Homo sapiens

10 known processes

TOPBP1

topoisomerase (DNA) II binding protein 1

(Aliases: TOP2BP1)

TOPBP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 0.992
dna conformation change GO:0071103 113 0.928
regulation of dna metabolic process GO:0051052 153 0.898
Worm
negative regulation of cell cycle GO:0045786 193 0.895
Fly
meiotic chromosome segregation GO:0045132 4 0.864
g2 dna damage checkpoint GO:0031572 26 0.837
Fly
regulation of mitotic cell cycle GO:0007346 189 0.801
Fly
organelle fission GO:0048285 149 0.781
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.735
dna repair GO:0006281 198 0.727
cell cycle checkpoint GO:0000075 117 0.717
Fly
dna recombination GO:0006310 77 0.698
purine nucleoside monophosphate catabolic process GO:0009128 158 0.656
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.638
Fly
ribonucleoside monophosphate catabolic process GO:0009158 158 0.630
apoptotic signaling pathway GO:0097190 268 0.622
negative regulation of mitotic cell cycle GO:0045930 102 0.585
Fly
negative regulation of cell cycle phase transition GO:1901988 89 0.545
Fly
chromosome segregation GO:0007059 114 0.514
purine nucleoside monophosphate metabolic process GO:0009126 186 0.496
centrosome cycle GO:0007098 32 0.490
nucleoside monophosphate metabolic process GO:0009123 191 0.471
mitotic dna integrity checkpoint GO:0044774 30 0.464
Fly
mitotic cell cycle checkpoint GO:0007093 68 0.458
Fly
intrinsic apoptotic signaling pathway GO:0097193 127 0.455
negative regulation of cell cycle process GO:0010948 121 0.434
Fly
nucleoside triphosphate catabolic process GO:0009143 394 0.431
dna dependent dna replication GO:0006261 44 0.430
nucleoside monophosphate catabolic process GO:0009125 159 0.418
mitotic cell cycle GO:0000278 326 0.398
Fly
regulation of mitotic cell cycle phase transition GO:1901990 118 0.395
Fly
regulation of cellular component biogenesis GO:0044087 281 0.346
mitotic dna replication checkpoint GO:0033314 2 0.313
Fly
mitotic dna damage checkpoint GO:0044773 28 0.305
Fly
atp catabolic process GO:0006200 157 0.302
mitotic cell cycle process GO:1903047 286 0.296
Fly
regulation of cell cycle GO:0051726 393 0.287
Fly
double strand break repair GO:0006302 101 0.277
meiosis i GO:0007127 4 0.270
ribonucleotide catabolic process GO:0009261 405 0.263
nuclear division GO:0000280 128 0.257
post embryonic development GO:0009791 2 0.255
dna damage checkpoint GO:0000077 68 0.245
Fly
regulation of response to dna damage stimulus GO:2001020 94 0.239
ribonucleoside monophosphate metabolic process GO:0009161 187 0.214
regulation of microtubule cytoskeleton organization GO:0070507 61 0.209
regulation of cell cycle phase transition GO:1901987 126 0.200
Fly
blastocyst development GO:0001824 3 0.184
ribonucleoside catabolic process GO:0042454 406 0.181
vesicle mediated transport GO:0016192 371 0.181
regulation of cell division GO:0051302 116 0.177
chromosome condensation GO:0030261 15 0.172
purine nucleotide catabolic process GO:0006195 405 0.166
nucleoside triphosphate metabolic process GO:0009141 422 0.164
cellular macromolecule catabolic process GO:0044265 380 0.160
double strand break repair via homologous recombination GO:0000724 50 0.155
double strand break repair via single strand annealing GO:0045002 4 0.152
regulation of double strand break repair GO:2000779 22 0.148
chromatin modification GO:0016568 298 0.144
cellular amino acid metabolic process GO:0006520 116 0.141
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.139
purine ribonucleoside metabolic process GO:0046128 437 0.138
regulation of dna dependent dna replication GO:0090329 19 0.135
recombinational repair GO:0000725 50 0.131
regulation of dna repair GO:0006282 47 0.126
regulation of microtubule based process GO:0032886 74 0.125
mitotic cell cycle phase transition GO:0044772 162 0.119
Fly
glycosyl compound catabolic process GO:1901658 413 0.119
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.118
negative regulation of cellular protein metabolic process GO:0032269 353 0.112
female gamete generation GO:0007292 2 0.110
regulation of cytoskeleton organization GO:0051493 177 0.109
positive regulation of cellular amine metabolic process GO:0033240 7 0.107
purine nucleoside triphosphate catabolic process GO:0009146 392 0.107
purine nucleoside triphosphate metabolic process GO:0009144 412 0.107
tube development GO:0035295 125 0.105
negative regulation of apoptotic process GO:0043066 316 0.103
negative regulation of dna metabolic process GO:0051053 57 0.099
protein autophosphorylation GO:0046777 123 0.095
embryo development GO:0009790 123 0.095
Worm
negative regulation of programmed cell death GO:0043069 321 0.094
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.093
dna replication GO:0006260 116 0.092
Worm
regulation of meiotic cell cycle GO:0051445 4 0.092
regulation of cellular response to stress GO:0080135 244 0.090
atp metabolic process GO:0046034 176 0.089
nervous system development GO:0007399 293 0.086
purine containing compound catabolic process GO:0072523 411 0.085
brain development GO:0007420 97 0.084
regulation of protein complex assembly GO:0043254 147 0.084
mitotic g2 dna damage checkpoint GO:0007095 7 0.083
Fly
purine ribonucleotide catabolic process GO:0009154 404 0.081
chromatin organization GO:0006325 351 0.079
purine ribonucleoside catabolic process GO:0046130 398 0.076
mitotic g2 m transition checkpoint GO:0044818 9 0.075
Fly
nucleotide catabolic process GO:0009166 408 0.070
amine metabolic process GO:0009308 44 0.069
regulation of cell cycle process GO:0010564 266 0.069
Fly
meiotic nuclear division GO:0007126 10 0.069
centrosome organization GO:0051297 58 0.067
head development GO:0060322 108 0.064
mitotic nuclear division GO:0007067 119 0.063
regulation of intracellular transport GO:0032386 195 0.059
nucleoside phosphate catabolic process GO:1901292 412 0.058
ribonucleoside triphosphate catabolic process GO:0009203 391 0.057
regulation of nuclear division GO:0051783 65 0.057
response to nitrogen compound GO:1901698 184 0.057
microtubule based process GO:0007017 210 0.056
mitotic sister chromatid segregation GO:0000070 53 0.056
reproductive process GO:0022414 106 0.055
negative regulation of catalytic activity GO:0043086 335 0.053
lipid metabolic process GO:0006629 381 0.052
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.052
organophosphate catabolic process GO:0046434 430 0.052
response to organic cyclic compound GO:0014070 204 0.051
growth GO:0040007 202 0.050
regulation of cellular ketone metabolic process GO:0010565 50 0.050
response to abiotic stimulus GO:0009628 336 0.049
response to hormone GO:0009725 175 0.049
embryo development ending in birth or egg hatching GO:0009792 34 0.047
Worm
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.047
response to inorganic substance GO:0010035 127 0.047
meiotic cell cycle GO:0051321 13 0.046
anatomical structure homeostasis GO:0060249 100 0.046
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.045
nucleoside catabolic process GO:0009164 408 0.044
negative regulation of cell death GO:0060548 345 0.044
dna integrity checkpoint GO:0031570 71 0.044
Fly
ribosome assembly GO:0042255 9 0.043
oocyte differentiation GO:0009994 2 0.042
purine nucleoside catabolic process GO:0006152 398 0.041
rna processing GO:0006396 255 0.041
protein modification by small protein conjugation GO:0032446 342 0.040
cell type specific apoptotic process GO:0097285 125 0.040
behavior GO:0007610 112 0.040
cytokinesis completion of separation GO:0007109 3 0.040
cellular response to endogenous stimulus GO:0071495 336 0.040
cellular macromolecular complex assembly GO:0034622 324 0.040
response to ionizing radiation GO:0010212 65 0.039
maintenance of location GO:0051235 112 0.039
regulation of meiosis GO:0040020 3 0.038
mrna catabolic process GO:0006402 56 0.038
intracellular protein transport GO:0006886 270 0.037
cellular component disassembly GO:0022411 92 0.037
peptidyl serine phosphorylation GO:0018105 101 0.037
spindle organization GO:0007051 53 0.036
positive regulation of protein transport GO:0051222 135 0.035
dna double strand break processing GO:0000729 10 0.034
cell development GO:0048468 328 0.034
cellular amine metabolic process GO:0044106 41 0.034
negative regulation of protein modification process GO:0031400 200 0.033
secretion GO:0046903 254 0.033
negative regulation of cellular component organization GO:0051129 235 0.033
positive regulation of dna metabolic process GO:0051054 73 0.033
Worm
regulation of protein catabolic process GO:0042176 155 0.031
telomere maintenance GO:0000723 32 0.031
cellular response to ionizing radiation GO:0071479 32 0.030
posttranscriptional regulation of gene expression GO:0010608 213 0.030
positive regulation of phosphorylation GO:0042327 394 0.030
dephosphorylation GO:0016311 209 0.030
regulation of anatomical structure morphogenesis GO:0022603 286 0.030
peptidyl serine modification GO:0018209 106 0.030
regulation of dna replication GO:0006275 68 0.030
Worm
single organism reproductive process GO:0044702 98 0.029
regulation of cell differentiation GO:0045595 393 0.028
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
negative regulation of organelle organization GO:0010639 126 0.028
gene looping GO:0090202 1 0.027
chromatin remodeling GO:0006338 55 0.027
mrna metabolic process GO:0016071 175 0.026
neuron development GO:0048666 113 0.026
cell cycle phase transition GO:0044770 173 0.026
Fly
negative regulation of developmental process GO:0051093 247 0.026
negative regulation of phosphate metabolic process GO:0045936 267 0.026
oogenesis GO:0048477 2 0.026
regulation of intracellular protein transport GO:0033157 123 0.025
sex differentiation GO:0007548 45 0.025
positive regulation of developmental process GO:0051094 314 0.025
regulation of dephosphorylation GO:0035303 96 0.025
negative regulation of dephosphorylation GO:0035305 63 0.025
gene silencing GO:0016458 49 0.024
cellular response to cytokine stimulus GO:0071345 181 0.024
cellular ketone metabolic process GO:0042180 80 0.024
nuclear transcribed mrna catabolic process GO:0000956 48 0.024
regulation of kinase activity GO:0043549 314 0.024
cell division GO:0051301 168 0.023
lymphocyte activation GO:0046649 133 0.023
response to radiation GO:0009314 151 0.023
microtubule organizing center organization GO:0031023 62 0.023
meiotic cell cycle process GO:1903046 8 0.023
regulation of phosphatase activity GO:0010921 81 0.023
g2 m transition of mitotic cell cycle GO:0000086 41 0.023
Fly
cell activation GO:0001775 213 0.022
regulation of protein kinase activity GO:0045859 289 0.022
protein localization to organelle GO:0033365 280 0.022
regulation of mitosis GO:0007088 63 0.022
mrna processing GO:0006397 133 0.022
endocytosis GO:0006897 159 0.021
response to oxidative stress GO:0006979 121 0.021
rna catabolic process GO:0006401 71 0.021
aging GO:0007568 66 0.021
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.021
Fly
microtubule cytoskeleton organization GO:0000226 176 0.021
reproductive system development GO:0061458 56 0.020
neurogenesis GO:0022008 169 0.020
generation of neurons GO:0048699 152 0.019
positive regulation of response to dna damage stimulus GO:2001022 43 0.019
isotype switching GO:0045190 3 0.019
sex determination GO:0007530 3 0.019
mature ribosome assembly GO:0042256 5 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.019
protein oligomerization GO:0051259 173 0.019
oocyte development GO:0048599 1 0.019
nuclear transport GO:0051169 179 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.018
regulation of cellular amine metabolic process GO:0033238 11 0.018
single organism cellular localization GO:1902580 332 0.018
system process GO:0003008 349 0.018
organelle assembly GO:0070925 176 0.018
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
chromosome separation GO:0051304 23 0.017
positive regulation of protein phosphorylation GO:0001934 313 0.017
leukocyte activation GO:0045321 164 0.017
response to oxygen containing compound GO:1901700 369 0.017
reproduction GO:0000003 63 0.017
Worm
central nervous system development GO:0007417 123 0.017
positive regulation of histone methylation GO:0031062 12 0.016
regulation of protein localization to nucleus GO:1900180 85 0.016
negative regulation of protein metabolic process GO:0051248 391 0.016
negative regulation of dna replication GO:0008156 29 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.016
multicellular organismal aging GO:0010259 3 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
positive regulation of kinase activity GO:0033674 204 0.016
nucleotide excision repair GO:0006289 31 0.016
regulation of transferase activity GO:0051338 355 0.016
gonad development GO:0008406 34 0.016
regulation of growth GO:0040008 165 0.016
response to uv GO:0009411 73 0.016
regulation of gene expression epigenetic GO:0040029 73 0.016
regulation of chromosome organization GO:0033044 103 0.016
cellular response to oxygen containing compound GO:1901701 276 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.015
regulation of chromosome segregation GO:0051983 44 0.015
skeletal system development GO:0001501 79 0.015
chordate embryonic development GO:0043009 34 0.015
polynucleotide dephosphorylation GO:0098501 3 0.015
development of primary sexual characteristics GO:0045137 35 0.015
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.015
protein maturation GO:0051604 233 0.014
nuclear import GO:0051170 106 0.014
chemical homeostasis GO:0048878 306 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
response to organonitrogen compound GO:0010243 156 0.014
neuron projection development GO:0031175 106 0.014
positive regulation of intracellular protein transport GO:0090316 76 0.013
blood vessel morphogenesis GO:0048514 162 0.013
metaphase plate congression GO:0051310 18 0.013
regulation of proteolysis GO:0030162 293 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
positive regulation of growth GO:0045927 58 0.013
dna packaging GO:0006323 77 0.013
positive regulation of organelle organization GO:0010638 195 0.013
signal transduction by p53 class mediator GO:0072331 72 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
developmental process involved in reproduction GO:0003006 66 0.012
mitotic recombination GO:0006312 8 0.012
sister chromatid segregation GO:0000819 54 0.012
multicellular organism reproduction GO:0032504 42 0.012
regulation of viral process GO:0050792 103 0.012
non recombinational repair GO:0000726 14 0.012
protein targeting GO:0006605 187 0.012
cardiovascular system development GO:0072358 262 0.012
cell part morphogenesis GO:0032990 137 0.012
cell morphogenesis GO:0000902 296 0.012
reciprocal meiotic recombination GO:0007131 4 0.012
single organism nuclear import GO:1902593 104 0.012
cytoplasmic transport GO:0016482 379 0.012
protein catabolic process GO:0030163 325 0.012
immune system development GO:0002520 195 0.012
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
regulation of dendritic cell chemotaxis GO:2000508 4 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
covalent chromatin modification GO:0016569 254 0.011
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.011
rna interference GO:0016246 4 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.011
leukocyte mediated immunity GO:0002443 59 0.011
snrna modification GO:0040031 1 0.011
protein localization to microtubule cytoskeleton GO:0072698 10 0.011
cerebellum development GO:0021549 2 0.011
stem cell differentiation GO:0048863 93 0.011
protein complex disassembly GO:0043241 52 0.011
microtubule depolymerization GO:0007019 18 0.011
negative regulation of cell cycle g2 m phase transition GO:1902750 10 0.011
Fly
dna hypermethylation GO:0044026 1 0.010
spermatid development GO:0007286 4 0.010
protein ubiquitination GO:0016567 314 0.010
mitotic spindle organization GO:0007052 27 0.010
cellular component morphogenesis GO:0032989 314 0.010
regulation of chromatin assembly GO:0010847 2 0.010

TOPBP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.053
disease of cellular proliferation DOID:14566 174 0.053
organ system cancer DOID:0050686 164 0.053