
Human
negative regulation of programmed cell death GO:0043069 321 0.016
Human
divalent inorganic cation homeostasis GO:0072507 136 0.016
positive regulation of kinase activity GO:0033674 204 0.016
organophosphate catabolic process GO:0046434 430 0.016
regulation of peptidase activity GO:0052547 180 0.016
cellular response to organic cyclic compound GO:0071407 127 0.016
response to decreased oxygen levels GO:0036293 96 0.016
Human
regulation of homeostatic process GO:0032844 121 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
ribonucleoside monophosphate metabolic process GO:0009161 187 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
carbohydrate metabolic process GO:0005975 207 0.016
Human
positive regulation of cell death GO:0010942 263 0.016
single organism carbohydrate metabolic process GO:0044723 193 0.016
Human
ribonucleotide catabolic process GO:0009261 405 0.016
organic hydroxy compound metabolic process GO:1901615 147 0.016
purine ribonucleotide catabolic process GO:0009154 404 0.016
calcium ion transport GO:0006816 147 0.016
organic acid biosynthetic process GO:0016053 97 0.016
Human
anterior posterior axis specification GO:0009948 2 0.016
ribonucleoside monophosphate catabolic process GO:0009158 158 0.016
intracellular protein transport GO:0006886 270 0.015
blastoderm segmentation GO:0007350 2 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
positive regulation of cell cycle GO:0045787 140 0.015
cellular cation homeostasis GO:0030003 163 0.015
purine nucleoside catabolic process GO:0006152 398 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
regulation of cellular component movement GO:0051270 334 0.015
epithelium development GO:0060429 227 0.015
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.015
regulation of protein processing GO:0070613 150 0.015
protein dephosphorylation GO:0006470 81 0.015
oocyte differentiation GO:0009994 2 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
neural tube formation GO:0001841 3 0.015
regulation of secretion GO:0051046 194 0.015
cellular modified amino acid metabolic process GO:0006575 64 0.015
positive regulation of catabolic process GO:0009896 310 0.015
positive regulation of protein kinase activity GO:0045860 190 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
microtubule based process GO:0007017 210 0.015
oocyte development GO:0048599 1 0.015
regulation of metal ion transport GO:0010959 120 0.015
small molecule catabolic process GO:0044282 92 0.015
regulation of cytokine production GO:0001817 232 0.014
cell morphogenesis GO:0000902 296 0.014
autophagy GO:0006914 88 0.014
cytokine production GO:0001816 247 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
defense response GO:0006952 315 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
anion transport GO:0006820 161 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
negative regulation of cell death GO:0060548 345 0.014
Human
cellular macromolecule catabolic process GO:0044265 380 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
response to oxidative stress GO:0006979 121 0.014
morphogenesis of embryonic epithelium GO:0016331 4 0.014
glycerophospholipid metabolic process GO:0006650 84 0.014
protein processing GO:0016485 226 0.014
actin filament based process GO:0030029 224 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
response to oxygen levels GO:0070482 100 0.014
Human
regulation of nucleoside metabolic process GO:0009118 209 0.014
cell cell signaling GO:0007267 155 0.014
cofactor metabolic process GO:0051186 87 0.014
Human
cell development GO:0048468 328 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
growth GO:0040007 202 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
negative regulation of transferase activity GO:0051348 124 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
regulation of transmembrane transport GO:0034762 139 0.013
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.013
cellular response to hormone stimulus GO:0032870 125 0.013
Human
positive regulation of transferase activity GO:0051347 227 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
long term memory GO:0007616 2 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.013
regeneration GO:0031099 4 0.013
regulation of protein ubiquitination GO:0031396 95 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
response to biotic stimulus GO:0009607 276 0.013
immune response GO:0006955 307 0.013
regulation of synaptic transmission dopaminergic GO:0032225 4 0.013
myeloid cell differentiation GO:0030099 117 0.013
response to axon injury GO:0048678 1 0.013
embryonic forelimb morphogenesis GO:0035115 4 0.013
regulation of membrane potential GO:0042391 95 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
protein targeting GO:0006605 187 0.013
regulation of peptidyl serine phosphorylation GO:0033135 50 0.013
regulation of cell differentiation GO:0045595 393 0.013
tube closure GO:0060606 3 0.012
protein destabilization GO:0031648 12 0.012
regulation of ion transmembrane transport GO:0034765 132 0.012
response to organonitrogen compound GO:0010243 156 0.012
Human
negative regulation of protein phosphorylation GO:0001933 140 0.012
embryonic epithelial tube formation GO:0001838 4 0.012
negative regulation of transport GO:0051051 176 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
regulation of binding GO:0051098 111 0.012
glutathione metabolic process GO:0006749 20 0.012
regulation of protein maturation GO:1903317 150 0.012
response to hypoxia GO:0001666 96 0.012
Human
regulation of protein binding GO:0043393 66 0.012
protein localization to membrane GO:0072657 160 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
organelle assembly GO:0070925 176 0.012
regulation of anatomical structure size GO:0090066 101 0.012
sensory perception of pain GO:0019233 4 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
cellular response to decreased oxygen levels GO:0036294 51 0.012
Human
meiotic chromosome segregation GO:0045132 4 0.012
regulation of calcium ion transport GO:0051924 79 0.012
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
cell cycle phase transition GO:0044770 173 0.012
protein oligomerization GO:0051259 173 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
mitochondrion organization GO:0007005 156 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
cellular protein complex assembly GO:0043623 188 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
nuclear division GO:0000280 128 0.012
nuclear transport GO:0051169 179 0.012
secretion GO:0046903 254 0.012
innate immune response GO:0045087 178 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
Human
rhythmic behavior GO:0007622 2 0.012
regulation of growth GO:0040008 165 0.012
adult locomotory behavior GO:0008344 1 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
negative regulation of cell cycle GO:0045786 193 0.011
positive regulation of secretion GO:0051047 116 0.011
spermatid differentiation GO:0048515 4 0.011
microtubule cytoskeleton organization GO:0000226 176 0.011
synaptic vesicle exocytosis GO:0016079 3 0.011
behavioral response to ethanol GO:0048149 2 0.011
protein acylation GO:0043543 138 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
plasma membrane organization GO:0007009 115 0.011
alpha amino acid metabolic process GO:1901605 72 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
dna repair GO:0006281 198 0.011
regulation of cell motility GO:2000145 299 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
primary neural tube formation GO:0014020 3 0.011
neurogenesis GO:0022008 169 0.011
cytosolic calcium ion homeostasis GO:0051480 89 0.011
tissue migration GO:0090130 119 0.011
generation of neurons GO:0048699 152 0.011
cell fate determination GO:0001709 3 0.011
negative regulation of protein processing GO:0010955 142 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
cellular component disassembly GO:0022411 92 0.011
rab protein signal transduction GO:0032482 4 0.011
cell type specific apoptotic process GO:0097285 125 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
Human
neuron differentiation GO:0030182 138 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
associative learning GO:0008306 1 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
response to growth factor GO:0070848 205 0.011
response to external biotic stimulus GO:0043207 261 0.011
epithelium migration GO:0090132 119 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
cation transmembrane transport GO:0098655 238 0.010
nucleoside phosphate biosynthetic process GO:1901293 109 0.010
cellular response to cytokine stimulus GO:0071345 181 0.010
organic anion transport GO:0015711 103 0.010
wnt signaling pathway GO:0016055 156 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
lipid catabolic process GO:0016042 84 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.010
regulation of cytoskeleton organization GO:0051493 177 0.010
glycerolipid biosynthetic process GO:0045017 51 0.010
energy derivation by oxidation of organic compounds GO:0015980 43 0.010
somatic muscle development GO:0007525 1 0.010
neural tube closure GO:0001843 3 0.010
chromosome segregation GO:0007059 114 0.010
sulfur compound metabolic process GO:0006790 101 0.010
Human
regulation of synaptic vesicle exocytosis GO:2000300 2 0.010
spermatid development GO:0007286 4 0.010
metencephalon development GO:0022037 2 0.010
negative regulation of peptidase activity GO:0010466 91 0.010
regulation of cell migration GO:0030334 289 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
negative regulation of dna metabolic process GO:0051053 57 0.010
mapk cascade GO:0000165 288 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
negative regulation of kinase activity GO:0033673 106 0.010
brain development GO:0007420 97 0.010
proteasomal protein catabolic process GO:0010498 176 0.010

PDK2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.168
inherited metabolic disorder DOID:655 242 0.168
central nervous system disease DOID:331 186 0.035
nervous system disease DOID:863 431 0.035
neurodegenerative disease DOID:1289 102 0.019
disease of cellular proliferation DOID:14566 174 0.016
amino acid metabolic disorder DOID:9252 50 0.015
cancer DOID:162 167 0.014
organ system cancer DOID:0050686 164 0.014
sensory system disease DOID:0050155 203 0.014
cardiovascular system disease DOID:1287 106 0.014
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012
synucleinopathy DOID:0050890 22 0.010
musculoskeletal system disease DOID:17 223 0.010