Homo sapiens

0 known processes

PSME4

proteasome (prosome, macropain) activator subunit 4

(Aliases: MGC138374,PA200,MGC142228,KIAA0077,FLJ21864)

PSME4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.309
cellular response to dna damage stimulus GO:0006974 379 0.283
Mouse
cellular macromolecular complex assembly GO:0034622 324 0.130
protein catabolic process GO:0030163 325 0.094
Mouse
protein modification by small protein removal GO:0070646 92 0.091
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.090
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.081
immune response GO:0006955 307 0.078
determination of adult lifespan GO:0008340 2 0.078
female gamete generation GO:0007292 2 0.077
negative regulation of cellular component organization GO:0051129 235 0.077
multicellular organismal aging GO:0010259 3 0.076
negative regulation of protein metabolic process GO:0051248 391 0.073
protein modification by small protein conjugation GO:0032446 342 0.072
response to other organism GO:0051707 261 0.068
cellular amine metabolic process GO:0044106 41 0.067
modification dependent macromolecule catabolic process GO:0043632 212 0.063
posttranscriptional regulation of gene expression GO:0010608 213 0.063
chromatin modification GO:0016568 298 0.062
Mouse
modification dependent protein catabolic process GO:0019941 209 0.059
cellular protein complex assembly GO:0043623 188 0.058
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.057
protein ubiquitination GO:0016567 314 0.057
positive regulation of cellular component organization GO:0051130 376 0.056
vesicle mediated transport GO:0016192 371 0.053
cellular amino acid metabolic process GO:0006520 116 0.052
cytoplasmic transport GO:0016482 379 0.052
cellular protein catabolic process GO:0044257 261 0.048
Mouse
cellular ketone metabolic process GO:0042180 80 0.048
amine metabolic process GO:0009308 44 0.048
regulation of cellular ketone metabolic process GO:0010565 50 0.047
system process GO:0003008 349 0.045
protein deubiquitination GO:0016579 79 0.044
regulation of translation GO:0006417 89 0.044
defense response GO:0006952 315 0.044
establishment of protein localization to organelle GO:0072594 172 0.043
intracellular protein transport GO:0006886 270 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
locomotory behavior GO:0007626 1 0.043
innate immune response GO:0045087 178 0.043
cellular macromolecule catabolic process GO:0044265 380 0.042
Mouse
regulation of anatomical structure morphogenesis GO:0022603 286 0.042
nervous system development GO:0007399 293 0.042
protein polyubiquitination GO:0000209 110 0.041
regulation of intracellular transport GO:0032386 195 0.041
negative regulation of catalytic activity GO:0043086 335 0.040
nucleocytoplasmic transport GO:0006913 176 0.040
response to biotic stimulus GO:0009607 276 0.039
inorganic ion transmembrane transport GO:0098660 231 0.039
response to abiotic stimulus GO:0009628 336 0.039
positive regulation of cellular amine metabolic process GO:0033240 7 0.039
embryo development GO:0009790 123 0.038
negative regulation of apoptotic process GO:0043066 316 0.038
ubiquitin dependent protein catabolic process GO:0006511 206 0.038
positive regulation of cellular catabolic process GO:0031331 284 0.038
regulation of cellular amino acid metabolic process GO:0006521 6 0.037
blastoderm segmentation GO:0007350 2 0.037
regulation of cellular response to stress GO:0080135 244 0.037
single organism cellular localization GO:1902580 332 0.036
oogenesis GO:0048477 2 0.036
negative regulation of cell death GO:0060548 345 0.036
positive regulation of phosphorylation GO:0042327 394 0.035
protein processing GO:0016485 226 0.035
segmentation GO:0035282 4 0.035
protein localization to organelle GO:0033365 280 0.035
regulation of proteolysis GO:0030162 293 0.034
Mouse
regulation of cellular amine metabolic process GO:0033238 11 0.033
cell development GO:0048468 328 0.033
Mouse
protein autophosphorylation GO:0046777 123 0.033
regulation of response to external stimulus GO:0032101 222 0.032
histone modification GO:0016570 251 0.032
proteasomal protein catabolic process GO:0010498 176 0.032
Mouse
morphogenesis of embryonic epithelium GO:0016331 4 0.032
negative regulation of protein modification process GO:0031400 200 0.032
ribonucleoprotein complex biogenesis GO:0022613 116 0.032
positive regulation of organelle organization GO:0010638 195 0.032
regulation of protein localization GO:0032880 296 0.031
apoptotic signaling pathway GO:0097190 268 0.031
small gtpase mediated signal transduction GO:0007264 78 0.031
positive regulation of transport GO:0051050 336 0.031
regulation of apoptotic signaling pathway GO:2001233 175 0.031
regulation of peptidase activity GO:0052547 180 0.031
Mouse
negative regulation of protein processing GO:0010955 142 0.031
neurological system process GO:0050877 163 0.031
response to growth factor GO:0070848 205 0.031
mitochondrion organization GO:0007005 156 0.030
epithelium development GO:0060429 227 0.030
regulation of homeostatic process GO:0032844 121 0.030
regulation of protein complex assembly GO:0043254 147 0.030
positive regulation of protein transport GO:0051222 135 0.030
response to external biotic stimulus GO:0043207 261 0.029
nuclear transport GO:0051169 179 0.029
chemical homeostasis GO:0048878 306 0.029
regulation of cytoskeleton organization GO:0051493 177 0.029
positive regulation of intracellular transport GO:0032388 104 0.029
regulation of nucleocytoplasmic transport GO:0046822 98 0.028
negative regulation of organelle organization GO:0010639 126 0.028
regulation of establishment of protein localization GO:0070201 242 0.028
chromatin organization GO:0006325 351 0.028
Mouse
protein targeting GO:0006605 187 0.028
glycosyl compound catabolic process GO:1901658 413 0.028
regulation of dna metabolic process GO:0051052 153 0.028
mitotic cell cycle GO:0000278 326 0.027
negative regulation of proteolysis GO:0045861 132 0.027
regulation of protein maturation GO:1903317 150 0.027
dna replication GO:0006260 116 0.027
protein maturation GO:0051604 233 0.027
cell projection organization GO:0030030 252 0.027
negative regulation of programmed cell death GO:0043069 321 0.027
regulation of cellular component biogenesis GO:0044087 281 0.027
behavior GO:0007610 112 0.026
regulation of cell cycle process GO:0010564 266 0.026
positive regulation of catabolic process GO:0009896 310 0.026
ribonucleoside catabolic process GO:0042454 406 0.026
neural tube formation GO:0001841 3 0.026
anion transport GO:0006820 161 0.026
protein import GO:0017038 130 0.025
spermatid differentiation GO:0048515 4 0.025
Mouse
regulation of protein processing GO:0070613 150 0.025
regulation of kinase activity GO:0043549 314 0.025
mapk cascade GO:0000165 288 0.025
dna repair GO:0006281 198 0.025
Mouse
carbohydrate derivative biosynthetic process GO:1901137 207 0.025
oocyte development GO:0048599 1 0.024
regulation of cytokine production GO:0001817 232 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
organelle assembly GO:0070925 176 0.024
neurogenesis GO:0022008 169 0.024
rna interference GO:0016246 4 0.024
negative regulation of cell cycle GO:0045786 193 0.024
signal transduction by phosphorylation GO:0023014 297 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
regulation of intracellular protein transport GO:0033157 123 0.024
positive regulation of cell proliferation GO:0008284 301 0.024
ribonucleoside triphosphate metabolic process GO:0009199 412 0.024
response to virus GO:0009615 126 0.024
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
negative regulation of intracellular signal transduction GO:1902532 183 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
Mouse
single organism carbohydrate metabolic process GO:0044723 193 0.023
cellular component morphogenesis GO:0032989 314 0.023
regeneration GO:0031099 4 0.023
response to nitrogen compound GO:1901698 184 0.023
regulation of transferase activity GO:0051338 355 0.023
carbohydrate metabolic process GO:0005975 207 0.023
cellular homeostasis GO:0019725 196 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.023
purine ribonucleotide catabolic process GO:0009154 404 0.023
ion transmembrane transport GO:0034220 338 0.023
regulation of cytoplasmic transport GO:1903649 149 0.023
covalent chromatin modification GO:0016569 254 0.023
positive regulation of protein phosphorylation GO:0001934 313 0.023
negative regulation of protein maturation GO:1903318 142 0.022
regulation of chromatin organization GO:1902275 56 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
single organism nuclear import GO:1902593 104 0.022
peptidyl serine phosphorylation GO:0018105 101 0.022
nitrogen compound transport GO:0071705 191 0.022
negative regulation of hydrolase activity GO:0051346 182 0.021
regulation of defense response GO:0031347 154 0.021
protein localization to nucleus GO:0034504 136 0.021
memory GO:0007613 3 0.021
regulation of endopeptidase activity GO:0052548 170 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
regulation of cell cycle GO:0051726 393 0.021
ras protein signal transduction GO:0007265 73 0.021
regulation of immune response GO:0050776 201 0.021
response to uv GO:0009411 73 0.021
response to radiation GO:0009314 151 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
metal ion transport GO:0030001 272 0.020
nucleoside phosphate catabolic process GO:1901292 412 0.020
microtubule based process GO:0007017 210 0.020
response to oxygen containing compound GO:1901700 369 0.020
lipid localization GO:0010876 106 0.020
photoreceptor cell differentiation GO:0046530 2 0.020
positive regulation of cellular component biogenesis GO:0044089 158 0.020
regulation of protein transport GO:0051223 213 0.019
regulation of chromosome organization GO:0033044 103 0.019
purine ribonucleoside metabolic process GO:0046128 437 0.019
defense response to other organism GO:0098542 129 0.019
peptidyl serine modification GO:0018209 106 0.019
immune effector process GO:0002252 159 0.019
nucleotide catabolic process GO:0009166 408 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.019
regulation of response to dna damage stimulus GO:2001020 94 0.019
negative regulation of peptidase activity GO:0010466 91 0.019
cellular lipid metabolic process GO:0044255 303 0.019
macromolecule methylation GO:0043414 97 0.019
lipid metabolic process GO:0006629 381 0.018
meiosis i GO:0007127 4 0.018
positive regulation of intracellular protein transport GO:0090316 76 0.018
positive regulation of cell death GO:0010942 263 0.018
protein polymerization GO:0051258 71 0.018
methylation GO:0032259 106 0.018
response to organic cyclic compound GO:0014070 204 0.018
extrinsic apoptotic signaling pathway GO:0097191 119 0.018
regulation of metal ion transport GO:0010959 120 0.018
protein import into nucleus GO:0006606 104 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.018
wnt signaling pathway GO:0016055 156 0.018
blastocyst development GO:0001824 3 0.018
transmembrane transport GO:0055085 399 0.018
circulatory system development GO:0072359 262 0.018
nucleoside catabolic process GO:0009164 408 0.018
cytokine production GO:0001816 247 0.017
negative regulation of chromosome organization GO:2001251 48 0.017
regulation of transmembrane transport GO:0034762 139 0.017
positive regulation of developmental process GO:0051094 314 0.017
cell growth GO:0016049 160 0.017
cardiac muscle cell contraction GO:0086003 4 0.017
negative regulation of developmental process GO:0051093 247 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
dephosphorylation GO:0016311 209 0.017
cell division GO:0051301 168 0.017
anterior posterior axis specification GO:0009948 2 0.017
purine containing compound catabolic process GO:0072523 411 0.017
adult locomotory behavior GO:0008344 1 0.017
actin filament based process GO:0030029 224 0.017
regulation of histone modification GO:0031056 47 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
regulation of cell differentiation GO:0045595 393 0.017
regulation of protein kinase activity GO:0045859 289 0.017
cellular response to abiotic stimulus GO:0071214 117 0.017
nuclear import GO:0051170 106 0.017
organophosphate biosynthetic process GO:0090407 163 0.016
single organism membrane organization GO:0044802 268 0.016
protein k63 linked ubiquitination GO:0070534 31 0.016
regulation of growth GO:0040008 165 0.016
cation transmembrane transport GO:0098655 238 0.016
anterior posterior axis specification embryo GO:0008595 2 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
oocyte differentiation GO:0009994 2 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
chemotaxis GO:0006935 157 0.016
regulation of cell development GO:0060284 161 0.016
organophosphate catabolic process GO:0046434 430 0.016
double strand break repair GO:0006302 101 0.016
positive regulation of immune system process GO:0002684 283 0.016
regulation of ion transport GO:0043269 189 0.016
sensory perception GO:0007600 103 0.016
regulation of protein localization to nucleus GO:1900180 85 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
intrinsic apoptotic signaling pathway GO:0097193 127 0.016
cell cycle checkpoint GO:0000075 117 0.015
organ morphogenesis GO:0009887 147 0.015
maintenance of location GO:0051235 112 0.015
regulation of protein serine threonine kinase activity GO:0071900 179 0.015
organic anion transport GO:0015711 103 0.015
regulation of microtubule cytoskeleton organization GO:0070507 61 0.015
negative regulation of dna metabolic process GO:0051053 57 0.015
negative regulation of cell cycle process GO:0010948 121 0.015
regulation of chromatin modification GO:1903308 51 0.015
single organism reproductive process GO:0044702 98 0.015
Mouse
stem cell division GO:0017145 2 0.015
regulation of locomotion GO:0040012 329 0.015
regulation of membrane potential GO:0042391 95 0.015
ribonucleoside triphosphate catabolic process GO:0009203 391 0.015
regulation of ion transmembrane transport GO:0034765 132 0.015
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
endomembrane system organization GO:0010256 196 0.015
spermatid development GO:0007286 4 0.015
Mouse
atp catabolic process GO:0006200 157 0.015
ossification GO:0001503 121 0.015
ncrna processing GO:0034470 83 0.015
actin mediated cell contraction GO:0070252 12 0.015
histone ubiquitination GO:0016574 31 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
neuroblast proliferation GO:0007405 4 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
striated muscle contraction GO:0006941 52 0.014
response to oxidative stress GO:0006979 121 0.014
regulation of protein import into nucleus GO:0042306 78 0.014
neuromuscular junction development GO:0007528 3 0.014
cell morphogenesis GO:0000902 296 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
actin filament based movement GO:0030048 17 0.014
vasculature development GO:0001944 181 0.014
atp metabolic process GO:0046034 176 0.014
tube closure GO:0060606 3 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
translation GO:0006412 132 0.014
blood vessel development GO:0001568 172 0.014
cellular chemical homeostasis GO:0055082 180 0.014
cell activation GO:0001775 213 0.014
neuron differentiation GO:0030182 138 0.014
neuron projection development GO:0031175 106 0.014
actin cytoskeleton organization GO:0030036 207 0.014
ncrna metabolic process GO:0034660 108 0.014
response to cytokine GO:0034097 232 0.013
regulation of transcription factor import into nucleus GO:0042990 39 0.013
regulation of small gtpase mediated signal transduction GO:0051056 156 0.013
regulation of mitotic cell cycle phase transition GO:1901990 118 0.013
cell cycle phase transition GO:0044770 173 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
response to light stimulus GO:0009416 87 0.013
negative regulation of endopeptidase activity GO:0010951 84 0.013
regulation of protein targeting GO:1903533 91 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
organic acid transport GO:0015849 65 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
cation transport GO:0006812 331 0.013
stem cell differentiation GO:0048863 93 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.013
positive regulation of kinase activity GO:0033674 204 0.013
reproductive process GO:0022414 106 0.013
Mouse
defense response to bacterium GO:0042742 63 0.013
regulation of cell growth GO:0001558 135 0.013
regulation of mapk cascade GO:0043408 262 0.013
primary neural tube formation GO:0014020 3 0.013
blood vessel morphogenesis GO:0048514 162 0.013
nls bearing protein import into nucleus GO:0006607 2 0.013
negative regulation of transport GO:0051051 176 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
regulation of cell motility GO:2000145 299 0.013
muscle contraction GO:0006936 73 0.013
regulation of proteasomal protein catabolic process GO:0061136 87 0.013
peripheral nervous system development GO:0007422 2 0.012
regulation of cell adhesion GO:0030155 166 0.012
nucleus organization GO:0006997 28 0.012
Mouse
regulation of protein catabolic process GO:0042176 155 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
regulation of cellular component movement GO:0051270 334 0.012
spindle elongation GO:0051231 4 0.012
immune system development GO:0002520 195 0.012
regulation of actin filament based process GO:0032970 141 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.012
protein targeting to nucleus GO:0044744 104 0.012
endocytosis GO:0006897 159 0.012
negative regulation of catabolic process GO:0009895 104 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
positive regulation of protein complex assembly GO:0031334 86 0.012
negative regulation of mitotic cell cycle GO:0045930 102 0.012
ion homeostasis GO:0050801 230 0.012
regulation of innate immune response GO:0045088 97 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.012
regulation of immune effector process GO:0002697 91 0.012
protein methylation GO:0006479 74 0.012
biological adhesion GO:0022610 331 0.012
positive regulation of cell cycle GO:0045787 140 0.012
microtubule cytoskeleton organization GO:0000226 176 0.012
angiogenesis GO:0001525 147 0.012
cell fate determination GO:0001709 3 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
regulation of neuron differentiation GO:0045664 70 0.012
positive regulation of wnt signaling pathway GO:0030177 54 0.012
growth GO:0040007 202 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
meiotic chromosome segregation GO:0045132 4 0.012
neuron development GO:0048666 113 0.012
hippocampus development GO:0021766 1 0.012
embryonic epithelial tube formation GO:0001838 4 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
response to bacterium GO:0009617 144 0.011
positive regulation of cytoplasmic transport GO:1903651 82 0.011
macromolecule glycosylation GO:0043413 63 0.011
generation of neurons GO:0048699 152 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
neural tube closure GO:0001843 3 0.011
secretion by cell GO:0032940 226 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
dna damage checkpoint GO:0000077 68 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
negative regulation of apoptotic signaling pathway GO:2001234 97 0.011
positive regulation of protein import into nucleus GO:0042307 46 0.011
regulation of multi organism process GO:0043900 157 0.011
glycoprotein metabolic process GO:0009100 110 0.011
sequestering of metal ion GO:0051238 24 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
compound eye development GO:0048749 1 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
protein localization to membrane GO:0072657 160 0.011
response to inorganic substance GO:0010035 127 0.011
response to wounding GO:0009611 168 0.011
glycoprotein biosynthetic process GO:0009101 91 0.011
positive regulation of growth GO:0045927 58 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.011
limbic system development GO:0021761 3 0.011
hemopoiesis GO:0030097 180 0.011
developmental process involved in reproduction GO:0003006 66 0.011
Mouse
reproductive structure development GO:0048608 55 0.010
positive regulation of cell migration GO:0030335 172 0.010
membrane organization GO:0061024 292 0.010
regulation of neurogenesis GO:0050767 82 0.010
regulation of binding GO:0051098 111 0.010
protein glycosylation GO:0006486 62 0.010
cellular amide metabolic process GO:0043603 69 0.010
associative learning GO:0008306 1 0.010
enzyme linked receptor protein signaling pathway GO:0007167 303 0.010
taxis GO:0042330 157 0.010
regulation of system process GO:0044057 101 0.010
regulation of dna repair GO:0006282 47 0.010
regulation of defense response to bacterium GO:1900424 2 0.010
regulation of protein ubiquitination GO:0031396 95 0.010
positive regulation of transferase activity GO:0051347 227 0.010
ribonucleoside monophosphate catabolic process GO:0009158 158 0.010
negative regulation of immune system process GO:0002683 136 0.010
mitotic cell cycle process GO:1903047 286 0.010
rrna metabolic process GO:0016072 40 0.010
protein oligomerization GO:0051259 173 0.010
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.010
actin filament organization GO:0007015 128 0.010
regulation of ras protein signal transduction GO:0046578 155 0.010
apoptotic mitochondrial changes GO:0008637 57 0.010
rho protein signal transduction GO:0007266 26 0.010

PSME4 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
organ system cancer DOID:0050686 164 0.017
sensory system disease DOID:0050155 203 0.011
nervous system disease DOID:863 431 0.011
disease of metabolism DOID:0014667 295 0.011