Homo sapiens

20 known processes

PIKFYVE

phosphoinositide kinase, FYVE finger containing

(Aliases: PIP5K3,PIP5K,FAB1,FLJ37746,MGC40423,CFD,KIAA0981)

PIKFYVE biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.138
glycerolipid metabolic process GO:0046486 107 0.130
Yeast Mouse
phosphatidylinositol metabolic process GO:0046488 53 0.118
Yeast Mouse
lipid metabolic process GO:0006629 381 0.113
Yeast Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.089
maintenance of location GO:0051235 112 0.075
amine metabolic process GO:0009308 44 0.062
vesicle mediated transport GO:0016192 371 0.062
regulation of transferase activity GO:0051338 355 0.058
positive regulation of cellular amine metabolic process GO:0033240 7 0.058
cytoplasmic transport GO:0016482 379 0.056
cellular ketone metabolic process GO:0042180 80 0.055
regulation of cellular amine metabolic process GO:0033238 11 0.055
oogenesis GO:0048477 2 0.053
phospholipid metabolic process GO:0006644 99 0.053
Yeast Mouse
glycerolipid biosynthetic process GO:0045017 51 0.053
positive regulation of transferase activity GO:0051347 227 0.053
cellular lipid metabolic process GO:0044255 303 0.051
Yeast Mouse
cellular macromolecular complex assembly GO:0034622 324 0.050
regulation of cellular ketone metabolic process GO:0010565 50 0.050
small gtpase mediated signal transduction GO:0007264 78 0.050
determination of adult lifespan GO:0008340 2 0.050
nervous system development GO:0007399 293 0.047
Mouse
ras protein signal transduction GO:0007265 73 0.046
organophosphate biosynthetic process GO:0090407 163 0.041
cation transport GO:0006812 331 0.041
chromatin organization GO:0006325 351 0.039
multicellular organismal aging GO:0010259 3 0.039
inner ear morphogenesis GO:0042472 4 0.039
regulation of kinase activity GO:0043549 314 0.038
glycosyl compound catabolic process GO:1901658 413 0.038
cellular protein complex assembly GO:0043623 188 0.036
positive regulation of kinase activity GO:0033674 204 0.036
memory GO:0007613 3 0.036
cellular amino acid metabolic process GO:0006520 116 0.036
biological adhesion GO:0022610 331 0.035
positive regulation of developmental process GO:0051094 314 0.034
oocyte development GO:0048599 1 0.033
microtubule organizing center organization GO:0031023 62 0.033
transmembrane transport GO:0055085 399 0.032
dephosphorylation GO:0016311 209 0.032
lipid modification GO:0030258 84 0.031
Yeast Mouse
female gamete generation GO:0007292 2 0.031
oocyte differentiation GO:0009994 2 0.030
cellular amine metabolic process GO:0044106 41 0.029
phosphatidylinositol biosynthetic process GO:0006661 25 0.029
protein localization to organelle GO:0033365 280 0.029
cell adhesion GO:0007155 325 0.029
glycerophospholipid metabolic process GO:0006650 84 0.029
Yeast Mouse
negative regulation of protein metabolic process GO:0051248 391 0.028
carbohydrate metabolic process GO:0005975 207 0.028
positive regulation of phosphorylation GO:0042327 394 0.028
morphogenesis of embryonic epithelium GO:0016331 4 0.027
chromatin modification GO:0016568 298 0.027
system process GO:0003008 349 0.026
membrane organization GO:0061024 292 0.026
glycerophospholipid biosynthetic process GO:0046474 40 0.026
covalent chromatin modification GO:0016569 254 0.026
phospholipid biosynthetic process GO:0008654 44 0.026
mitotic cell cycle GO:0000278 326 0.025
cellular response to dna damage stimulus GO:0006974 379 0.025
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.025
metal ion transport GO:0030001 272 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.024
single organism cellular localization GO:1902580 332 0.024
negative regulation of transport GO:0051051 176 0.024
dna repair GO:0006281 198 0.024
regulation of cellular component biogenesis GO:0044087 281 0.024
positive regulation of protein phosphorylation GO:0001934 313 0.023
regulation of cell differentiation GO:0045595 393 0.023
neurological system process GO:0050877 163 0.023
mitotic cell cycle process GO:1903047 286 0.023
macromolecule methylation GO:0043414 97 0.023
protein modification by small protein conjugation GO:0032446 342 0.022
ribonucleoside triphosphate catabolic process GO:0009203 391 0.022
inorganic ion transmembrane transport GO:0098660 231 0.022
small molecule biosynthetic process GO:0044283 157 0.022
neuromuscular junction development GO:0007528 3 0.022
nitrogen compound transport GO:0071705 191 0.022
lipid localization GO:0010876 106 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
forelimb morphogenesis GO:0035136 4 0.022
organelle fission GO:0048285 149 0.022
embryonic epithelial tube formation GO:0001838 4 0.021
purine containing compound catabolic process GO:0072523 411 0.021
microtubule based process GO:0007017 210 0.021
reactive oxygen species metabolic process GO:0072593 75 0.021
negative regulation of cell death GO:0060548 345 0.021
spinal cord development GO:0021510 4 0.021
carbohydrate derivative biosynthetic process GO:1901137 207 0.021
negative regulation of apoptotic process GO:0043066 316 0.021
neuron differentiation GO:0030182 138 0.021
secretion GO:0046903 254 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
hindbrain development GO:0030902 3 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
positive regulation of nucleotide metabolic process GO:0045981 230 0.020
nuclear division GO:0000280 128 0.020
nucleotide catabolic process GO:0009166 408 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
negative regulation of phosphate metabolic process GO:0045936 267 0.020
cellular component morphogenesis GO:0032989 314 0.020
Mouse
cation transmembrane transport GO:0098655 238 0.020
metencephalon development GO:0022037 2 0.020
nucleoside catabolic process GO:0009164 408 0.020
intracellular protein transport GO:0006886 270 0.020
spermatid development GO:0007286 4 0.020
protein ubiquitination GO:0016567 314 0.020
response to oxygen containing compound GO:1901700 369 0.020
regulation of growth GO:0040008 165 0.020
negative regulation of multicellular organismal process GO:0051241 317 0.020
negative regulation of protein modification process GO:0031400 200 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
purine ribonucleoside metabolic process GO:0046128 437 0.019
response to other organism GO:0051707 261 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
reactive nitrogen species metabolic process GO:2001057 3 0.019
actin filament based process GO:0030029 224 0.019
chemotaxis GO:0006935 157 0.019
cell morphogenesis GO:0000902 296 0.019
generation of neurons GO:0048699 152 0.019
oxidation reduction process GO:0055114 396 0.018
growth GO:0040007 202 0.018
rna processing GO:0006396 255 0.018
regulation of cell cycle GO:0051726 393 0.018
organelle assembly GO:0070925 176 0.018
spindle elongation GO:0051231 4 0.018
cell projection organization GO:0030030 252 0.018
endosomal transport GO:0016197 129 0.018
nerve development GO:0021675 4 0.018
immune response GO:0006955 307 0.018
cerebellum development GO:0021549 2 0.017
regulation of ion transport GO:0043269 189 0.017
response to growth factor GO:0070848 205 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.017
morphogenesis of a polarized epithelium GO:0001738 3 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
positive regulation of phagocytosis engulfment GO:0060100 1 0.017
inorganic cation transmembrane transport GO:0098662 194 0.017
nucleoside triphosphate metabolic process GO:0009141 422 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
mapk cascade GO:0000165 288 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
establishment of tissue polarity GO:0007164 3 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
reproductive process GO:0022414 106 0.017
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.017
cell growth GO:0016049 160 0.017
mitotic spindle elongation GO:0000022 4 0.017
regulation of phagocytosis engulfment GO:0060099 2 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
cellular response to abiotic stimulus GO:0071214 117 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
positive regulation of synaptic transmission GO:0050806 4 0.017
microtubule cytoskeleton organization GO:0000226 176 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
rna interference GO:0016246 4 0.016
neuron development GO:0048666 113 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
positive regulation of hydrolase activity GO:0051345 331 0.016
maintenance of protein location GO:0045185 57 0.016
cellular macromolecule catabolic process GO:0044265 380 0.016
maintenance of protein location in cell GO:0032507 56 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
establishment of planar polarity GO:0001736 3 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
regulation of small gtpase mediated signal transduction GO:0051056 156 0.016
response to abiotic stimulus GO:0009628 336 0.016
wnt signaling pathway GO:0016055 156 0.016
regulation of cell cycle process GO:0010564 266 0.016
response to biotic stimulus GO:0009607 276 0.016
ossification GO:0001503 121 0.016
regulation of intracellular transport GO:0032386 195 0.016
segmentation GO:0035282 4 0.016
guanosine containing compound catabolic process GO:1901069 239 0.016
cellular chemical homeostasis GO:0055082 180 0.015
response to external biotic stimulus GO:0043207 261 0.015
cellular protein catabolic process GO:0044257 261 0.015
canonical wnt signaling pathway GO:0060070 116 0.015
endocytosis GO:0006897 159 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
regulation of protein kinase activity GO:0045859 289 0.015
histone modification GO:0016570 251 0.015
regulation of wnt signaling pathway GO:0030111 123 0.015
peptidyl serine modification GO:0018209 106 0.015
mitochondrion organization GO:0007005 156 0.015
positive regulation of transport GO:0051050 336 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
Mouse
g protein coupled receptor signaling pathway GO:0007186 207 0.015
cellular response to organonitrogen compound GO:0071417 124 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
cell division GO:0051301 168 0.015
protein targeting GO:0006605 187 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
cell part morphogenesis GO:0032990 137 0.015
positive regulation of immune system process GO:0002684 283 0.015
positive regulation of organelle organization GO:0010638 195 0.014
protein complex disassembly GO:0043241 52 0.014
protein catabolic process GO:0030163 325 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.014
response to axon injury GO:0048678 1 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
anion transport GO:0006820 161 0.014
centrosome organization GO:0051297 58 0.014
cellular component disassembly GO:0022411 92 0.014
spindle stabilization GO:0043146 4 0.014
mitotic nuclear division GO:0007067 119 0.014
immune system development GO:0002520 195 0.014
organophosphate catabolic process GO:0046434 430 0.014
neuron projection development GO:0031175 106 0.014
cytokine production GO:0001816 247 0.014
hair cell differentiation GO:0035315 2 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
regulation of peptidyl serine phosphorylation GO:0033135 50 0.013
mitotic sister chromatid segregation GO:0000070 53 0.013
lipid biosynthetic process GO:0008610 177 0.013
myosin filament assembly GO:0031034 2 0.013
nuclear transport GO:0051169 179 0.013
retrograde transport endosome to golgi GO:0042147 45 0.013
negative regulation of developmental process GO:0051093 247 0.013
spermatid differentiation GO:0048515 4 0.013
male meiosis GO:0007140 1 0.013
regulation of dna metabolic process GO:0051052 153 0.013
negative regulation of organelle organization GO:0010639 126 0.013
regulation of cell division GO:0051302 116 0.013
circadian behavior GO:0048512 2 0.013
locomotory behavior GO:0007626 1 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
microtubule anchoring GO:0034453 24 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
sister chromatid segregation GO:0000819 54 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
regulation of multi organism process GO:0043900 157 0.013
purine nucleoside triphosphate metabolic process GO:0009144 412 0.013
regulation of mapk cascade GO:0043408 262 0.013
actin cytoskeleton organization GO:0030036 207 0.013
multi organism cellular process GO:0044764 156 0.013
regulation of protein localization GO:0032880 296 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
leukocyte activation GO:0045321 164 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
peptidyl lysine methylation GO:0018022 37 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
taxis GO:0042330 157 0.013
rho protein signal transduction GO:0007266 26 0.013
single organism reproductive process GO:0044702 98 0.013
atp catabolic process GO:0006200 157 0.012
long term memory GO:0007616 2 0.012
protein alkylation GO:0008213 74 0.012
regulation of protein transport GO:0051223 213 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
amide transport GO:0042886 76 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
primary neural tube formation GO:0014020 3 0.012
atp metabolic process GO:0046034 176 0.012
striated muscle myosin thick filament assembly GO:0071688 2 0.012
chemical homeostasis GO:0048878 306 0.012
maintenance of location in cell GO:0051651 62 0.012
regulation of proteolysis GO:0030162 293 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
serotonin uptake GO:0051610 2 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
adult locomotory behavior GO:0008344 1 0.012
response to hormone GO:0009725 175 0.012
mating GO:0007618 1 0.012
peripheral nervous system development GO:0007422 2 0.012
neural tube formation GO:0001841 3 0.012
neural tube closure GO:0001843 3 0.012
embryo development GO:0009790 123 0.012
cellular homeostasis GO:0019725 196 0.012
tube closure GO:0060606 3 0.012
meiosis i GO:0007127 4 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
response to nitrogen compound GO:1901698 184 0.012
motor neuron axon guidance GO:0008045 2 0.012
cardiovascular system development GO:0072358 262 0.012
endomembrane system organization GO:0010256 196 0.012
protein localization to nucleus GO:0034504 136 0.012
regulation of microtubule cytoskeleton organization GO:0070507 61 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
cell activation GO:0001775 213 0.012
regulation of secretion GO:0051046 194 0.011
compound eye development GO:0048749 1 0.011
regulation of chromosome organization GO:0033044 103 0.011
innate immune response GO:0045087 178 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
organic anion transport GO:0015711 103 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
cell projection morphogenesis GO:0048858 129 0.011
regulation of meiosis GO:0040020 3 0.011
blastoderm segmentation GO:0007350 2 0.011
t cell differentiation in thymus GO:0033077 4 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
protein maturation GO:0051604 233 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
mrna metabolic process GO:0016071 175 0.011
glycosylation GO:0070085 71 0.011
regulation of cytokine production GO:0001817 232 0.011
apoptotic signaling pathway GO:0097190 268 0.011
regulation of viral process GO:0050792 103 0.011
chromosome segregation GO:0007059 114 0.011
response to cytokine GO:0034097 232 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
cellular response to epinephrine stimulus GO:0071872 2 0.011
skeletal system development GO:0001501 79 0.011
regeneration GO:0031099 4 0.011
viral process GO:0016032 146 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
protein dephosphorylation GO:0006470 81 0.011
organic acid transport GO:0015849 65 0.011
cell development GO:0048468 328 0.011
regulation of protein complex assembly GO:0043254 147 0.011
interspecies interaction between organisms GO:0044419 156 0.011
regulation of cellular response to stress GO:0080135 244 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
response to fungus GO:0009620 4 0.011
negative regulation of synaptic transmission GO:0050805 2 0.011
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.011
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
neuroblast proliferation GO:0007405 4 0.011
embryonic camera type eye development GO:0031076 2 0.011
protein polymerization GO:0051258 71 0.011
tripartite regional subdivision GO:0007351 2 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
intracellular receptor signaling pathway GO:0030522 104 0.011
blood vessel morphogenesis GO:0048514 162 0.011
serotonin transport GO:0006837 3 0.011
embryonic eye morphogenesis GO:0048048 2 0.010
neurogenesis GO:0022008 169 0.010
response to oxygen levels GO:0070482 100 0.010
embryonic placenta development GO:0001892 1 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.010
glycoprotein metabolic process GO:0009100 110 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
purine containing compound biosynthetic process GO:0072522 88 0.010
regulation of canonical wnt signaling pathway GO:0060828 88 0.010
hemopoiesis GO:0030097 180 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
nucleoside phosphate biosynthetic process GO:1901293 109 0.010
negative regulation of dephosphorylation GO:0035305 63 0.010
regulation of apoptotic signaling pathway GO:2001233 175 0.010
nucleoside monophosphate metabolic process GO:0009123 191 0.010
regulation of secretion by cell GO:1903530 177 0.010

PIKFYVE disease predictions

Disease DO term ID Size Probability Func Analog Org
urinary system disease DOID:18 40 0.021
central nervous system disease DOID:331 186 0.019
nervous system disease DOID:863 431 0.019
cancer DOID:162 167 0.016
disease of cellular proliferation DOID:14566 174 0.016
organ system cancer DOID:0050686 164 0.016
muscular disease DOID:0080000 114 0.014
musculoskeletal system disease DOID:17 223 0.014
sensory system disease DOID:0050155 203 0.013
eye and adnexa disease DOID:1492 150 0.010
eye disease DOID:5614 149 0.010
muscle tissue disease DOID:66 113 0.010