Homo sapiens

80 known processes

HIST2H4B

histone cluster 2, H4b

(Aliases: HIST1H4C,HIST1H4B,HIST1H4A,HIST4H4,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4K,HIST1H4J,H4/o,HIST1H4H,HIST1H4L,HIST1H4I,HIST2H4A)

HIST2H4B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication dependent nucleosome assembly GO:0006335 32 0.621
negative regulation of megakaryocyte differentiation GO:0045653 16 0.433
dna replication independent nucleosome assembly GO:0006336 27 0.290
dna replication dependent nucleosome organization GO:0034723 32 0.230
chromatin assembly GO:0031497 61 0.220
chromatin assembly or disassembly GO:0006333 78 0.216
dna replication independent nucleosome organization GO:0034724 27 0.212
nucleosome assembly GO:0006334 50 0.211
chromatin organization GO:0006325 351 0.175
nucleosome organization GO:0034728 66 0.156
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.128
regulation of megakaryocyte differentiation GO:0045652 22 0.120
dna conformation change GO:0071103 113 0.114
cellular macromolecular complex assembly GO:0034622 324 0.099
protein dna complex assembly GO:0065004 64 0.091
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.089
cellular response to dna damage stimulus GO:0006974 379 0.081
myeloid cell differentiation GO:0030099 117 0.080
protein dna complex subunit organization GO:0071824 80 0.075
negative regulation of immune system process GO:0002683 136 0.071
dna repair GO:0006281 198 0.069
regulation of myeloid cell differentiation GO:0045637 81 0.066
dna packaging GO:0006323 77 0.066
negative regulation of multicellular organismal process GO:0051241 317 0.065
negative regulation of myeloid cell differentiation GO:0045638 42 0.060
post embryonic development GO:0009791 2 0.057
hematopoietic or lymphoid organ development GO:0048534 186 0.053
histone modification GO:0016570 251 0.052
negative regulation of developmental process GO:0051093 247 0.049
hemopoiesis GO:0030097 180 0.048
cellular amino acid metabolic process GO:0006520 116 0.047
macromolecule methylation GO:0043414 97 0.045
anatomical structure formation involved in morphogenesis GO:0048646 284 0.044
regulation of cell differentiation GO:0045595 393 0.042
immune system development GO:0002520 195 0.042
histone methylation GO:0016571 60 0.037
cellular ketone metabolic process GO:0042180 80 0.037
regulation of cellular amino acid metabolic process GO:0006521 6 0.037
megakaryocyte differentiation GO:0030219 25 0.036
regulation of cellular amine metabolic process GO:0033238 11 0.036
regulation of cellular ketone metabolic process GO:0010565 50 0.035
cellular amine metabolic process GO:0044106 41 0.035
chromatin modification GO:0016568 298 0.034
determination of adult lifespan GO:0008340 2 0.034
rna processing GO:0006396 255 0.034
amine metabolic process GO:0009308 44 0.034
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
histone h3 k79 methylation GO:0034729 2 0.033
multicellular organismal aging GO:0010259 3 0.033
negative regulation of cell differentiation GO:0045596 171 0.032
methylation GO:0032259 106 0.032
response to abiotic stimulus GO:0009628 336 0.030
protein methylation GO:0006479 74 0.030
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
defense response GO:0006952 315 0.029
covalent chromatin modification GO:0016569 254 0.028
mrna metabolic process GO:0016071 175 0.028
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 18 0.028
female gamete generation GO:0007292 2 0.028
hematopoietic progenitor cell differentiation GO:0002244 38 0.028
immune response GO:0006955 307 0.028
system process GO:0003008 349 0.027
response to biotic stimulus GO:0009607 276 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
cellular macromolecule catabolic process GO:0044265 380 0.026
oogenesis GO:0048477 2 0.025
segmentation GO:0035282 4 0.025
cell cycle checkpoint GO:0000075 117 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
neuromuscular junction development GO:0007528 3 0.024
innate immune response GO:0045087 178 0.024
regulation of proteolysis GO:0030162 293 0.024
mrna processing GO:0006397 133 0.024
protein alkylation GO:0008213 74 0.023
locomotory behavior GO:0007626 1 0.023
cytoplasmic transport GO:0016482 379 0.023
response to radiation GO:0009314 151 0.023
protein catabolic process GO:0030163 325 0.022
histone lysine methylation GO:0034968 50 0.022
ras protein signal transduction GO:0007265 73 0.022
positive regulation of hydrolase activity GO:0051345 331 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
memory GO:0007613 3 0.022
cellular response to abiotic stimulus GO:0071214 117 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
regulation of cell cycle GO:0051726 393 0.021
small gtpase mediated signal transduction GO:0007264 78 0.021
protein localization to organelle GO:0033365 280 0.021
protein maturation GO:0051604 233 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
response to uv GO:0009411 73 0.021
organophosphate catabolic process GO:0046434 430 0.021
response to other organism GO:0051707 261 0.021
protein complex disassembly GO:0043241 52 0.021
regulation of gene expression epigenetic GO:0040029 73 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
response to oxygen containing compound GO:1901700 369 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
regeneration GO:0031099 4 0.020
positive regulation of phosphorylation GO:0042327 394 0.020
purine containing compound catabolic process GO:0072523 411 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.020
single organism cellular localization GO:1902580 332 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
cellular component disassembly GO:0022411 92 0.020
ribonucleotide catabolic process GO:0009261 405 0.020
cellular protein catabolic process GO:0044257 261 0.019
ribonucleoside triphosphate catabolic process GO:0009203 391 0.019
nucleotide catabolic process GO:0009166 408 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
negative regulation of programmed cell death GO:0043069 321 0.019
negative regulation of cell death GO:0060548 345 0.019
response to external biotic stimulus GO:0043207 261 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.019
lipid metabolic process GO:0006629 381 0.019
protein processing GO:0016485 226 0.019
regulation of cell cycle process GO:0010564 266 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
transmembrane transport GO:0055085 399 0.019
glycosyl compound catabolic process GO:1901658 413 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
blastoderm segmentation GO:0007350 2 0.018
cellular lipid metabolic process GO:0044255 303 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
regulation of transferase activity GO:0051338 355 0.018
gene silencing GO:0016458 49 0.018
purine nucleotide catabolic process GO:0006195 405 0.018
peripheral nervous system development GO:0007422 2 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
single organism membrane organization GO:0044802 268 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
apoptotic signaling pathway GO:0097190 268 0.018
positive regulation of transport GO:0051050 336 0.018
signal transduction by phosphorylation GO:0023014 297 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.017
regulation of protein localization GO:0032880 296 0.017
positive regulation of catabolic process GO:0009896 310 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
regulation of cellular response to stress GO:0080135 244 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
dephosphorylation GO:0016311 209 0.017
anterior posterior axis specification GO:0009948 2 0.017
cation transport GO:0006812 331 0.017
positive regulation of immune system process GO:0002684 283 0.017
negative regulation of apoptotic process GO:0043066 316 0.017
biological adhesion GO:0022610 331 0.017
intracellular protein transport GO:0006886 270 0.017
response to light stimulus GO:0009416 87 0.017
regulation of protein kinase activity GO:0045859 289 0.017
positive regulation of organelle organization GO:0010638 195 0.017
actin filament based process GO:0030029 224 0.017
cellular response to radiation GO:0071478 65 0.017
chemical homeostasis GO:0048878 306 0.017
vesicle mediated transport GO:0016192 371 0.016
regulation of response to external stimulus GO:0032101 222 0.016
cell morphogenesis GO:0000902 296 0.016
regulation of kinase activity GO:0043549 314 0.016
mitotic cell cycle GO:0000278 326 0.016
regulation of cellular component movement GO:0051270 334 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
mitotic cell cycle process GO:1903047 286 0.016
nucleoside catabolic process GO:0009164 408 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
spermatid differentiation GO:0048515 4 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
negative regulation of cell cycle GO:0045786 193 0.016
defense response to other organism GO:0098542 129 0.016
ion homeostasis GO:0050801 230 0.016
organ formation GO:0048645 3 0.016
oocyte development GO:0048599 1 0.016
membrane organization GO:0061024 292 0.016
cell adhesion GO:0007155 325 0.015
regulation of protein transport GO:0051223 213 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
mapk cascade GO:0000165 288 0.015
cell fate determination GO:0001709 3 0.015
organonitrogen compound biosynthetic process GO:1901566 200 0.015
negative regulation of protein modification process GO:0031400 200 0.015
motor neuron axon guidance GO:0008045 2 0.015
maintenance of location GO:0051235 112 0.015
compound eye development GO:0048749 1 0.015
oocyte differentiation GO:0009994 2 0.015
protein ubiquitination GO:0016567 314 0.015
regulation of locomotion GO:0040012 329 0.015
cellular component morphogenesis GO:0032989 314 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
embryonic epithelial tube formation GO:0001838 4 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
regulation of protein catabolic process GO:0042176 155 0.015
associative learning GO:0008306 1 0.015
protein modification by small protein conjugation GO:0032446 342 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
positive regulation of cell death GO:0010942 263 0.015
protein targeting GO:0006605 187 0.015
rho protein signal transduction GO:0007266 26 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
regulation of intracellular transport GO:0032386 195 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
regulation of mitotic cell cycle GO:0007346 189 0.014
cellular response to uv GO:0034644 32 0.014
morphogenesis of embryonic epithelium GO:0016331 4 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
regulation of protein maturation GO:1903317 150 0.014
reactive oxygen species biosynthetic process GO:1903409 4 0.014
growth GO:0040007 202 0.014
response to bacterium GO:0009617 144 0.014
cell growth GO:0016049 160 0.014
negative regulation of proteolysis GO:0045861 132 0.014
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
oxidation reduction process GO:0055114 396 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.014
regulation of cell motility GO:2000145 299 0.014
regulation of cell migration GO:0030334 289 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
adult locomotory behavior GO:0008344 1 0.014
negative regulation of protein processing GO:0010955 142 0.014
spermatid development GO:0007286 4 0.014
metal ion transport GO:0030001 272 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
regulation of gene silencing GO:0060968 24 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
carbohydrate metabolic process GO:0005975 207 0.014
tissue regeneration GO:0042246 3 0.014
positive regulation of transferase activity GO:0051347 227 0.014
regulation of cytokine production GO:0001817 232 0.014
nervous system development GO:0007399 293 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
cell projection organization GO:0030030 252 0.014
regulation of mapk cascade GO:0043408 262 0.014
protein oligomerization GO:0051259 173 0.014
tripartite regional subdivision GO:0007351 2 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
macromolecular complex disassembly GO:0032984 60 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
response to cytokine GO:0034097 232 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
regulation of protein processing GO:0070613 150 0.013
mitochondrion organization GO:0007005 156 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
regulation of growth GO:0040008 165 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
neurological system process GO:0050877 163 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of immune response GO:0050776 201 0.013
rhythmic behavior GO:0007622 2 0.013
positive regulation of synaptic transmission GO:0050806 4 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
hindbrain development GO:0030902 3 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
negative regulation of protein maturation GO:1903318 142 0.013
cell cycle phase transition GO:0044770 173 0.013
epithelium development GO:0060429 227 0.013
nuclear transport GO:0051169 179 0.013
nerve development GO:0021675 4 0.013
microtubule based process GO:0007017 210 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
neurotransmitter secretion GO:0007269 4 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
reproductive process GO:0022414 106 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
negative regulation of cell proliferation GO:0008285 228 0.012
regulation of neural precursor cell proliferation GO:2000177 4 0.012
interspecies interaction between organisms GO:0044419 156 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
endomembrane system organization GO:0010256 196 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
response to fungus GO:0009620 4 0.012
secretion by cell GO:0032940 226 0.012
gtp metabolic process GO:0046039 239 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
cation homeostasis GO:0055080 189 0.012
circadian behavior GO:0048512 2 0.012
positive regulation of kinase activity GO:0033674 204 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
secretion GO:0046903 254 0.012
cellular protein complex assembly GO:0043623 188 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
metencephalon development GO:0022037 2 0.012
stem cell division GO:0017145 2 0.012
cytokine production GO:0001816 247 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
ion transmembrane transport GO:0034220 338 0.012
actin cytoskeleton organization GO:0030036 207 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
lipid biosynthetic process GO:0008610 177 0.012
regulation of secretion GO:0051046 194 0.012
inner ear morphogenesis GO:0042472 4 0.012
single organism reproductive process GO:0044702 98 0.012
response to axon injury GO:0048678 1 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
multi organism cellular process GO:0044764 156 0.012
postreplication repair GO:0006301 12 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
visual behavior GO:0007632 2 0.011
regulation of multi organism process GO:0043900 157 0.011
regulation of cell growth GO:0001558 135 0.011
response to growth factor GO:0070848 205 0.011
positive regulation of developmental process GO:0051094 314 0.011
divalent metal ion transport GO:0070838 152 0.011
limbic system development GO:0021761 3 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
response to organic cyclic compound GO:0014070 204 0.011
regulation of peptidase activity GO:0052547 180 0.011
cellular homeostasis GO:0019725 196 0.011
anion transport GO:0006820 161 0.011
cellular chemical homeostasis GO:0055082 180 0.011
positive regulation of cell migration GO:0030335 172 0.011
cell division GO:0051301 168 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
cell development GO:0048468 328 0.011
cellular ion homeostasis GO:0006873 168 0.011
cellular cation homeostasis GO:0030003 163 0.011
nitrogen compound transport GO:0071705 191 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
mating GO:0007618 1 0.011
response to nitrogen compound GO:1901698 184 0.011
cell activation GO:0001775 213 0.011
positive regulation of locomotion GO:0040017 186 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
sequestering of metal ion GO:0051238 24 0.011
thymus development GO:0048538 3 0.011
t cell differentiation in thymus GO:0033077 4 0.011
regulation of dna metabolic process GO:0051052 153 0.011
atp metabolic process GO:0046034 176 0.011
organelle assembly GO:0070925 176 0.011
gtp catabolic process GO:0006184 237 0.011
negative regulation of organelle organization GO:0010639 126 0.011
myoblast fusion GO:0007520 1 0.011
neural tube formation GO:0001841 3 0.011
regulation of defense response GO:0031347 154 0.011
protein localization to membrane GO:0072657 160 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
small molecule biosynthetic process GO:0044283 157 0.011
response to wounding GO:0009611 168 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
wnt signaling pathway GO:0016055 156 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
glycoprotein metabolic process GO:0009100 110 0.011
negative regulation of transport GO:0051051 176 0.011
negative regulation of catabolic process GO:0009895 104 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
dna damage checkpoint GO:0000077 68 0.011
negative regulation of transferase activity GO:0051348 124 0.010
regulation of nucleotide catabolic process GO:0030811 205 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010
response to lipid GO:0033993 206 0.010
metal ion homeostasis GO:0055065 169 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
regulation of secretion by cell GO:1903530 177 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.010
neuroblast proliferation GO:0007405 4 0.010
microtubule cytoskeleton organization GO:0000226 176 0.010
primary neural tube formation GO:0014020 3 0.010
glial cell migration GO:0008347 4 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
salivary gland morphogenesis GO:0007435 4 0.010
specification of organ identity GO:0010092 3 0.010
regulation of protein complex assembly GO:0043254 147 0.010
rna interference GO:0016246 4 0.010
peptidyl tyrosine modification GO:0018212 170 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
positive regulation of neural precursor cell proliferation GO:2000179 2 0.010
sequestering of calcium ion GO:0051208 17 0.010
positive regulation of cell differentiation GO:0045597 211 0.010
organelle fission GO:0048285 149 0.010
regulation of protein serine threonine kinase activity GO:0071900 179 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
calcium ion transport GO:0006816 147 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
tube closure GO:0060606 3 0.010
cardiovascular system development GO:0072358 262 0.010
developmental programmed cell death GO:0010623 3 0.010

HIST2H4B disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.029
sensory system disease DOID:0050155 203 0.023
nervous system disease DOID:863 431 0.023
musculoskeletal system disease DOID:17 223 0.022
inherited metabolic disorder DOID:655 242 0.018
central nervous system disease DOID:331 186 0.017
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
disease of cellular proliferation DOID:14566 174 0.016
cancer DOID:162 167 0.015
organ system cancer DOID:0050686 164 0.015
connective tissue disease DOID:65 109 0.014
immune system disease DOID:2914 155 0.013
bone disease DOID:0080001 88 0.013
retinal disease DOID:5679 118 0.012
myopathy DOID:423 104 0.012
muscular disease DOID:0080000 114 0.012
muscle tissue disease DOID:66 113 0.012
neurodegenerative disease DOID:1289 102 0.012
brain disease DOID:936 73 0.010